Works about PI3K/AKT pathway

Results: 2049

Delta 4-desaturase sphingolipid 2 enhances prostate cancer stem-like traits through phytoceramide-mediated PI3K-AKT signaling pathway.

Published in:

Carcinogenesis, 2025, v. 46, n. 2, p. 1, doi. 10.1093/carcin/bgaf024

By:

Luo, Yuanyuan;
Yu, Jiachuan;
Li, Qi;
Wang, Xiaolin;
Liu, Xinyu;
Xu, Guowang;
Qin, Wangshu

Publication type:

Article

Paradoxical regulation of IGF2 in promoting lipid metabolism in adipose tissues.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08458-1

By:

Zhou, Caiping;
Gui, Weiwei;
Zhu, Weifen;
Zhao, Hanxin;
Wu, Dingting;
Wu, Fang;
Wang, Gangliang;
Lin, Xihua

Publication type:

Article

Unveiling the anticancer potential of Curcuma amada rhizome extract against prostate cancer through computational and experimental approaches.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10761-0

By:

Priyadarshini, Arpita;
Mohanty, Debajani;
Mohanty, Swagat;
Kerry, Rout George;
Sahoo, Ambika;
Dash, Biswabhusan;
Panda, Pratap Chandra;
Nayak, Sanghamitra;
Ray, Asit;
Jena, Sudipta

Publication type:

Article

LncRNA HOXB-AS4 Promotes Tumor Malignant Phenotype in Head and Neck Squamous Cell Carcinoma and Serves as a Prognosis Marker.

Published in:

Journal of Cancer, 2025, v. 16, n. 9, p. 2997, doi. 10.7150/jca.111037

By:

Shanshan Lv;
Jie Guo;
Lin Du;
Yanwei Luo;
Hao Tian;
Yan Liu

Publication type:

Article

HnRNP-F promotes the proliferation of bladder cancer cells mediated by PI3K/AKT/FOXO1.

Published in:

Journal of Cancer, 2021, v. 12, n. 1, p. 281, doi. 10.7150/jca.50490

By:

Fei Li;
Weiwei Xie;
Yunze Fang;
Kunfeng Xie;
Wendong Liu;
Lina Hou;
Wanlong Tan

Publication type:

Article

Shikonin inhibits migration and invasion of triplenegative breast cancer cells by suppressing epithelialmesenchymal transition via miR-17-5p/PTEN/Akt pathway.

Published in:

Journal of Cancer, 2021, v. 12, n. 1, p. 76, doi. 10.7150/jca.47553

By:

Chang Bao;
Tao Liu;
Lingbo Qian;
Chi Xiao;
Xinru Zhou;
Heng Ai;
Jue Wang;
Weimin Fan;
Jie Pan

Publication type:

Article

Exploring research trends and hotspots in PI3K/Akt signaling pathway in ischemic stroke: a bibliometric analysis.

Published in:

Frontiers in Molecular Neuroscience, 2025, p. 1, doi. 10.3389/fnmol.2025.1613702

By:

Liu, Yingquan;
Ye, Yu;
Bai, Lin;
Dai, Fan;
Su, Xingxing;
Hu, Peijia;
Cheng, Hongliang

Publication type:

Article

Jujuboside B Inhibits the Proliferation and Migration of Non-Small Cell Lung Cancer H1299 Cells Through Inhibiting PI3K/Akt and Wnt/β-Catenin Pathways.

Published in:

Cancer Management & Research, 2025, v. 17, p. 1143, doi. 10.2147/CMAR.S526130

By:

Chen, Mengzhu;
Li, Jian;
Hu, Shaodan;
Wang, Yuhan;
Wang, Keju;
Wang, Tan

Publication type:

Article

Mechanistic study of CTHRC1 in promoting Wilms' tumor progression by regulating M2-type tumor-associated macrophages polarization.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06752-4

By:

Zhuo, Yingquan;
Feng, Xiaoyun;
Zhang, Wenqi;
Du, Jun;
Sun, Xu;
Luo, Xi;
Wang, Wei;
Jiang, Hua;
Gu, Huajian

Publication type:

Article

CXCR4/CXCL12 axis promotes lymphatic metastasis in tongue squamous cell carcinoma via PI3K/AKT signaling pathway.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06707-9

By:

Lou, Huiquan;
Xia, Yichao;
Shao, Shengjie;
Liu, Xiang;
Li, Zengzheng;
Yu, Hongbin;
Li, Yongsheng

Publication type:

Article

Tumor-secreted RGS17 impairs CD8 + T cell function in lung adenocarcinoma through affecting glucose metabolism mediated by PI3K/AKT pathway.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02850-3

By:

Lou, Ming;
Tong, Ji-Chun;
Wu, Qi-Yong;
Zhu, Zheng;
Mao, Xiao-Liang;
Lu, Jia-Wei

Publication type:

Article

Protective effects of apricot kernel oil and metformin against BPA-induced ovarian toxicity in rat models of polycystic ovary syndrome: insights into PI3K/AKT and mitochondrial apoptosis pathways.

Published in:

Toxicology Research, 2025, v. 14, n. 3, p. 1, doi. 10.1093/toxres/tfaf071

By:

Jiao, Xuejuan;
Zhang, Qianqian;
Ye, Guoliu;
Xing, Fang;
Xie, Dongmei;
Wang, Liqun

Publication type:

Article

Aptamer as a Molecular Tethering Agent Induces PrP<sup>C</sup> Aggregation and Degradation to Inhibit Melanoma Proliferation.

Published in:

Angewandte Chemie, 2025, v. 137, n. 28, p. 1, doi. 10.1002/ange.202425051

By:

Xie, Tiantian;
Zhang, Yibin;
Ling, Neng;
Yuan, Yijun;
Liu, Weibin;
Guo, Junxiao;
Wei, Xianhua;
Peng, Tianhuan;
Wang, Zhiyan;
Dai, Jing;
Chen, Wenjing;
Yan, Ming;
Wu, Xiaoqiu;
Wu, Wencan;
Ye, Mao;
Tan, Weihong

Publication type:

Article

A computational study of cardiac glycosides from Vernonia amygdalina as PI3K inhibitors for targeting HER2 positive breast cancer.

Published in:

Journal of Computer-Aided Molecular Design, 2025, v. 39, n. 1, p. 1, doi. 10.1007/s10822-025-00621-4

By:

Tafrihani, Ahmad Syauqy;
Hanif, Naufa;
Yoga, I Made Bayu Kresna;
Irmasari, Irmasari;
Fakih, Taufik Muhammad;
Novitasari, Dhania;
Hasibuan, Poppy Anjelisa Zaitun;
Satria, Denny;
Huda, Fathul;
Muchtaridi, Muchtaridi;
Hermawan, Adam

Publication type:

Article

Network pharmacology-based prediction and "gut microbiota-inflammation-brain axis" validation of the active ingredients and potential mechanisms of Plantagins Herba for treating diabetes-related cognitive dysfunction.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1601689

By:

Huang, Zhixuan;
Liu, Jian;
Li, Hui;
Ai, Yangwen;
Zhou, Dongyue

Publication type:

Article

PI3K/AKT signaling pathway plays an important role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-07612-3

By:

Shao, Cuiping;
Xu, Youqing

Publication type:

Article

Effects of Pathway Interactions on the Quality of Tan Lamb during Post-slaughter Storage Period.

Published in:

Journal of Chinese Institute of Food Science & Technology / Zhongguo Shipin Xuebao, 2025, v. 25, n. 5, p. 406, doi. 10.16429/j.1009-7848.2025.037

By:

WANG Yanyun;
WANG Jinxia;
LUO Ruiming;
HOU Yanru

Publication type:

Article

MYO1B promotes radioresistance in head and neck squamous cell carcinoma by regulating tumor stemness and DNA damage repair via the PI3K/AKT pathway.

Published in:

Cancer Cell International, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12935-025-03863-2

By:

Li, Yanan;
Liu, Jiahao;
Wang, Zhen;
Zhang, Yilei;
Liu, Baiying;
Chu, Ling

Publication type:

Article

Peripheral Blood-Derived Mesenchymal Stem Cells Promote A2 Phenotype Polarization in Astrocytes via TGF-β-Mediated PI3K/Akt Pathway Activation.

