Works matching DE "PREGNANE X receptor"

Results: 407

Dolutegravir and Risk of Neuropsychiatric Adverse Events: A Pharmacogenetic Study.

Published in:

Journal of Infectious Diseases, 2025, v. 231, n. 6, p. 1425, doi. 10.1093/infdis/jiaf098

By:

Greef, Julien De;
Yombi, Jean Cyr;
Vincent, Anne;
Vandercam, Bernard;
Timary, Philippe de;
Boland, Lidvine;
Philippeau, Magali;
Panin, Nadtha;
Elens, Laure;
Haufroid, Vincent;
Belkhir, Leïla

Publication type:

Article

Dual effects of indoxyl sulfate on modulation of human hepatic CYP3A activity, with individual differences.

Published in:

PLoS ONE, 2025, v. 20, n. 7, p. 1, doi. 10.1371/journal.pone.0328182

By:

Togao, Masao;
Asakawa, Naoyuki;
Wagai, Gaku;
Ohta-Takada, Yuki;
Otsuka, Jun;
Ando, Minoru;
Kurita, Akinobu;
Kawakami, Koji

Publication type:

Article

Exploring the Role of Bifenthrin in Recurrent Implantation Failure and Pregnancy Loss Through Network Toxicology and Molecular Docking.

Published in:

Toxics, 2025, v. 13, n. 6, p. 454, doi. 10.3390/toxics13060454

By:

Jiang, Shengyuan;
Wang, Yixiao;
Chen, Haiyan;
Teng, Yuanyuan;
Zhu, Qiaoying;
Xie, Kaipeng

Publication type:

Article

Characterization and treatment of persistent hepatocellular secretory failure.

Published in:

Liver International, 2015, v. 35, n. 4, p. 1478, doi. 10.1111/liv.12603

By:

Dijk, Remco;
Kremer, Andreas E.;
Smit, Wouter;
Elzen, Bram;
Gulik, Thomas;
Gouma, Dirk;
Lameris, Johan S.;
Bikker, Hennie;
Enemuo, Valentine;
Stokkers, Pieter C. F.;
Feist, Mark;
Bosma, Piter;
Jansen, Peter L. M.;
Beuers, Ulrich

Publication type:

Article

Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00658-x

By:

Wang, Shuang;
Xiong, Liangzhi;
Ruan, Zhihua;
Gong, Xiaofang;
Luo, Yanrong;
Wu, Chengyi;
Wang, Yu;
Shang, Hui;
Chen, Jingyi

Publication type:

Article

Oxidative stress‐mediated up‐regulation of ABC transporters in lung cancer cells.

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 8, p. 1, doi. 10.1002/jbt.23095

By:

Yuan, Tongkuo;
Hu, Jia;
Zhu, Xiaoming;
Yin, Huancai;
Yin, Jian

Publication type:

Article

Self‐protective transcriptional alterations in ZF4 cells exposed to Pb(NO3)2 and AgNO3.

Published in:

Journal of Biochemical & Molecular Toxicology, 2019, v. 33, n. 12, p. N.PAG, doi. 10.1002/jbt.22408

By:

Liu, Guangxing;
Tian, Jingjing;
Yin, Huancai;
Yin, Jian;
Tang, Yuguo

Publication type:

Article

The Effect of Natural Products on the Metabolism of Boar Taint Compounds in Porcine Hepatocytes.

Published in:

Journal of Animal Science, 2023, v. 101, p. 314, doi. 10.1093/jas/skad281.374

By:

Bone, Christine;
Squires, E. James

Publication type:

Article

Transcriptional profiling of hepatic constitutive androstane receptor and target genes in relation to boar taint compounds in backfat of pigs.

Published in:

Journal of Animal Science, 2006, v. 84, p. 350

By:

Greger, D. L.;
Morel, C.;
Bee, G.;
Ampuero, S.;
Baumrucker, C. R.;
Blum, J. W.

Publication type:

Article

Protective Effect of Beta -Carotene against Myeloperoxidase- Mediated Oxidative Stress and Inflammation in Rat Ischemic Brain Injury.

