Works matching DE "PREGNANE X receptor"

Results: 402

The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells.

Published in:

Frontiers in Endocrinology, 2025, p. 1, doi. 10.3389/fendo.2024.1430781

By:

Martinot, Emmanuelle;
Holota, Hélène;
de Haze, Angélique;
Beaudoin, Claude;
Volle, David H.

Publication type:

Article

Two Apriona Species Sharing a Host Niche Have Different Gut Microbiome Diversity.

Published in:

Microbial Ecology, 2022, v. 83, n. 4, p. 1059, doi. 10.1007/s00248-021-01799-4

By:

Zhang, Shou-Ke;
Wang, Yi;
Li, Zi-Kun;
Xue, Huai-Jun;
Zhou, Xu-Dong;
Huang, Jun-Hao

Publication type:

Article

Role of JNK in the Regulation of Xenobiotic Metabolizing Function of Hepatocytes.

Published in:

Bulletin of Experimental Biology & Medicine, 2021, v. 172, n. 2, p. 146, doi. 10.1007/s10517-021-05352-8

By:

Bryushinina, O. S.;
Zyuz'kova, Yu. G.;
Yanovskaya, E. A.;
Abdrashitova, N. Y.;
Frelikh, G. A.;
Lakeev, A. P.;
Tsuran, D. V.;
Udut, V. V.;
Zyuz'kov, G. N.

Publication type:

Article

PXR haplotype clusters will affect the pharmacokinetics of ciclosporin in Chinese renal transplant recipients.

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 2, p. 271, doi. 10.1111/jphp.13206

By:

Li, Danying;
Zhu, Huaijun;
Luo, Xuemei;
Ge, Weihong

Publication type:

Article

Nuclear receptor HR96 up‐regulates cytochrome P450 for insecticide detoxification in Tribolium castaneum.

Published in:

Pest Management Science, 2022, v. 78, n. 1, p. 230, doi. 10.1002/ps.6626

By:

Kim, In‐Young;
Choi, Byungyoon;
Park, Woo‐Ram;
Kim, Yu‐Ji;
Kim, Bo‐Eun;
Mun, Seulgi;
Choi, Hueng‐Sik;
Kim, Don‐Kyu

Publication type:

Article

Effects of Pregnane X Receptor Genetic Polymorphisms on Stable Warfarin Doses.

Published in:

2015

By:

Jung Yeon Moon;
Byung Chul Chang;
Kyung Eun Lee;
Jun Seok Bang;
Hye Sun Gwak;
Moon, Jung Yeon;
Chang, Byung Chul;
Lee, Kyung Eun;
Bang, Jun Seok;
Gwak, Hye Sun

Publication type:

journal article

Transcriptional profiling of hepatic constitutive androstane receptor and target genes in relation to boar taint compounds in backfat of pigs.

Published in:

Journal of Animal Science, 2006, v. 84, p. 350

By:

Greger, D. L.;
Morel, C.;
Bee, G.;
Ampuero, S.;
Baumrucker, C. R.;
Blum, J. W.

Publication type:

Article

Restoration of Memory Potential by Piper betel Leaves Extract in High-Fat Diet (HFD)-Induced Dementia in Mice.

Published in:

Journal of Drug Delivery & Therapeutics, 2025, v. 15, n. 1, p. 19, doi. 10.22270/jddt.v15i1.6943

By:

Sharma, Pooja;
Rani, Ritu;
Singh, Ajeet Pal;
Singh, Amar Pal

Publication type:

Article

Pregnane X receptor expression in skin: the good and the bad.

Published in:

2015

By:

Bikle, Daniel D.

Publication type:

Opinion

Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor.