Published in:

European Journal of Medical Research, 2025, v. 30, n. 1, p. 1, doi. 10.1186/s40001-025-02814-x

By:

Yang, Rui-Lin;
Zhao, De-Zhi;
Wei, Han-Xiao;
Chen, Si-Yu;
Yang, Yi-Bing;
Yang, Kang;
Yan, Wen;
Zhang, Tao

Publication type:

Article

Network pharmacology mechanisms and experimental verification of Hedyotis Diffusae Herba-Scutellariae Barbatae Herba drug pair extract in the treatment of nasopharyngeal carcinoma.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1601725

By:

Li, Tiantian;
Chen, Haijun;
Zhang, Jing;
Liu, Jiaxin;
Tang, Rundong;
Zhang, Liang;
Feng, Tian;
Xiao, Yanchun;
Liu, Shiwen;
Chen, Xiangjun

Publication type:

Article

The novel functions of chemokines in lung cancer progression.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1607225

By:

Gong, Xiaorui;
Wang, Xueying;
Jin, Jing;
Gong, Zhiqiang

Publication type:

Article

Carnosine Postconditioning Does not Evoke PI3K/Akt Mediated Cardioprotection in Isolated Rat Heart Upon Ischemia-Reperfusion.

Published in:

International Journal of Peptide Research & Therapeutics, 2025, v. 31, n. 5, p. 1, doi. 10.1007/s10989-025-10737-8

By:

Yamada, Mariko;
Nakadate, Yosuke;
Oguchi, Takeshi;
Omiya, Keisuke;
Abe, Masako;
Inomata, Shinichi

Publication type:

Article

Inhibition of LPS-induced inflammation and signaling pathways in fallopian tube epithelial cells by estrogen and progesterone.

Published in:

BMC Veterinary Research, 2025, v. 21, p. 1, doi. 10.1186/s12917-025-04874-x

By:

Li, Qianqian;
Liu, Jianqi;
Nashun, Bayaer;
Bai, Sarina;
Guo, Xiaozhen;
Wu, Ling;
Bao, Tuya

Publication type:

Article

Deciphering the role of ERK and PI3K/Akt as crosstalk pathways between fibroblast-like synoviocytes and osteoclasts; novel therapeutic approach for rheumatoid arthritis.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10769-9

By:

Hassani, Seyede-Sara;
Farhadi, Elham;
Esmaeili, Seyed-Alireza;
Mahmoudi, Mahdi;
Mahmoudi, Mahmoud;
Afshari, Jalil Tavakol;
Akhlaghi, Masoumeh;
Jamshidi, Ahmadreza

Publication type:

Article

Bone Implants with Promoted Antibacterial and Osteointegration Performances via a One‐Step Surface‐Bioactivation Strategy Based on Polyphenol‐Amine Chemistry.

Published in:

Advanced Functional Materials, 2025, v. 35, n. 26, p. 1, doi. 10.1002/adfm.202423639

By:

Xu, Chi;
Sun, Meizhou;
Lv, Shuai;
Liu, Xuanzhi;
Zhao, Nana;
Li, Yang;
Duan, Shun;
Xu, Fu‐Jian;
Geng, Wei;
Sun, Yujie

Publication type:

Article

Acid phosphatase type 6 promotes endometrial cancer progression via activating PI3K/AKT pathway.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10761-3

By:

Lin, Qingling;
Liang, Xiaolei;
Ma, Liangjian;
Ma, Xing;
Li, Bin;
Yang, Yongxiu;
Yang, Kehu

Publication type:

Article

Amelioration of Liver Fibrosis via In Situ Hepatic Stellate Cell Conversion Through Co‐Inhibition of TGF‐β and GSK‐3 Signalling.

