Works matching DE "PRODRUGS"

Results: 1669

Application of photodynamic activation of prodrugs combined with phototherapy in tumor treatment.

Published in:

2025

By:

Du, Yining;
Zhao, Jingyuan;
Li, Shuai;
Yuan, Hong

Publication type:

Abstract

Epigallocatechin Gallate as a Potential Therapeutic Agent in Endometriosis: A Narrative Review.

Published in:

Nutrients, 2025, v. 18, n. 13, p. 2068, doi. 10.3390/nu17132068

By:

Markowska, Anna;
Kojs, Zbigniew;
Antoszczak, Michał;
Markowska, Janina;
Huczyński, Adam

Publication type:

Article

"Non-Classical" Platinum Complexes: A Concise Review.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6270, doi. 10.3390/ijms26136270

By:

Bakalova, Adriana;
Ruseva, Nina;
Cherneva, Emiliya

Publication type:

Article

Single atom engineering for radiotherapy-activated immune agonist prodrugs.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60768-4

By:

Ding, Zexuan;
Yin, Xiaozhe;
Zheng, Yuedan;
Li, Yiyan;
Ge, Huanhuan;
Feng, Jianshu;
Wang, Ziyang;
Qiao, Simiao;
Sun, Qi;
Yu, Fashuo;
Hou, Zhanshan;
Fu, Yang-Xin;
Liu, Zhibo

Publication type:

Article

On‐Membrane Supramolecular Assemblies Serving as Bioorthogonal Gating for Melphalan.

Published in:

Angewandte Chemie, 2025, v. 137, n. 27, p. 1, doi. 10.1002/ange.202502922

By:

Xu, Hanlin;
Yao, Qingxin;
Hu, Xiaoqian;
Zheng, Debin;
Ren, Chao;
Ren, Zhibin;
Gao, Yuan

Publication type:

Article

Pharmacokinetics and Metabolism of Broad-Spectrum Antivirals Remdesivir and Obeldesivir with a Consideration to Metabolite GS-441524: Same, Similar, or Different?

Published in:

Viruses (1999-4915), 2025, v. 17, n. 6, p. 836, doi. 10.3390/v17060836

By:

Babusis, Darius;
Kim, Cynthia;
Yang, Jesse;
Zhao, Xiaofeng;
Geng, Guoju;
Ip, Carmen;
Kozon, Nathan;
Le, Hoa;
Leung, Jennifer;
Pitts, Jared;
Siegel, Dustin S.;
Kalla, Rao;
Murray, Bernard;
Bilello, John P.;
Bannister, Roy;
Mackman, Richard L.;
Subramanian, Raju

Publication type:

Article

Nanoerythrocyte Membrane–Enveloped ROS‐Responsive 5‐Aminolevulinic Acid Prodrug Nanostructures with Robust Atheroprotection.

Published in:

Particle & Particle Systems Characterization, 2020, v. 37, n. 5, p. 1, doi. 10.1002/ppsc.202000021

By:

Maruf, Ali;
Wang, Yi;
Luo, Li;
Zhong, Yuan;
Nurhidayah, Deti;
Liu, Boyan;
Tang, Dan;
Rouf, Muhammad Abdul;
Zhang, Haijun;
Yin, Yuxia;
Wu, Wei;
Wang, Guixue

Publication type:

Article

Drug‐Conjugation Induced Self‐Assembly of Feather Keratin‐Based Prodrug for Tumor Intracellular Reduction Triggered Drug Delivery.

Published in:

Particle & Particle Systems Characterization, 2019, v. 36, n. 10, p. N.PAG, doi. 10.1002/ppsc.201900189

By:

Zhang, Huifang;
Liu, Peng

Publication type:

Article

Cisplatin-Prodrug-Constructed Liposomes as a Versatile Theranostic Nanoplatform for Bimodal Imaging Guided Combination Cancer Therapy.

Published in:

Advanced Functional Materials, 2016, v. 26, n. 13, p. 2207, doi. 10.1002/adfm.201504899

By:

Feng, Liangzhu;
Gao, Min;
Tao, Danlei;
Chen, Qian;
Wang, Hairong;
Dong, Ziliang;
Chen, Meiwan;
Liu, Zhuang

Publication type:

Article

Self-Assembling Prodrugs by Precise Programming of Molecular Structures that Contribute Distinct Stability, Pharmacokinetics, and Antitumor Efficacy.

