Works matching DE "PROARRHYTHMIA"

Results: 152

Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91911

By:

Grandits, Thomas;
Augustin, Christoph M.;
Haase, Gundolf;
Jost, Norbert;
Mirams, Gary R.;
Niederer, Steven A.;
Plank, Gernot;
Varró, András;
Virág, László;
Jung, Alexander

Publication type:

Article

In silico predictions of drug-induced changes in human cardiac contractility align with experimental recordings.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1500668

By:

Trovato, Cristian;
Longobardi, Stefano;
Passini, Elisa;
Beattie, Kylie A.;
Holmes, Maxx;
Chaudhary, Khuram W.;
Rossman, Eric I.;
Rodriguez, Blanca

Publication type:

Article

The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00649

By:

Bögeholz, Nils;
Schulte, Jan S.;
Kaese, Sven;
Bauer, B. Klemens;
Pauls, Paul;
Dechering, Dirk G.;
Frommeyer, Gerrit;
Goldhaber, Joshua I.;
Kirchhefer, Uwe;
Eckardt, Lars;
Pott, Christian;
Müller, Frank U.

Publication type:

Article

Authors' Response to Braillon's Comment on: "Limited Evidence for Risk Factors for Proarrhythmia and Sudden Cardiac Death in Patients Using Antidepressants: Dutch Consensus on ECG Monitoring".

Published in:

2018

By:

Simoons, Mirjam;
Seldenrijk, Adrie;
Mulder, Hans;
van Roon, Eric;
Bakker, Roberto;
Ruhé, Henricus

Publication type:

Letter

Comment on: "Limited Evidence for Risk Factors for Proarrhythmia and Sudden Cardiac Death in Patients Using Antidepressants: Dutch Consensus on ECG Monitoring".

Published in:

2018

By:

Braillon, Alain

Publication type:

Letter

Evaluation of cardiac pro-arrhythmic risks using the artificial neural network with ToR-ORd in silico model output.

Published in:

Frontiers in Physiology, 2024, p. 1, doi. 10.3389/fphys.2024.1374355

By:

Mahardika T., Nurul Qashri;
Qauli, Ali Ikhsanul;
Marcellinus, Aroli;
Ki Moo Lim

Publication type:

Article

Rhythm control strategies and the role of antiarrhythmic drugs in the management of atrial fibrillation: focus on clinical outcomes.

Published in:

2011

By:

Bunch, T. Jared;
Gersh, Bernard J.

Publication type:

journal article

ICH S7B In Vitro Assays Do Not Address Mechanisms of QTC Prolongation for Peptides and Proteins – Data in Support of Not Needing Dedicated QTC Studies.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 6, p. 1332, doi. 10.1002/cpt.3047

By:

Wu, Wendy W.;
Choe, Moran;
Johannesen, Lars;
Vicente, Jose;
Bende, Girish;
Stockbridge, Norman L.;
Strauss, David G.;
Garnett, Christine

Publication type:

Article

Utility of Normalized TdP Score System in Drug Proarrhythmic Potential Assessment: A Blinded in vitro Study of CiPA Drugs.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 6, p. 1606, doi. 10.1002/cpt.2133

By:

Liu, Tengxian;
Liu, Jiang;
Lu, Hua Rong;
Li, Haiyan;
Gallacher, David J.;
Chaudhary, Khuram;
Wang, Yaning;
Yan, Gan‐Xin

Publication type:

Article

Translational Models and Tools to Reduce Clinical Trials and Improve Regulatory Decision Making for QTc and Proarrhythmia Risk (ICH E14/S7B Updates).

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 2, p. 319, doi. 10.1002/cpt.2137

By:

Strauss, David G.;
Wu, Wendy W.;
Li, Zhihua;
Koerner, John;
Garnett, Christine

Publication type:

Article

In This Issue.

