Works matching DE "PRESENILINS"

Results: 860

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements.

Published in:

PLoS Biology, 2008, v. 6, n. 10, p. 2314, doi. 10.1371/journal.pbio.0060257

By:

Hemming, Matthew L.;
Elias, Joshua E.;
Gygi, Steven P.;
Selkoe, Dennis J.

Publication type:

Article

Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells.

Published in:

Psychogeriatrics, 2006, v. 6, n. 3, p. 107, doi. 10.1111/j.1479-8301.2006.00142.x

By:

Fukumori, Akio;
Jiang, Jingwei;
Tanii, Hisashi;
Morihara, Takashi;
Kamino, Kojin;
Tanaka, Toshihisa;
Kudo, Takashi;
Ito, Naohiro;
Tagami, Shinji;
Okochi, Masayasu;
Takeda, Masatoshi

Publication type:

Article

Presenilin genes are downregulated during somitogenesis in the cadmium-induced omphalocele chick model.

Published in:

Pediatric Surgery International, 2012, v. 28, n. 2, p. 129, doi. 10.1007/s00383-011-2994-1

By:

Doi, Takashi;
Fujiwara, Naho;
Puri, Prem;
Bannigan, John;
Thompson, Jennifer

Publication type:

Article

Effects of lipids on the activity and structural dynamics of gamma secretase: A study using coarse-grained molecular dynamics simulations.

Published in:

ChemPhysMater, 2024, v. 3, n. 3, p. 303, doi. 10.1016/j.chphma.2024.03.005

By:

Sajjad, Ahmad;
Jinfei Mei;
Chuanbo Wang;
Hongqi Ai

Publication type:

Article

Neurodegenerative disease: New dimensions in Alzheimer's modelling.

Published in:

Nature Reviews Neuroscience, 2014, v. 15, n. 12, p. 765, doi. 10.1038/nrn3860

By:

Whalley, Katherine

Publication type:

Article

Report of a case with CARD14‐associated papulosquamous eruptions and multiple skin cancers.

Published in:

Photodermatology, Photoimmunology & Photomedicine, 2024, v. 40, n. 3, p. 1, doi. 10.1111/phpp.12969

By:

Hsu, Chia‐Jung;
Tsai, Tsen‐Fang

Publication type:

Article

姜黄素对小鼠海马 Aβ 生成酶和降解酶的影响.

Published in:

Journal of Beijing University of Traditional Chinese Medicine, 2016, v. 39, n. 3, p. 230, doi. 10.3969/j.issn.1006-2157.2016.03.011

By:

董云芳;
冯慧利;
何瑛琨;
樊惠;
党惠子;
映;
王蓬文

Publication type:

Article

Potential digenic inheritance of familial hypertrophic cardiomyopathy identified by whole‐exome sequencing.

Published in:

Molecular Genetics & Genomic Medicine, 2020, v. 8, n. 3, p. 1, doi. 10.1002/mgg3.1150

By:

Ren, Ming‐Bao;
Chai, Xiao‐Rui;
Li, Lin;
Wang, Xin;
Yin, Chenghong

Publication type:

Article

Amyloid Precursor Protein and Notch Intracellular Domains are Generated after Transport of their Precursors to the Cell Surface.

Published in:

Traffic, 2006, v. 7, n. 4, p. 408, doi. 10.1111/j.1600-0854.2006.00396.x

By:

Kaether, Christoph;
Schmitt, Stephanie;
Willem, Michael;
Haass, Christian

Publication type:

Article

Presenilin-1-mediated Retention of APP Derivatives in Early Biosynthetic Compartments.

