Works matching DE "PROGERIN"

Results: 46

Modeling early phenotypes of Parkinson's disease by age-induced midbrain-striatum assembloids.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07273-4

By:

Barmpa, Kyriaki;
Saraiva, Claudia;
Lopez-Pigozzi, Diego;
Gomez-Giro, Gemma;
Gabassi, Elisa;
Spitz, Sarah;
Brandauer, Konstanze;
Rodriguez Gatica, Juan E.;
Antony, Paul;
Robertson, Graham;
Sabahi-Kaviani, Rahman;
Bellapianta, Alessandro;
Papastefanaki, Florentia;
Luttge, Regina;
Kubitscheck, Ulrich;
Salti, Ahmad;
Ertl, Peter;
Bortolozzi, Mario;
Matsas, Rebecca;
Edenhofer, Frank

Publication type:

Article

Mechanotransduction of the vasculature in Hutchinson-Gilford Progeria Syndrome.

Published in:

Frontiers in Physiology, 2024, p. 1, doi. 10.3389/fphys.2024.1464678

By:

Shores, Kevin L.;
Truskey, George A.

Publication type:

Article

Forced expression of mouse progerin attenuates the osteoblast differentiation interrupting β-catenin signal pathway in vitro.

Published in:

Cell & Tissue Research, 2019, v. 375, n. 3, p. 655, doi. 10.1007/s00441-018-2930-y

By:

Tsukune, Naoya;
Naito, Masako;
Ohashi, Akiko;
Ninomiya, Tadashi;
Sato, Shuichi;
Takahashi, Tomihisa

Publication type:

Article

Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-020-01540-w

By:

Kang, So-mi;
Yoon, Min-Ho;
Ahn, Jinsook;
Kim, Ji-Eun;
Kim, So Young;
Kang, Seock Yong;
Joo, Jeongmin;
Park, Soyoung;
Cho, Jung-Hyun;
Woo, Tae-Gyun;
Oh, Ah-Young;
Chung, Kyu Jin;
An, So Yon;
Hwang, Tae Sung;
Lee, Soo Yong;
Kim, Jeong-Su;
Ha, Nam-Chul;
Song, Gyu-Yong;
Park, Bum-Joon

Publication type:

Article

Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson–Gilford Progeria Syndrome.

Published in:

Cells (2073-4409), 2023, v. 12, n. 9, p. 1232, doi. 10.3390/cells12091232

By:

Kang, So-mi;
Seo, Seungwoon;
Song, Eun Ju;
Kweon, Okhee;
Jo, Ah-hyeon;
Park, Soyoung;
Woo, Tae-Gyun;
Kim, Bae-Hoon;
Oh, Goo Taeg;
Park, Bum-Joon

Publication type:

Article

Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3.

Published in:

Cells (2073-4409), 2022, v. 11, n. 23, p. 3918, doi. 10.3390/cells11233918

By:

Bai, Yangqiu;
Liu, Jinying;
Jiang, Xiaoke;
Li, Xiuling;
Zhang, Bingyong;
Luo, Xiaoying

Publication type:

Article

MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients' Cells.

Published in:

Cells (2073-4409), 2022, v. 11, n. 4, p. 610, doi. 10.3390/cells11040610

By:

Harhouri, Karim;
Cau, Pierre;
Casey, Frank;
Guedenon, Koffi Mawuse;
Doubaj, Yassamine;
Van Maldergem, Lionel;
Mejia-Baltodano, Gerardo;
Bartoli, Catherine;
De Sandre-Giovannoli, Annachiara;
Lévy, Nicolas

Publication type:

Article

Impact of Progerin Expression on Adipogenesis in Hutchinson—Gilford Progeria Skin-Derived Precursor Cells.

Published in:

Cells (2073-4409), 2021, v. 10, n. 7, p. 1598, doi. 10.3390/cells10071598

By:

Najdi, Farah;
Krüger, Peter;
Djabali, Karima

Publication type:

Article

ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA.