Published in:: Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 11, doi. 10.1002/cpt.1704
Publication type:: Article

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 102, doi. 10.1002/cpt.1647

By:

Li, Zhihua;
Mirams, Gary R.;
Yoshinaga, Takashi;
Ridder, Bradley J.;
Han, Xiaomei;
Chen, Janell E.;
Stockbridge, Norman L.;
Wisialowski, Todd A.;
Damiano, Bruce;
Severi, Stefano;
Morissette, Pierre;
Kowey, Peter R.;
Holbrook, Mark;
Smith, Godfrey;
Rasmusson, Randall L.;
Liu, Michael;
Song, Zhen;
Qu, Zhilin;
Leishman, Derek J.;
Steidl‐Nichols, Jill

Publication type:

Article

Association of atrial fibrillation with lamotrigine: An observational cohort study.

Published in:

Pharmacotherapy, 2025, v. 45, n. 1, p. 20, doi. 10.1002/phar.4633

By:

Kim, Sodam;
Welch, Landon;
Santos, Bertha De Los;
Radwański, Przemysław B.;
Munger, Mark A.;
Kim, Kibum

Publication type:

Article

Uncertainty assessment of proarrhythmia predictions derived from multi-level in silico models.

Published in:

Archives of Toxicology, 2023, v. 97, n. 10, p. 2721, doi. 10.1007/s00204-023-03557-6

By:

Kopańska, Karolina;
Rodríguez-Belenguer, Pablo;
Llopis-Lorente, Jordi;
Trenor, Beatriz;
Saiz, Javier;
Pastor, Manuel

Publication type:

Article

Application of Convolutional Neural Networks Using Action Potential Shape for In-Silico Proarrhythmic Risk Assessment.

Published in:

Biomedicines, 2023, v. 11, n. 2, p. 406, doi. 10.3390/biomedicines11020406

By:

Jeong, Da Un;
Yoo, Yedam;
Marcellinus, Aroli;
Lim, Ki Moo

Publication type:

Article

Minimizing Repolarization-Related Proarrhythmic Risk in Drug Development and Clinical Practice.

Published in:

Drugs, 2010, v. 70, n. 5, p. 573, doi. 10.2165/11535230-000000000-00000

By:

Farkas, Attila S.;
Nattel, Stanley

Publication type:

Article

Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29726-2

By:

Jahed, Zeinab;
Yang, Yang;
Tsai, Ching-Ting;
Foster, Ethan P.;
McGuire, Allister F.;
Yang, Huaxiao;
Liu, Aofei;
Forro, Csaba;
Yan, Zen;
Jiang, Xin;
Zhao, Ming-Tao;
Zhang, Wei;
Li, Xiao;
Li, Thomas;
Pawlosky, Annalisa;
Wu, Joseph C.;
Cui, Bianxiao

Publication type:

Article

Sacubitril Does Not Exert Proarrhythmic Effects in Combination with Different Antiarrhythmic Drugs.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 2, p. 230, doi. 10.3390/ph18020230

By:

Ellermann, Christian;
Mengel, Carlo;
Wolfes, Julian;
Wegner, Felix K.;
Rath, Benjamin;
Köbe, Julia;
Eckardt, Lars;
Frommeyer, Gerrit

Publication type:

Article

The Properties of the Transient Outward, Inward Rectifier and Acetylcholine-Sensitive Potassium Currents in Atrial Myocytes from Dogs in Sinus Rhythm and Experimentally Induced Atrial Fibrillation Dog Models.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 9, p. 1138, doi. 10.3390/ph17091138

By:

Kohajda, Zsófia;
Corici, Claudia;
Kristóf, Attila;
Virág, László;
Husti, Zoltán;
Baczkó, István;
Sághy, László;
Varró, András;
Jost, Norbert

Publication type:

Article

Pharmacological Management of Atrial Fibrillation: One, None, One Hundred Thousand.

Published in:

Cardiology Research & Practice, 2011, p. 1, doi. 10.4061/2011/874802

By:

Lucà, Fabiana;
LaMeir, Mark;
Rao, Carmelo Massimiliano;
Parise, Orlando;
Vasquez, Ludovico;
Carella, Rocco;
Lorusso, Roberto;
Daniela, Benedetto;
Maessen, Jos;
Gensini, Gian Franco;
Gelsomino, Sandro

Publication type:

Article

Atrial Tachycardias Arising from Ablation of Atrial Fibrillation: A Proarrhythmic Bump or an Antiarrhythmic Turn?

