Works matching DE "PI3K/AKT pathway"

Results: 1890

Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02471-w

By:

Hedayati, Neda;
Safari, Mohamad Hosein;
Milasi, Yaser Eshaghi;
Kahkesh, Samaneh;
Farahani, Najma;
Khoshnazar, Seyedeh Mahdieh;
Dorostgou, Zahra;
Alaei, Elmira;
Alimohammadi, Mina;
Rahimzadeh, Payman;
Taheriazam, Afshin;
Hashemi, Mehrdad

Publication type:

Article

Tanshinone IIA Regulates Synaptic Plasticity in Mg2+-Free-Induced Epileptic Hippocampal Neurons via the PI3K/Akt Signaling Pathway.

Published in:

Journal of Integrative Neuroscience, 2024, v. 23, n. 3, p. 1, doi. 10.31083/j.jin2303061

By:

Meile Ma;
Xi Hua;
Chen Jia;
Nan Xiao;
Li Zhang;
Liming Wei;
Haisheng Jiao

Publication type:

Article

Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.

Published in:

Journal of Integrative Neuroscience, 2024, v. 23, n. 1, p. 1, doi. 10.31083/j.jin2301014

By:

Shuai Yu;
Wei Xiong;
Wanjing Xu;
Yafen Chen

Publication type:

Article

Cyp2e1 knockdown attenuates high glucose-induced apoptosis and oxidative stress of cardiomyocytes by activating PI3K/Akt signaling.

Published in:

Acta Diabetologica, 2023, v. 60, n. 9, p. 1219, doi. 10.1007/s00592-023-02110-2

By:

Wang, Jianying;
Yang, Han;
Wang, Chao;
Kan, Cuie

Publication type:

Article

Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes.

Published in:

Acta Diabetologica, 2022, v. 59, n. 5, p. 661, doi. 10.1007/s00592-021-01840-5

By:

Dai, Hang-Bing;
Wang, Hong-Yu;
Wang, Fang-Zheng;
Qian, Pei;
Gao, Qing;
Zhou, Hong;
Zhou, Ye-Bo

Publication type:

Article

Epoxyeicosatrienoic Acids Attenuate LPS-Induced NIH/3T3 Cell Fibrosis through the A2AR and PI3K/Akt Signaling Pathways.

Published in:

Bulletin of Experimental Biology & Medicine, 2024, v. 177, n. 2, p. 185, doi. 10.1007/s10517-024-06153-5

By:

Lv, B.;
Yang, L.;
Gao, Y.;
Li, G.

Publication type:

Article

Dehydrocostus Lactone Reduced Malignancy of HepG2 Human Hepatocellular Carcinoma Cells via Down-Regulation of the PI3K/AKT Signaling Pathway.

Published in:

Bulletin of Experimental Biology & Medicine, 2023, v. 174, n. 3, p. 360, doi. 10.1007/s10517-023-05708-2

By:

Gu, W.;
Zhao, H.;
Yuan, H.;
Zhao, S.

Publication type:

Article

Tonkinensine B induces apoptosis through mitochondrial dysfunction and inactivation of the PI3K/AKT pathway in triple-negative breast cancer cells.

Published in:

Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 10, p. 1397, doi. 10.1093/jpp/rgab108

By:

Sun, Xuanrong;
Zhang, Tianwei;
Cai, Yue;
Yang, Ke;
Peng, Tingting;
Liu, Renhao;
Li, Xing-Nuo

Publication type:

Article

O2-(2,4-dinitrophenyl) diazeniumdiolate derivative induces G2/M arrest via PTEN-mediated inhibition of PI3K/Akt pathway in hepatocellular carcinoma cells.

Published in:

Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 10, p. 1330, doi. 10.1093/jpp/rgab092

By:

Liu, Ling;
Xu, Jinglei;
Zhai, Ziyu;
Cao, Mengyao;
Huang, Zile;
Xing, Yihao;
Chen, Jingjing

Publication type:

Article

Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation.

Published in:

Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 8, p. 1101, doi. 10.1093/jpp/rgab056

By:

Su Bo;
Jing Lai;
Honyu Lin;
Xue Luo;
Yiqiong Zeng;
Tianying Du

Publication type:

Article

PI3K/Akt/CncC signaling pathway mediates the response to EPN‐Bt infection in Holotrichia parallela larvae.