Published in:

Traffic, 2006, v. 7, n. 3, p. 354, doi. 10.1111/j.1600-0854.2006.00388.x

By:

Réchards, Marloes;
Weiming Xia;
Oorschot, Viola;
van Dijk, Suzanne;
Annaert, Willem;
Selkoe, Dennis J.;
Klumperman, Judith

Publication type:

Article

Odor identification score as an alternative method for early identification of amyloidogenesis in Alzheimer's disease.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-54322-3

By:

Igeta, Yukifusa;
Hemmi, Isao;
Yuyama, Kohei;
Ouchi, Yasuyoshi

Publication type:

Article

Odor identification score as an alternative method for early identification of amyloidogenesis in Alzheimer's disease.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-54322-3

By:

Igeta, Yukifusa;
Hemmi, Isao;
Yuyama, Kohei;
Ouchi, Yasuyoshi

Publication type:

Article

Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer's disease.

Published in:

Frontiers in Pharmacology, 2024, p. 01, doi. 10.3389/fphar.2024.1365051

By:

Puris, Elena;
Saveleva, Liudmila;
Auriola, Seppo;
Gynther, Mikko;
Kanninen, Katja M.;
Fricker, Gert

Publication type:

Article

Combination strategy employing BACE1 inhibitor and memantine to boost cognitive benefits in Alzheimer's disease therapy.

Published in:

Psychopharmacology, 2024, v. 241, n. 5, p. 975, doi. 10.1007/s00213-024-06525-9

By:

Tarif, Abu Md Mamun;
Huhe, Hasi;
Ohno, Masuo

Publication type:

Article

Cognitive changes in the preclinical phase of familial Alzheimer's disease.

Published in:

Journal of Clinical & Experimental Neuropsychology, 2007, v. 29, n. 8, p. 892, doi. 10.1080/13803390601174151

By:

Arango-Lasprilla, Juan Carlos;
Cuetos, Fernando;
Valencia, Claudia;
Uribe, Claramonika;
Lopera, Francisco

Publication type:

Article

Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.

Published in:

Oncogene, 2014, v. 33, n. 44, p. 5193, doi. 10.1038/onc.2014.128

By:

Yun, H-M;
Park, M H;
Kim, D H;
Ahn, Y J;
Park, K-R;
Kim, T M;
Yun, N Y;
Jung, Y S;
Hwang, D Y;
Yoon, D Y;
Han, S B;
Hong, J T

Publication type:

Article

A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42704-6

By:

Aron, Liviu;
Qiu, Chenxi;
Ngian, Zhen Kai;
Liang, Marianna;
Drake, Derek;
Choi, Jaejoon;
Fernandez, Marty A.;
Roche, Perle;
Bunting, Emma L.;
Lacey, Ella K.;
Hamplova, Sara E.;
Yuan, Monlan;
Wolfe, Michael S.;
Bennett, David A.;
Lee, Eunjung A.;
Yankner, Bruce A.

Publication type:

Article

Plasma biomarkers predict Alzheimer's disease before clinical onset in Chinese cohorts.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42596-6

By:

Cai, Huimin;
Pang, Yana;
Fu, Xiaofeng;
Ren, Ziye;
Jia, Longfei

Publication type:

Article

Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.

Published in:

Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.00796

By:

Contino, Sabrina;
Porporato, Paolo E.;
Bird, Matthew;
Marinangeli, Claudia;
Opsomer, Rémi;
Sonveaux, Pierre;
Bontemps, Françoise;
Dewachter, Ilse;
Octave, Jean-Noël;
Bertrand, Luc;
Stanga, Serena;
Kienlen-Campard, Pascal

Publication type:

Article

Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD.

Published in:

Frontiers in Aging Neuroscience, 2016, p. 1, doi. 10.3389/fnagi.2016.00051

By:

Nuomin Li;
Kefu Liu;
Yunjie Qiu;
Zehui Ren;
Rongji Dai;
Yulin Deng;
Hong Qing;
Delgado-García, José M.;
Petersen, Robert

Publication type:

Article

Ral inhibits ligand-independent Notch signaling in Drosophila.

Published in:

Small GTPases, 2012, v. 3, n. 3, p. 186, doi. 10.4161/sgtp.19802

By:

Cho, Bomsoo;
Fischer, Janice A.

Publication type:

Article

Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism Dictyostelium discoideum.

Published in:: Journal of Biomedical Science, 2012, v. 19, n. 1, p. 41, doi. 10.1186/1423-0127-19-41
Publication type:: Article

siRNA against presenilin 1 (PS1) down regulates amyloid b42 production in IMR-32 cells.