Published in:

Antioxidants, 2022, v. 11, n. 12, p. 2344, doi. 10.3390/antiox11122344

By:

Althurwi, Hassan N.;
Abdel-Rahman, Rehab F.;
Soliman, Gamal A.;
Ogaly, Hanan A.;
Alkholifi, Faisal K.;
Abd-Elsalam, Reham M.;
Alqasoumi, Saleh I.;
Abdel-Kader, Maged S.

Publication type:

Article

Ameliorative impacts of chrysin against gibberellic acid-induced liver and kidney damage through the regulation of antioxidants, oxidative stress, inflammatory cytokines, and apoptosis biomarkers.

Published in:

Toxicology Research, 2022, v. 11, n. 1, p. 235, doi. 10.1093/toxres/tfac003

By:

Soliman, Mohamed Mohamed;
Aldhahrani, Adil;
Gaber, Ahmed;
Alsanie, Walaa F;
Mohamed, Wafaa Abdou;
Metwally, Mohamed M M;
Elbadawy, Mohamed;
Shukry, Mustafa

Publication type:

Article

Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1448744

By:

Lynch, Caitlin;
Margolis, Ryan;
Niebler, Jacob;
Travers, Jameson;
Sakamuru, Srilatha;
Zhao, Tongan;
Klumpp-Thomas, Carleen;
Huang, Ruili;
Xia, Menghang

Publication type:

Article

Induction of cytochrome P450 via upregulation of CAR and PXR: a potential mechanism for altered florfenicol metabolism by macranthoidin B in vivo.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1460948

By:

Si-cong Li;
Bin Wang;
Min Zhang;
Qin Yin;
Zi-yi Yang;
Xu-ting Li;
Ge Liang

Publication type:

Article

Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00693

By:

Jiachao Guo;
Weijin Li;
Yingxing Wu;
Xingzhi Jing;
Junming Huang;
Jiaming Zhang;
Wei Xiang;
Ranyue Ren;
Zhengtao Lv;
Jun Xiao;
Fengjing Guo

Publication type:

Article

An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56624-0

By:

Wang, Xiaojuan;
Zhang, Guohui;
Bian, Zhiwei;
Chow, Vimanda;
Grimaldi, Marina;
Carivenc, Coralie;
Sirounian, Savannah;
Li, Hao;
Sladekova, Lucia;
Motta, Stefano;
Luperi, Yulia;
Gong, Yufeng;
Costello, Cait;
Li, Linhao;
Jachimowicz, Matthew;
Guo, Miao;
Hu, Shian;
Wilson, Derek;
Balaguer, Patrick;
Bourguet, William

Publication type:

Article

The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56642-y

By:

Dusek, Jan;
Mejdrová, Ivana;
Dohnalová, Klára;
Smutny, Tomas;
Chalupsky, Karel;
Krutakova, Maria;
Skoda, Josef;
Rashidian, Azam;
Pavkova, Ivona;
Škach, Kryštof;
Hricová, Jana;
Chocholouskova, Michaela;
Smutna, Lucie;
Kamaraj, Rajamanikkam;
Hroch, Miloš;
Leníček, Martin;
Mičuda, Stanislav;
Pijnenburg, Dirk;
van Beuningen, Rinie;
Holčapek, Michal

Publication type:

Article

B3galt5 functions as a PXR target gene and regulates obesity and insulin resistance by maintaining intestinal integrity.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50198-z

By:

Zhang, Jinhang;
Huang, Ya;
Li, Hong;
Xu, Pengfei;
Liu, Qinhui;
Sun, Yang;
Zhang, Zijing;
Wu, Tong;
Tang, Qin;
Jia, Qingyi;
Xia, Yan;
Xu, Ying;
Jing, Xiandan;
Li, Jiahui;
Mo, Li;
Xie, Wen;
Qu, Aijuan;
He, Jinhan;
Li, Yanping

Publication type:

Article

Effect of copper nanoparticles on brain cytochrome P450 enzymes in rats.

Published in:

Molecular Medicine Reports, 2019, v. 20, n. 1, p. 771, doi. 10.3892/mmr.2019.10302

By:

Wang, Yanyan;
Tang, Huaqiao;
Xu, Min;
Luo, Jie;
Zhao, Ling;
Shi, Fei;
Ye, Gang;
Lv, Cheng;
Li, Yinglun

Publication type:

Article

Recent advances in fungal xenobiotic metabolism: enzymes and applications.

