Works matching DE "PROARRHYTHMIA"

Results: 152

Hydroxychloroquine in COVID-19 Therapy: Protection Versus Proarrhythmia.

Published in:

Journal of Cardiovascular Pharmacology & Therapeutics, 2020, v. 25, n. 6, p. 497, doi. 10.1177/1074248420935740

By:

Stremmel, Christopher;
Kellnar, Antonia;
Massberg, Steffen;
Kääb, Stefan

Publication type:

Article

Utility of the JT Peak Interval and the JT Area in Determining the Proarrhythmic Potential of QT-Shortening Agents.

Published in:

2019

By:

Qiu, Bo;
Wang, Yuhong;
Li, Congxin;
Guo, Huicai;
Xu, Yanfang

Publication type:

journal article

Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91911

By:

Grandits, Thomas;
Augustin, Christoph M.;
Haase, Gundolf;
Jost, Norbert;
Mirams, Gary R.;
Niederer, Steven A.;
Plank, Gernot;
Varró, András;
Virág, László;
Jung, Alexander

Publication type:

Article

Proarrhytmic effect of amiodarone can cause "electrical storm" in patient with ischaemic cardiomyopathy and implantable cardioverter defibrillator.

Published in:

Cardiologia Croatica, 2014, v. 9, n. 5/6, p. 211, doi. 10.15836/ccar.2014.211

By:

Angebrandt, Petra;
Golubić, Karlo;
Šmalcelj, Anton

Publication type:

Article

Assessment of the proarrhythmic effects of repurposed antimalarials for COVID-19 treatment using a comprehensive in vitro proarrhythmia assay (CiPA).

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1220796

By:

Seung-Hyun Yoon;
Hyun-Lee Lee;
Da Un Jeong;
Ki Moo Lim;
Seong-Jun Park;
Ki-Suk Kim

Publication type:

Article

Proarrhythmia associated with antiarrhythmic drugs: a comprehensive disproportionality analysis of the FDA adverse event reporting system.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1170039

By:

Feifei Wang;
Bingfeng Zhou;
Hongwei Sun;
Xinan Wu

Publication type:

Article

The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00649

By:

Bögeholz, Nils;
Schulte, Jan S.;
Kaese, Sven;
Bauer, B. Klemens;
Pauls, Paul;
Dechering, Dirk G.;
Frommeyer, Gerrit;
Goldhaber, Joshua I.;
Kirchhefer, Uwe;
Eckardt, Lars;
Pott, Christian;
Müller, Frank U.

Publication type:

Article

Supraventricular tachycardias in neonates and infants: factors associated with fatal or near-fatal outcome.

Published in:

2021

By:

Környei, László;
Szabó, Andrea;
Róth, György;
Ferenci, Tamás;
Kardos, Attila

Publication type:

journal article

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment.

Published in:

Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.00917

By:

Chang, Kelly C.;
Dutta, Sara;
Mirams, Gary R.;
Beattie, Kylie A.;
Sheng, Jiansong;
Tran, Phu N.;
Min Wu;
Wu, Wendy W.;
Colatsky, Thomas;
Strauss, David G.;
Zhihua Li

Publication type:

Article

In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details.

Published in:

Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.00934

By:

Lee, William;
Windley, Monique J.;
Vandenberg, Jamie I.;
Hill, Adam P.

Publication type:

Article

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment.

Published in:

Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.00616

By:

Dutta, Sara;
Chang, Kelly C.;
Beattie, Kylie A.;
Sheng, Jiansong;
Tran, Phu N.;
Wu, Wendy W.;
Wu, Min;
Strauss, David G.;
Colatsky, Thomas;
Li, Zhihua

Publication type:

Article

Proarrhythmic major adverse cardiac events with donepezil: A systematic review with meta‐analysis.

Published in:

Journal of the American Geriatrics Society, 2024, v. 72, n. 8, p. 2552, doi. 10.1111/jgs.18909

By:

Nham, Tina;
Garcia, Michael Cristian;
Tsang, Kai La Jennifer;
Silva, Jessyca Matos;
Schneider, Tyler;
Deng, Jiawen;
Lohit, Simran;
Mbuagbaw, Lawrence;
Holbrook, Anne

Publication type:

Article

Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study.

Published in:

Theoretical Biology & Medical Modelling, 2013, v. 10, n. 1, p. 1, doi. 10.1186/1742-4682-10-7

By:

Fijorek, Kamil;
Patel, Nikunjkumar;
Klima, Łukasz;
Stolarz-Skrzypek, Katarzyna;
Kawecka-Jaszcz, Kalina;
Polak, Sebastian

Publication type:

Article

Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators.