Published in:

Advanced Functional Materials, 2015, v. 25, n. 31, p. 4956, doi. 10.1002/adfm.201501953

By:

Wang, Hangxiang;
Xie, Haiyang;
Wang, Jianguo;
Wu, Jiaping;
Ma, Xueji;
Li, Lingling;
Wei, Xuyong;
Ling, Qi;
Song, Penghong;
Zhou, Lin;
Xu, Xiao;
Zheng, Shusen

Publication type:

Article

Contents: (Adv. Funct. Mater. 31/2015).

Published in:: Advanced Functional Materials, 2015, v. 25, n. 31, p. 4923, doi. 10.1002/adfm.201570210
Publication type:: Article

Enzyme Prodrug Therapy Engineered into Biomaterials.

Published in:

Advanced Functional Materials, 2014, v. 24, n. 33, p. 5202, doi. 10.1002/adfm.201304312

By:

Mendes, Ana C.;
Zelikin, Alexander N.

Publication type:

Article

Synthesis and thermal study of the prodrug of oxamniquine.

Published in:

Journal of Thermal Analysis & Calorimetry, 2006, v. 83, n. 2, p. 277, doi. 10.1007/s10973-005-6875-5

By:

Almeida, A;
Ferreira, A;
Crespi, M;
Andrade, Z;
Chung, M

Publication type:

Article

Neuro-oncology biotech industry progress report.

Published in:

Journal of Neuro-Oncology, 2016, v. 128, n. 1, p. 175, doi. 10.1007/s11060-016-2087-z

By:

Chakraborty, Shamik;
Bodhinayake, Imithri;
Chiluwal, Amrit;
Langer, David;
Ruggieri, Rosamaria;
Symons, Marc;
Boockvar, John

Publication type:

Article

Double suicide gene therapy using human neural stem cells against glioblastoma: double safety measures.

Published in:

Journal of Neuro-Oncology, 2014, v. 116, n. 1, p. 49, doi. 10.1007/s11060-013-1264-6

By:

Lee, Ji;
Lee, Do-Hun;
Kim, Hyung;
Choi, Seung-Ah;
Lee, Hong;
Park, Chul-Kee;
Phi, Ji;
Wang, Kyu-Chang;
Kim, Seung;
Kim, Seung-Ki

Publication type:

Article

Concurrent capecitabine and whole-brain radiotherapy for treatment of brain metastases in breast cancer patients.

Published in:

Journal of Neuro-Oncology, 2009, v. 93, n. 3, p. 379

By:

Cyrus Chargari;
Youlia Kirova;
Véronique Diéras;
Pablo Pena;
Francois Campana;
Paul Cottu;
JeanYves Pierga;
Alain Fourquet

Publication type:

Article

Evaluation of NfsA-like nitroreductases from <italic>Neisseria meningitidis</italic> and <italic>Bartonella henselae</italic> for enzyme-prodrug therapy, targeted cellular ablation, and dinitrotoluene bioremediation.

Published in:

Biotechnology Letters, 2018, v. 40, n. 2, p. 359, doi. 10.1007/s10529-017-2472-5

By:

Rich, Michelle H.;
Sharrock, Abigail V.;
Hall, Kelsi R.;
Ackerley, David F.;
MacKichan, Joanna K.

Publication type:

Article

Development of Nitroreductase‐Activatable Fluoroquinolone Prodrugs Exhibiting Attenuated Magnesium Ion Binding.

Published in:

Helvetica Chimica Acta, 2023, v. 106, n. 10, p. 1, doi. 10.1002/hlca.202300100

By:

Zhao, Zhenxiang;
Yadav, Anuj K.;
Weng, Yourong;
Chan, Jefferson

Publication type:

Article

Derivatives of 3′‐Azidothymidine with 6‐Cyanopyridone as Base or as Phosphoramidate Ester and their Antiretroviral Activity.

Published in:

Helvetica Chimica Acta, 2023, v. 106, n. 1, p. 1, doi. 10.1002/hlca.202200157

By:

Han, Jianyang;
Arnold, Jakob;
Pannecouque, Christophe;
Andrei, Graciela;
Snoeck, Robert;
Richert, Clemens

Publication type:

Article

Hydrogen as a Bio‐Orthogonal Trigger for Spatiotemporally Controlled Caged Prodrug Activation.