Published in:

Experimental Dermatology, 2015, v. 24, n. 11, p. 835, doi. 10.1111/exd.12766

By:

Elentner, Andreas;
Ortner, Daniela;
Clausen, Björn;
Gonzalez, Frank J.;
Fernández‐Salguero, Pedro M.;
Schmuth, Matthias;
Dubrac, Sandrine

Publication type:

Article

Impact of various high fat diets on gene expression and the microbiome across the mouse intestines.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-49555-7

By:

Martinez-Lomeli, Jose;
Deol, Poonamjot;
Deans, Jonathan R.;
Jiang, Tao;
Ruegger, Paul;
Borneman, James;
Sladek, Frances M.

Publication type:

Article

Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00693

By:

Jiachao Guo;
Weijin Li;
Yingxing Wu;
Xingzhi Jing;
Junming Huang;
Jiaming Zhang;
Wei Xiang;
Ranyue Ren;
Zhengtao Lv;
Jun Xiao;
Fengjing Guo

Publication type:

Article

Extracts of Immature Orange (Aurantii fructus immaturus) and Citrus Unshiu Peel (Citri unshiu pericarpium) Induce P-Glycoprotein and Cytochrome P450 3A4 Expression via Upregulation of Pregnane X Receptor.

Published in:

Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00084

By:

Naoto Okada;
Aki Murakami;
Shiori Urushizaki;
Misa Matsuda;
Kazuyoshi Kawazoe;
Keisuke Ishizawa

Publication type:

Article

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions.

Published in:

Frontiers in Pharmacology, 2016, v. 7, p. 1, doi. 10.3389/fphar.2016.00456

By:

Pavek, Petr

Publication type:

Article

Potential roles of gut microbial tryptophan metabolites in the complex pathogenesis of acne vulgaris.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.942027

By:

Yukun Huang;
Lu Liu;
Zhenyu Hao;
Lingna Chen;
Qian Yang;
Xia Xiong;
Yongqiong Deng

Publication type:

Article

Systems Biology of Gut Microbiota-Human Receptor Interactions: Toward Anti-inflammatory Probiotics.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.846555

By:

Koduru, Lokanand;
Lakshmanan, Meiyappan;
Hoon, Shawn;
Lee, Dong-Yup;
Lee, Yuan Kun;
Ow, Dave Siak-Wei

Publication type:

Article

Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations.

Published in:

Frontiers in Microbiology, 2021, v. 12, p. 1, doi. 10.3389/fmicb.2021.761067

By:

Al Bataineh, Mohammad Tahseen;
Henschel, Andreas;
Mousa, Mira;
Daou, Marianne;
Waasia, Fathimathuz;
Kannout, Hussein;
Khalili, Mariam;
Kayasseh, Mohd Azzam;
Alkhajeh, Abdulmajeed;
Uddin, Maimunah;
Alkaabi, Nawal;
Tay, Guan K.;
Feng, Samuel F.;
Yousef, Ahmed F.;
Alsafar, Habiba S.

Publication type:

Article

Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats.

Published in:

Psychopharmacology, 2014, v. 231, n. 17, p. 3375, doi. 10.1007/s00213-014-3569-3

By:

Frye, C.;
Koonce, C.;
Walf, A.

Publication type:

Article

Expression of cytochrome P450 2C and 3A in female rat liver after long-term administration of gonadoliberin analogs.

Published in:

2016

By:

SKOWRONEK, RAFAŁ;
CZEKAJ, PIOTR;
SUSZKA-ŚWITEK, ALEKSANDRA;
CZECH, EWA;
WIADERKIEWICZ, ANNA;
PLEWKA, DANUTA;
BRYZEK, ALEKSANDRA;
Skowronek, Rafał

Publication type:

journal article

Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39118-9

By:

Fan, Shengjie;
Yan, Yingxuan;
Xia, Ying;
Zhou, Zhenyu;
Luo, Lingling;
Zhu, Mengnan;
Han, Yongli;
Yao, Deqiang;
Zhang, Lijun;
Fang, Minglv;
Peng, Lina;
Yu, Jing;
Liu, Ying;
Gao, Xiaoyan;
Guan, Huida;
Li, Hongli;
Wang, Changhong;
Wu, Xiaojun;
Zhu, Huanhu;
Cao, Yu

Publication type:

Article

Macrophage inhibitory cytokine-1 aggravates diet-induced gallstone formation via increased ABCG5/ABCG8 expression.