Published in:

NPJ Digital Medicine, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s41746-024-01370-8

By:

Dominguez-Gomez, Paula;
Zingaro, Alberto;
Baldo-Canut, Laura;
Balzotti, Caterina;
Darpo, Borje;
Morton, Christopher;
Vázquez, Mariano;
Aguado-Sierra, Jazmin

Publication type:

Article

Application of Convolutional Neural Networks Using Action Potential Shape for In-Silico Proarrhythmic Risk Assessment.

Published in:

Biomedicines, 2023, v. 11, n. 2, p. 406, doi. 10.3390/biomedicines11020406

By:

Jeong, Da Un;
Yoo, Yedam;
Marcellinus, Aroli;
Lim, Ki Moo

Publication type:

Article

Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes.

Published in:

Frontiers in Physiology, 2018, p. N.PAG, doi. 10.3389/fphys.2018.01785

By:

Wen, Hairuo;
Zhao, Zhenghang;
Fefelova, Nadezhda;
Xie, Lai-Hua

Publication type:

Article

Journal Watch.

Published in:: Pharmaceutical Medicine, 2010, v. 24, n. 2, p. 121, doi. 10.1007/BF03256806
Publication type:: Article

Transtelephonic ECG Monitoring to Guide Outpatient Antiarrhythmic Drug Therapy in Patients With Non-Permanent Atrial Fibrillation: Efficacy and Safety From a Single-Center Experience.

Published in:

JAFIB: Journal of Atrial Fibrillation, 2019, v. 11, n. 6, p. 1

By:

Klingenheben, Thomas;
Albakri, Aref;
Helms, Thomas M.

Publication type:

Article

Rapid Responses and Mechanism of Action for Low-Dose Bisphenol S on ex Vivo Rat Hearts and Isolated Myocytes: Evidence of Female-Specific Proarrhythmic Effects.

Published in:

Environmental Health Perspectives, 2015, v. 123, n. 6, p. 571, doi. 10.1289/ehp.1408679

By:

Gao, Xiaoqian;
Ma, Jianyong;
Chen, Yamei;
Wang, Hong-Sheng

Publication type:

Article

Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: A Computational Analysis.

Published in:

PLoS Computational Biology, 2013, v. 9, n. 8, p. 1, doi. 10.1371/journal.pcbi.1003202

By:

Heijman, Jordi;
Zaza, Antonio;
Johnson, Daniel M.;
Rudy, Yoram;
Peeters, Ralf L. M.;
Volders, Paul G. A.;
Westra, Ronald L.

Publication type:

Article

Moving beyond the comprehensive in vitro proarrhythmia assay: Use of human‐induced pluripotent stem cell‐derived cardiomyocytes to assess contractile effects associated with drug‐induced structural cardiotoxicity.

Published in:

Journal of Applied Toxicology, 2018, v. 38, n. 9, p. 1166, doi. 10.1002/jat.3611

By:

Yang, Xi;
Papoian, Thomas

Publication type:

Article

New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta.

Published in:

Korean Journal of Physiology & Pharmacology, 2023, v. 27, n. 3, p. 267, doi. 10.4196/kjpp.2023.27.3.267

By:

Jin Ryeol An;
Seo-Yeong Mun;
In Kyo Jung;
Kwan Soo Kim;
Chan Hyeok Kwon;
Sun Ok Choi;
Won Sun Park

Publication type:

Article

Characterizing Spatial Dynamics of Bifurcation to Alternans in Isolated Whole Rabbit Hearts Based on Alternate Pacing.

Published in:

BioMed Research International, 2015, v. 2015, p. 1, doi. 10.1155/2015/170768

By:

Kulkarni, Kanchan;
Visweswaran, Ramjay;
Xiaopeng Zhao;
Tolkacheva, Elena G.

Publication type:

Article

Minimizing Repolarization-Related Proarrhythmic Risk in Drug Development and Clinical Practice.

Published in:

Drugs, 2010, v. 70, n. 5, p. 573, doi. 10.2165/11535230-000000000-00000

By:

Farkas, Attila S.;
Nattel, Stanley

Publication type:

Article

Evaluation of cardiac pro-arrhythmic risks using the artificial neural network with ToR-ORd in silico model output.

Published in:

Frontiers in Physiology, 2024, p. 1, doi. 10.3389/fphys.2024.1374355

By:

Mahardika T., Nurul Qashri;
Qauli, Ali Ikhsanul;
Marcellinus, Aroli;
Ki Moo Lim

Publication type:

Article

Early drug development: assessment of proarrhythmic risk and cardiovascular safety.

Published in:

Expert Review of Clinical Pharmacology, 2016, v. 9, n. 12, p. 1611, doi. 10.1080/17512433.2016.1245142

By:

Lester, Robert M.;
Olbertz, Joy

Publication type:

Article

L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes.

