Works matching DE "PRESENILINS"

Results: 860

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements.

Published in:

PLoS Biology, 2008, v. 6, n. 10, p. 2314, doi. 10.1371/journal.pbio.0060257

By:

Hemming, Matthew L.;
Elias, Joshua E.;
Gygi, Steven P.;
Selkoe, Dennis J.

Publication type:

Article

Kanuka bush leaves for Alzheimer’s disease: Improved inhibition of β-secretase enzyme, antioxidant capacity and yield of extracts by ultrasound assisted extraction.

Published in:

Food & Bioproducts Processing: Transactions of the Institution of Chemical Engineers Part C, 2021, v. 128, p. 109, doi. 10.1016/j.fbp.2021.04.018

By:

Majid, Hafiz;
Silva, Filipa V. M.

Publication type:

Article

Presenilin genes are downregulated during somitogenesis in the cadmium-induced omphalocele chick model.

Published in:

Pediatric Surgery International, 2012, v. 28, n. 2, p. 129, doi. 10.1007/s00383-011-2994-1

By:

Doi, Takashi;
Fujiwara, Naho;
Puri, Prem;
Bannigan, John;
Thompson, Jennifer

Publication type:

Article

The Circadian Regulation of Presenilin‐2 Gene Expression.

Published in:

Chronobiology International: The Journal of Biological & Medical Rhythm Research, 2006, v. 23, n. 4, p. 747, doi. 10.1080/07420520600827087

By:

Bélanger, Valérie;
Picard, Nathalie;
Cermakian, Nicolas

Publication type:

Article

Abnormal Lipoproteins Trigger Oxidative Stress-Mediated Apoptosis of Renal Cells in LCAT Deficiency.

Published in:

Antioxidants, 2023, v. 12, n. 8, p. 1498, doi. 10.3390/antiox12081498

By:

Gomaraschi, Monica;
Turri, Marta;
Strazzella, Arianna;
Lhomme, Marie;
Pavanello, Chiara;
Le Goff, Wilfried;
Kontush, Anatol;
Calabresi, Laura;
Ossoli, Alice

Publication type:

Article

Anagliptin protects neuronal cells against endogenous amyloid β (Aβ)-induced cytotoxicity and apoptosis.

Published in:

Artificial Cells, Nanomedicine & Biotechnology, 2019, v. 47, n. 1, p. 2213, doi. 10.1080/21691401.2019.1609979

By:

Chen, Zhenbo;
Tao, Shanwei;
Li, Xiaohui;
Zeng, Xudong;
Zhang, Mirong;
Yao, Qinghe

Publication type:

Article

Presenilin-1 Exists in Both Pre- and Post-Golgi Compartments and Recycles Via COPI-Coated Membranes.

Published in:

Traffic, 2003, v. 4, n. 8, p. 553, doi. 10.1034/j.1600-0854.2003.t01-1-00114.x

By:

Réchards, Marloes;
Xia, Weiming;
Oorschot, Viola M. J.;
Selkoe, Dennis J.;
Klumperman, Judith

Publication type:

Article

A comprehensive mini-review on amyloidogenesis of different SARS-CoV-2 proteins and its effect on amyloid formation in various host proteins.

Published in:

3 Biotech, 2022, v. 12, n. 11, p. 1, doi. 10.1007/s13205-022-03390-1

By:

Seth, Prakriti;
Sarkar, Nandini

Publication type:

Article

Alzheimer's disease Inhibitors: Current status and future prospects.

Published in:

International Journal of Pharmacy & Life Sciences, 2014, v. 5, n. 8, p. 3734

By:

Singh, Ankit

Publication type:

Article

Turning the tide on Alzheimer's disease: modulation of γ-secretase.

Published in:

Cell & Bioscience, 2022, v. 12, n. 1, p. 1, doi. 10.1186/s13578-021-00738-7

By:

Luo, Joanna E.;
Li, Yue-Ming

Publication type:

Article

κ-opioid receptor agonist, U50488H, inhibits pyroptosis through NLRP3 via the Ca2+/CaMKII/CREB signaling pathway and improves synaptic plasticity in APP/PS1 mice.

Published in:

Molecular Medicine Reports, 2021, v. 24, n. 1, p. N.PAG, doi. 10.3892/mmr.2021.12168

By:

Song, Xiaofu;
Cui, Zhiqiang;
He, Jiahuan;
Yang, Tuo;
Sun, Xiaohong

Publication type:

Article

Protocatechuic acid attenuates β-secretase activity and okadaic acid-induced autophagy via the Akt/GSK-3β/MEF2D pathway in PC12 cells.