Published in:

PLoS ONE, 2023, v. 18, n. 6, p. 1, doi. 10.1371/journal.pone.0287146

By:

Kim, Min Hee;
Lee, Eun-Ji;
Kim, Su-Jeong;
Jung, Yun-Jae;
Park, Woo-Jae;
Park, Inkeun

Publication type:

Article

Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid.

Published in:

Neurochemical Research, 2017, v. 42, n. 8, p. 2167, doi. 10.1007/s11064-017-2224-x

By:

Yu, Nian;
Zhang, Yan-fang;
Zhang, Kang;
Cheng, Yong-fei;
Ma, Hai-yan;
Di, Qing

Publication type:

Article

Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).

Published in:

Journal of Toxicologic Pathology, 2021, v. 34, n. 4, p. 283, doi. 10.1293/tox.2021-0027

By:

Tomoya Yamada

Publication type:

Article

Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer.

Published in:

Medicinal Research Reviews, 2020, v. 40, n. 3, p. 1061, doi. 10.1002/med.21648

By:

Chai, Sergio C.;
Wright, William C.;
Chen, Taosheng

Publication type:

Article

Genome Scan for Variable Genes Involved in Environmental Adaptations of Nubian Ibex.

Published in:

Journal of Molecular Evolution, 2021, v. 89, n. 7, p. 448, doi. 10.1007/s00239-021-10015-3

By:

Chebii, Vivien J.;
Mpolya, Emmanuel A.;
Oyola, Samuel O.;
Kotze, Antoinette;
Entfellner, Jean-Baka Domelevo;
Mutuku, J. Musembi

Publication type:

Article

The Effect of Plastic-Related Compounds on Transcriptome-Wide Gene Expression on CYP2C19-Overexpressing HepG2 Cells.

Published in:

Molecules, 2023, v. 28, n. 16, p. 5952, doi. 10.3390/molecules28165952

By:

Rosellini, Matteo;
Schulze, Alicia;
Omer, Ejlal A.;
Ali, Nadeen T.;
Marini, Federico;
Küpper, Jan-Heiner;
Efferth, Thomas

Publication type:

Article

Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists.

Published in:

Molecules, 2023, v. 28, n. 6, p. 2840, doi. 10.3390/molecules28062840

By:

Finamore, Claudia;
Festa, Carmen;
Fiorillo, Bianca;
Leva, Francesco Saverio Di;
Roselli, Rosalinda;
Marchianò, Silvia;
Biagioli, Michele;
Spinelli, Lucio;
Fiorucci, Stefano;
Limongelli, Vittorio;
Zampella, Angela;
De Marino, Simona

Publication type:

Article

Gene Expression and Protein Abundance of Nuclear Receptors in Human Intestine and Liver: A New Application for Mass Spectrometry-Based Targeted Proteomics.

Published in:

Molecules, 2022, v. 27, n. 14, p. N.PAG, doi. 10.3390/molecules27144629

By:

Wenzel, Christoph;
Gödtke, Lisa;
Reichstein, Anne;
Keiser, Markus;
Busch, Diana;
Drozdzik, Marek;
Oswald, Stefan

Publication type:

Article

Enzyme Activity of Natural Products on Cytochrome P450.

Published in:

Molecules, 2022, v. 27, n. 2, p. 515, doi. 10.3390/molecules27020515

By:

Zuo, Hua-Li;
Huang, Hsi-Yuan;
Lin, Yang-Chi-Dung;
Cai, Xiao-Xuan;
Kong, Xiang-Jun;
Luo, Dai-Lin;
Zhou, Yu-Heng;
Huang, Hsien-Da

Publication type:

Article

Lycium Barbarum Polysaccharides and Wolfberry Juice Prevent DEHP-Induced Hepatotoxicity via PXR-Regulated Detoxification Pathway.