Published in:

Liver International, 2025, v. 45, n. 7, p. 1, doi. 10.1111/liv.70187

By:

Zhu, Xiang‐Jie;
Zhong, Zhi;
Du, Jiang‐Chuan;
Zhang, Jiu‐Yu;
Zhang, Xu;
Cui, Xiu‐Liang;
Guan, Ling‐Ting;
Hu, Yan‐Yu;
Chen, Can;
Wang, Han;
Wu, Xiang‐Yu;
Zhang, Wei‐Jia;
Zhang, Pei‐Lin;
Wang, Hong‐Yang

Publication type:

Article

Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1541820

By:

Zhang, Lin-Ting;
Zhou, Yuejia;
Wang, Tiantian;
Chen, Boran;
Cai, Zhigao;
Wang, Shubin;
Tong, Gangling

Publication type:

Article

Apigenin Inhibits Cell Ferroptosis by Activating the PI3K/Akt Pathway and Alleviates Renal Injury Caused by Hypertension.

Published in:

Dose-Response, 2025, v. 23, n. 2, p. 1, doi. 10.1177/15593258251335814

By:

Zhang, Haina;
Cao, Yanhua;
Jiao, Liting;
Wan, Jianwei

Publication type:

Article

SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05797-4

By:

Cai, Rui;
Li, Cong;
Shi, Wenhui;
Xie, Fenfen;
Fan, Mengmeng;
Zhang, Hao;
Liu, Zhuang;
Chen, Yuanhua;
Hong, Qiang

Publication type:

Article

Anti‐Osteoporosis Activity of Lycopene Through ESR1: Network Pharmacology, Molecular Docking, Imaging Technology, and Experimental Validation.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 6, p. 1, doi. 10.1111/cbdd.70135

By:

Zhao, Benqian;
Chen, Lulu;
Wang, Wei;
Xu, Weinan;
Xu, Bing

Publication type:

Article

Combined Network Pharmacology, Transcriptomics and Metabolomics Strategies Reveal the Mechanism of Action of Lang Chuang Wan to Ameliorate Lupus Nephritis in MRL/lpr Mice.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 916, doi. 10.3390/ph18060916

By:

Li, Cuicui;
Ji, Guoxin;
Zhang, Xinru;
Yu, Hang;
Li, Zhimeng;
Yang, Bo;
Yao, Zhuangzhuang;
Wang, Shilei;
Jiang, Tongwei;
Wang, Shumin

Publication type:

Article

Metabolites from the Dendrobium Endophyte Pseudomonas protegens CM-YJ44 Alleviate Insulin Resistance in HepG2 Cells via the IRS1/PI3K/Akt/GSK3β/GLUT4 Pathway.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 817, doi. 10.3390/ph18060817

By:

Qin, Luqi;
Zhou, Yixia;
Fan, Bei;
Zheng, Jiahuan;
Diao, Rao;
Liu, Jiameng;
Wang, Fengzhong

Publication type:

Article

The Therapeutic Potential of Bombyx Batryticatus for Chronic Atrophic Gastritis Precancerous Lesions via the PI3K/AKT/mTOR Pathway Based on Network Pharmacology of Blood-Entering Components.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 791, doi. 10.3390/ph18060791

By:

Wang, Xiaojie;
Chang, Miaomiao;
Feng, Kun;
Wang, Qingyue;
Li, Bowen;
Gao, Weijuan

Publication type:

Article

2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00611-y

By:

Jing, Doudou;
Chen, Xuanzuo;
Zhang, Zhenhao;
Chen, Fengxia;
Huang, Fuhua;
Zhang, Zhicai;
Wu, Wei;
Shao, Zengwu;
Pu, Feifei

Publication type:

Article

Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00416-x

By:

En, Qiao;
Zeping, Huang;
Yuetang, Wang;
Xu, Wang;
Wei, Wang

Publication type:

Article

Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00393-1

By:

Cheng, Hui;
Ding, Jie;
Tang, Gusheng;
Huang, Aijie;
Gao, Lei;
Yang, Jianmin;
Chen, Li

Publication type:

Article

ARID1A serves as a receivable biomarker for the resistance to EGFR-TKIs in non-small cell lung cancer.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00400-5

By:

Sun, Dantong;
Teng, Fei;
Xing, Puyuan;
Li, Junling

Publication type:

Article

RNA‐Binding Protein DHX9 Enhances Radioresistance in Metastatic Hepatocellular Carcinoma by Activation of the PI3K/Akt Pathway Through Enhanced EEF1A2 mRNA Stability.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 6, p. 1, doi. 10.1002/jbt.70356