Published in:

Helvetica Chimica Acta, 2018, v. 101, n. 11, p. N.PAG, doi. 10.1002/hlca.201800134

By:

Herzog, Antoine F.;
Schneider, Elia M.;
Stark, Wendelin J.

Publication type:

Article

A Concise Route to Valacyclovir Hydrochloride.

Published in:

Helvetica Chimica Acta, 2011, v. 94, n. 4, p. 592, doi. 10.1002/hlca.201000303

By:

Vetukuri, Prasada Raju V. N. K. V.;
Vedantham, Ravindra;
Mathad, Vijayavitthal Thippannachar;
Padi, Pratap Reddy;
Ramasamy, Vijaya Anand

Publication type:

Article

Tumor-targeting Salmonella typhimurium, a natural tool for activation of prodrug 6MePdR and their combination therapy in murine melanoma model.

Published in:

Applied Microbiology & Biotechnology, 2013, v. 97, n. 10, p. 4393, doi. 10.1007/s00253-012-4321-8

By:

Chen, Guo;
Tang, Bo;
Yang, Bing-Ya;
Chen, Jian-Xiang;
Zhou, Jia-Hua;
Li, Jia-Huang;
Hua, Zi-Chun

Publication type:

Article

Pharmacologie comparée des fluoropyrimidines orales.

Published in:

Oncologie (Tech Science Press), 2004, v. 6, n. 1, p. 46, doi. 10.1007/s10269-004-0014-y

By:

Milano, G.

Publication type:

Article

Phase I Study of Two Schedules of Oral S-1 in Combination with Fixed Doses of Oxaliplatin and Bevacizumab in Patients with Advanced Solid Tumors.

Published in:

Oncology, 2011, v. 81, n. 2, p. 65, doi. 10.1159/000331010

By:

Chung, Ki Y.;
Saito, Kaku;
Zergebel, Christopher;
Hollywood, Ellen;
Segal, Michal;
Saltz, Leonard B.

Publication type:

Article

Clinical Unmet Needs in Hypoparathyroidism and Current Pipeline Agents.

Published in:

Endocrinology Research & Practice, 2024, v. 28, n. 4, p. 240, doi. 10.5152/erp.2024.516

By:

Cetin, Ecesu;
Pedersen, Brian;
Burak, Mehmet Furkan

Publication type:

Article

Design of an IV Formulation of an Unstable Prodrug Candidate for Prostate Cancer Treatment: Solution Chemistry of N-(glutaryl-hyp-ala-ser-cyclohexylglycyl-gln-ser-leu)-doxorubicin.

Published in:

Drug Development & Industrial Pharmacy, 2006, v. 32, n. 3, p. 327, doi. 10.1080/03639040500518997

By:

Karki, Shyam B.;
Treemaneekarn, Varaporn;
Ostovic, Drazen;
Nerurkar, Maneesh;
Almarsson, Örn

Publication type:

Article

In Vitro Release Studies on Matrix Type Transdermal Drug Delivery Systems of Naltrexone and Its Acetyl Pro drug.

Published in:

Drug Development & Industrial Pharmacy, 2005, v. 31, n. 9, p. 871, doi. 10.1080/03639040500271944

By:

Nalluri, Buchi N.;
Milligan, Caitlin;
Chen, Jianhong;
Crooks, Peter A.;
Stinchcomb, Audra L.

Publication type:

Article

Alginate-Based In Situ Gelling Suspensions and Emulsions Comprising N 4 -Alkyloxycarbonyl Derivatives of Cytosine: Zero-Order Release and Effect of Physicochemical Properties.

Published in:

Drug Development & Industrial Pharmacy, 2005, v. 31, n. 7, p. 667, doi. 10.1080/03639040500216394

By:

Petersson, Karsten;
Larsen, Claus

Publication type:

Article

Ketoprofen 1-Alkylazacycloalkan-2-one Esters as Dermal Prodrugs: In Vivo and In Vitro Evaluations.

Published in:

Drug Development & Industrial Pharmacy, 2003, v. 29, n. 2, p. 181, doi. 10.1081/DDC-120016726

By:

Bonina, Francesco;
Santagati, Natale Alfredo;
Puglia, Carmelo

Publication type:

Article

Synthesis and Evaluation of a Nonsteroidal Anti-inflammatory Polymeric Prodrug for Sustained and Site-Specific Delivery.

