Works matching DE "PREGNANE X receptor"
Results: 395
An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice.
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- Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56624-0
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Editorial: Unraveling the molecular mechanisms of cytokine signaling in regulating inflammatory diseases.
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- Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1563469
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Proteomics Profiling Reveals Pharmaceutical Excipient PEG400 Induces Nuclear-Receptor-Activation-Affected Lipid Metabolism and Metabolic Enzyme Expression.
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- International Journal of Molecular Sciences, 2025, v. 26, n. 4, p. 1732, doi. 10.3390/ijms26041732
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孕烷X 受体双荧光素酶报告基因方法建立及有机磷 酸酯阻燃剂的受体激活效应研究
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- Asian Journals of Ecotoxicology, 2023, v. 18, n. 2, p. 34, doi. 10.7524/AJE.1673-5897.20221115001
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Advances in drug resistance of osteosarcoma caused by pregnane X receptor.
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- Drug Metabolism Reviews, 2024, v. 56, n. 4, p. 385, doi. 10.1080/03602532.2024.2366948
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Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models.
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- Drug Metabolism Reviews, 2023, v. 55, n. 4, p. 405, doi. 10.1080/03602532.2023.2254525
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Pregnane X receptor as a therapeutic target for cholestatic liver injury.
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- Drug Metabolism Reviews, 2023, v. 55, n. 4, p. 371, doi. 10.1080/03602532.2023.2248680
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Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms.
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- Drug Metabolism Reviews, 2023, v. 55, n. 3, p. 239, doi. 10.1080/03602532.2023.2215478
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Implication of metabolomics and transporter modulation based strategies to minimize multidrug resistance and enhance site-specific bioavailability: a needful consideration toward modern anticancer drug discovery.
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- Drug Metabolism Reviews, 2022, v. 54, n. 2, p. 101, doi. 10.1080/03602532.2022.2048007
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Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism.
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- Drug Metabolism Reviews, 2022, v. 54, n. 1, p. 46, doi. 10.1080/03602532.2022.2039688
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Sulfotransferase genes: Regulation by nuclear receptors in response to xeno/endo-biotics.
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- Drug Metabolism Reviews, 2013, v. 45, n. 4, p. 441, doi. 10.3109/03602532.2013.835630
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- Article
Antioxidant Peptides Derived from Millet Bran Promote Longevity and Stress Resistance in Caenorhabditis elegans.
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- Plant Foods for Human Nutrition, 2023, v. 78, n. 4, p. 790, doi. 10.1007/s11130-023-01100-7
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Gene expression and immune infiltration analysis comparing lesioned and preserved subchondral bone in osteoarthritis.
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- PeerJ, 2024, p. 1, doi. 10.7717/peerj.17417
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Transcriptional profiling of hepatic constitutive androstane receptor and target genes in relation to boar taint compounds in backfat of pigs.
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- Journal of Animal Science, 2006, v. 84, p. 350
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The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice.
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- Microbiome, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40168-021-01050-9
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Mix-match synthesis of nanosynbiotics from probiotics and prebiotics to counter gut dysbiosis via AI integrated formulation profiling.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-69515-z
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Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment.
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- Biomolecules (2218-273X), 2021, v. 11, n. 8, p. 1142, doi. 10.3390/biom11081142
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Vitamin K in Vertebrates' Reproduction: Further Puzzling Pieces of Evidence from Teleost Fish Species.
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- Biomolecules (2218-273X), 2020, v. 10, n. 9, p. 1303, doi. 10.3390/biom10091303
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Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR.
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- Frontiers in Pharmacology, 2019, p. 1, doi. 10.3389/fphar.2019.01111
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Bile Acid Synthesis: From Nature to the Chemical Modification and Synthesis and Their Applications as Drugs and Nutrients.
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- Frontiers in Pharmacology, 2018, p. N.PAG, doi. 10.3389/fphar.2018.00939
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- Article
A Comparative Genomic and Phylogenetic Investigation of the Xenobiotic Metabolism Enzymes of Cytochrome P450 in Elephants Shows Loss in CYP2E and CYP4A.
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- Animals (2076-2615), 2023, v. 13, n. 12, p. 1939, doi. 10.3390/ani13121939
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Effect of Pregnane X Receptor on CYP3A29 Expression in Porcine Alveolar Macrophages during Mycoplasma hyopneumoniae Infection.
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- Animals (2076-2615), 2021, v. 11, n. 2, p. 349, doi. 10.3390/ani11020349
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- Article
Hepatoprotective effect of date palm fruit extract against doxorubicin intoxication in Wistar rats: In vivo and in silico studies.
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- Asian Pacific Journal of Tropical Biomedicine, 2022, v. 12, n. 8, p. 357, doi. 10.4103/2221-1691.350184
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The role of pregnane X receptor (PXR) in substance metabolism.
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- Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.959902
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The role of pregnane X receptor (PXR) in substance metabolism.