Published in:

Cardiology Research & Practice, 2010, p. 1, doi. 10.4061/2010/950763

By:

Shah, Ashok J.;
Jadidi, Amir;
Xingpeng Liu;
Miyazaki, Shinsuke;
Forclaz, Andrei;
Nault, Isabelle;
Rivard, Lena;
Linton, Nick;
Xhaet, Olivier;
Derval, Nicolas;
Sacher, Frederic;
Bordachar, Pierre;
Ritter, Philippe;
Hocini, Meleze;
Jais, Pierre;
Haissaguerre, Michel

Publication type:

Article

Journal Watch.

Published in:: Pharmaceutical Medicine, 2010, v. 24, n. 2, p. 121, doi. 10.1007/BF03256806
Publication type:: Article

Advanced Cardiovascular Toxicity Screening: Integrating Human iPSC-Derived Cardiomyocytes with 2D In Silico Models.

Published in:

Cardiovascular Toxicology, 2025, v. 25, n. 5, p. 790, doi. 10.1007/s12012-025-09987-1

By:

Sinitsyna, Anastasiya;
Berezhnoy, Andrey;
Semidetnov, Ivan;
Naumov, Vadim;
Sergeeva, Tatyana;
Bakumenko, Sergey;
Slotvitsky, Mikhail;
Tsvelaya, Valeriya;
Agladze, Konstantin

Publication type:

Article

Concomitant Treatment with Proton Pump Inhibitors and Cephalosporins Does Not Enhance QT-Associated Proarrhythmia in Isolated Rabbit Hearts.

Published in:

Cardiovascular Toxicology, 2020, v. 20, n. 6, p. 531, doi. 10.1007/s12012-020-09577-3

By:

Wolfes, Julian;
Ellermann, Christian;
Burde, Sophie;
Leitz, Patrick;
Bögeholz, Nils;
Willy, Kevin;
Fehr, Michael;
Eckardt, Lars;
Frommeyer, Gerrit

Publication type:

Article

Proarrhythmic Effect of Acetylcholine-Esterase Inhibitors Used in the Treatment of Alzheimer's Disease: Benefit of Rivastigmine in an Experimental Whole-Heart Model.

Published in:

Cardiovascular Toxicology, 2020, v. 20, n. 2, p. 168, doi. 10.1007/s12012-019-09543-8

By:

Ellermann, Christian;
Coenen, Alix;
Niehues, Philipp;
Leitz, Patrick;
Kochhäuser, Simon;
Dechering, Dirk G.;
Fehr, Michael;
Eckardt, Lars;
Frommeyer, Gerrit

Publication type:

Article

Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators.

Published in:

NPJ Digital Medicine, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s41746-024-01370-8

By:

Dominguez-Gomez, Paula;
Zingaro, Alberto;
Baldo-Canut, Laura;
Balzotti, Caterina;
Darpo, Borje;
Morton, Christopher;
Vázquez, Mariano;
Aguado-Sierra, Jazmin

Publication type:

Article

HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research.

Published in:

NPJ Systems Biology & Applications, 2017, v. 3, n. 1, p. N.PAG, doi. 10.1038/s41540-016-0001-0

By:

Furutani, Kazuharu;
Tsumoto, Kunichika;
Kurachi, Yoshihisa

Publication type:

Article

New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta.

Published in:

Korean Journal of Physiology & Pharmacology, 2023, v. 27, n. 3, p. 267, doi. 10.4196/kjpp.2023.27.3.267

By:

Jin Ryeol An;
Seo-Yeong Mun;
In Kyo Jung;
Kwan Soo Kim;
Chan Hyeok Kwon;
Sun Ok Choi;
Won Sun Park

Publication type:

Article

The use of serum bepridil concentration as a safe rhythm control strategy in patients with atrial tachyarrhythmias

Published in:

Journal of Arrhythmia, 2012, v. 28, n. 3, p. 187, doi. 10.1016/j.joa.2012.02.015

By:

Miura, Seiji;
Sumiyoshi, Masataka;
Tsuchiya, Hiroto;
Maruyama, Masaki;
Seigen, I;
Okai, Iwao;
Masaki, Yoshiyuki;
Okazaki, Shinya;
Inoue, Kenji;
Fujiwara, Yasumasa;
Komatsu, Kaoru;
Hayashi, Hidemori;
Sekita, Gaku;
Tokano, Takashi;
Nakazato, Yuji;
Daida, Hiroyuki

Publication type:

Article

Supraventricular tachycardias in neonates and infants: factors associated with fatal or near-fatal outcome.

