Works matching DE "PI3K/AKT/MTOR pathway"

Results: 59

Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2‐Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation.

Published in:

Immunity, Inflammation & Disease, 2025, v. 13, n. 2, p. 1, doi. 10.1002/iid3.70154

By:

Hu, Jia;
Bu, Wenjing;
Ding, Yongfang;
Li, Xin;
Zhang, Bo;
Shen, Bo;
Wu, Cong;
Xu, Youqi;
Zhang, Xiaoyang

Publication type:

Article

Erratum to "Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway".

Published in:

Mediators of Inflammation, 2021, p. 1, doi. 10.1155/2021/3710790

By:

Yang, Yi;
Sun, Yingfei;
Xu, Jinrui;
Bao, Kangda;
Luo, Meihui;
Liu, Xiaoming;
Wang, Yujiong

Publication type:

Article

Hesperetin regulates PI3K/Akt and mTOR pathways to exhibit its antiproliferative effect against colon cancer cells.

Published in:

Biotechnic & Histochemistry, 2024, v. 99, n. 6, p. 287, doi. 10.1080/10520295.2024.2382764

By:

Saiprasad, Gowrikumar;
Chitra, Palanivel;
Manikandan, Ramar;
Koodalingam, Arunagirinathan;
Sudhandiran, Ganaspasam

Publication type:

Article

Downregulation of LncRNA CCAT1 Enhances Chemosensitivity in Cisplatin‐Resistant Gastric Cancer Cells.

Published in:

Drug Development Research, 2025, v. 86, n. 1, p. 1, doi. 10.1002/ddr.70048

By:

Wu, Qiong;
Zhu, Chenglou;
Zhao, Tiantian;
Liu, Tianxiang;
Da, Mingxu

Publication type:

Article

The effects of lithium, metformin and everolimus substances on cell growth in 2D and 3D Ishikawa endometrial carcinoma cell culture.

Published in:

Pamukkale Medical Journal, 2024, v. 17, n. 3, p. 560, doi. 10.31362/patd.1490977

By:

Tural, Emine;
Çil, Nazlı;
Seçme, Mücahit;
Mete, Gülçin Abban;
Darıcı, Hakan;
Bilir, Ayhan;
Karaöz, Erdal

Publication type:

Article

Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-78646-y

By:

Fujimoto, Yumi;
Morita, Tomoko Yamamori;
Ohashi, Akihiro;
Haeno, Hiroshi;
Hakozaki, Yumi;
Fujii, Masanori;
Kashima, Yukie;
Kobayashi, Susumu S.;
Mukohara, Toru

Publication type:

Article

Fucoxanthin inhibits cell proliferation and stimulates apoptosis through downregulation of PI3K/AKT/mTOR signaling pathway in human ovarian cancer cells.

Published in:

Pharmacognosy Magazine, 2020, v. 16, n. 69, p. 311, doi. 10.4103/pm.pm_330_19

By:

Li, Yan;
Tao, Leisi;
Bao, Lei;
Chinnathambi, Arunachalam;
Alharbi, Sulaiman;
Cui, Jianying

Publication type:

Article

Influence of pathogenetic factors of type 2 diabetes on activation of PI3K/AkT/mTOR pathway and on the development of endometrial and breast cancer.

Published in:

Regulatory Mechanisms in Biosystems, 2019, v. 10, n. 3, p. 295, doi. 10.15421/021945

By:

Vatseba, T. S.

Publication type:

Article

Investigation of the Effects of Cetuximab and Agomelatine Drugs on Proliferation and Apoptosis in Prostate Cancer Cells.

Published in:

Erzincan University Journal of Science & Technology, 2024, v. 17, n. 3, p. 703, doi. 10.18185/erzifbed.1415213

By:

ALBAYRAK, Kevser;
TOPAL KIZILOĞLU, Halime;
KÖSE, Rukiye;
GÜNEY, Betül Nur;
KARA, Adem

Publication type:

Article

β-LAPachone is renoprotective in streptozotocin-induced diabetic mice via regulating the PI3K/Akt/mTOR signaling pathway.

