Works matching DE "POLYGLUTAMINE"

Results: 444

Small Heat Shock Proteins Potentiate Amyloid Dissolution by Protein Disaggregases from Yeast and Humans.

Published in:

PLoS Biology, 2012, v. 10, n. 6, p. 1, doi. 10.1371/journal.pbio.1001346

By:

Duennwald, Martin L.;
Echeverria, AnaLisa;
Shorter, James

Publication type:

Article

Alteraciones de los movimientos oculares sacádicos en las enfermedades poliglutamínicas.

Published in:

Revista Mexicana de Neurociencia, 2013, v. 14, n. 3, p. 150

By:

Rodríguez-Labrada, Roberto;
Velázquez-Pérez, Luis

Publication type:

Article

Modification of Huntington's disease by short tandem repeats.

Published in:

Brain Communications, 2024, v. 6, n. 2, p. 1, doi. 10.1093/braincomms/fcae016

By:

Hong, Eun Pyo;
Ramos, Eliana Marisa;
Aziz, N Ahmad;
Massey, Thomas H;
McAllister, Branduff;
Lobanov, Sergey;
Jones, Lesley;
Holmans, Peter;
Kwak, Seung;
Orth, Michael;
Ciosi, Marc;
Lomeikaite, Vilija;
Monckton, Darren G;
Long, Jeffrey D;
Lucente, Diane;
Wheeler, Vanessa C;
Gillis, Tammy;
MacDonald, Marcy E;
Sequeiros, Jorge;
Gusella, James F

Publication type:

Article

Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy.

Published in:

Nature Reviews Neuroscience, 2015, v. 16, n. 6, p. 372, doi. 10.1038/nrn3974

By:

Soltesz, Ivan;
Alger, Bradley E.;
Kano, Masanobu;
Lee, Sang-Hun;
Lovinger, David M.;
Ohno-Shosaku, Takako;
Watanabe, Masahiko

Publication type:

Article

骆驼蓬多糖提取及对秀丽隐杆线虫多聚谷氨酰胺聚集毒性的影响.

Published in:

Journal of Beijing University of Traditional Chinese Medicine, 2017, v. 40, n. 11, p. 954, doi. 10.3969/j.issn.1006-2157.2017.11.014

By:

全庆华;
姬瑞芳;
袁将;
王加利;
刘一冰;
邹媛;
郭晓宇;
张伽妹;
刘永刚;
高增平

Publication type:

Article

Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington’s disease.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.89782

By:

Doo Eun Choi;
Jun Wan Shin;
Zeng, Sophia;
Hong, Eun Pyo;
Jae-Hyun Jang;
Loupe, Jacob M.;
Wheeler, Vanessa C.;
Stutzman, Hannah E.;
Kleinstiver, Ben;
Jong-Min Lee

Publication type:

Article

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.86939

By:

Kandola, Tej;
Venkatesan, Shriram;
Jiahui Zhang;
Lerbakken, Brooklyn T.;
Von Schulze, Alex;
Blanck, Jillian F.;
Jianzheng Wu;
Unruh, Jay R.;
Berry, Paula;
Lange, Jeffrey J.;
Box, Andrew C.;
Cook, Malcolm;
Sagui, Celeste;
Halfmann, Randal

Publication type:

Article

Possible Role for Allelic Variation in Yeast MED15 in Ecological Adaptation.

Published in:

Frontiers in Microbiology, 2021, v. 12, p. 1, doi. 10.3389/fmicb.2021.741572

By:

Cooper, David G.;
Jiang, Yishuo;
Skuodas, Sydney;
Wang, Luying;
Fassler, Jan S.

Publication type:

Article

Polyglutamine (polyQ) disorders.

Published in:

Nucleus (1949-1034), 2012, v. 3, n. 5, p. 1, doi. 10.4161/nucl.21481

By:

Cohen-Carmon, Dorit;
Meshorer, Eran

Publication type:

Article

The emerging role of the first 17 amino acids of huntingtin in Huntington's disease.

Published in:

Biomolecular Concepts, 2015, v. 6, n. 1, p. 33, doi. 10.1515/bmc-2015-0001

By:

Arndt, James R.;
Chaibva, Maxmore;
Legleiter, Justin

Publication type:

Article

No evidence of cardiomyopathy in spinal and bulbar muscular atrophy.

Published in:

Acta Neurologica Scandinavica, 2013, v. 128, n. 6, p. e30, doi. 10.1111/ane.12140

By:

Querin, G.;
Melacini, P.;
D'Ascenzo, C.;
Morandi, L.;
Mazzini, L.;
Silani, V.;
Romito, S.;
Mandrioli, J.;
Raimondi, M.;
Pegoraro, E.;
Soraru', G.