Published in:

Molecular Medicine Reports, 2020, v. 21, n. 3, p. 1328, doi. 10.3892/mmr.2019.10905

By:

Huang, Liping;
Zhong, Xiaoqin;
Qin, Shaochen;
Deng, Minzhen

Publication type:

Article

Ginsenoside Rg1 ameliorates hippocampal long-term potentiation and memory in an Alzheimer's disease model.

Published in:

Molecular Medicine Reports, 2016, v. 13, n. 6, p. 4904, doi. 10.3892/mmr.2016.5103

By:

FENGLING LI;
XIQING WU;
JING LI;
QINGLIANG NIU

Publication type:

Article

Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain-derived neurotrophic factor in APP/PS1 transgenic mice.

Published in:

Molecular Medicine Reports, 2016, v. 13, n. 2, p. 1611, doi. 10.3892/mmr.2015.4751

By:

RUHUI LIN;
JIXIANG CHEN;
XIAOJIE LI;
JINGJIE MAO;
YUNAN WU;
PEIYUAN ZHUO;
YINZHENG ZHANG;
WEILIN LIU;
JIA HUANG;
JING TAO;
LI-DIAN CHEN

Publication type:

Article

Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 4, p. N.PAG, doi. 10.3390/v14040804

By:

Crite, Mac;
DiMaio, Daniel

Publication type:

Article

Mutations in SORL1 and MTHFDL1 possibly contribute to the development of Alzheimer's disease in a multigenerational Colombian Family.

Published in:

PLoS ONE, 2022, v. 17, n. 7, p. 1, doi. 10.1371/journal.pone.0269955

By:

Tejada Moreno, Johanna Alexandra;
Villegas Lanau, Andrés;
Madrigal Zapata, Lucia;
Baena Pineda, Ana Yulied;
Velez Hernandez, Juan;
Campo Nieto, Omer;
Soto Ospina, Alejandro;
Araque Marín, Pedronel;
Rishishwar, Lavanya;
Norris, Emily T.;
Chande, Aroon T.;
Jordan, I. King;
Bedoya Berrio, Gabriel

Publication type:

Article

Discovery of novel benzophenone integrated derivatives as anti-Alzheimer's agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach.

Published in:

PLoS ONE, 2022, v. 17, n. 4, p. 1, doi. 10.1371/journal.pone.0265022

By:

Martiz, Reshma Mary;
Patil, Shashank M.;
Ramu, Ramith;
M. K., Jayanthi;
P., Ashwini;
Ranganatha, Lakshmi V.;
Khanum, Shaukath Ara;
Silina, Ekaterina;
Stupin, Victor;
Achar, Raghu Ram

Publication type:

Article

Ovariectomy exacerbates the disturbance of excitation-inhibition balance in the brain of APP/PS-1/tau mice.

Published in:

Frontiers in Molecular Neuroscience, 2024, p. 1, doi. 10.3389/fnmol.2024.1391082

By:

Fuwang Liu;
Yanman Liu;
Xuri Shen;
Jiarui Du;
Hanting Zhang;
Xueqin Hou

Publication type:

Article

Epigenetic modifications of DNA and RNA in Alzheimer's disease.

Published in:

Frontiers in Molecular Neuroscience, 2024, p. 1, doi. 10.3389/fnmol.2024.1398026

By:

Martinez-Feduchi, Paula;
Peng Jin;
Bing Yao

Publication type:

Article

Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.

Published in:

Nature Biotechnology, 2004, v. 22, n. 6, p. 724, doi. 10.1038/nbt969

By:

Schmitt-Ulms, Gerold;
Hansen, Kirk;
Jialing Liu;
Cowdrey, Cynthia;
Jian Yang;
DeArmond, Stephen J;
Cohen, Fred E;
Prusiner, Stanley B;
Baldwin, Michael A

Publication type:

Article

Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease.

Published in:

Brain Structure & Function, 2011, v. 216, n. 3, p. 227, doi. 10.1007/s00429-011-0305-1

By:

Lemmens, Marijke;
Sierksma, Annerieke;
Rutten, Bart;
Dennissen, Frank;
Steinbusch, Harry;
Lucassen, Paul;
Schmitz, Christoph

Publication type:

Article

Presenilin transgenic mice as models of Alzheimer’s disease.