Published in:

Drug Development & Industrial Pharmacy, 2001, v. 27, n. 9, p. 959, doi. 10.1081/DDC-100107677

By:

Chandrasekar, M. J. N.;
Ravichandran, M.;
Nanjan, M. J.;
Suresh, B.

Publication type:

Article

Synthesis and Properties of Dextran–Nalidixic Acid Ester as a Colon-Specific Prodrug of Nalidixic Acid.

Published in:

Drug Development & Industrial Pharmacy, 2001, v. 27, n. 4, p. 331, doi. 10.1081/DDC-100103732

By:

Lee, Jeoung Soo;
Jung, Yun Jin;
Doh, Min Ju;
Kim, Young Mi

Publication type:

Article

Activity Profile of Glycolamide Ester Prodrugs of Ibuprofen.

Published in:

Drug Development & Industrial Pharmacy, 2001, v. 27, n. 1, p. 63, doi. 10.1081/DDC-100000129

By:

Bansal, Arvind K.;
Khar, Roop K.;
Dubey, Ratan;
Sharma, Arun K.

Publication type:

Article

Development of Prodrugs for PDT-Based Combination Therapy Using a Singlet-Oxygen-Sensitive Linker and Quantitative Systems Pharmacology.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 12, p. 2198, doi. 10.3390/jcm8122198

By:

Nguyen, Luong;
Li, Mengjie;
Woo, Sukyung;
You, Youngjae

Publication type:

Article

New Drug, Fospropofol Disodium: A Propofol Prodrug.

Published in:

AANA Journal, 2009, v. 77, n. 4, p. 301

By:

Welliver, Mark;
Rugari, Susan M.

Publication type:

Article

Integrated PrEP and STI Services for Transgender Women in Uganda: Qualitative Findings from a Randomized Trial.

Published in:

AIDS & Behavior, 2025, v. 29, n. 1, p. 133, doi. 10.1007/s10461-024-04469-x

By:

Mujugira, Andrew;
Nakyanzi, Agnes;
Bagaya, Monica;
Mugisha, Jackson;
Kamusiime, Brenda;
Nalumansi, Alisaati;
Kasiita, Vicent;
Ssebuliba, Timothy;
Nampewo, Olivia;
Nsubuga, Rogers;
Muwonge, Timothy R.;
Bukenya, Musa;
Gandhi, Monica;
Wyatt, Monique A.;
Ware, Norma C.;
Haberer, Jessica E.

Publication type:

Article

Simultaneous determination of AM80 (tamibarotene) and WJD-A-1 in rat plasma by ultra high-performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.

Published in:

Artificial Cells, Nanomedicine & Biotechnology, 2018, v. 46, p. 1131, doi. 10.1080/21691401.2018.1446443

By:

Leng, Ping;
Yang, Zhao;
Ma, Baohua;
Li, Jing;
Sun, Jialin;
Xie, Yiming;
Sun, Yong

Publication type:

Article

Passive delivery of protein drugs through transdermal route.

Published in:

Artificial Cells, Nanomedicine & Biotechnology, 2018, v. 46, p. 472, doi. 10.1080/21691401.2018.1430695

By:

Chaulagain, Bivek;
Jain, Ankit;
Tiwari, Ankita;
Verma, Amit;
Jain, Sanjay K.

Publication type:

Article

Synthetic Approaches for the Preparation of Phosphoramidate Prodrugs of 2′-Deoxypseudoisocytidine.

Published in:

ChemistryOpen, 2017, v. 6, n. 3, p. 424, doi. 10.1002/open.201700019

By:

Serpi, Michaela;
De Biasi, Roberto;
Pertusati, Fabrizio;
Slusarczyk, MagdalENa;
McGuigan, Christopher

Publication type:

Article

Anti-Inflammatory and Anticoagulant Activities of Synthesized NSAID Prodrug Esters.

Published in:

Scientifica, 2020, p. 1, doi. 10.1155/2020/9817502

By:

Abualhasan, Murad N.;
Al- Masri, Motasem Y.;
Manasara, Rufaida;
Yadak, Lana;
Abu-Hasan, Nael S.

