Works matching DE "PROPROTEIN convertases"

Results: 377

Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength.

Published in:

PLoS Biology, 2025, v. 23, n. 5, p. 1, doi. 10.1371/journal.pbio.3003171

By:

Shao, Jiajie;
Liewald, Jana F.;
Steuer Costa, Wagner;
Ruse, Christiane;
Gruber, Jens;
Djamshedzad, Mohammad S.;
Gebhardt, Wulf;
Gottschalk, Alexander

Publication type:

Article

Current perspectives in genetic cardiovascular disorders: from basic to clinical aspects.

Published in:

Heart & Vessels, 2014, v. 29, n. 2, p. 129, doi. 10.1007/s00380-013-0391-5

By:

Kawashiri, Masa-aki;
Hayashi, Kenshi;
Konno, Tetsuo;
Fujino, Noboru;
Ino, Hidekazu;
Yamagishi, Masakazu

Publication type:

Article

Association of Level of Proprotein Convertase Subtilisin/Kexin Type 9 with Intima-Media Thickness in Patients with Familial Hypercholesterolemia.

Published in:

Bulletin of Experimental Biology & Medicine, 2017, v. 163, n. 2, p. 199, doi. 10.1007/s10517-017-3765-3

By:

Benimetskaya, K.;
Ragino, Yu.;
Shakhtshneider, E.;
Makarenkova, K.;
Shchepina, Yu.;
Stakhneva, E.;
Voevoda, M.

Publication type:

Article

PCSK9 in African Americans and Caucasians in Relation to Lp(a) Level, Apo(a) Size and Heritability.

Published in:

Journal of the Endocrine Society, 2020, v. 4, n. 7, p. 1, doi. 10.1210/jendso/bvaa073

By:

Enkhmaa, Byambaa;
Kim, Kyoungmi;
Zhang, Wei;
Prakash, Nishant;
Truax, Kevin;
Anuurad, Erdembileg;
Berglund, Lars

Publication type:

Article

PCSK9 Inhibitors in a Statin-Intolerant Transgender Man With Heterozygous Familial Hypercholesterolemia: A Case Report.

Published in:

2019

By:

Pirazzi, Carlo;
Tavaglione, Federica;
Tivesten, Åsa;
Romeo, Stefano

Publication type:

Case Study

The Effect of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition on Sterol Absorption Markers in a Cohort of Real-World Patients.

Published in:

2019

By:

Brandt, Eric J.;
Benes, Lane B.;
Lee, Linda;
Dayspring, Thomas D.;
Sorrentino, Matthew;
Davidson, Michael

Publication type:

journal article

Proprotein Convertase Subtilisin/Kexin 9 Inhibitors: An Emerging Lipid-Lowering Therapy?

Published in:

Journal of Cardiovascular Pharmacology & Therapeutics, 2015, v. 20, n. 2, p. 157, doi. 10.1177/1074248414539562

By:

Dragan, Simona;
Serban, Maria-Corina;
Banach, Maciej

Publication type:

Article

Bioinformatics analysis of bovine neuropeptides.

Published in:

Journal of Animal Science, 2006, v. 84, p. 168

By:

Tegge, A. N.;
Southey, B. R.;
Andinet, A.;
Sweedler, J. V.;
Rodriguez-Zas, S. L.

Publication type:

Article

Bio-Crystallography IV: Structure-based drug design.

Published in:: 2019
Publication type:: Abstract

FOURIER & PCSK9 RNAi: Towards enhancing durability and efficacy of PCSK9 inhibitors.

Published in:

Global Cardiology Science & Practice, 2017, v. 2017, n. 2, p. 1, doi. 10.21542/gcsp.2017.13

By:

Hassan, Mohamed

Publication type:

Article

The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol.

Published in:

Global Cardiology Science & Practice, 2015, v. 2015, n. 4, p. 1, doi. 10.5339/gcsp.2015.59

By:

Seidah, Nabil G.

Publication type:

Article

OSLER and ODYSSEY LONG TERM: PCSK9 inhibitors on the right track of reducing cardiovascular events.

Published in:

Global Cardiology Science & Practice, 2015, v. 2015, n. 2, p. 1, doi. 10.5339/gcsp.2015.20

By:

Hassan, Mohamed

Publication type:

Article

GAUSS-2, RUTHERFORD-2, LAPLACE-2, DESCARTES, and TESLA Part B: PCSK9 inhibitors gain momentum.

Published in:

Global Cardiology Science & Practice, 2014, v. 2014, n. 4, p. 184, doi. 10.5339/gcsp.2014.49

By:

Hassan, Mohamed;
Yacoub, Magdi

Publication type:

Article

The discovery of PCSK9 inhibitors: A tale of creativity and multifaceted translational research.

Published in:

2013

By:

Elguindy, Ahmed;
Yacoub, Magdi H.