Publication type:

Article

Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila.

Published in:: Journal of Biomedical Science, 2012, v. 19, n. 1, p. 52, doi. 10.1186/1423-0127-19-52
Publication type:: Article

The polyglutamine domain is the primary driver of seeding in huntingtin aggregation.

Published in:

PLoS ONE, 2024, v. 19, n. 3, p. 1, doi. 10.1371/journal.pone.0298323

By:

Skeens, Adam;
Siriwardhana, Chathuranga;
Massinople, Sophia E.;
Wunder, Michelle M.;
Ellis, Zachary L.;
Keith, Kaitlyn M.;
Girman, Tyler;
Frey, Shelli L.;
Legleiter, Justin

Publication type:

Article

Structure of puromycin-sensitive aminopeptidase and polyglutamine binding.

Published in:

PLoS ONE, 2023, v. 18, n. 7, p. 1, doi. 10.1371/journal.pone.0287086

By:

Madabushi, Sowmya;
Chow, K. Martin;
Song, Eun Suk;
Goswami, Anwesha;
Hersh, Louis B.;
Rodgers, David W.

Publication type:

Article

Infantile Onset Spinocerebellar Ataxia 2 (SCA2): A Clinical Report With Review of Previous Cases.

Published in:

2014

By:

Singh, Ankur;
Faruq, Mohammed;
Mukerji, Mitali;
Dwivedi, Manish Kumar;
Pruthi, Sumit;
Kapoor, Seema

Publication type:

Case Study

Editorial: The role of posttranslational modifications in polyglutamine diseases.

Published in:

Frontiers in Molecular Neuroscience, 2023, p. 1, doi. 10.3389/fnmol.2023.1271226

By:

Weber, Jonasz Jeremiasz;
do Carmo Costa, Maria;
Scaglione, K. Matthew;
Todi, Sokol V.;
Huu Phuc Nguyen

Publication type:

Article

Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00571

By:

Niewiadomska-Cimicka, Anna;
Hache, Antoine;
Trottier, Yvon

Publication type:

Article

The Mechanisms of Nuclear Proteotoxicity in Polyglutamine Spinocerebellar Ataxias.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00489

By:

Lee, Davin;
Lee, Yun-Il;
Lee, Young-Sam;
Lee, Sung Bae

Publication type:

Article

Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice.

Published in:

Neurochemical Research, 2015, v. 40, n. 4, p. 800, doi. 10.1007/s11064-015-1530-4

By:

Chen, Zhi-Zhong;
Wang, Chien-Ming;
Lee, Guan-Chiun;
Hsu, Ho-Chiang;
Wu, Tzu-Ling;
Lin, Chia-Wei;
Ma, Chih-Kang;
Lee-Chen, Guey-Jen;
Huang, Hei-Jen;
Hsieh-Li, Hsiu

Publication type:

Article

The P42 peptide and Peptide-based therapies for Huntington's disease.

Published in:

2016

By:

Marelli, Cecilia;
Maschat, Florence

Publication type:

journal article

Information content in data sets for a nucleated-polymerization model.

Published in:

Journal of Biological Dynamics, 2015, v. 9, n. 1, p. 172, doi. 10.1080/17513758.2015.1050465

By:

Banks, H.T.;
Doumic, Marie;
Kruse, Carola;
Prigent, Stephanie;
Rezaei, Human

Publication type:

Article

Differential nuclear localization of complexes may underlie in vivo intrabody efficacy in Huntington's disease.

Published in:

PEDS: Protein Engineering, Design & Selection, 2014, v. 27, n. 10, p. 359, doi. 10.1093/protein/gzu041

By:

Butler, D.C.;
Snyder-Keller, A.;
De Genst, E.;
Messer, A.

Publication type:

Article

RNA toxicity induced by expanded CAG repeats in Huntington's disease.

Published in:

Brain Pathology, 2016, v. 26, n. 6, p. 779, doi. 10.1111/bpa.12427

By:

Martí, Eulàlia

Publication type:

Article

XVIII International Congress of Neuropathology September 17, 2014.

Published in:: 2014
Publication type:: Abstract

Huntington's Disease ( HD): Degeneration of Select Nuclei, Widespread Occurrence of Neuronal Nuclear and Axonal Inclusions in the Brainstem.

Published in:

Brain Pathology, 2014, v. 24, n. 3, p. 247, doi. 10.1111/bpa.12115

By:

Rüb, Udo;
Hentschel, Matthias;
Stratmann, Katharina;
Brunt, Ewout;
Heinsen, Helmut;
Seidel, Kay;
Bouzrou, Mohamed;
Auburger, Georg;
Paulson, Henry;
Vonsattel, Jean‐Paul;
Lange, Herwig;
Korf, Horst‐Werner;
Dunnen, Wilfred

Publication type:

Article

Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice.