Published in:: Journal of Biomedical Science, 2012, v. 19, n. 1, p. 2, doi. 10.1186/1423-0127-19-2
Publication type:: Article

Early chronic suppression of microglial p38α in a model of Alzheimer's disease does not significantly alter amyloid-associated neuropathology.

Published in:

PLoS ONE, 2023, v. 18, n. 5, p. 1, doi. 10.1371/journal.pone.0286495

By:

Braun, David J.;
Frazier, Hilaree N.;
Davis, Verda A.;
Coleman, Meggie J.;
Rogers, Colin B.;
Van Eldik, Linda J.

Publication type:

Article

Behavioral Changes in Transgenic Mice Expressing Both Amyloid Precursor Protein and Presenilin-1 Mutations: Lack of Association with Amyloid Deposits.

Published in:

Behavior Genetics, 1999, v. 29, n. 3, p. 177, doi. 10.1023/A:1021691918517

By:

Holcomb, Leigh A.;
Gordon, Marcia N.;
Jantzen, Paul;
Hsiao, Karen;
Duff, Karen;
Morgan, Dave;
Driscoll, Peter

Publication type:

Article

Epigenetic modifications of DNA and RNA in Alzheimer's disease.

Published in:

Frontiers in Molecular Neuroscience, 2024, p. 1, doi. 10.3389/fnmol.2024.1398026

By:

Martinez-Feduchi, Paula;
Peng Jin;
Bing Yao

Publication type:

Article

Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease.

Published in:

Frontiers in Molecular Neuroscience, 2023, p. 1, doi. 10.3389/fnmol.2023.1279740

By:

Nordvall, Gunnar;
Lundkvist, Johan;
Sandin, Johan

Publication type:

Article

The Effect of TCM-Induced HAMP on Key Enzymes in the Hydrolysis of AD Model Cells.

Published in:

Neurochemical Research, 2021, v. 46, n. 5, p. 1068, doi. 10.1007/s11064-021-03235-y

By:

Xian-Hui, Dong;
Dong-Xue, Ma;
Tian-Ci, Zhang;
Xiao-Ping, He;
Li-Jun, Xu;
Ya-Lei, Liu;
Hao, Li;
Wei-Juan, Gao

Publication type:

Article

Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease.

Published in:

2020

By:

Zhang, Yidan;
Zhao, Yuan;
Zhang, Jian;
Yang, Guofeng

Publication type:

Literature Review

Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae.

Published in:

Neurochemical Research, 2017, v. 42, n. 10, p. 2959, doi. 10.1007/s11064-017-2327-4

By:

Nery, Laura;
Silva, Natalia;
Fonseca, Raphaela;
Vianna, Monica

Publication type:

Article

Effects of Aluminium on β-Amyloid (1-42) and Secretases (APP-Cleaving Enzymes) in Rat Brain.

Published in:

Neurochemical Research, 2014, v. 39, n. 7, p. 1338, doi. 10.1007/s11064-014-1317-z

By:

Wang, Linping;
Hu, Jiali;
Zhao, Yue;
Lu, Xiaoting;
Zhang, Qinli;
Niu, Qiao

Publication type:

Article

Cell Signaling Abnormalities May Drive Neurodegeneration in Familial Alzheimer Disease.

Published in:

Neurochemical Research, 2014, v. 39, n. 3, p. 570, doi. 10.1007/s11064-013-1003-6

By:

Robakis, Nikolaos

Publication type:

Article

Processing of the Platelet Amyloid Precursor Protein in the Mild Cognitive Impairment (MCI).

Published in:

Neurochemical Research, 2013, v. 38, n. 7, p. 1415, doi. 10.1007/s11064-013-1039-7

By:

Bermejo-Bescós, Paloma;
Martín-Aragón, Sagrario;
Jiménez-Aliaga, Karim;
Benedí, Juana;
Felici, Emanuela;
Gil, Pedro;
Ribera, José;
Villar, Ángel

Publication type:

Article

Increased Phosphorylation of Tau and Synaptic Protein Loss in the Aged Transgenic Mice Expressing Familiar Alzheimer's Disease-Linked Presenilin 1 Mutation.