Publication type:

Editorial

Nedostatci sadašnjeg snizivanja LDL kolesterola i uloga inhibitora PCSK9.

Published in:

Cardiologia Croatica, 2016, v. 11, n. 8, p. 330, doi. 10.15836/ccar.2016.330

By:

Rončević, Sanja Matijević;
Gobić, David;
Jurjević, Teodora Zaninović;
Miculinić, Željka Rubeša;
Zaputović, Luka

Publication type:

Article

C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01030

By:

Zhao, Fei;
Afonso, Sara;
Lindner, Susanne;
Hartmann, Andrea;
Löschmann, Ina;
Nilsson, Bo;
Ekdahl, Kristina N.;
Weber, Lutz T.;
Habbig, Sandra;
Schalk, Gesa;
Kirschfink, Michael;
Zipfel, Peter F.;
Skerka, Christine

Publication type:

Article

Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models.

Published in:

Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.01691

By:

Zwarthoff, Seline A.;
Berends, Evelien T. M.;
Mol, Sanne;
Ruyken, Maartje;
Aerts, Piet C.;
Józsi, Mihály;
de Haas, Carla J. C.;
Rooijakkers, Suzan H. M.;
Gorham, Ronald D.

Publication type:

Article

Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases.

Published in:

Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00612

By:

Michels, Marloes A. H. M.;
van de Kar, Nicole C. A. J.;
Okrój, Marcin;
Blom, Anna M.;
van Kraaij, Sanne A. W.;
Volokhina, Elena B.;
van den Heuvel, Lambertus P. W. J.

Publication type:

Article

Adiposity Blunts the Positive Relationship of Thyrotropin with Proprotein Convertase Subtilisin-Kexin Type 9 Levels in Euthyroid Subjects.

Published in:

Thyroid, 2013, v. 23, n. 2, p. 166, doi. 10.1089/thy.2012.0434

By:

Kwakernaak, Arjan J.;
Lambert, Gilles;
Muller Kobold, Anneke C.;
Dullaart, Robin P.F.

Publication type:

Article

Furin as a therapeutic target in cystic fibrosis airways disease.

Published in:

European Respiratory Review, 2023, v. 32, n. 168, p. 1, doi. 10.1183/16000617.0256-2022

By:

Douglas, Lisa E. J.;
Reihill, James A.;
Montgomery, Bethany M.;
Martin, S. Lorraine

Publication type:

Article

Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel.

Published in:

BMC Research Notes, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13104-019-4237-9

By:

Dencker, Magnus;
Björgell, Ola;
Hlebowicz, Joanna

Publication type:

Article

Current and emerging treatments for hypercholesterolemia: A focus on statins and proprotein convertase subtilisin/kexin Type 9 inhibitors for perioperative clinicians.

Published in:

Journal of Anaesthesiology Clinical Pharmacology, 2016, v. 32, n. 4, p. 440, doi. 10.4103/0970-9185.194773

By:

Trentman, Terrence L.;
Avey, Steven G.;
Ramakrishna, Harish

Publication type:

Article

Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9.

Published in:

PEDS: Protein Engineering, Design & Selection, 2015, v. 28, n. 5, p. 117, doi. 10.1093/protein/gzv008

By:

Geschwindner, Stefan;
Andersson, Gunilla M. K.;
Beisel, Hans-Georg;
Breuer, Sebastian;
Hallberg, Carina;
Kihlberg, Britt-Marie;
Lindqvist, Ann-Margret;
O'Mahony, Gavin;
Plowright, Alleyn T.;
Raubacher, Florian;
Knecht, Wolfgang

Publication type:

Article

Engineering of α1-antitrypsin variants with improved specificity for the proprotein convertase furin using site-directed random mutagenesis.

Published in:

PEDS: Protein Engineering, Design & Selection, 2013, v. 26, n. 2, p. 123, doi. 10.1093/protein/gzs091

By:

Hada, Koichiro;
Isshiki, Kinuka;
Matsuda, Shinya;
Yuasa, Keizo;
Tsuji, Akihiko

Publication type:

Article

Role of PCSK9 in the Development of Mouse Periodontitis Before and After Treatment: A Double-Edged Sword.

Published in:

2018

By:

Hua Ling Sun;
Yan Ru Wu;
Fang Fang Song;
Jing Gan;
Li Yuan Huang;
Lu Zhang;
Cui Huang;
Sun, Hua Ling;
Wu, Yan Ru;
Song, Fang Fang;
Gan, Jing;
Huang, Li Yuan;
Zhang, Lu;
Huang, Cui

Publication type:

journal article

Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity.