Published in:

Molecules, 2021, v. 26, n. 4, p. 859, doi. 10.3390/molecules26040859

By:

Liu, Huan;
Zhou, Xiong;
Huang, Shaowen;
Yang, Jie;
Liu, Ruijing;
Liu, Chunhong;
Colliec-Jouault, Sylvia

Publication type:

Article

Modulation of Cytochrome P450, P-glycoprotein and Pregnane X Receptor by Selected Antimalarial Herbs -- Implication for Herb-Drug Interaction.

Published in:

Molecules, 2017, v. 22, n. 12, p. 2049, doi. 10.3390/molecules22122049

By:

Fasinu, Pius S.;
Manda, Vamshi K.;
Dale, Olivia R.;
Egiebor, Nosa O.;
Walker, Larry A.;
Khan, Shabana I.

Publication type:

Article

Highlight report: hepatotoxicity of triazole fungicides.

Published in:

2019

By:

Albrecht, Wiebke

Publication type:

Editorial

Pregnane X receptor mediates steatotic effects of propiconazole and tebuconazole in human liver cell lines.

Published in:

Archives of Toxicology, 2019, v. 93, n. 5, p. 1311, doi. 10.1007/s00204-019-02445-2

By:

Knebel, Constanze;
Buhrke, Thorsten;
Lampen, Alfonso;
Braeuning, Albert;
Süssmuth, Roderich;
Marx-Stoelting, Philip

Publication type:

Article

Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

Published in:

Archives of Toxicology, 2018, v. 92, n. 4, p. 1435, doi. 10.1007/s00204-018-2165-4

By:

Burk, Oliver;
Kuzikov, Maria;
Kronenberger, Thales;
Jeske, Judith;
Keminer, Oliver;
Thasler, Wolfgang E.;
Schwab, Matthias;
Wrenger, Carsten;
Windshügel, Björn

Publication type:

Article

Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.

Published in:

Archives of Toxicology, 2017, v. 91, n. 6, p. 2375, doi. 10.1007/s00204-017-1948-3

By:

Jeske, Judith;
Windshügel, Björn;
Thasler, Wolfgang;
Schwab, Matthias;
Burk, Oliver

Publication type:

Article

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.

Published in:

Archives of Toxicology, 2015, v. 89, n. 11, p. 2089, doi. 10.1007/s00204-014-1348-x

By:

Bitter, Andreas;
Rümmele, Petra;
Klein, Kathrin;
Kandel, Benjamin;
Rieger, Jessica;
Nüssler, Andreas;
Zanger, Ulrich;
Trauner, Michael;
Schwab, Matthias;
Burk, Oliver

Publication type:

Article

Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane X receptor ligands formed by enhanced cholesterol metabolism.

Published in:

Archives of Toxicology, 2015, v. 89, n. 4, p. 579, doi. 10.1007/s00204-014-1268-9

By:

Je, Young-Tae;
Sim, Woo-Cheol;
Kim, Dong-Gwang;
Jung, Byung-Hwa;
Shin, Ho-Sang;
Lee, Byung-Hoon

Publication type:

Article

Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.

Published in:

Archives of Toxicology, 2015, v. 89, n. 1, p. 57, doi. 10.1007/s00204-014-1230-x

By:

Lim, Yun-Ping;
Cheng, Ching-Hao;
Hung, Dong-Zong;
Chen, Chao-Jung;
Chen, Wei-Cheng;
Ma, Wei-Chih;
Lin, Yu-Hsien;
Chen, Cing-Yu;
Chang, Shih-Yu;
Chen, Jih-Jung;
Wan, Lei;
Yokoi, Tsuyoshi;
Nakajima, Miki

Publication type:

Article

Increase in tacrolimus exposure after steroid tapering is influenced by CYP3A5 and pregnane X receptor genetic polymorphisms in renal transplant recipients.