Published in:

2018

By:

Mcloughlin, Hayley S.;
Moore, Lauren R.;
Chopra, Ravi;
Komlo, Robert;
Mckenzie, Megan;
Blumenstein, Kate G.;
Zhao, Hien;
Kordasiewicz, Holly B.;
Shakkottai, Vikram G.;
Paulson, Henry L.

Publication type:

journal article

Neuroprotective Potential of Eugenol in Polyglutamine-Mediated Neurodegenerative Disease Using Transgenic Drosophila Model.

Published in:

Dose-Response, 2024, v. 22, n. 4, p. 1, doi. 10.1177/15593258241291652

By:

Chongtham, Anjalika;
Agrawal, Namita

Publication type:

Article

Development of an isogenic human cell trio that models polyglutamine disease.

Published in:

Genes & Genetic Systems, 2023, v. 98, n. 4, p. 179, doi. 10.1266/ggs.22-00030

By:

Tomoyuki Ohno;
Takeshi Nakane;
Taichi Akase;
Hikaru Kurasawa;
Yasunori Aizawa

Publication type:

Article

New hope for therapy in neurodegenerative diseases.

Published in:

Cell Research, 2013, v. 23, n. 10, p. 1159, doi. 10.1038/cr.2013.96

By:

do Carmo Costa, Maria;
Paulson, Henry L

Publication type:

Article

Polyglutamine tracts as modulators of transcriptional activation from yeast to mammals.

Published in:

Biological Chemistry, 2012, v. 393, n. 1/2, p. 63, doi. 10.1515/BC-2011-252

By:

Atanesyan, Lilit;
Günther, Viola;
Dichtl, Bernhard;
Georgiev, Oleg;
Schaffner, Walter

Publication type:

Article

A Model for Small Heat Shock Protein Inhibition of Polyglutamine Aggregation.

Published in:

Cell Biochemistry & Biophysics, 2014, v. 69, n. 2, p. 275, doi. 10.1007/s12013-013-9795-1

By:

Healy, Eamonn;
Little, Carley;
King, Peter

Publication type:

Article

Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress.

Published in:

Molecules, 2014, v. 19, n. 6, p. 7757, doi. 10.3390/molecules19067757

By:

Lingyun Xiao;
Haifeng Li;
Ju Zhang;
Fan Yang;
Aizhen Huang;
Jingjing Deng;
Ming Liang;
Fangli Ma;
Minghua Hu;
Zebo Huang

Publication type:

Article

The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease.

Published in:

Acta Neuropathologica, 2017, v. 134, n. 6, p. 839, doi. 10.1007/s00401-017-1770-2

By:

Hernández, Ivó;
Torres-Peraza, Jesús;
Santos-Galindo, María;
Ramos-Morón, Eloísa;
Fernández-Fernández, M.;
Pérez-Álvarez, María;
Miranda-Vizuete, Antonio;
Lucas, José

Publication type:

Article

Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet.

Published in:

Acta Neuropathologica, 2016, v. 132, n. 1, p. 127, doi. 10.1007/s00401-016-1550-4

By:

Rocchi, Anna;
Milioto, Carmelo;
Parodi, Sara;
Armirotti, Andrea;
Borgia, Doriana;
Pellegrini, Matteo;
Urciuolo, Anna;
Molon, Sibilla;
Morbidoni, Valeria;
Marabita, Manuela;
Romanello, Vanina;
Gatto, Pamela;
Blaauw, Bert;
Bonaldo, Paolo;
Sambataro, Fabio;
Robins, Diane;
Lieberman, Andrew;
Sorarù, Gianni;
Vergani, Lodovica;
Sandri, Marco

Publication type:

Article

Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats.

Published in:

Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0187-3

By:

Ostrowski, Lauren A.;
Hall, Amanda C.;
Szafranski, Kirk J.;
Oshidari, Roxanne;
Abraham, Karan J.;
Chan, Janet N. Y.;
Krustev, Christian;
Zhang, Kevin;
Wang, Ashley;
Liu, Yupeng;
Guo, Ru;
Mekhail, Karim

Publication type:

Article

Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane.

Published in:

Biomedicines, 2022, v. 10, n. 9, p. 2294, doi. 10.3390/biomedicines10092294

By:

Swaih, Aisha M.;
Breda, Carlo;
Sathyasaikumar, Korrapati V.;
Allcock, Natalie;
Collier, Mary E. W.;
Mason, Robert P.;
Feasby, Adam;
Herrera, Federico;
Outeiro, Tiago F.;
Schwarcz, Robert;
Repici, Mariaelena;
Giorgini, Flaviano

Publication type:

Article

Polyglutamine Ataxias: Our Current Molecular Understanding and What the Future Holds for Antisense Therapies.