Published in:

Iranian Journal of Basic Medical Sciences, 2021, v. 24, n. 5, p. 650, doi. 10.22038/ijbms.2021.55565.12422

By:

Sanajou, Davoud;
Bahrambeigi, Saman;
Aslani, Somayeh

Publication type:

Article

Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E.

Published in:

PLoS Pathogens, 2020, v. 16, n. 6, p. 1, doi. 10.1371/journal.ppat.1008610

By:

Zhan, Yuan;
Yu, Shengqing;
Yang, Shen;
Qiu, Xusheng;
Meng, Chunchun;
Tan, Lei;
Song, Cuiping;
Liao, Ying;
Liu, Weiwei;
Sun, Yingjie;
Ding, Chan

Publication type:

Article

Knockdown of NEIL3 inhibits the growth of breast cancer cells by mediating the PI3K/Akt/mTOR axis.

Published in:

European Journal of Gynaecological Oncology, 2025, v. 46, n. 3, p. 105, doi. 10.22514/ejgo.2025.042

By:

Wanqiong Zheng;
Ye Tian;
Yiming Zhang;
Binnan Li

Publication type:

Article

Expression of the PI3K/AKT/mTOR pathway as a prognostic factor in patients with advanced high grade serous ovarian carcinoma treated with neoadjuvant chemotherapy.

Published in:

European Journal of Gynaecological Oncology, 2019, v. 40, n. 5, p. 744, doi. 10.12892/ejgo4575.2019

By:

Cierniak, S.;
Koktysz, R.;
Jesiotr, M.;
Gąsowska-Bodnar, A.;
Bodnar, L.

Publication type:

Article

右归丸通过PI3K/Akt/mTOR信号通路对膝骨关节炎模型鼠软骨组织保护作用的研究.

Published in:

Chinese Journal of Osteoporosis, 2020, v. 26, n. 3, p. 318, doi. 10.3969/j.issn.1006.7108.2020.03.002

By:

颜春鲁;
李盛华;
安方玉;
孙仕华;
刘永琦;
蔺兴遥;
张艳霞;
杨译;
马正民;
牛彦强

Publication type:

Article

Sirtuin 5 alleviates apoptosis and autophagy stimulated by ammonium chloride in bovine mammary epithelial cells.

Published in:

Experimental & Therapeutic Medicine, 2024, v. 28, n. 1, p. N.PAG, doi. 10.3892/etm.2024.12584

By:

He, Junhui;
Feng, Luping;
Yang, Hanlin;
Gao, Shikai;
Dong, Jinru;
Lu, Guangyang;
Liu, Luya;
Zhang, Xinyi;
Zhong, Kai;
Guo, Shuang;
Zha, Guangming;
Han, Liqiang;
Li, Heping;
Wang, Yueying

Publication type:

Article

Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours.

Published in:

Cell & Bioscience, 2020, v. 10, n. 1, p. 1, doi. 10.1186/s13578-020-00416-0

By:

Xu, Fei;
Na, Lixin;
Li, Yanfei;
Chen, Linjun

Publication type:

Article

Plumbagin inhibits proliferation and promotes apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inactivating PI3K/Akt/mTOR pathway.

Published in:

Animal Cells & Systems, 2020, v. 24, n. 4, p. 197, doi. 10.1080/19768354.2020.1790416

By:

Cai, Zhaowei;
He, Shaojuan;
Li, Tao;
Zhao, Li;
Zhang, Kerong

Publication type:

Article

Somatic frameshift mutation in PIK3CA causes CLOVES syndrome by provoking PI3K/AKT/mTOR pathway.

Published in:

Hereditas, 2021, v. 158, n. 1, p. 1, doi. 10.1186/s41065-021-00184-y

By:

Yan, Wei;
Zhang, Bin;
Wang, Huijun;
Mo, Ran;
Jiang, Xingyuan;
Qin, Wen;
Ma, Lin;
Lin, Zhimiao

Publication type:

Article

Puerarin 6″‐O‐xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/mTOR.