Published in:

PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0168435

By:

Wu, Jianjun;
Wang, Xiangchong;
Chung, Ying Ying;
Koh, Cai Hong;
Liu, Zhenfeng;
Guo, Huicai;
Yuan, Qiang;
Wang, Chuan;
Su, Suwen;
Wei, Heming

Publication type:

Article

Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0166925

By:

Johannesen, Lars;
Vicente, Jose;
Hosseini, Meisam;
Strauss, David G.

Publication type:

Article

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0163619

By:

Vicente, Jose;
Johannesen, Lars;
Hosseini, Meisam;
Mason, Jay W.;
Sager, Philip T.;
Pueyo, Esther;
Strauss, David G.

Publication type:

Article

Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0167348

By:

Yamamoto, Wataru;
Asakura, Keiichi;
Ando, Hiroyuki;
Taniguchi, Tomohiko;
Ojima, Atsuko;
Uda, Takaaki;
Osada, Tomoharu;
Hayashi, Seiji;
Kasai, Chieko;
Miyamoto, Norimasa;
Tashibu, Hiroyuki;
Yoshinaga, Takashi;
Yamazaki, Daiju;
Sugiyama, Atsushi;
Kanda, Yasunari;
Sawada, Kohei;
Sekino, Yuko

Publication type:

Article

How to Prescribe Drugs With an Identified Proarrhythmic Liability.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, n. 3, p. 284, doi. 10.1002/jcph.1551

By:

Thind, Munveer;
Rodriguez, Ignacio;
Kosari, Sam;
Turner, J. Rick

Publication type:

Article

Evaluation of the Effect of 5 QT‐Positive Drugs on the JTpeak Interval — An Analysis of ECGs From the IQ‐CSRC Study.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, n. 1, p. 125, doi. 10.1002/jcph.1502

By:

Darpo, Borje;
Benson, Charles;
Brown, Randy;
Dota, Corina;
Ferber, Georg;
Ferry, Jim;
Jarugula, Venkat;
Keirns, James;
Ortemann‐Renon, Catherine;
Pham, Thuan;
Riley, Steve;
Sarapa, Nenad;
Ticktin, Mark;
Zareba, Wojciech;
Couderc, Jean‐Philippe

Publication type:

Article

The Potential Role of the J‐Tpeak Interval in Proarrhythmic Cardiac Safety: Current State of the Science From the American College of Clinical Pharmacology and the Cardiac Safety Research Consortium.

Published in:

Journal of Clinical Pharmacology, 2019, v. 59, n. 7, p. 909, doi. 10.1002/jcph.1411

By:

Vicente, Jose;
Strauss, David G.;
Upreti, Vijay V.;
Fossler, Michael J.;
Sager, Philip T.;
Noveck, Robert

Publication type:

Article

Methods of Subject‐Specific Heart Rate Corrections.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 8, p. 1020, doi. 10.1002/jcph.1269

By:

Malik, Marek

Publication type:

Article

Individual‐Specific QT Interval Correction for Drugs With Substantial Heart Rate Effect Using Holter ECGs Extracted Over a Wide Range of Heart Rates.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 8, p. 1013, doi. 10.1002/jcph.1258

By:

Panicker, Gopi Krishna;
Kadam, Pramod;
Chakraborty, Saikat;
Kothari, Snehal;
Turner, J. Rick;
Karnad, Dilip R.

Publication type:

Article

Drug‐induced Proarrhythmia and Torsade de Pointes: A Primer for Students and Practitioners of Medicine and Pharmacy.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 8, p. 997, doi. 10.1002/jcph.1129

By:

Turner, J. Rick;
Rodriguez, Ignacio;
Mantovani, Emily;
Gintant, Gary;
Kowey, Peter R.;
Klotzbaugh, Ralph J.;
Prasad, Krishna;
Sager, Philip T.;
Stockbridge, Norman;
Strnadova, Colette;
the Cardiac Safety Research Consortium

Publication type:

Article

Creation of a Knowledge Management System for QT Analyses.

Published in:

Journal of Clinical Pharmacology, 2011, v. 51, n. 7, p. 1035, doi. 10.1177/0091270010378408

By:

Tornøe, Christoffer W.;
Garnett, Christine E.;
Wang, Yaning;
Florian, Jeffry;
Li, Michael;
Gobburu, Jogarao V.

Publication type:

Article

Antiarrhythmic and cardiac electrophysiological effects of SZV-270, a novel compound with combined Class I/B and Class III effects, in rabbits and dogs.

Published in:

Canadian Journal of Physiology & Pharmacology, 2021, v. 99, n. 1, p. 89, doi. 10.1139/cjpp-2020-0412

By:

Varga, Richárd S.;
Hornyik, Tibor;
Husti, Zoltán;
Kohajda, Zsófia;
Krajsovszky, Gábor;
Nagy, Norbert;
Jost, Norbert;
Virág, László;
Tálosi, László;
Mátyus, Péter;
Varró, András;
Baczkó, István

Publication type:

Article

Short-term beat-to-beat variability of the QT interval is increased and correlates with parameters of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy1.