Published in:

World Journal of Microbiology & Biotechnology, 2023, v. 39, n. 11, p. 1, doi. 10.1007/s11274-023-03737-7

By:

Khan, Mohd Faheem;
Hof, Carina;
Niemcová, Patricie;
Murphy, Cormac D.

Publication type:

Article

An In Silico Approach to Analyze the Potential Compound of Andrographis paniculata Against the Targets Involved in the Apoptotic and Inflammatory Pathways.

Published in:

Indian Journal of Pharmaceutical Sciences, 2023, v. 85, n. 5, p. 1291

By:

MANISHA, P.;
PRINCE, SABINA EVAN

Publication type:

Article

A Case to Support the Continued Use of Rifampin in Clinical Drug–Drug Interaction Studies.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 1, p. 34, doi. 10.1002/cpt.3256

By:

Bercu, Joel P.;
Ponting, David J.;
Ripp, Sharon L.;
Dobo, Krista L.;
Totah, Rheem A.;
Bolleddula, Jayaprakasam

Publication type:

Article

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 6, p. 1505, doi. 10.1002/cpt.2141

By:

Bachmann, Fabio;
Duthaler, Urs;
Meyer zu Schwabedissen, Henriette E.;
Puchkov, Maxim;
Huwyler, Jörg;
Haschke, Manuel;
Krähenbühl, Stephan

Publication type:

Article

3D Spheroids of Primary Human Hepatocytes: An In Vitro Model That Will Make Pharmacotherapy Safer?

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 5, p. 1186, doi. 10.1002/cpt.2019

By:

Pavek, Petr

Publication type:

Article

In this Issue.

Published in:: Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 9, doi. 10.1002/cpt.2110
Publication type:: Article

Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 55, doi. 10.1002/cpt.1916

By:

Zamek‐Gliszczynski, Maciej J.;
Patel, Mitesh;
Yang, Xinning;
Lutz, Justin D.;
Chu, Xiaoyan;
Brouwer, Kim L. R.;
Lai, Yurong;
Lee, Caroline A.;
Neuhoff, Sibylle;
Paine, Mary F.;
Sugiyama, Yuichi;
Taskar, Kunal S.;
Galetin, Aleksandra

Publication type:

Article

Pregnane X Receptor Activator Rifampin Increases Blood Pressure and Stimulates Plasma Renin Activity.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 4, p. 856, doi. 10.1002/cpt.1871

By:

Hassani‐Nezhad‐Gashti, Fatemeh;
Salonurmi, Tuire;
Hautajärvi, Heidi;
Rysä, Jaana;
Hakkola, Jukka;
Hukkanen, Janne

Publication type:

Article

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 4, p. 844, doi. 10.1002/cpt.1860

By:

Hendriks, Delilah F.G.;
Vorrink, Sabine U.;
Smutny, Tomas;
Sim, Sarah C.;
Nordling, Åsa;
Ullah, Shahid;
Kumondai, Masaki;
Jones, Barry C.;
Johansson, Inger;
Andersson, Tommy B.;
Lauschke, Volker M.;
Ingelman‐Sundberg, Magnus

Publication type:

Article

Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV‐Infected Women.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 2, p. 315, doi. 10.1002/cpt.1605

By:

Tamraz, Bani;
Huang, Yong;
French, Audrey L.;
Kassaye, Seble;
Anastos, Kathryn;
Nowicki, Marek J.;
Gange, Stephen;
Gustafson, Deborah R.;
Bacchetti, Peter;
Greenblatt, Ruth M.;
Hysi, Pirro G.;
Aouizerat, Bradley E.

Publication type:

Article

A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization.

Published in:

Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 5, p. 1083, doi. 10.1002/cpt.1516

By:

Cheung, Kit Wun Kathy;
Groen, Bianca D.;
Spaans, Edwin;
Borselen, Marjolein D.;
Bruijn, Adrianus C.J.M.;
Simons‐Oosterhuis, Ytje;
Tibboel, Dick;
Samsom, Janneke N.;
Verdijk, Robert M.;
Smeets, Bart;
Zhang, Lei;
Huang, Shiew‐Mei;
Giacomini, Kathleen M.;
Wildt, Saskia N.