Published in:

Cells (2073-4409), 2020, v. 9, n. 9, p. 1981, doi. 10.3390/cells9091981

By:

Messner, Moritz;
Ghadge, Santhosh Kumar;
Maurer, Thomas;
Graber, Michael;
Staggl, Simon;
Christine Maier, Sarah;
Pölzl, Gerhard;
Zaruba, Marc-Michael

Publication type:

Article

Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells.

Published in:

Cells (2073-4409), 2020, v. 9, n. 5, p. 1201, doi. 10.3390/cells9051201

By:

Bidault, Guillaume;
Garcia, Marie;
Capeau, Jacqueline;
Morichon, Romain;
Vigouroux, Corinne;
Béréziat, Véronique

Publication type:

Article

Vascular Smooth Muscle Cell-Specific Progerin Expression Provokes Contractile Impairment in a Mouse Model of Hutchinson-Gilford Progeria Syndrome that Is Ameliorated by Nitrite Treatment.

Published in:

Cells (2073-4409), 2020, v. 9, n. 3, p. 656, doi. 10.3390/cells9030656

By:

del Campo, Lara;
Sánchez-López, Amanda;
González-Gómez, Cristina;
Andrés-Manzano, María Jesús;
Dorado, Beatriz;
Andrés, Vicente

Publication type:

Article

Antisense-Based Progerin Downregulation in HGPS-Like Patients' Cells.

Published in:

Cells (2073-4409), 2016, v. 5, n. 3, p. 31, doi. 10.3390/cells5030031

By:

Harhouri, Karim;
Navarro, Claire;
Baquerre, Camille;
Da Silva, Nathalie;
Bartoli, Catherine;
Casey, Frank;
Mawuse, Guedenon Koffi;
Doubaj, Yassamine;
Lévy, Nicolas;
De Sandre-Giovannoli, Annachiara

Publication type:

Article

Neonatal progeria: increased ratio of progerin to lamin A leads to progeria of the newborn.

Published in:

European Journal of Human Genetics, 2012, v. 20, n. 9, p. 933, doi. 10.1038/ejhg.2012.36

By:

Reunert, Janine;
Wentzell, Rüdiger;
Walter, Michael;
Jakubiczka, Sibylle;
Zenker, Martin;
Brune, Thomas;
Rust, Stephan;
Marquardt, Thorsten

Publication type:

Article

Longwave UV Light Induces the Aging-Associated Progerin.

Published in:

Journal of Investigative Dermatology, 2013, v. 133, n. 7, p. 1857, doi. 10.1038/jid.2013.71

By:

Takeuchi, Hirotaka;
Rünger, Thomas M

Publication type:

Article

Inflammation and Fibrosis in Progeria: Organ-Specific Responses in an HGPS Mouse Model.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 17, p. 9323, doi. 10.3390/ijms25179323

By:

Krüger, Peter;
Schroll, Moritz;
Fenzl, Felix;
Lederer, Eva-Maria;
Hartinger, Ramona;
Arnold, Rouven;
Cagla Togan, Deniz;
Guo, Runjia;
Liu, Shiyu;
Petry, Andreas;
Görlach, Agnes;
Djabali, Karima

Publication type:

Article

Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11733, doi. 10.3390/ijms231911733

By:

Camafeita, Emilio;
Jorge, Inmaculada;
Rivera-Torres, José;
Andrés, Vicente;
Vázquez, Jesús

Publication type:

Article

High Body Mass Index is Associated with Elevated Blood Levels of Progerin mRNA.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 8, p. 1976, doi. 10.3390/ijms20081976

By:

Messner, Moritz;
Ghadge, Santhosh Kumar;
Schuetz, Thomas;
Seiringer, Herbert;
Pölzl, Gerhard;
Zaruba, Marc-Michael

Publication type:

Article

iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis.

Published in:

Stem Cell Research & Therapy, 2015, v. 6, n. 1, p. 1, doi. 10.1186/s13287-015-0110-5

By:

Mateos, Jesús;
Landeira-Abia, Arancha;
Fafián-Labora, Juan Antonio;
Fernández-Pernas, Pablo;
Lesende-Rodríguez, Iván;
Fernández-Puente, Patricia;
Fernández-Moreno, Mercedes;
Delmiro, Aitor;
Martín, Miguel A.;
Blanco, Francisco J.;
Arufe, María C.