Published in:

2021

By:

Környei, László;
Szabó, Andrea;
Róth, György;
Ferenci, Tamás;
Kardos, Attila

Publication type:

journal article

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment.

Published in:

Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.00616

By:

Dutta, Sara;
Chang, Kelly C.;
Beattie, Kylie A.;
Sheng, Jiansong;
Tran, Phu N.;
Wu, Wendy W.;
Wu, Min;
Strauss, David G.;
Colatsky, Thomas;
Li, Zhihua

Publication type:

Article

L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes.

Published in:

PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0168435

By:

Wu, Jianjun;
Wang, Xiangchong;
Chung, Ying Ying;
Koh, Cai Hong;
Liu, Zhenfeng;
Guo, Huicai;
Yuan, Qiang;
Wang, Chuan;
Su, Suwen;
Wei, Heming

Publication type:

Article

Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0166925

By:

Johannesen, Lars;
Vicente, Jose;
Hosseini, Meisam;
Strauss, David G.

Publication type:

Article

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0163619

By:

Vicente, Jose;
Johannesen, Lars;
Hosseini, Meisam;
Mason, Jay W.;
Sager, Philip T.;
Pueyo, Esther;
Strauss, David G.

Publication type:

Article

Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0167348

By:

Yamamoto, Wataru;
Asakura, Keiichi;
Ando, Hiroyuki;
Taniguchi, Tomohiko;
Ojima, Atsuko;
Uda, Takaaki;
Osada, Tomoharu;
Hayashi, Seiji;
Kasai, Chieko;
Miyamoto, Norimasa;
Tashibu, Hiroyuki;
Yoshinaga, Takashi;
Yamazaki, Daiju;
Sugiyama, Atsushi;
Kanda, Yasunari;
Sawada, Kohei;
Sekino, Yuko

Publication type:

Article

P134Regional heterogeneity in cardiac electrophysiological effects from sympathetic nerve stimulation; evidence for cardiotopic sympathetic innervation.

Published in:

2018

By:

Chauhan, R A;
Coote, J H;
Wake, E;
Pongpaopattanakul, P;
Ng, G A

Publication type:

Abstract

Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal.

Published in:

Cardiovascular Research, 2016, v. 109, n. 4, p. 542, doi. 10.1093/cvr/cvw002

By:

Mesubi, Olurotimi O.;
Anderson, Mark E.

Publication type:

Article

P640 New in vitro model for proarrhythmia screening: iks inhibition potentiates the qtc prolonging effect of ikr inhibitors in isolated guinea pig hearts.

Published in:

Cardiovascular Research, 2014, v. 103, n. suppl_1, p. S116, doi. 10.1093/cvr/cvu098.67

By:

Kui, P;
Orosz, SZ;
Sarusi, A;
Cseko, CS;
Forster, T;
Varro, A;
Farkas, A;
Farkas, AS

Publication type:

Article

Anti-KCNQ1 K+ channel autoantibodies increase IKs current and are associated with QT interval shortening in dilated cardiomyopathy.

Published in:

Cardiovascular Research, 2013, v. 98, n. 3, p. 496, doi. 10.1093/cvr/cvt046

By:

Li, Jin;
Seyler, Claudia;
Wiedmann, Felix;
Schmidt, Constanze;
Schweizer, Patrick A.;
Becker, Rüdiger;
Katus, Hugo A.;
Thomas, Dierk

Publication type:

Article

Early prediction of proarrhythmic cardiotoxicity in the drug development process.

Published in:

Cardiovascular Research, 2011, v. 91, n. 1, p. 7, doi. 10.1093/cvr/cvr130

By:

Anyukhovsky, Evgeny P.