Published in:

Cancer Medicine, 2020, v. 9, n. 17, p. 6399, doi. 10.1002/cam4.3285

By:

Li, Long;
Liu, Jun‐Dong;
Gao, Guo‐Dong;
Zhang, Kai;
Song, Yu‐Wei;
Li, Hong‐Bo

Publication type:

Article

Network Pharmacology-Based Strategy for the Investigation of the Anti-Osteoporosis Effects and Underlying Mechanism of Zhuangguguanjie Formulation.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.727808

By:

Gong, Wang;
Chen, Xingren;
Shi, Tianshu;
Shao, Xiaoyan;
An, Xueying;
Qin, Jianghui;
Chen, Xiang;
Jiang, Qing;
Guo, Baosheng

Publication type:

Article

Imatinib inhibits oral squamous cell carcinoma by suppressing the PI3K/AKT/mTOR signaling pathway.

Published in:

Journal of Cancer, 2024, v. 15, n. 3, p. 659, doi. 10.7150/jca.88555

By:

Lei Ma;
Ke Huang;
Haibo Zhang;
Eungyung Kim;
Hyeonjin Kim;
Zhibin Liu;
Chae Yeon Kim;
Kanghyun Park;
Raza, Muhammad Atif;
Kirim Kim;
Junkoo Yi;
Yonghun Sung;
Zae Young Ryoo;
Yong-Gun Kim;
Myoung Ok Kim

Publication type:

Article

Molecular landscape of CD8<sup>+</sup> T cells in pure red cell aplasia.

Published in:

Annals of Hematology, 2025, v. 104, n. 2, p. 953, doi. 10.1007/s00277-025-06220-5

By:

Liu, Yumei;
Liu, Mengyuan;
He, Xiaoman;
Yang, Liyan;
Zhang, Mengying;
Tang, Pu;
Xing, Limin;
Niu, Haiyue;
Wang, Huaquan

Publication type:

Article

Understanding the Polyamine and mTOR Pathway Interaction in Breast Cancer Cell Growth.

Published in:

Medical Sciences, 2022, v. 10, n. 3, p. 51, doi. 10.3390/medsci10030051

By:

Akinyele, Oluwaseun;
Wallace, Heather M.

Publication type:

Article

Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4<sup>+</sup> T Cell Proliferation via PI3K/AKT/mTOR Pathway Activation.

Published in:

Cardiovascular Therapeutics, 2020, p. 1, doi. 10.1155/2020/1389312

By:

Li, Kun-Peng;
Zhang, Hai-Yan;
Xu, Xiao-Dong;
Ming-Yang;
Li, Tie-Jun;
Song, Shu-Tian

Publication type:

Article

Claudin-14 promotes colorectal cancer progression via the PI3K/AKT/mTOR pathway.

Published in:

Neoplasma, 2021, v. 68, n. 5, p. 947, doi. 10.4149/neo_2021_210210N203

By:

Tian-Yu QIAO;
Zi-Ming YUAN;
Tian-Yi MA;
Han-Qing HU;
Yi-Hao ZHU;
Wei-Yuan ZHANG;
Qian ZHANG;
Rui HUANG;
Qing-Chao TANG;
Gui-Yu WANG;
Xi-Shan WANG

Publication type:

Article

Tumor-associated macrophages increase COX-2 expression promoting endocrine resistance in breast cancer via the PI3K/Akt/mTOR pathway.

Published in:

Neoplasma, 2021, v. 68, n. 5, p. 938, doi. 10.4149/neo_2021_201226N1404

By:

Qi QIN;
Hongfei JI;
Dongbo LI;
Han ZHANG;
Ziwen ZHANG;
Qingyuan ZHANG

Publication type:

Article

PTEN-Akt/mTOR Expression Level in A549 Lung Cancer Cells in Response to Cisplatin, Carotenoids, and their Combination.

Published in:

Tropical Journal of Natural Product Research, 2024, v. 8, n. 1, p. 5774, doi. 10.26538/tjnpr/v8i1.9

By:

Nurcahyanti, Agustina D. R.;
Tenia, Teresa F.;
Candra, Ferdy

Publication type:

Article

MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.