Published in:

Journal of Infectious Diseases, 2015, v. 211, n. 6, p. 889, doi. 10.1093/infdis/jiu407

By:

Gierer, Stefanie;
Müller, Marcel A.;
Heurich, Adeline;
Ritz, Daniel;
Springstein, Benjamin L.;
Karsten, Christina B.;
Schendzielorz, Alexander;
Gnirß, Kerstin;
Drosten, Christian;
Pöhlmann, Stefan

Publication type:

Article

Inclisiran Lowers LDL-C and PCSK9 Irrespective of Diabetes Status: The ORION-1 Randomized Clinical Trial.

Published in:

2019

By:

Leiter, Lawrence A.;
Hwee Teoh;
Kallend, David;
Wright, R. Scott;
Landmesser, Ulf;
Wijngaard, Peter L. J.;
Kastelein, John J. P.;
Ray, Kausik K.;
Teoh, Hwee

Publication type:

journal article

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors and Incident Type 2 Diabetes: A Systematic Review and Meta-analysis With Over 96,000 Patient-Years.

Published in:

2018

By:

de Carvalho, Luiz Sérgio F.;
Campos, Alessandra M.;
Sposito, Andrei C.

Publication type:

journal article

PCSK9 Is Increased in Youth With Type 1 Diabetes.

Published in:

2017

By:

Levenson, Amy E.;
Wadwa, R. Paul;
Shah, Amy S.;
Khoury, Philip R.;
Kimball, Thomas R.;
Urbina, Elaine M.;
de Ferranti, Sarah D.;
Bishop, Franziska K.;
Maahs, David M.;
Dolan, Lawrence M.;
Biddinger, Sudha B.

Publication type:

Letter

Sudden Fall in the Lipid-Lowering Effect of Evolocumab: The Butler Is Not Always Guilty.

Published in:

2021

By:

Fogacci, Federica;
Borghi, Claudio;
Micoli, Antonio Di;
Cicero, Arrigo F. G.

Publication type:

Case Study

Histopathological characteristics of renal changes in human renin-angiotensinogen double transgenic rats.

Published in:

Journal of Toxicologic Pathology, 2016, v. 29, n. 2, p. 125, doi. 10.1293/tox.2015-0055

By:

Tomoaki Tochitani;
Masaya Mori;
Koichi Matsuda;
Mami Kouchi;
Yuta Fujii;
Izumi Matsumoto

Publication type:

Article

Cellular response to small molecules that selectively stall protein synthesis by the ribosome.

Published in:

PLoS Genetics, 2019, v. 15, n. 3, p. 1, doi. 10.1371/journal.pgen.1008057

By:

Liaud, Nadège;
Horlbeck, Max A.;
Gilbert, Luke A.;
Gjoni, Ketrin;
Weissman, Jonathan S.;
Cate, Jamie H. D.

Publication type:

Article

A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice.

Published in:

Biological Chemistry, 2018, v. 399, n. 12, p. 1363, doi. 10.1515/hsz-2018-0194

By:

Essalmani, Rachid;
Weider, Elodie;
Marcinkiewicz, Jadwiga;
Chamberland, Ann;
Susan-Resiga, Delia;
Roubtsova, Anna;
Seidah, Nabil G.;
Prat, Annik

Publication type:

Article

Cilia-based peptidergic signaling.

Published in:

PLoS Biology, 2019, v. 17, n. 12, p. 1, doi. 10.1371/journal.pbio.3000566

By:

Luxmi, Raj;
Kumar, Dhivya;
Mains, Richard E.;
King, Stephen M.;
Eipper, Betty A.

Publication type:

Article

Efficacy and Safety of the PCSK9 Inhibitor Evolocumab in Patients with Mixed Hyperlipidemia.

Published in:

Cardiovascular Drugs & Therapy, 2016, v. 30, n. 3, p. 305, doi. 10.1007/s10557-016-6666-1

By:

Rosenson, Robert;
Jacobson, Terry;
Preiss, David;
Djedjos, C.;
Dent, Ricardo;
Bridges, Ian;
Miller, Michael

Publication type:

Article

Cardiovascular Safety of Evolocumab: a Systematic Review and Meta-Analysis.

Published in:

2016

By:

Krittanawong, Chayakrit;
Kitai, Takeshi;
Zhang, HongJu;
Sun, Tao

Publication type:

Editorial

Erratum to: Efficacy and Safety of the PCSK9 Inhibitor Evolocumab in Patients with Mixed Hyperlipidemia.

Published in:

2016

By:

Rosenson, Robert;
Jacobson, Terry;
Preiss, David;
Djedjos, Stephen;
Dent, Ricardo;
Bridges, Ian;
Miller, Michael

Publication type:

Erratum

PCSK9: the Critical Role of Familial Hypercholesterolemia from Discovery to Benefit for all.

Published in:

2016

By:

Stein, Evan

Publication type:

Editorial

Clinical Profile of Statin Intolerance in the Phase 3 GAUSS-2 Study.