Published in:

Biomedicines, 2021, v. 9, n. 11, p. 1499, doi. 10.3390/biomedicines9111499

By:

McIntosh, Craig S.;
Li, Dunhui;
Wilton, Steve D.;
Aung-Htut, May T.

Publication type:

Article

PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-87382-w

By:

Yue, Hong-Wei;
Hong, Jun-Ye;
Zhang, Shu-Xian;
Jiang, Lei-Lei;
Hu, Hong-Yu

Publication type:

Article

The difficulty to model Huntington's disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-85656-x

By:

Le Cann, Kim;
Foerster, Alec;
Rösseler, Corinna;
Erickson, Andelain;
Hautvast, Petra;
Giesselmann, Sebastian;
Pensold, Daniel;
Kurth, Ingo;
Rothermel, Markus;
Mattis, Virginia B.;
Zimmer-Bensch, Geraldine;
von Hörsten, Stephan;
Denecke, Bernd;
Clarner, Tim;
Meents, Jannis;
Lampert, Angelika

Publication type:

Article

Analysis of mutant and total huntingtin expression in Huntington's disease murine models.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-78790-5

By:

Fodale, Valentina;
Pintauro, Roberta;
Daldin, Manuel;
Altobelli, Roberta;
Spiezia, Maria Carolina;
Bisbocci, Monica;
Macdonald, Douglas;
Bresciani, Alberto

Publication type:

Article

Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-65046-5

By:

Rodríguez-González, Claudio;
Lin, Shiying;
Arkan, Sertan;
Hansen, Christian

Publication type:

Article

Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients.

Published in:

Science Translational Medicine, 2024, v. 16, n. 772, p. 1, doi. 10.1126/scitranslmed.adn5449

By:

Bartelt, Luke C.;
Switonski, Pawel M.;
Adamek, Grażyna;
Longo, Fabiana;
Carvalho, Juliana;
Duvick, Lisa A.;
Jarrah, Sabrina I.;
McLoughlin, Hayley S.;
Scoles, Daniel R.;
Pulst, Stefan M.;
Orr, Harry T.;
Hull, Court;
Lowe, Craig B.;
La Spada, Albert R.

Publication type:

Article

Between Interactions and Aggregates: The PolyQ Balance.

Published in:

Genome Biology & Evolution, 2021, v. 13, n. 11, p. 1, doi. 10.1093/gbe/evab246

By:

Mier, Pablo;
Andrade-Navarro, Miguel A

Publication type:

Article

PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model.

Published in:

Frontiers in Cellular Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fncel.2017.00121

By:

Carnemolla, Alisia;
Michelazzi, Silvia;
Agostoni, Elena

Publication type:

Article

Reduction of Huntington's Disease RNA Foci by CAG Repeat-Targeting Reagents.

Published in:

Frontiers in Cellular Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fncel.2017.00082

By:

Urbanek, Martyna O.;
Fiszer, Agnieszka;
Krzyzosiak, Wlodzimierz J.

Publication type:

Article

The 11S Proteasomal Activator REGg Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms.

Published in:

Frontiers in Molecular Neuroscience, 2017, v. 10, p. 1, doi. 10.3389/fnmol.2017.00159

By:

Yersak, Jill M.;
Montie, Heather L.;
Chevalier-Larsen, Erica S.;
Liu, Yuhong;
Huang, Lan;
Rechsteiner, Martin;
Merry, Diane E.

Publication type:

Article

Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases.

Published in:

Frontiers in Molecular Neuroscience, 2017, v. 10, p. 1, doi. 10.3389/fnmol.2017.00101

By:

Shemesh, Netta;
Shai, Nadav;
Meshnik, Lana;
Katalan, Rotem;
Ben-Zvi, Anat

Publication type:

Article

The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine Disease.

Published in:

Frontiers in Molecular Neuroscience, 2017, v. 10, p. 1, doi. 10.3389/fnmol.2017.00078

By:

Nath, Samir R.;
Lieberman, Andrew P.

Publication type:

Article

Detection of ubiquitinated huntingtin species in intracellular aggregates.

Published in:

Frontiers in Molecular Neuroscience, 2015, v. 8, p. 1, doi. 10.3389/fnmol.2015.00001

By:

Juenemann, Katrin;
Wiemhoefer, Anne;
Reits, Eric A.

Publication type:

Article

Ubiquitin-proteasome system involvement in Huntington's disease.

Published in:

Frontiers in Molecular Neuroscience, 2014, v. 7, p. 10, doi. 10.3389/fnmol.2014.00077

By:

Ortega, Zaira;
Lucas, Jose J.

Publication type:

Article