Published in:

Brain Structure & Function, 2010, v. 214, n. 2/3, p. 127, doi. 10.1007/s00429-009-0227-3

By:

Elder, Gregory;
Gama Sosa, Miguel;
Gasperi, Rita;
Dickstein, Dara;
Hof, Patrick

Publication type:

Article

Systematic Pharmacological Mechanisms of Biatractylolide Treating Vascular Dementia.

Published in:

Indian Journal of Pharmaceutical Sciences, 2022, v. 84, p. 217

By:

BOYANG LIU

Publication type:

Article

Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release.

Published in:

Journal of Neuroscience, 2018, v. 38, n. 4, p. 901, doi. 10.1523/JNEUROSCI.1357-17.2017

By:

Martinez-Mir, Amalia;
Servián-Morilla, Emilia;
Robles-Lanuza, Estefanía;
Sánchez-Eiidalgo, Ana C.;
Camacho-Garcia, Rafael J.;
Paez-Gomez, Juan A.;
Scholl, Francisco G.;
Mavillard, Fabiola;
Saura, Carlos A.

Publication type:

Article

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

Published in:

Journal of Neuroscience, 2017, v. 37, n. 50, p. 12272, doi. 10.1523/JNEUROSCI.1628-17.2017

By:

Tetsuo Cai;
Masahiro Yonaga;
Taisuke Tomita

Publication type:

Article

Synaptic Adhesion Molecule Pcdh-γC5 Mediates Synaptic Dysfunction in Alzheimer's Disease.

Published in:

Journal of Neuroscience, 2017, v. 37, n. 38, p. 9259, doi. 10.1523/JNEUROSCI.1051-17.2017

By:

YanfangLi;
Zhicai Chen;
Yue Gao;
Gaojie Pan;
Honghua Zheng;
Yunwu Zhang;
Huaxi Xu;
Guojun Bu;
Hui Zheng

Publication type:

Article

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 4, p. 1362, doi. 10.1523/JNEUROSCI.5090-14.2016

By:

Aya Tominaga;
Tetsuo Cai;
Shizuka Takagi-Niidome;
Takeshi Iwatsubo;
Taisuke Tomita

Publication type:

Article

Cooperative Roles of Hydrophilic Loop 1 and the C-Terminus of Presenilin 1 in the Substrate-Gating Mechanism of γ-Secretase.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 6, p. 2646, doi. 10.1523/JNEUROSCI.3164-14.2015

By:

Shizuka Takagi-Niidome;
Tomoki Sasaki;
Satoko Osawa;
Takeshi Sato;
Kanan Morishima;
Tetsuo Cai;
Takeshi Iwatsubo;
Taisuke Tomita

Publication type:

Article

Partial Loss of Presenilin Impairs Age-Dependent Neuronal Survival in the Cerebral Cortex.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 48, p. 15912, doi. 10.1523/JNEUROSCI.3261-14.2014

By:

Hirotaka Watanabe;
Iqbal, Minah;
Jin Zheng;
Wines-Samuelson, Mary;
Jie Shen

Publication type:

Article

Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis.

Published in:

British Journal of Cancer, 2013, v. 109, n. 8, p. 2217, doi. 10.1038/bjc.2013.536

By:

Warneke, V S;
Behrens, H-M;
Haag, J;
Krüger, S;
Simon, E;
Mathiak, M;
Ebert, M P A;
Röcken, C

Publication type:

Article

Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegans.

Published in:

BMC Genetics, 2009, v. 10, p. 1, doi. 10.1186/1471-2156-10-14

By:

Gontijo, Alisson M.;
Aubert, Sylvie;
Roelens, Ingele;
Lakowski, Bernard

Publication type:

Article

Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta.

Published in:

BMC Biology, 2016, v. 14, p. 1, doi. 10.1186/s12915-016-0248-3

By:

Kuzuya, Akira;
Zoltowska, Katarzyna M.;
Post, Kathryn L.;
Arimon, Muriel;
Xuejing Li;
Svirsky, Sarah;
Maesako, Masato;
Muzikansky, Alona;
Gautam, Vivek;
Kovacs, Dora;
Hyman, Bradley T.;
Berezovska, Oksana

Publication type:

Article

Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells.