Published in:

Cardiovascular Drugs & Therapy, 2016, v. 30, n. 3, p. 297, doi. 10.1007/s10557-016-6655-4

By:

Cho, Leslie;
Rocco, Michael;
Colquhoun, David;
Sullivan, David;
Rosenson, Robert;
Dent, Ricardo;
Xue, Allen;
Scott, Rob;
Wasserman, Scott;
Stroes, Erik

Publication type:

Article

PCSK9 Inhibition: Discovery, Current Evidence, and Potential Effects on LDL-C and Lp(a).

Published in:

Cardiovascular Drugs & Therapy, 2015, v. 29, n. 3, p. 295, doi. 10.1007/s10557-015-6588-3

By:

Ferdinand, Keith;
Nasser, Samar

Publication type:

Article

Discovery of Flavonoids from Scutellaria baicalensis with Inhibitory Activity Against PCSK 9 Expression: Isolation, Synthesis and Their Biological Evaluation.

Published in:

Molecules, 2018, v. 23, n. 2, p. 504, doi. 10.3390/molecules23020504

By:

Nhoek, Piseth;
Chae, Hee-Sung;
Masagalli, Jagadeesh Nagarajappa;
Mailar, Karabasappa;
Pel, Pisey;
Kim, Young-Mi;
Choi, Won Jun;
Chin, Young-Won

Publication type:

Article

Molecular disease presentation in diabetic nephropathy.

Published in:

Nephrology Dialysis Transplantation, 2015, v. 30, p. iv17, doi. 10.1093/ndt/gfv267

By:

Heinzel, Andreas;
Mühlberger, Irmgard;
Stelzer, Gil;
Lancet, Doron;
Oberbauer, Rainer;
Martin, Maria;
Perco, Paul

Publication type:

Article

COPEPTIN IN CKD.

Published in:: Nephrology Dialysis Transplantation, 2014, v. 29, n. suppl_3, p. iii35, doi. 10.1093/ndt/gfu124
Publication type:: Article

Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome.

Published in:

Nephrology Dialysis Transplantation, 2014, v. 29, n. 3, p. 538, doi. 10.1093/ndt/gft439

By:

Liu, Shuman;
Vaziri, Nosratola D.

Publication type:

Article

The association of serum proprotein convertase furin/PCSK3 concentrations with stable coronary artery disease and coroner artery lesion severity.

Published in:

International Journal of Medical Biochemistry, 2024, v. 7, n. 1, p. 18, doi. 10.14744/ijmb.2023.09326

By:

Yucesan, Fulya Balaban;
Orem, Asim;
Orem, Cihan;
Ilter, Abdulselam;
Yaman, Serap Ozer;
Yaman, Huseyin;
Akcan, Buket;
Sen, Tugba Mazlum

Publication type:

Article

Stigmasterol accumulation causes cardiac injury and promotes mortality.

Published in:

Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0245-x

By:

Tao, Caroline;
Shkumatov, Artem A.;
Alexander, Shawn T.;
Ason, Brandon L.;
Zhou, Mingyue

Publication type:

Article

Label-Free Electrochemical Test of Protease Interaction with a Peptide Substrate Modified Gold Electrode.

Published in:

Chemosensors, 2021, v. 9, n. 8, p. 199, doi. 10.3390/chemosensors9080199

By:

Wcisło, Anna;
Małuch, Izabela;
Niedziałkowski, Paweł;
Ossowski, Tadeusz;
Prahl, Adam

Publication type:

Article

What Are the Roles of Proprotein Convertases in the Immune Escape of Tumors?

Published in:

Biomedicines, 2022, v. 10, n. 12, p. 3292, doi. 10.3390/biomedicines10123292

By:

Mehranzadeh, Elham;
Crende, Olatz;
Badiola, Iker;
Garcia-Gallastegi, Patricia

Publication type:

Article

Polymorphisms of rs2483205 and rs562556 in the PCSK9 gene are associated with coronary artery disease and cardiovascular risk factors.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-90975-0

By:

Gai, Min-Tao;
Adi, Dilare;
Chen, Xiao-Cui;
Liu, Fen;
Xie, Xiang;
Yang, Yi-Ning;
Gao, Xiao-Ming;
Ma, Xiang;
Fu, Zhen-Yan;
Ma, Yi-Tong;
Chen, Bang-dang

Publication type:

Article

Endogenous PCSK9 may influence circulating CD45neg/CD34bright and CD45neg/CD34bright/CD146neg cells in patients with type 2 diabetes mellitus.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-88941-x

By:

Tripaldi, Romina;
Lanuti, Paola;
Simeone, Paola Giustina;
Liani, Rossella;
Bologna, Giuseppina;
Ciotti, Sonia;
Simeone, Pasquale;
Di Castelnuovo, Augusto;
Marchisio, Marco;
Cipollone, Francesco;
Santilli, Francesca

Publication type:

Article