Published in:

Nephrology Dialysis Transplantation, 2018, v. 33, n. 9, p. 1668, doi. 10.1093/ndt/gfy096

By:

Stifft, Frank;
Kuijk, Sander M J van;
Bekers, Otto;
Christiaans, Maarten H L

Publication type:

Article

Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83742-8

By:

Guo, Hanze;
Chi, Yan;
Chi, Naiyu

Publication type:

Article

Genetic variation in the farnesoid X-receptor predicts Crohn's disease severity in female patients.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-68686-9

By:

Wilson, Aze;
Wang, Qian;
Almousa, Ahmed A.;
Jansen, Laura E.;
Choi, Yun-hee;
Schwarz, Ute I.;
Kim, Richard B.

Publication type:

Article

Impact of genetic polymorphisms of drug transporters ABCB1 and ABCG2 and regulators of xenobiotic transport and metabolism PXR and CAR on clinical efficacy of dasatinib in chronic myeloid leukemia.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.952640

By:

Madejczyk, Anna Marta;
Canzian, Federico;
Góra-Tybor, Joanna;
Campa, Daniele;
Sacha, Tomasz;
Link-Lenczowska, Dorota;
Florek, Izabela;
Prejzner, Witold;
Całbecka, M.;
Rymko, M.;
Dudziński, M.;
Orzechowska, Magdalena Julita;
Jamroziak, Krzysztof

Publication type:

Article

Role of nuclear receptor PXR in immune cells and inflammatory diseases.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.969399

By:

Le Sun;
Zhenzhen Sun;
Qian Wang;
Yue Zhang;
Zhanjun Jia

Publication type:

Article

Editorial: Molecular Pathways Controlling Epithelial Inflammation in the Gut.

Published in:

2022

By:

Moon, Yuseok

Publication type:

Editorial

DNA methylation determines the regulation of pregnane X receptor on CYP3A4 expression.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2021, v. 48, n. 2, p. 250, doi. 10.1111/1440-1681.13420

By:

Wang, Xiaofei;
Wei, Luman;
Yang, Jingke;
Wang, Yiting;
Chen, Shitong;
Yang, Kun;
Meng, Xiangguang;
Zhang, Lirong

Publication type:

Article

Splice isoforms as therapeutic targets for colorectal cancer.

Published in:

Carcinogenesis, 2012, v. 33, n. 12, p. 2311, doi. 10.1093/carcin/bgs347

By:

Miura, Koh;
Fujibuchi, Wataru;
Unno, Michiaki

Publication type:

Article

SPA70 is a potent antagonist of human pregnane X receptor.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00780-5

By:

Wenwei Lin;
Yue-Ming Wang;
Chai, Sergio C.;
Lili Lv;
Jie Zheng;
Jing Wu;
Qijun Zhang;
Yong-Dong Wang;
Griffin, Patrick R.;
Taosheng Chen

Publication type:

Article

Unlocking the Clinical Significance of Cytochrome P450 Enzymes.

Published in:

International Journal of Pharmaceutical Investigation, 2024, v. 14, n. 1, p. 30, doi. 10.5530/ijpi.14.1.5

By:

Hadia, Rajesh;
Singh, Vishal;
Solanki, Nidhi;
Sharma, Shiwanand;
Saggu, Varunsingh;
Sajan, Cyril;
Trivedi, Rahul;
Kardani, Sunil;
Baile, Sunil;
Rajput, Hemraj Singh;
Maheshwari, Rajesh

Publication type:

Article

Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation.

Published in:

Toxins, 2022, v. 14, n. 9, p. 645, doi. 10.3390/toxins14090645

By:

Madella, Avra Melina;
Van Bergenhenegouwen, Jeroen;
Garssen, Johan;
Masereeuw, Rosalinde;
Overbeek, Saskia Adriana

Publication type:

Article

An evaluation of the anti-inflammatory properties of the pregnane X receptor gene isoforms PXR1 and PXR3.

Published in:

2019

By:

Alleyne, Jerusalem

Publication type:

Letter