Publication type:

Article

Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells.

Published in:

Nucleus (1949-1034), 2020, v. 11, n. 1, p. 194, doi. 10.1080/19491034.2020.1802906

By:

Danielsson, Brooke E.;
Tieu, Katie V.;
Bathula, Kranthidhar;
Armiger, Travis J.;
Vellala, Pragna S.;
Taylor, Rebecca E.;
Dahl, Kris Noel;
Conway, Daniel E.

Publication type:

Article

Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells.

Published in:

Nucleus (1949-1034), 2018, v. 9, n. 1, p. 235, doi. 10.1080/19491034.2018.1460185

By:

Cho, Sangkyun;
Abbas, Amal;
Irianto, Jerome;
Ivanovska, Irena L.;
Xia, Yuntao;
Tewari, Manu;
Discher, Dennis E.

Publication type:

Article

Comparing lamin proteins post-translational relative stability using a 2A peptide-based system reveals elevated resistance of progerin to cellular degradation.

Published in:

Nucleus (1949-1034), 2016, v. 7, n. 6, p. 585, doi. 10.1080/19491034.2016.1260803

By:

Wu, Di;
Yates, Phillip A.;
Zhang, Haoyue;
Cao, Kan

Publication type:

Article

Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting.

Published in:

Nucleus (1949-1034), 2014, v. 5, n. 1, p. 1, doi. 10.4161/nucl.28068

By:

Wu, Di;
Flannery, Andrew R;
Cai, Helen;
Ko, Eunae;
Cao, Kan

Publication type:

Article

Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy.

Published in:

PLoS ONE, 2018, v. 13, n. 4, p. 1, doi. 10.1371/journal.pone.0196739

By:

Messner, Moritz;
Ghadge, Santhosh Kumar;
Goetsch, Valentina;
Wimmer, Andreas;
Dörler, Jakob;
Pölzl, Gerhard;
Zaruba, Marc-Michael

Publication type:

Article

New look at the role of progerin in skin aging.

Published in:

Menopausal Review / Przegląd Menopauzalny, 2015, v. 14, n. 1, p. 53, doi. 10.5114/pm.2015.49532

By:

Skoczyńska, Anna;
Budzisz, Elżbieta;
Dana, Agnieszka;
Rotsztejn, Helena

Publication type:

Article

Progerin can induce DNA damage in the absence of global changes in replication or cell proliferation.

Published in:

PLoS ONE, 2024, v. 19, n. 12, p. 1, doi. 10.1371/journal.pone.0315084

By:

Joudeh, Liza A.;
Schuck, P. Logan;
Van, Nina M.;
DiCintio, Alannah J.;
Stewart, Jason A.;
Waldman, Alan S.

Publication type:

Article

Disease pathogenicity in Hutchinson–Gilford progeria syndrome mice: insights from lung-associated alterations.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01165-x

By:

Wang, Jingjing;
Guan, Yuelin;
Wang, Yue;
Tan, Junyi;
Cao, Zhongkai;
Ding, Yuhan;
Gao, Langping;
Fu, Haidong;
Chen, Xiangjun;
Lin, Jianyu;
Shen, Ning;
Fu, Xudong;
Wang, Fangqin;
Mao, Jianhua;
Hu, Lidan

Publication type:

Article

Disease pathogenicity in Hutchinson–Gilford progeria syndrome mice: insights from lung-associated alterations.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01165-x

By:

Wang, Jingjing;
Guan, Yuelin;
Wang, Yue;
Tan, Junyi;
Cao, Zhongkai;
Ding, Yuhan;
Gao, Langping;
Fu, Haidong;
Chen, Xiangjun;
Lin, Jianyu;
Shen, Ning;
Fu, Xudong;
Wang, Fangqin;
Mao, Jianhua;
Hu, Lidan

Publication type:

Article

The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway.