Published in:

Pest Management Science, 2023, v. 79, n. 5, p. 1660, doi. 10.1002/ps.7337

By:

Li, Er‐Tao;
Wu, Han‐Jia;
Wang, Zhi‐Min;
Li, Ke‐Bin;
Zhang, Shuai;
Cao, Ya‐Zhong;
Yin, Jiao

Publication type:

Article

Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-023-00489-3

By:

Tan, Yan Qin;
Chiou, Yi-Shiou;
Guo, Hui;
Zhang, Shuwei;
Huang, Xiaoming;
Dukanya, Dukanya;
Kumar, Arun M.;
Basappa, Shreeja;
Liu, Suling;
Zhu, Tao;
Basappa, Basappa;
Pandey, Vijay;
Lobie, Peter E.

Publication type:

Article

Tetrahedral framework nucleic acids enhance the chondrogenic potential of human umbilical cord mesenchymal stem cells via the PI3K/AKT axis.

Published in:

Regenerative Biomaterials, 2023, v. 10, p. 1, doi. 10.1093/rb/rbad085

By:

Fu, Liwei;
Li, Pinxue;
Wu, Jiang;
Zheng, Yazhe;
Ning, Chao;
Liao, Zhiyao;
Yuan, Xun;
Ding, Zhengang;
Zhang, Zhichao;
Sui, Xiang;
Shi, Sirong;
Liu, Shuyun;
Guo, Quanyi

Publication type:

Article

ABHD11-AS1: An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies.

Published in:

Non-Coding RNA, 2022, v. 8, n. 2, p. N.PAG, doi. 10.3390/ncrna8020021

By:

Golla, Upendarrao;
Sesham, Kishore;
Dallavalasa, Siva;
Manda, Naresh Kumar;
Unnam, Sambamoorthy;
Sanapala, Arun Kumar;
Nalla, Sharada;
Kondam, Susmitha;
Kumar, Rajesh

Publication type:

Article

TIMP1 represses sorafenib-triggered ferroptosis in colorectal cancer cells by activating the PI3K/Akt signaling pathway.

Published in:

Immunopharmacology & Immunotoxicology, 2023, v. 45, n. 4, p. 419, doi. 10.1080/08923973.2022.2160731

By:

Wang, Ling;
Wang, Jin;
Chen, Ling

Publication type:

Article

The role of PI3K/AKT-related proteins in di(2-ethyl)hexylphthalate-induced BG-1 and MCF-7 cell proliferation, and inhibition by metformin.

Published in:

Immunopharmacology & Immunotoxicology, 2023, v. 45, n. 3, p. 378, doi. 10.1080/08923973.2022.2151915

By:

Zhang, Jiatai;
Zhao, Chenyang;
Hu, Tengteng;
Yang, Jipeng;
Wu, Qian;
Wang, Cheng;
Dong, Shuying

Publication type:

Article

IGF2BP3 aggravates lung adenocarcinoma progression by modulation of PI3K/AKT signaling pathway.

Published in:

Immunopharmacology & Immunotoxicology, 2023, v. 45, n. 3, p. 370, doi. 10.1080/08923973.2022.2150636

By:

Chen, Xiaoyu;
Zhu, Xunxia;
Shen, Xiaoyong;
Liu, Yang;
Fu, Wentao;
Wang, Bin

Publication type:

Article

LncRNA DLEU2 silencing impedes the migration, invasion and EMT in gastric cancer cell by suppressing PI3K/AKT signaling pathway.

Published in:

Immunopharmacology & Immunotoxicology, 2022, v. 44, n. 5, p. 719, doi. 10.1080/08923973.2022.2078727

By:

Hu, Jun;
Wang, Mingyun;
Yang, Yang;
Xing, Yajun;
Li, Shuanggen

Publication type:

Article

LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling.

Published in:

Immunopharmacology & Immunotoxicology, 2022, v. 44, n. 4, p. 510, doi. 10.1080/08923973.2022.2055565

By:

Wu, Xinyang;
Pu, Lijun;
Chen, Wei;
Zhao, Qi;
Wu, Geping;
Li, Di;
Zhu, Hongyan

Publication type:

Article

STAT1 mediates the PI3K/AKT pathway through promoting microRNA-18a in nasal polyps.