By:

Wang, HaiBo;
Cui, Wei

Publication type:

Article

EIF3B Promotes KRAS Gene Mutation‐Driven Colon Adenocarcinoma Progression Through the TBK1 and PI3K/AKT Signaling Pathways.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 6, p. 1, doi. 10.1002/jbt.70353

By:

Ren, Chongren;
Qin, Yaxin;
Cao, Dujuan;
Ren, Xiaojing;
Zhao, Haoliang;
Han, Jianli;
Du, Gang

Publication type:

Article

Cancer‐Associated Fibroblast‐Derived RIPK4 Confers Cisplatin Resistance in Gastric Cancer by Activating the PI3K/AKT Pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 6, p. 1, doi. 10.1002/jbt.70320

By:

Chen, Rui;
Dai, Junfang;
Wang, Bo;
Peng, Guofei;
Xun, Yao;
Li, Yan

Publication type:

Article

Synergistic Anticancer Effects of Silibinin and Sulforaphane: Targeting Gastric Cancer via PI3K/AKT and ERK1/2 MAPK Pathway Inhibition and Molecular Docking Insights.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 4, p. 1, doi. 10.1002/jbt.70237

By:

Liu, Yanfeng;
Zhang, Ming

Publication type:

Article

FTO‐mediated m6A Methylation of KCNAB2 Inhibits Tumor Property of Non‐Small Cell Lung Cancer Cells and M2 Macrophage Polarization by Inactivating the PI3K/AKT Pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 4, p. 1, doi. 10.1002/jbt.70232

By:

Li, Yanguang;
Niu, Jieting;
Sun, Zhiguang;
Liu, Junfeng

Publication type:

Article

Silencing of PODXL2 Modulates Cell Viability and Tumor Immune Microenvironment of Prostate Cancer and Involves PI3K/AKT Pathway Inactivation.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 4, p. 1, doi. 10.1002/jbt.70210

By:

Su, Yaowu;
Zhou, Liang;
Yu, Qin;
Liu, Weihua;
Liu, Wei

Publication type:

Article

Anti‐Proliferation Effect of Nodosin on Hepatocellular Carcinoma Cells Via The ERCC6L/PI3K/AKT/Axis.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 11, p. 1, doi. 10.1002/jbt.70049

By:

Wang, Qingling;
Gong, Qingquan;
Zhang, Chun;
Lin, Jianyuan;
Xiao, Dexian;
Li, Dianlian;
Lin, Feng;
Guo, Dengfang

Publication type:

Article

SPAG4 enhances mitochondrial respiration and aerobic glycolysis in colorectal cancer cells by activating the PI3K/Akt signaling pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 11, p. 1, doi. 10.1002/jbt.70009

By:

Zhou, Jiehao;
Sun, Haobo;
Zhou, Hang;
Liu, Ying

Publication type:

Article

Asiaticoside protected brain injury in hypertensive intracerebral hemorrhage via activation of the PI3K/AKT pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 9, p. 1, doi. 10.1002/jbt.23843

By:

Wang, Jicun;
Wang, Jianxin

Publication type:

Article

Let‐7 reduces the proliferation and migration of oral cancer cells via PI3K/AKT signaling pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 9, p. 1, doi. 10.1002/jbt.23834

By:

Liu, Yang;
Li, Kunshan;
Zhang, Jing;
Jin, Linyu;
Xu, Hui;
Duan, Yanhao

Publication type:

Article

Unveiling myricetin's pharmacological potency: A comprehensive exploration of the molecular pathways with special focus on PI3K/AKT and Nrf2 signaling.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 6, p. 1, doi. 10.1002/jbt.23739

By:

Goyal, Ahsas;
Sikarwar, Om;
Verma, Aanchal;
Solanki, Kunal;
Agrawal, Neetu;
Dubey, Nandini;
Yadav, Harlokesh Narayan

Publication type:

Article

Correction to "antidiabetic activity of eupafolin through peroxisome Proliferator‐Activated Receptor‐Gamma and PI3K/Akt signaling in type 2 diabetic rats".

Published in:: 2024
Publication type:: Correction Notice