Published in:

Psychogeriatrics, 2006, v. 6, n. 3, p. 107, doi. 10.1111/j.1479-8301.2006.00142.x

By:

Fukumori, Akio;
Jiang, Jingwei;
Tanii, Hisashi;
Morihara, Takashi;
Kamino, Kojin;
Tanaka, Toshihisa;
Kudo, Takashi;
Ito, Naohiro;
Tagami, Shinji;
Okochi, Masayasu;
Takeda, Masatoshi

Publication type:

Article

3D Blockage Mapping for Identifying Familial Point Mutations in Single Amyloid‐β Peptides with a Nanopore.

Published in:

Angewandte Chemie, 2022, v. 134, n. 44, p. 1, doi. 10.1002/ange.202209970

By:

Xin, Kai‐Li;
Hu, Zheng‐Li;
Liu, Shao‐Chuang;
Li, Xin‐Yi;
Li, Jun‐Ge;
Niu, Hongyan;
Ying, Yi‐Lun;
Long, Yi‐Tao

Publication type:

Article

Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset of Resistance Mutations in Kinases*.

Published in:

Angewandte Chemie, 2022, v. 134, n. 28, p. 1, doi. 10.1002/ange.202200983

By:

Shekhar, Mrinal;
Smith, Zachary;
Seeliger, Markus A.;
Tiwary, Pratyush

Publication type:

Article

From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein‐Templated Synthesis.

Published in:

Angewandte Chemie, 2021, v. 133, n. 35, p. 19493, doi. 10.1002/ange.202106295

By:

Nozal, Vanesa;
García‐Rubia, Alfonso;
Cuevas, Eva P.;
Pérez, Concepción;
Tosat‐Bitrián, Carlota;
Bartolomé, Fernando;
Carro, Eva;
Ramírez, David;
Palomo, Valle;
Martínez, Ana

Publication type:

Article

A unifying hypothesis of Alzheimer's disease. III. Risk factors.

Published in:

Human Psychopharmacology: Clinical & Experimental, 2000, v. 15, n. 1, p. 1, doi. 10.1002/(SICI)1099-1077(200001)15:1<1::AID-HUP153>3.0.CO;2-1

By:

Heininger, Kurt

Publication type:

Article

TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity.

Published in:

2006

By:

Fusheng Chen;
Hasegawa, Hiroshi;
Schmitt-Ulms, Gerold;
Kawarai, Toshitaka;
Bohm, Christopher;
Katayama, Taiichi;
Yongjun Gu;
Sanjo, Nobuo;
Glista, Michael;
Rogaeva, Ekaterina;
Wakutani, Yosuke;
Pardossi-Piquard, Raphaëlle;
Xueying Ruan;
Tandon, Anurag;
Checler, Frédéric;
Marambaud, Philippe;
Hansen, Kirk;
Westaway, David;
St. George-Hyslop, Peter;
Fraser, Paul

Publication type:

Letter

Neurobiology: Double trouble for neurons.

Published in:

Nature, 2003, v. 425, n. 6958, p. 565, doi. 10.1038/425565a

By:

Fortini, Mark E.

Publication type:

Article

The Role of Vitamin K in the Development of Neurodegenerative Diseases.

Published in:

Biochemistry (00062979), 2024, v. 89, p. S57, doi. 10.1134/S0006297924140049

By:

Diachenko, Anna I.;
Rodin, Igor A.;
Krasnova, Tatiana N.;
Klychnikov, Oleg I.;
Nefedova, Lidia N.

Publication type:

Article

Presenilin-1 Established ER-Ca<sup>2+</sup> Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, v. 53, n. 3, p. 573, doi. 10.33594/000000158

By:

Klec, Christiane;
Madreiter-Sokolowski, Corina T.;
Ziomek, Gabriela;
Stryeck, Sarah;
Sachdev, Vinay;
Duta-Mare, Madalina;
Gottschalk, Benjamin;
Depaoli, Maria R.;
Rost, Rene;
Hay, Jesse;
Waldeck-Weiermair, Markus;
Kratky, Dagmar;
Madl, Tobias;
Malli, Roland;
Graier, Wolfgang F.