Published in:

Immunopharmacology & Immunotoxicology, 2022, v. 44, n. 2, p. 194, doi. 10.1080/08923973.2021.2025388

By:

Jian, Baoshan;
Yin, Peng

Publication type:

Article

MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway.

Published in:

Immunopharmacology & Immunotoxicology, 2022, v. 44, n. 1, p. 17, doi. 10.1080/08923973.2021.1991372

By:

Su, Dongna

Publication type:

Article

Mechanism of neuroprotective effect of stevioside on cerebral ischemia-reperfusion injury via PPAR-γ activation.

Published in:

Immunopharmacology & Immunotoxicology, 2021, v. 43, n. 6, p. 704, doi. 10.1080/08923973.2021.1966034

By:

Zhang, Yanli

Publication type:

Article

IL-1β promotes esophageal squamous cell carcinoma growth and metastasis through FOXO3A by activating the PI3K/AKT pathway.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02008-0

By:

Chen, Shuangshuang;
Yang, Ying;
Zheng, Zhaoyang;
Zhang, Man;
Chen, Xixian;
Xiao, Nan;
Liu, Hongchun

Publication type:

Article

METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01959-8

By:

Wang, Jianwei;
Yin, Hongli;
Li, Gen;
Wu, Di;
Xu, Yunyun;
Chen, Yanling;
Wang, Xiaodong;
Xing, Yujiao;
Zhang, Ting;
Fei, Danhong;
Yang, Pengcheng;
Fang, Fang;
Tao, Yanfang;
Li, Xiaolu;
Yu, Juanjuan;
Yang, Yang;
Li, Zhiheng;
Shi, Lei;
Zhang, Zimu;
Pan, Jian

Publication type:

Article

Gemcitabine elaidate and ONC201 combination therapy for inhibiting pancreatic cancer in a KRAS mutated syngeneic mouse model.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01920-9

By:

Kumar, Virender;
Sethi, Bharti;
Staller, Dalton W.;
Shrestha, Prakash;
Mahato, Ram I.

Publication type:

Article

RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01719-0

By:

Yang, Qingqing;
Meng, Xiangrui;
Chen, Jin;
Li, Xiangsu;
Huang, Yang;
Xiao, Xueyi;
Li, Rongqing;
Wu, Xudong

Publication type:

Article

USP35 promotes HCC development by stabilizing ABHD17C and activating the PI3K/AKT signaling pathway.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01714-5

By:

Wang, Linpei;
Wang, Jiawei;
Ma, Xiaoqiu;
Ju, Guomin;
Shi, Chunfeng;
Wang, Wei;
Wu, Jian

Publication type:

Article

The involvement of caspases in the process of nuclear removal during lens fiber cell differentiation.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01680-y

By:

Gheyas, Rifah;
Menko, A. Sue

Publication type:

Article

δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01653-1

By:

He, Xiao;
Wang, Dawei;
Yi, Yi;
Tan, Yufang;
Wu, Min;
Wang, Haiping;
Hu, Weijie;
Chen, Hongbo;
Zhang, Qi;
Wu, Yiping

Publication type:

Article

Knockdown of KIF15 suppresses proliferation of prostate cancer cells and induces apoptosis through PI3K/Akt signaling pathway.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01625-5

By:

Bi, Hai;
Hou, Xiaofei;
Shen, Qiyang;
Liu, Zenan;
Zhu, Xuehua;
Ma, Lulin;
Lu, Jian

Publication type:

Article

Depletion of peroxiredoxin II promotes keratinocyte apoptosis and alleviates psoriatic skin lesions via the PI3K/AKT/GSK3β signaling axis.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01566-z

By:

Han, Ying-Hao;
Feng, Lin;
Lee, Seung-Jae;
Zhang, Yong-Qing;
Wang, Ai-Guo;
Jin, Mei-Hua;
Sun, Hu-Nan;
Kwon, Taeho

Publication type:

Article

Natural Compounds as Potential Regulators of the Phosphatidylinositol 3' Kinase (PI3K) Pathway in Breast Cancer.