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- Frontiers in Endocrinology, 2022, v. 13, p. 01, doi. 10.3389/fendo.2022.959902
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Role of nuclear pregnane X receptor in Cu-induced lipid metabolism and xenobiotic responses in largemouth bass (Micropterus salmoides).
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- Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.950985
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Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease.
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- PLoS ONE, 2019, v. 14, n. 10, p. 1, doi. 10.1371/journal.pone.0221924
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Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury.
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- PLoS ONE, 2019, v. 14, n. 9, p. 1, doi. 10.1371/journal.pone.0222033
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Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer.
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- Molecular Cancer, 2017, v. 16, p. 1, doi. 10.1186/s12943-017-0641-8
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Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture.
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- Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09471-z
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Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by down-regulating periostin expression.
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- Biochemical Journal, 2024, v. 481, n. 18, p. 1173, doi. 10.1042/BCJ20240172
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Role of JNK in the Regulation of Xenobiotic Metabolizing Function of Hepatocytes.
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- Bulletin of Experimental Biology & Medicine, 2021, v. 172, n. 2, p. 146, doi. 10.1007/s10517-021-05352-8
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Regulation of hepatic xenosensor function by HNF4alpha.
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- Toxicological Sciences, 2024, v. 200, n. 2, p. 346, doi. 10.1093/toxsci/kfae069
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Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression.
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- Toxicological Sciences, 2024, v. 200, n. 2, p. 324, doi. 10.1093/toxsci/kfae057
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Maternal PBDE exposure disrupts gut microbiome and promotes hepatic proinflammatory signaling in humanized PXR-transgenic mouse offspring over time.
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- Toxicological Sciences, 2023, v. 194, n. 2, p. 209, doi. 10.1093/toxsci/kfad056
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Myclobutanil-mediated alteration of liver-gut FXR signaling in mice.
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- Toxicological Sciences, 2023, v. 191, n. 2, p. 387, doi. 10.1093/toxsci/kfac129
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Complementary biological and computational approaches identify distinct mechanisms of chlorpyrifos versus chlorpyrifos-oxon-induced dopaminergic neurotoxicity.
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- Toxicological Sciences, 2023, v. 191, n. 1, p. 163, doi. 10.1093/toxsci/kfac114
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2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (Tiparp<sup>H532A</sup>) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality.
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- Toxicological Sciences, 2021, v. 183, n. 1, p. 154, doi. 10.1093/toxsci/kfab075
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Liver Toxicity Observed With Lorlatinib When Combined With Strong CYP3A Inducers: Evaluation of Cynomolgus Monkey as a Nonclinical Model for Assessing the Mechanism of Combinational Toxicity.
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- Toxicological Sciences, 2021, v. 182, n. 2, p. 183, doi. 10.1093/toxsci/kfab056
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Targeting Xenobiotic Nuclear Receptors PXR and CAR to Prevent Cobicistat Hepatotoxicity.
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- Toxicological Sciences, 2021, v. 181, n. 1, p. 58, doi. 10.1093/toxsci/kfab023
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Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice.
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- Toxicological Sciences, 2020, v. 177, n. 2, p. 362, doi. 10.1093/toxsci/kfaa125
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Gut Microbiome Critically Impacts PCB-induced Changes in Metabolic Fingerprints and the Hepatic Transcriptome in Mice.
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- Toxicological Sciences, 2020, v. 177, n. 1, p. 168, doi. 10.1093/toxsci/kfaa090
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Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.
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- Toxicological Sciences, 2020, v. 176, n. 2, p. 329, doi. 10.1093/toxsci/kfaa076
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CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae.
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- Toxicological Sciences, 2020, v. 174, n. 1, p. 51, doi. 10.1093/toxsci/kfz246
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Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data.
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- Toxicological Sciences, 2019, v. 172, n. 2, p. 316, doi. 10.1093/toxsci/kfz189
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Epigenetic Memory Is Involved in the Persistent Alterations of Drug-Processing Genes in Adult Mice Due to PCN-Activated PXR During Early Life.
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- Toxicological Sciences, 2019, v. 172, n. 1, p. 98, doi. 10.1093/toxsci/kfz177
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Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis.
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- Toxicological Sciences, 2019, v. 168, n. 1, p. 40, doi. 10.1093/toxsci/kfy271
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Sequence Variations in pxr (nr1i2) From Zebrafish (Danio rerio) Strains Affect Nuclear Receptor Function.
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- Toxicological Sciences, 2019, v. 168, n. 1, p. 28, doi. 10.1093/toxsci/kfy269
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- Article
Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library.
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- Toxicological Sciences, 2019, v. 167, n. 1, p. 282, doi. 10.1093/toxsci/kfy242
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Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells.
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- Toxicological Sciences, 2018, v. 163, n. 1, p. 170, doi. 10.1093/toxsci/kfy026
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