Publication type:

Article

Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca<sup>2+</sup> Leak Directed to Mitochondria in Pancreatic Islets and β-Cells.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, v. 52, n. 1, p. 57, doi. 10.33594/000000005

By:

Klec, Christiane;
Madreiter-Sokolowski, Corina T.;
Stryeck, Sarah;
Sachdev, Vinay;
Duta-Mare, Madalina;
Gottschalk, Benjamin;
Depaoli, Maria R.;
Rost, Rene;
Hay, Jesse;
Waldeck-Weiermair, Markus;
Kratky, Dagmar;
Madl, Tobias;
Malli, Roland;
Graier, Wolfgang F.

Publication type:

Article

Presenilin-1 controls the growth and differentiation of endothelial progenitor cells through its β-catenin-binding region

Published in:

Cell Biology International, 2006, v. 30, n. 3, p. 239, doi. 10.1016/j.cellbi.2005.11.003

By:

Nakajima, Mitsunari;
Ogawa, Minetaro;
Shimoda, Yuri;
Hiraoka, Shuichi;
Iida, Midori;
Koseki, Haruhiko;
Shirasawa, Takuji;
Furukawa, Kiyoshi

Publication type:

Article

Atypical presentation of a novel Presenilin 1 R377W mutation: sporadic, late-onset Alzheimer disease with epilepsy and frontotemporal atrophy.

Published in:

Neurological Sciences, 2012, v. 33, n. 2, p. 375, doi. 10.1007/s10072-011-0714-1

By:

Borroni, Barbara;
Pilotto, Andrea;
Bonvicini, Cristian;
Archetti, Silvana;
Alberici, Antonella;
Lupi, Andrea;
Gennarelli, Massimo;
Padovani, Alessandro

Publication type:

Article

Presenilin-2 gene mutation presenting as Lewy Body dementia?

Published in:

2011

By:

Raciti, Loredana;
Nicoletti, Alessandra;
Pira, Francesco;
Andreoli, Virginia;
Contrafatto, Donatella;
Lanzafame, Salvatore;
Maci, Tiziana;
Gambardella, Antonio;
Quattrone, Aldo;
Zappia, Mario

Publication type:

Letter

Novel MAPT Val75Ala mutation and PSEN2 Arg62Hys in two siblings with frontotemporal dementia.

Published in:

Neurological Sciences, 2010, v. 31, n. 1, p. 65, doi. 10.1007/s10072-009-0132-9

By:

Gallo, Maura;
Tomaino, Carmine;
Puccio, Gianfranco;
Frangipane, Francesca;
Curcio, Sabrina A. M.;
Bernardi, Livia;
Geracitano, Silvana;
Anfossi, Maria;
Mirabelli, Maria;
Colao, Rosanna;
Vasso, Franca;
Smirne, Nicoletta;
Maletta, Raffaele G.;
Bruni, Amalia Cecilia

Publication type:

Article

A novel presenilin 1 L166H mutation in a pseudo-sporadic case of early-onset Alzheimer’s disease.

Published in:

Neurological Sciences, 2005, v. 26, n. 5, p. 349, doi. 10.1007/s10072-005-0499-1

By:

Pantieri, R.;
Pardini, M.;
Cecconi, M.;
Dagna-Bricarelli, F.;
Vitali, A.;
Piccini, A.;
Russo, R.;
Borghi, R.;
Tabaton, M.

Publication type:

Article

Therapeutic effect of Rho kinase inhibitor FSD-C10 in a mouse model of Alzheimer's disease.

Published in:

Experimental & Therapeutic Medicine, 2018, v. 16, n. 5, p. 3929, doi. 10.3892/etm.2018.6701

By:

Gu, Qing-Fang;
Yu, Jie-Zhong;
Wu, Hao;
Li, Yan-Hua;
Liu, Chun-Yun;
Feng, Ling;
Zhang, Guang-Xian;
Xiao, Bao-Guo;
Ma, Cun-Gen

Publication type:

Article

Unraveling the genes implicated in Alzheimer's disease (Review).

Published in:

Biomedical Reports, 2017, v. 7, n. 2, p. 105, doi. 10.3892/br.2017.927

By:

GIRI, MOHAN;
SHAH, ABHILASHA;
UPRETI, BIBHUTI;
RAI, JAYANTI CHAMLING

Publication type:

Article

Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity.

Published in:

Pathology International, 2002, v. 52, n. 9, p. 551, doi. 10.1046/j.1440-1827.2002.01398.x

By:

Maezawa, Izumi;
Wang, Baiping;
Hu, Qubai;
Martin, George M.;
Jin, Lee-Way;
Oshima, Junko

Publication type:

Article