Publication type:

Article

Perinatal Bisphenol A Exposure Increases Atherosclerosis in Adult Male PXR-Humanized Mice.

Published in:

Endocrinology, 2018, v. 159, n. 4, p. 1595, doi. 10.1210/en.2017-03250

By:

Sui, Yipeng;
Park, Se-Hyung;
Wang, Fang;
Zhou, Changcheng

Publication type:

Article

Evolutionary history of the cytochrome P450s from Colletotrichum species and prediction of their putative functional roles during host-pathogen interactions.

Published in:

BMC Genomics, 2024, v. 25, n. 1, p. 1, doi. 10.1186/s12864-023-09858-5

By:

Ortiz-Álvarez, Jossue;
Becerra, Sioly;
Baroncelli, Riccardo;
Hernández-Rodríguez, César;
Sukno, Serenella A.;
Thon, Michael R.

Publication type:

Article

Bidirectional pharmacokinetic drug interactions between olaparib and metformin.

Published in:

Cancer Chemotherapy & Pharmacology, 2024, v. 93, n. 1, p. 79, doi. 10.1007/s00280-023-04591-y

By:

Stanisławiak-Rudowicz, Joanna;
Karbownik, Agnieszka;
Szkutnik-Fiedler, Danuta;
Otto, Filip;
Grabowski, Tomasz;
Wolc, Anna;
Grześkowiak, Edmund;
Szałek, Edyta

Publication type:

Article

Effects of polymorphisms in pregnane X receptor and ABC transporters on afatinib in Japanese patients with non-small cell lung cancer: pharmacogenomic–pharmacokinetic and exposure–response analysis.

Published in:

Cancer Chemotherapy & Pharmacology, 2023, v. 92, n. 4, p. 315, doi. 10.1007/s00280-023-04569-w

By:

Yokota, Hayato;
Sato, Kazuhiro;
Sakamoto, Sho;
Okuda, Yuji;
Asano, Mariko;
Takeda, Masahide;
Nakayama, Katsutoshi;
Miura, Masatomo

Publication type:

Article

Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor.

Published in:

2021

By:

Chen, Yakun;
Tang, Yong;
Nie, Jeffrey Z.;
Zhang, Yuanqin;
Nie, Daotai

Publication type:

journal article

The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity.

Published in:

Archives of Toxicology, 2025, v. 99, n. 3, p. 1203, doi. 10.1007/s00204-024-03942-9

By:

Attema, Brecht;
Kummu, Outi;
Krutáková, Mária;
Pavek, Petr;
Hakkola, Jukka;
Hooiveld, Guido J. E. J.;
Kersten, Sander

Publication type:

Article

A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells.

Published in:

Archives of Toxicology, 2024, v. 98, n. 9, p. 2919, doi. 10.1007/s00204-024-03796-1

By:

Wuerger, Leonie T. D.;
Sprenger, Heike;
Krasikova, Ksenia;
Templin, Markus;
Stahl, Aaron;
Herfurth, Uta M.;
Sieg, Holger;
Braeuning, Albert

Publication type:

Article

Metabolic effects of nuclear receptor activation in vivo after 28-day oral exposure to three endocrine-disrupting chemicals.

Published in:

Archives of Toxicology, 2024, v. 98, n. 3, p. 911, doi. 10.1007/s00204-023-03658-2

By:

Attema, Brecht;
Kummu, Outi;
Pitkänen, Sini;
Weisell, Jonna;
Vuorio, Taina;
Pennanen, Erika;
Vorimo, Maria;
Rysä, Jaana;
Kersten, Sander;
Levonen, Anna-Liisa;
Hakkola, Jukka

Publication type:

Article

Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia.

Published in:

Archives of Toxicology, 2023, v. 97, n. 11, p. 2861, doi. 10.1007/s00204-023-03575-4

By:

Itkonen, Anna;
Hakkola, Jukka;
Rysä, Jaana

Publication type:

Article

Comprehensive in vitro analysis evaluating the variable drug–drug interaction risk of rifampicin compared to rifabutin.