Published in:

GeroScience, 2025, v. 47, n. 3, p. 3849, doi. 10.1007/s11357-024-01501-9

By:

Monterrubio-Ledezma, Feliciano;
Salcido-Gómez, Ashley;
Zavaleta-Vásquez, Tania;
Navarro-García, Fernando;
Cisneros, Bulmaro;
Massieu, Lourdes

Publication type:

Article

Atypical structure of the nuclear membrane, distribution of nuclear pores and lamin B1 in spermatozoa of patients with complete and partial globozoospermia.

Published in:

Frontiers in Genetics, 2024, p. 01, doi. 10.3389/fgene.2024.1427838

By:

Bragina, Elizaveta;
Kurchashova, Svetlana;
Suhomlinova, Marina;
Gasanova, Tatiana;
Ermolaeva, Svetlana;
Sorokina, Tatyana;
Kirs, Eva;
Arifulin, Evgeniy;
Solovova, Olga;
Ryzhkova, Oxana;
Khayat, Sabina;
Andreeva, Marina;
Chernykh, Vyacheslav

Publication type:

Article

One week of exposure to sunlight induces progerin expression in human skin.

Published in:

2017

By:

Lesiak, Aleksandra;
Bednarski, Igor;
Rogowski-Tylman, Michał;
Sobjanek, Michał;
Woźniacka, Anna;
Danilewicz, Marian;
Young, Anthony;
Narbutt, Joanna

Publication type:

Letter to the Editor

Progerin Inhibits the Proliferation and Migration of Melanoma Cells by Regulating the Expression of Paxillin.

Published in:

OncoTargets & Therapy, 2024, v. 17, p. 227, doi. 10.2147/OTT.S442504

By:

Liu, Weixian;
Huang, Xinxian;
Luo, Weizhao;
Liu, Xinguang;
Chen, Weichun

Publication type:

Article

Overexpression of Progerin Results in Impaired Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 2629, doi. 10.2147/OTT.S237016

By:

Hu, Xiao-Ting;
Song, Hao-Chang;
Yu, Hui;
Wu, Zu-Chun;
Liu, Xin-Guang;
Chen, Wei-Chun

Publication type:

Article

Promotion of tumor development in prostate cancer by progerin.

Published in:

Cancer Cell International, 2010, v. 10, p. 47, doi. 10.1186/1475-2867-10-47

By:

Yong Tang;
Yakun Chen;
Hongmei Jiang;
Daotai Nie

Publication type:

Article

Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation.

Published in:

Genes & Environment, 2015, v. 37, n. 1, p. 1, doi. 10.1186/s41021-015-0018-4

By:

Asao Noda;
Shuji Mishima;
Yuko Hirai;
Kanya Hamasaki;
Landes, Reid D.;
Hiroshi Mitani;
Kei Haga;
Tohru Kiyono;
Nori Nakamura;
Yoshiaki Kodama

Publication type:

Article

Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-88325-1

By:

Kang, So-mi;
Yoon, Min-Ho;
Lee, Su-Jin;
Ahn, Jinsook;
Yi, Sang Ah;
Nam, Ki Hong;
Park, Soyoung;
Woo, Tae-Gyun;
Cho, Jung-Hyun;
Lee, Jaecheol;
Ha, Nam-Chul;
Park, Bum-Joon

Publication type:

Article

ESCRT-III controls nuclear envelope deformation induced by progerin.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-75852-6

By:

Arii, Jun;
Maeda, Fumio;
Maruzuru, Yuhei;
Koyanagi, Naoto;
Kato, Akihisa;
Mori, Yasuko;
Kawaguchi, Yasushi

Publication type:

Article

Antisense Oligonucleotide Induction of Progerin in Human Myogenic Cells.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0098306

By:

Luo, Yue-Bei;
Mitrpant, Chalermchai;
Adams, Abbie M.;
Johnsen, Russell D.;
Fletcher, Sue;
Mastaglia, Frank L.;
Wilton, Steve D.