Publication type:

Article

Aging Model for Analyzing Drug-Induced Proarrhythmia Risks Using Cardiomyocytes Differentiated from Progeria-Patient-Derived Induced Pluripotent Stem Cells.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 15, p. 11959, doi. 10.3390/ijms241511959

By:

Daily, Neil;
Elson, Julian;
Wakatsuki, Tetsuro

Publication type:

Article

MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8607, doi. 10.3390/ijms23158607

By:

Uddin, Muhammad Erfan;
Eisenmann, Eric D.;
Li, Yang;
Huang, Kevin M.;
Garrison, Dominique A.;
Talebi, Zahra;
Gibson, Alice A.;
Jin, Yan;
Nepal, Mahesh;
Bonilla, Ingrid M.;
Fu, Qiang;
Sun, Xinxin;
Millar, Alec;
Tarasov, Mikhail;
Jay, Christopher E.;
Cui, Xiaoming;
Einolf, Heidi J.;
Pelis, Ryan M.;
Smith, Sakima A.;
Radwański, Przemysław B.

Publication type:

Article

L-Type Ca2+ Channel Responses to Bay K 8644 in Stem Cell-Derived Cardiomyocytes Are Unusually Dependent on Holding Potential and Charge Carrier.

Published in:

Assay & Drug Development Technologies, 2014, v. 12, n. 6, p. 352, doi. 10.1089/adt.2014.596

By:

Ji, Junzhi;
Kang, Jiesheng;
Rampe, David

Publication type:

Article

Impedance-Based Detection of Beating Rhythm and Proarrhythmic Effects of Compounds on Stem Cell-Derived Cardiomyocytes.

Published in:

Assay & Drug Development Technologies, 2011, v. 9, n. 6, p. 589, doi. 10.1089/adt.2011.0396

By:

Malin K.B. Jonsson;
Qing-Dong Wang;
Bruno Becker

Publication type:

Article

Proarrhytmic effect of amiodarone can cause "electrical storm" in patient with ischaemic cardiomyopathy and implantable cardioverter defibrillator.

Published in:

Cardiologia Croatica, 2014, v. 9, n. 5/6, p. 211, doi. 10.15836/ccar.2014.211

By:

Angebrandt, Petra;
Golubić, Karlo;
Šmalcelj, Anton

Publication type:

Article

Transgenic Rabbit Models in Proarrhythmia Research.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.00853

By:

Baczkó, István;
Hornyik, Tibor;
Brunner, Michael;
Koren, Gideon;
Odening, Katja E.

Publication type:

Article

Evaluating cardiac risk: exposure response analysis in early clinical drug development.

Published in:

Drug, Healthcare & Patient Safety, 2018, v. 10, p. 27, doi. 10.2147/DHPS.S133286

By:

Grenier, Julie;
Paglialunga, Sabina;
Morimoto, Bruce H;
Lester, Robert M

Publication type:

Article

The Interaction between Adult Cardiac Fibroblasts and Embryonic Stem Cell-Derived Cardiomyocytes Leads to Proarrhythmic Changes in In Vitro Cocultures.

Published in:

Stem Cells International, 2016, p. 1, doi. 10.1155/2016/2936126

By:

Trieschmann, Jan;
Bettin, Daniel;
Haustein, Moritz;
Köster, Annette;
Molcanyi, Marek;
Halbach, Marcel;
Hanna, Mira;
Fouad, Mariam;
Brockmeier, Konrad;
Hescheler, Jürgen;
Pfannkuche, Kurt;
Hannes, Tobias

Publication type:

Article

Antiarrhythmic drugs part 2: rhythm-control drugs.

Published in:

British Journal of Cardiac Nursing, 2019, v. 14, n. 10, p. 1, doi. 10.12968/bjca.2019.0057

By:

Sampson, Michael

Publication type:

Article

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

Published in:

Cardiovascular Research, 2008, v. 77, n. 3, p. 481, doi. 10.1093/cvr/cvm069

By:

Lin Wu;
Rajamani, Sridharan;
Shryock, John C.;
Hong Li;
Ruskin, Jeremy;
Antzelevitch, Charles;
Belardinelli, Luiz

Publication type:

Article