Published in:

Neurochemical Research, 2012, v. 37, n. 1, p. 15, doi. 10.1007/s11064-011-0575-2

By:

Yang, Xifei;
Yang, Ying;
Liu, Jianjun;
Li, Geng;
Yang, Edward

Publication type:

Article

The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid.

Published in:

Neurochemical Research, 2007, v. 32, n. 4/5, p. 609

By:

Samuel Gandy

Publication type:

Article

Identification of new BACE1 inhibitors for treating Alzheimer's disease.

Published in:

Journal of Molecular Modeling, 2021, v. 27, n. 2, p. 1, doi. 10.1007/s00894-021-04679-3

By:

Kushwaha, Pragya;
Singh, Vineeta;
Somvanshi, Pallavi;
Bhardwaj, Tulika;
Barreto, George E.;
Ashraf, Ghulam Md.;
Mishra, Bhartendu Nath;
Chundawat, Rajendra Singh;
Haque, Shafiul

Publication type:

Article

Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease.

Published in:

Brain Pathology, 2022, v. 32, n. 6, p. 1, doi. 10.1111/bpa.13097

By:

Littau, Jessica Lisa;
Velilla, Lina;
Hase, Yoshiki;
Villalba‐Moreno, Nelson David;
Hagel, Christian;
Drexler, Dagmar;
Osorio Restrepo, Santiago;
Villegas, Andres;
Lopera, Francisco;
Vargas, Sergio;
Glatzel, Markus;
Krasemann, Susanne;
Quiroz, Yakeel T.;
Arboleda‐Velasquez, Joseph F.;
Kalaria, Rajesh;
Sepulveda‐Falla, Diego

Publication type:

Article

Familial Dementia With Frontotemporal Features Associated With M146V Presenilin-1 Mutation.

Published in:

Brain Pathology, 2013, v. 23, n. 5, p. 595, doi. 10.1111/bpa.12051

By:

Riudavets, Miguel A.;
Bartoloni, Leonardo;
Troncoso, Juan C.;
Pletnikova, Olga;
St. George‐Hyslop, Peter;
Schultz, Marcelo;
Sevlever, Gustavo;
Allegri, Ricardo F.

Publication type:

Article

Calsenilin Contributes to Neuronal Cell Death in Ischemic Stroke.

Published in:

Brain Pathology, 2013, v. 23, n. 4, p. 402, doi. 10.1111/bpa.12013

By:

Park, Jong‐Sung;
Manzanero, Silvia;
Chang, Jae‐Woong;
Choi, Yuri;
Baik, Sang‐Ha;
Cheng, Yi‐Lin;
Li, Yu‐I;
Gwon, A‐Ryeong;
Woo, Ha‐Na;
Jang, Jiyeon;
Choi, In‐Young;
Lee, Joo‐Yong;
Jung, Yong‐Keun;
Tang, Sung‐Chun;
Sobey, Christopher G.;
Arumugam, Thiruma V.;
Jo, Dong‐Gyu

Publication type:

Article

Deposition of Hyperphosphorylated Tau in Cerebellum of PS1 E280A Alzheimer's Disease.

Published in:

Brain Pathology, 2011, v. 21, n. 4, p. 452, doi. 10.1111/j.1750-3639.2010.00469.x

By:

Sepulveda-Falla, Diego;
Matschke, Jakob;
Bernreuther, Christian;
Hagel, Christian;
Puig, Berta;
Villegas, Andres;
Garcia, Gloria;
Zea, Julian;
Gomez-Mancilla, Baltazar;
Ferrer, Isidre;
Lopera, Francisco;
Glatzel, Markus

Publication type:

Article

Oleic Acid Ameliorates Amyloidosis in Cellular and Mouse Models of Alzheimer's Disease.