Publication type:

Article

Differential Temporal and Spatial Progerin Expression during Closure of the Ductus Arteriosus in Neonates.

Published in:

PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0023975

By:

Bökenkamp, Regina;
Raz, Vered;
Venema, Andrea;
DeRuiter, Marco C.;
Munsteren, Conny van;
Olive, Michelle;
Nabel, Elizabeth G.;
Groot, Adriana C. Gittenberger-de

Publication type:

Article

Baricitinib and Lonafarnib Synergistically Target Progerin and Inflammation, Improving Lifespan and Health in Progeria Mice.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4849, doi. 10.3390/ijms26104849

By:

Krüger, Peter;
Schroll, Moritz;
Fenzl, Felix Quirin;
Hartinger, Ramona;
Lederer, Eva-Maria;
Görlach, Agnes;
Gordon, Leslie B.;
Cavalcante, Paola;
Iacomino, Nicola;
Rathkolb, Birgit;
Pimentel, Juan Antonio Aguilar;
Östereicher, Manuela;
Spielmann, Nadine;
Wolf, Cordula Maria;
de Angelis, Martin Hrabe;
Djabali, Karima

Publication type:

Article

Progerin mRNA Is Associated with Smoking and Signs of Increased Microvascular Damage in Patients with Diabetic Macular Edema.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 5, p. 2099, doi. 10.3390/ijms26052099

By:

Zaruba, Marc-Michael;
Angermann, Reinhard;
Staggl, Simon;
Jeyakumar, Vivek;
Mair, Sofia;
Stöckl, Victoria;
Neyer, Julia;
Maurer, Thomas;
Ungericht, Maria;
Gavranovic-Novakovic, Jasmina;
Bauer, Axel;
Zehetner, Claus;
Messner, Moritz

Publication type:

Article

Angiopoietin-2: A Therapeutic Target for Vascular Protection in Hutchinson–Gilford Progeria Syndrome.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 24, p. 13537, doi. 10.3390/ijms252413537

By:

Vakili, Sahar;
Cao, Kan

Publication type:

Article

Progerin and Its Role in Accelerated and Natural Aging.

Published in:

Molecular Biology, 2022, v. 56, n. 2, p. 125, doi. 10.1134/S0026893322020091

By:

Mosevitsky, M. I.

Publication type:

Article

Progerin reduces LAP2α-telomere association in Hutchinson-Gilford Progeria.

Published in:

eLife, 2015, p. 1, doi. 10.7554/eLife.07759

By:

Chojnowski, Alexandre;
Peh Fern Ong;
Wong, Esther Sook Miin;
SY. Lim, John;
Mutalif, Rafidah A.;
Navasankari, Raju;
Dutta, Bamaprasad;
Yang, Henry;
Yi Ying Liow;
Siu Kwan Sze;
Boudier, Thomas;
Wright, Graham D.;
Colman, Alan;
Burke, Brian;
Stewart, Colin L.;
Dreesen, Oliver

Publication type:

Article

Author Correction: Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.

Published in:

2021

By:

Kang, So‑mi;
Yoon, Min‑Ho;
Lee, Su‑Jin;
Ahn, Jinsook;
Yi, Sang Ah;
Nam, Ki Hong;
Park, Soyoung;
Woo, Tae‑Gyun;
Cho, Jung‑Hyun;
Lee, Jaecheol;
Ha, Nam‑Chul;
Park, Bum‑Joon

Publication type:

Correction Notice

Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-92631-z

By:

Kychygina, Anna;
Dall'Osto, Marina;
Allen, Joshua A. M.;
Cadoret, Jean-Charles;
Piras, Vincent;
Pickett, Hilda A.;
Crabbe, Laure

Publication type:

Article

Use of Farnesyl Transferase Inhibitors in an Ageing Model in Drosophila.

Published in:

Journal of Developmental Biology, 2023, v. 11, n. 4, p. 40, doi. 10.3390/jdb11040040

By:

Brandt, Annely;
Petrovsky, Roman;
Kriebel, Maria;
Großhans, Jörg

Publication type:

Article