Published in:

South Asian Journal of Experimental Biology, 2021, v. 11, n. 5, p. 524, doi. 10.38150/sajeb.11(5).p524-538

By:

Roy, Anirban;
Chakraborty, Indira;
Banerji, Aniruddha

Publication type:

Article

Silicon-substituted calcium phosphate promotes osteogenic-angiogenic coupling by activating the TLR4/PI3K/AKT signaling axis.

Published in:

Journal of Biomaterials Applications, 2022, v. 37, n. 3, p. 459, doi. 10.1177/08853282221105303

By:

Kong, Yuanhang;
Zhang, Xin;
Ma, Xinnan;
Wu, Leilei;
Chen, Dechun;
Su, Bo;
Liu, Daqian;
Wang, Xintao

Publication type:

Article

壳寡糖对乙醇诱导的炎症反应的保护作用.

Published in:

Journal of Chinese Institute of Food Science & Technology / Zhongguo Shipin Xuebao, 2024, v. 24, n. 8, p. 216, doi. 10.16429/j.1009-7848.2024.08.021

By:

王斌;
赵宇珂;
姜启兴;
许艳顺;
夏文水

Publication type:

Article

The Inhibitory Effect of Geraniol on CCL4-induced Hepatorenal Toxicity in Pregnant Mice through the PI3K/AKT Signaling Pathway.

Published in:

Saudi Journal of Medicine & Medical Sciences, 2024, v. 12, n. 1, p. 17, doi. 10.4103/sjmms.sjmms_225_23

By:

Alzahrani, Sabah Ali;
Bekhet, Gamal M.;
Ben Ammar, Rebai;
Abdallah, Basem M.;
Ali, Enas Mohamed;
Al-Ramadan, Saeed Y.;
Althumairy, Duaa;
Rajendran, Peramaiyan

Publication type:

Article

EGFR‐rich extracellular vesicles derived from highly metastatic nasopharyngeal carcinoma cells accelerate tumour metastasis through PI3K/AKT pathway‐suppressed ROS.

Published in:

Journal of Extracellular Vesicles, 2020, v. 10, p. 1, doi. 10.1002/jev2.12003

By:

Li, Fei;
Zhao, Xin;
Sun, Rui;
Ou, Jinxin;
Huang, Junyu;
Yang, Nanyan;
Xu, Ting;
Li, Jingyao;
He, Xiner;
Li, Chaoyi;
Yang, Mo;
Zhang, Qing

Publication type:

Article

Association between MAPK and PI3K/Akt signaling pathway‐related gene polymorphisms and migraine.

Published in:

Molecular Genetics & Genomic Medicine, 2024, v. 12, n. 8, p. 1, doi. 10.1002/mgg3.2503

By:

Wang, Mingxue;
Gu, Yujia;
Meng, Shuhan;
Kang, Lixin;
Yang, Jing;
Sun, Degang;
Liu, Yuxing;
Wan, Ze;
Shan, Yi;
Xue, Dongjie;
Su, Chang;
Li, Shufen;
RanYan;
Liu, Yu;
Pan, Yonghui;
Zhao, Yashuang

Publication type:

Article

A somatic splice‐site variant in PIK3R1 in a patient with vascular overgrowth and low immunoglobulin levels: A case report.

Published in:

2023

By:

Wilke, Matheus V. M. B.;
Schimmenti, Lisa;
Lopour, Madeline Q. R.;
Tollefson, Megha M.;
Klee, Eric W.

Publication type:

Case Study

Synergistic effects of PI3K inhibition and pioglitazone against acute promyelocytic leukemia cells.

Published in:

Molecular Genetics & Genomic Medicine, 2023, v. 11, n. 3, p. 1, doi. 10.1002/mgg3.2106

By:

Esmaeili, Shadi;
Yousefi, Amir‐Mohammad;
Delshad, Mahda;
Bashash, Davood

Publication type:

Article

Somatic TEK variant with intraarticular venous malformation and knee hemarthrosis treated with rapamycin.