Published in:

Canadian Journal of Physiology & Pharmacology, 2015, v. 93, n. 9, p. 765, doi. 10.1139/cjpp-2014-0526

By:

Orosz, Andrea;
Baczkó, István;
Nagy, Viktória;
Gavallér, Henriette;
Csanády, Miklós;
Forster, Tamás;
Papp, Julius Gy.;
Varró, András;
Lengyel, Csaba;
Sepp, Róbert

Publication type:

Article

Cardiac heterogeneity and drug-provoked arrhythmias.

Published in:

2017

By:

Ravens, U.;
Aalkjaer, C.

Publication type:

Editorial

Impaired epicardial activation-repolarization coupling contributes to the proarrhythmic effects of hypokalaemia and dofetilide in guinea pig ventricles.

Published in:

Acta Physiologica, 2014, v. 211, n. 1, p. 48, doi. 10.1111/apha.12259

By:

Osadchii, O. E.

Publication type:

Article

Uncertainty assessment of proarrhythmia predictions derived from multi-level in silico models.

Published in:

Archives of Toxicology, 2023, v. 97, n. 10, p. 2721, doi. 10.1007/s00204-023-03557-6

By:

Kopańska, Karolina;
Rodríguez-Belenguer, Pablo;
Llopis-Lorente, Jordi;
Trenor, Beatriz;
Saiz, Javier;
Pastor, Manuel

Publication type:

Article

HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research.

Published in:

NPJ Systems Biology & Applications, 2017, v. 3, n. 1, p. N.PAG, doi. 10.1038/s41540-016-0001-0

By:

Furutani, Kazuharu;
Tsumoto, Kunichika;
Kurachi, Yoshihisa

Publication type:

Article

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials.

Published in:

BMC Pharmacology & Toxicology, 2016, v. 17, p. 1, doi. 10.1186/s40360-016-0053-1

By:

Wiśniowska, Barbara;
Tylutki, Zofia;
Wyszogrodzka, Gabriela;
Polak, Sebastian

Publication type:

Article

Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency – Role of physiological and other non‐drug related parameters.

Published in:

Journal of Clinical Pharmacy & Therapeutics, 2022, v. 47, n. 12, p. 2152, doi. 10.1111/jcpt.13762

By:

Wiśniowska, Barbara;
Holbrook, Mark;
Pollard, Christopher;
Polak, Sebastian

Publication type:

Article

Early afterdepolarizations in cardiac action potentials as mixed mode oscillations due to a folded node singularity.

Published in:

PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0209498

By:

Kügler, Philipp;
Erhardt, André H.;
Bulelzai, M. A. K.

Publication type:

Article

Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19.

Published in:

CTS: Clinical & Translational Science, 2021, v. 14, n. 3, p. 1133, doi. 10.1111/cts.13011

By:

Delaunois, Annie;
Abernathy, Matthew;
Anderson, Warren D.;
Beattie, Kylie A.;
Chaudhary, Khuram W.;
Coulot, Julie;
Gryshkova, Vitalina;
Hebeisen, Simon;
Holbrook, Mark;
Kramer, James;
Kuryshev, Yuri;
Leishman, Derek;
Lushbough, Isabel;
Passini, Elisa;
Redfern, Will S.;
Rodriguez, Blanca;
Rossman, Eric I.;
Trovato, Cristian;
Wu, Caiyun;
Valentin, Jean‐Pierre

Publication type:

Article

Rhythm control strategies and the role of antiarrhythmic drugs in the management of atrial fibrillation: focus on clinical outcomes.

Published in:

2011

By:

Bunch, T. Jared;
Gersh, Bernard J.

Publication type:

journal article

Mechanistic Model-Informed Proarrhythmic Risk Assessment of Drugs: Review of the 'CiPA' Initiative and Design of a Prospective Clinical Validation Study.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 1, p. 54, doi. 10.1002/cpt.896

By:

Vicente, Jose;
Zusterzeel, Robbert;
Johannesen, Lars;
Mason, Jay;
Sager, Philip;
Patel, Vikram;
Matta, Murali K.;
Li, Zhihua;
Liu, Jiang;
Garnett, Christine;
Stockbridge, Norman;
Zineh, Issam;
Strauss, David G.

Publication type:

Article

A Quantitative Framework to Evaluate Proarrhythmic Risk in a First-in-Human Study to Support Waiver of a Thorough QT Study.

Published in:

Clinical Pharmacology & Therapeutics, 2015, v. 98, n. 6, p. 630, doi. 10.1002/cpt.204

By:

Nelson, CH;
Wang, L;
Fang, L;
Weng, W;
Cheng, F;
Hepner, M;
Lin, J;
Garnett, C;
Ramanathan, S

Publication type:

Article