Publication type:

Article

Impact of mycophenolate mofetil (MMF)-related gastrointestinal complications and MMF dose alterations on transplant outcomes and healthcare costs in renal transplant recipients.

Published in:

Clinical Transplantation, 2005, v. 19, n. 6, p. 779, doi. 10.1111/j.1399-0012.2005.00421.x

By:

Tierce, J. C.;
Porterfield-Baxa, J.;
Petrilla, A. A.;
Kilburg, A.;
Ferguson, R. M.

Publication type:

Article

Modular adeno-associated virus (rAAV) vectors used for cellular virus-directed enzyme prodrug therapy.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep03759

By:

Hagen, Sven;
Baumann, Tobias;
Wagner, Hanna J.;
Morath, Volker;
Kaufmann, Beate;
Fischer, Adrian;
Bergmann, Stefan;
Schindler, Patrick;
Arndt, Katja M.;
Müller, Kristian M.

Publication type:

Article

Population Pharmacokinetic Analysis of BMS‐986166, a Novel Selective Sphingosine‐1‐Phosphate‐1 Receptor Modulator, and Exposure‐Response Assessment of Lymphocyte Counts and Heart Rate in Healthy Participants.

Published in:

Clinical Pharmacology in Drug Development, 2021, v. 10, n. 1, p. 8, doi. 10.1002/cpdd.878

By:

Bihorel, Sébastien;
Singhal, Shalabh;
Shevell, Diane;
Sun, Huadong;
Xie, Jenny;
Basdeo, Shenita;
Liu, Ang;
Dutta, Santanu;
Ludwig, Elizabeth;
Huang, Hannah;
Lin, Kuan‐ju;
Fura, Aberra;
Throup, John;
Girgis, Ihab G.

Publication type:

Article

Impact of the Norepinephrine Prodrug Droxidopa on the QTc Interval in Healthy Individuals.

Published in:

Clinical Pharmacology in Drug Development, 2018, v. 7, n. 3, p. 332, doi. 10.1002/cpdd.393

By:

White, William B.;
Hewitt, L. Arthur;
Mehdirad, Ali A.

Publication type:

Article

Effects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies.

Published in:

Clinical Pharmacology in Drug Development, 2016, v. 5, n. 3, p. 170, doi. 10.1002/cpdd.243

By:

Martin, Paul;
Gillen, Michael;
Millson, David;
Oliver, Stuart;
Brealey, Clive;
Surry, Dominic;
Sweeny, David;
Lau, David;
Leese, Philip

Publication type:

Article

Barking up the wrong genome - we are not alone.

Published in:

Journal of Clinical Pharmacy & Therapeutics, 2011, v. 36, n. 2, p. 125, doi. 10.1111/j.1365-2710.2010.01240.x

By:

Li-Wan-Po, A.;
Farndon, P.

Publication type:

Article

In vivo validation of psilacetin as a prodrug yielding modestly lower peripheral psilocin exposure than psilocybin.

Published in:

Frontiers in Psychiatry, 2024, p. 1, doi. 10.3389/fpsyt.2023.1303365

By:

Jones, Nathan T.;
Wagner, Laura;
Pellitteri Hahn, Molly C.;
Scarlett, Cameron O.;
Wenthur, Cody J.

Publication type:

Article

Design, synthesis, and biological assessment of prodrugs for nitroreductase-based HSP90 inhibitor BIIB021: exploring their potential as anticancer agents.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2024, v. 33, n. 1, p. 15, doi. 10.5246/jcps.2024.01.002

By:

Zhengrong Wu;
Qinjian Xie;
Peng Jing;
Tianfeng Zhang;
Jiaxi Han;
Dian He

Publication type:

Article

Tumour endoproteases: the cutting edge of cancer drug delivery?

Published in:

2008

By:

Atkinson, J. M.;
Siller, C. S.;
Gill, J. H.

Publication type:

journal article

FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.

Published in:

2007

By:

Xin, C.;
Ren, S.;
Eberhardt, W.;
Pfeilschifter, J.;
Huwiler, A.

Publication type:

journal article

Antiviral prodrugs – the development of successful prodrug strategies for antiviral chemotherapy.

Published in:

British Journal of Pharmacology, 2006, v. 147, n. 1, p. 1, doi. 10.1038/sj.bjp.0706446

By:

De Clercq, Erik;
Field, Hugh J.

Publication type:

Article