Published in:

Molecular Genetics & Genomic Medicine, 2022, v. 10, n. 6, p. 1, doi. 10.1002/mgg3.1931

By:

Adham, Salma;
Revencu, Nicole;
Mestre, Sandrine;
Nou‐Howaldt, Monira;
Vernhet‐Kovacsik, Hélène;
Quéré, Isabelle

Publication type:

Article

Active Compounds, Targets, and Mechanisms of Salvia miltiorrhiza Bunge in Treating Interstitial Cystitis/Bladder Pain Syndrome.

Published in:

Immunity, Inflammation & Disease, 2025, v. 13, n. 4, p. 1, doi. 10.1002/iid3.70173

By:

Wang, Liang;
Yu, Bei;
Wang, YaRong;
Qu, Xi;
Tang, Wei

Publication type:

Article

LncRNA HOTAIR regulates the PI3K/AKT pathway via the miR‐126‐3p/PIK3R2 axis to participate in synovial angiogenesis in rheumatoid arthritis.

Published in:

Immunity, Inflammation & Disease, 2023, v. 11, n. 10, p. 1, doi. 10.1002/iid3.1064

By:

Liu, Feifei;
Wang, Yuan;
Huang, Dan;
Sun, Yanqiu

Publication type:

Article

Death receptor 3 is involved in preeclampsia through regulating placental trophoblast cell physiology by inactivating the PI3K/AKT pathway.

Published in:

Immunity, Inflammation & Disease, 2023, v. 11, n. 9, p. 1, doi. 10.1002/iid3.995

By:

Yin, Cheng;
Wang, Jiahui;
Zhang, Yu;
Zhang, Xinping;
Zhao, Wei;
Shen, Yanxiang;
Liu, Shi;
Liu, Su

Publication type:

Article

Vasoactive intestinal peptide exerts therapeutic action by regulating PTEN in a model of Sjögren's disease.

Published in:

Immunity, Inflammation & Disease, 2023, v. 11, n. 7, p. 1, doi. 10.1002/iid3.936

By:

Li, Yixi;
Zhu, Wen;
Lin, Rui;
Zhao, Junjie;
Wang, Yue

Publication type:

Article

Epimedium sagittatum Maxim ameliorates adriamycin‐induced nephropathy by restraining inflammation and apoptosis via the PI3K/AKT signaling pathway.

Published in:

Immunity, Inflammation & Disease, 2023, v. 11, n. 6, p. 1, doi. 10.1002/iid3.904

By:

Wang, Ru;
Zeng, Mengnan;
Zhang, Beibei;
Zhang, Qinqin;
Xie, Shuangshuang;
Hu, Yingbo;
Fan, Ruyi;
Wang, Mengya;
Yu, Xiao;
Zhang, Yuhan;
Zheng, Xiaoke;
Feng, Weisheng

Publication type:

Article

SPTBN1 attenuates rheumatoid arthritis synovial cell proliferation, invasion, migration and inflammatory response by binding to PIK3R2.

Published in:

Immunity, Inflammation & Disease, 2022, v. 10, n. 12, p. 1, doi. 10.1002/iid3.724

By:

Dai, Li‐ping;
Xu, Xiao‐dong;
Yang, Ting‐ting;
Yin, Zhi‐hua;
Ye, Zhi‐zhong;
Wei, Ya‐zhi

Publication type:

Article

Efficacy of rigosertib, a small molecular RAS signaling disrupter for the treatment of KRAS-mutant colorectal cancer.

Published in:

Cancer Biology & Medicine, 2022, v. 19, n. 2, p. 213, doi. 10.20892/j.issn.2095-3941.2020.0532

By:

Xinyi Zhou;
Qian Xiao;
Dongliang Fu;
Haochen Zhang;
Yang Tang;
Jinjie He;
Yeting Hu;
Xiangxing Kong;
Fei Teng;
Xiangrui Liu;
Ying Yuan;
Kefeng Ding

Publication type:

Article

MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-52940-5

By:

Entezari, Maryam;
Soltani, Bahram M.;
Sadeghizadeh, Majid

Publication type:

Article

HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-53854-y

By:

Ma, Sijia;
Wang, Jia;
Cui, Zhiwei;
Yang, Xiling;
Cui, Xi;
Li, Xu;
Zhao, Le

Publication type:

Article

Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-52066-8

By:

Gao, Shan;
Zhao, Xiaoshuai;
Leng, Yan;
Xia, Zhongyuan

Publication type:

Article