Published in:

Archives of Toxicology, 2023, v. 97, n. 8, p. 2219, doi. 10.1007/s00204-023-03531-2

By:

Nilles, Julie;
Weiss, Johanna;
Sauter, Max;
Haefeli, Walter E.;
Ruez, Stephanie;
Theile, Dirk

Publication type:

Article

A review on immunomodulatory effects of BPA analogues.

Published in:

Archives of Toxicology, 2023, v. 97, n. 7, p. 1831, doi. 10.1007/s00204-023-03519-y

By:

Kodila, Anja;
Franko, Nina;
Sollner Dolenc, Marija

Publication type:

Article

How to avoid misinterpretation of dual reporter gene assay data affected by cell damage.

Published in:

Archives of Toxicology, 2022, v. 96, n. 9, p. 2501, doi. 10.1007/s00204-022-03323-0

By:

Nilles, Julie;
Weiss, Johanna;
Haefeli, Walter E.;
Ruez, Stephanie;
Theile, Dirk

Publication type:

Article

Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.

Published in:

Archives of Toxicology, 2022, v. 96, n. 1, p. 195, doi. 10.1007/s00204-021-03177-y

By:

Smutny, Tomas;
Bernhauerova, Veronika;
Smutna, Lucie;
Tebbens, Jurjen Duintjer;
Pavek, Petr

Publication type:

Article

The "EU chemicals strategy for sustainability" questions regulatory toxicology as we know it: is it all rooted in sound scientific evidence?

Published in:

2021

By:

Herzler, Matthias;
Marx-Stoelting, Philip;
Pirow, Ralph;
Riebeling, Christian;
Luch, Andreas;
Tralau, Tewes;
Schwerdtle, Tanja;
Hensel, Andreas

Publication type:

Editorial

Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.

Published in:

Archives of Toxicology, 2021, v. 95, n. 1, p. 11, doi. 10.1007/s00204-020-02916-x

By:

Smutny, Tomas;
Hyrsova, Lucie;
Braeuning, Albert;
Ingelman-Sundberg, Magnus;
Pavek, Petr

Publication type:

Article

Regulation of hepatic P-gp expression and activity by genistein in rats.

Published in:

Archives of Toxicology, 2020, v. 94, n. 5, p. 1625, doi. 10.1007/s00204-020-02708-3

By:

Semeniuk, M.;
Ceré, L. I.;
Ciriaci, N.;
Bucci-Muñoz, M.;
Villanueva, S. S. M.;
Mottino, A. D.;
Catania, V. A.;
Rigalli, J. P.;
Ruiz, María Laura

Publication type:

Article

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells.

Published in:

Archives of Toxicology, 2020, v. 94, n. 5, p. 1637, doi. 10.1007/s00204-020-02706-5

By:

Li, Dongying;
Wu, Leihong;
Knox, Bridgett;
Chen, Si;
Tolleson, William H.;
Liu, Fang;
Yu, Dianke;
Guo, Lei;
Tong, Weida;
Ning, Baitang

Publication type:

Article

Highlight report: hepatotoxicity of triazole fungicides.

Published in:

2019

By:

Albrecht, Wiebke

Publication type:

Editorial

Pregnane X receptor mediates steatotic effects of propiconazole and tebuconazole in human liver cell lines.

Published in:

Archives of Toxicology, 2019, v. 93, n. 5, p. 1311, doi. 10.1007/s00204-019-02445-2

By:

Knebel, Constanze;
Buhrke, Thorsten;
Lampen, Alfonso;
Braeuning, Albert;
Süssmuth, Roderich;
Marx-Stoelting, Philip

Publication type:

Article

Increase in tacrolimus exposure after steroid tapering is influenced by CYP3A5 and pregnane X receptor genetic polymorphisms in renal transplant recipients.

Published in:

Nephrology Dialysis Transplantation, 2018, v. 33, n. 9, p. 1668, doi. 10.1093/ndt/gfy096

By:

Stifft, Frank;
Kuijk, Sander M J van;
Bekers, Otto;
Christiaans, Maarten H L

Publication type:

Article

Boost-RS: boosted embeddings for recommender systems and its application to enzyme–substrate interaction prediction.

Published in:

Bioinformatics, 2022, v. 38, n. 10, p. 2832, doi. 10.1093/bioinformatics/btac201

By:

Li, Xinmeng;
Liu, Li-Ping;
Hassoun, Soha

Publication type:

Article