Published in:

Brain Pathology, 2011, v. 21, n. 3, p. 321, doi. 10.1111/j.1750-3639.2010.00449.x

By:

Amtul, Zareen;
Westaway, David;
Cechetto, David F.;
Rozmahel, Richard F.

Publication type:

Article

Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling.

Published in:

EMBO Journal, 2006, v. 25, n. 6, p. 1242, doi. 10.1038/sj.emboj.7601031

By:

Georgakopoulos, Anastasios;
Litterst, Claudia;
Ghersi, Enrico;
Baki, Lia;
ChiJie Xu;
Serban, Geo;
Robakis, Nikolaos K.

Publication type:

Article

The presenilin C-terminus is required for ER-retention, nicastrin-binding and?-secretase activity.

Published in:

EMBO Journal, 2004, v. 23, n. 24, p. 4738, doi. 10.1038/sj.emboj.7600478

By:

Kaether, Christoph;
Capell, Anja;
Edbauer, Dieter;
Winkler, Edith;
Novak, Bozidar;
Steiner, Harald;
Haass, Christian

Publication type:

Article

A novel PSENEN mutation in a patient with complaints of memory loss and a family history of dementia

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2007, v. 3, n. 3, p. 235, doi. 10.1016/j.jalz.2007.04.375

By:

Albani, Diego;
Batelli, Sara;
Pesaresi, Marzia;
Prato, Francesca;
Polito, Letizia;
Forloni, Gianluigi;
Pantieri, Roberta

Publication type:

Article

CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin-1 E280A Mutation Is Related to Epilepsy.

Published in:

Epilepsia (Series 4), 2004, v. 45, n. 7, p. 751, doi. 10.1111/j.0013-9580.2004.55403.x

By:

Velez-Pardo, Carlos;
Arellano, Jon I.;
Cardona-Gomez, Patricia;
Jimenez Del Rio, Marlene;
Lopera, Francisco;
De Felipe, Javier

Publication type:

Article

Processive proteolysis by γ-secretase and the mechanism of Alzheimer's disease.

Published in:

Biological Chemistry, 2012, v. 393, n. 9, p. 899, doi. 10.1515/hsz-2012-0140

By:

Wolfe, Michael S.

Publication type:

Article

Structure, mechanism and inhibition of γ-secretase and presenilin-like proteases.

Published in:

Biological Chemistry, 2010, v. 391, n. 8, p. 839, doi. 10.1515/BC.2010.086

By:

Wolfe, Michael S.

Publication type:

Article

APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases.

Published in:

2017

By:

Lanoiselée, Hélène-Marie;
Nicolas, Gaël;
Wallon, David;
Rovelet-Lecrux, Anne;
Lacour, Morgane;
Rousseau, Stéphane;
Richard, Anne-Claire;
Pasquier, Florence;
Rollin-Sillaire, Adeline;
Martinaud, Olivier;
Quillard-Muraine, Muriel;
de la Sayette, Vincent;
Boutoleau-Bretonniere, Claire;
Etcharry-Bouyx, Frédérique;
Chauviré, Valérie;
Sarazin, Marie;
le Ber, Isabelle;
Epelbaum, Stéphane;
Jonveaux, Thérèse;
Rouaud, Olivier

Publication type:

journal article

Membrane Topology of Human Presenilin-1 in SK-N-SH Cells Determined by Fluorescence Correlation Spectroscopy and Fluorescent Energy Transfer.

Published in:

Cell Biochemistry & Biophysics, 2014, v. 70, n. 2, p. 923, doi. 10.1007/s12013-014-9999-z

By:

Midde, Krishna;
Rich, Ryan;
Saxena, Ashwini;
Gryczynski, Ignacy;
Borejdo, Julian;
Das, Hriday

Publication type:

Article

A unifying hypothesis of Alzheimer's disease. III. Risk factors.

Published in:

Human Psychopharmacology: Clinical & Experimental, 2000, v. 15, n. 1, p. 1, doi. 10.1002/(SICI)1099-1077(200001)15:1<1::AID-HUP153>3.0.CO;2-1

By:

Heininger, Kurt

Publication type:

Article