Published in:

Histochemistry & Cell Biology, 2020, v. 153, n. 5, p. 357, doi. 10.1007/s00418-020-01847-z

By:

Zhang, Minghao;
Li, Fan;
Wang, Xiuyu;
Gong, Jian;
Xian, Yushan;
Wang, Guan;
Zheng, Zihan;
Shang, Chenxu;
Wang, Bo;
He, Yanhao;
Wang, Weirong;
Lin, Rong

Publication type:

Article

miR-126-5p suppresses HeLa and Ishikawa cell proliferation and migration via the RICTOR/AKT pathway.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02306-8

By:

Zhang, Xuan;
Yang, Yanjing;
Li, Yaqin;
Zhang, Wei;
Song, Xianfang

Publication type:

Article

ANAPC10 expression predicts poor prognosis in oral squamous cell carcinoma and promotes tumor growth via the PI3K/AKT/mTOR pathway.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02125-x

By:

Fang, Jing;
Duan, Yanhao;
Qiu, Yongle;
Liu, Shanshan;
Bai, Xue;
Cai, Hong;
Zhang, Meijie;
Liu, Wei

Publication type:

Article

Actin-Like Protein 8 Promotes the Progression of Triple-Negative Breast Cancer via Activating PI3K/AKT/mTOR Pathway.

Published in:

OncoTargets & Therapy, 2021, v. 14, p. 2463, doi. 10.2147/OTT.S291403

By:

Fan, Shaoxia;
Yan, Shen;
Yang, Yang;
Shang, Jian;
Hao, Min

Publication type:

Article

Novel Small Molecular Compound AE-848 Potently Induces Human Multiple Myeloma Cell Apoptosis by Modulating the NF-κB and PI3K/Akt/mTOR Signaling Pathways.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 13063, doi. 10.2147/OTT.S270090

By:

Xu, Yaqi;
Feng, Xiaoli;
Zhou, Qian;
Jiang, Wen;
Dai, Yibo;
Jiang, Yang;
Liu, Xiaoli;
Li, Shuo;
Wang, Yongjing;
Wang, Fang;
Li, Ai;
Zheng, Chengyun

Publication type:

Article

MiR-1224-5p Activates Autophagy, Cell Invasion and Inhibits Epithelial-to-Mesenchymal Transition in Osteosarcoma Cells by Directly Targeting PLK1 Through PI3K/AKT/mTOR Signaling Pathway.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 11807, doi. 10.2147/OTT.S274451

By:

Jin, Bicheng;
Jin, Dongfang;
Zhuo, Zhaozhen;
Zhang, Bo;
Chen, Kun

Publication type:

Article

α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 10535, doi. 10.2147/OTT.S264409

By:

Wang, Weina;
Guo, Xin;
Dan, Huiwen

Publication type:

Article

Novel lncRNA SFTA1P Promotes Tumor Growth by Down-Regulating miR-4766-5p via PI3K/AKT/mTOR Signaling Pathway in Hepatocellular Carcinoma.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 9759, doi. 10.2147/OTT.S248660

By:

Huang, Guohong;
Yang, Yimei;
Lv, Mengxin;
Huang, Tian;
Zhan, Xiaoyan;
Kang, Wei;
Hou, Jianghou

Publication type:

Article

MicroRNA-6071 Suppresses Glioblastoma Progression Through the Inhibition of PI3K/AKT/mTOR Pathway by Binding to ULBP2.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 9429, doi. 10.2147/OTT.S265791

By:

Zhou, Yunyan;
An, Hongwei;
Wu, Gang

Publication type:

Article

HSPA12B Secreted by Tumor-Associated Endothelial Cells Might Induce M2 Polarization of Macrophages via Activating PI3K/Akt/mTOR Signaling.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 9103, doi. 10.2147/OTT.S254985

By:

Zhou, Jingjie;
Zhang, Aiping;
Fan, Liang

Publication type:

Article

Down-Regulation of SREBP via PI3K/AKT/mTOR Pathway Inhibits the Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 8951, doi. 10.2147/OTT.S266073

By:

Zhang, Bo;
Wu, Jianchun;
Guo, Peng;
Wang, Yi;
Fang, Zhihong;
Tian, Jianhui;
Yu, Yongchun;
Teng, Wenjing;
Luo, Yingbin;
Li, Yan

Publication type:

Article

miR-188-5p Promotes Tumor Growth by Targeting CD2AP Through PI3K/AKT/mTOR Signaling in Children with Acute Promyelocytic Leukemia.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 6681, doi. 10.2147/OTT.S244813

By:

Wang, Dao;
Chen, Jiao;
Ding, Yanjie;
Kong, Huimin;
You, Hongliang;
Zhao, Yanting;
Wei, Huixia;
Liu, Yufeng

Publication type:

Article

The Delivery of Mimic miRNA-7 into Glioblastoma Cells and Tumour Tissue by Graphene Oxide Nanosystems.

Published in:

Nanotechnology, Science & Applications, 2024, v. 17, p. 167, doi. 10.2147/NSA.S469193

By:

Kutwin, Marta;
Sosnowska-Ławnicka, Malwina;
Nasiłowska, Barbara;
Lange, Agata;
Wierzbicki, Mateusz;
Jaworski, Sławomir

Publication type:

Article

Eriodictyol modulates glioma cell autophagy and apoptosis by inhibition of PI3K/Akt/mTOR signaling pathway.

Published in:

Tropical Journal of Pharmaceutical Research, 2020, v. 19, n. 11, p. 2329, doi. 10.4314/tjpr.v19i11.12

By:

Lang Zeng;
Wen Fan;
Liang Tao;
Song Cao;
Yuefei Wang;
Qin Tu

Publication type:

Article

Bone mesenchymal stem cell-derived exosomes prevent hyperoxia-induced apoptosis of primary type II alveolar epithelial cells in vitro.

Published in:

PeerJ, 2022, p. 1, doi. 10.7717/peerj.13692

By:

Wei Yang;
Chao Huang;
Wenjian Wang;
Baozhu Zhang;
Yunbin Chen;
Xinlin Xie

Publication type:

Article

Statement of Retraction.

Published in:: Artificial Cells, Nanomedicine & Biotechnology, 2021, v. 49, n. 1, p. 674, doi. 10.1080/21691401.2021.2003042
Publication type:: Article

Tanshinone ⅡA participates in the treatment of endometriosis by regulating adhesion, invasion, angiogenesis and inhibition of PI3K/Akt/mTOR signaling pathway.

Published in:

Molecular Medicine Reports, 2023, v. 28, n. 5, p. N.PAG, doi. 10.3892/mmr.2023.13108

By:

Zhang, Xiaoxiao;
Li, Shumiao;
Chen, Zhenzhen;
Liang, Wei;
Pei, Shuting;
Gou, Feiyue;
Jia, Zhicheng;
Geng, Zhaoyang;
Gong, Xin

Publication type:

Article

MicroRNA‑494 suppresses hypoxia/reoxygenation‑induced cardiomyocyte apoptosis and autophagy via the PI3K/AKT/mTOR signaling pathway by targeting SIRT1.

Published in:

Molecular Medicine Reports, 2020, v. 22, n. 6, p. 5231, doi. 10.3892/mmr.2020.11636

By:

SHUWEI NING;
ZHIYING LI;
ZHENYU JI;
DANDAN FAN;
KEKE WANG;
QIAN WANG;
LEI HUA;
JUNYUE ZHANG;
XIANGGUANG MENG;
YIQIANG YUAN

Publication type:

Article

Wild-type IDH1 affects cell migration by modulating the PI3K/AKT/mTOR pathway in primary glioblastoma cells.

Published in:

Molecular Medicine Reports, 2020, v. 22, n. 3, p. 1949, doi. 10.3892/mmr.2020.11250

By:

Shen, Xiaopeng;
Wu, Shen;
Zhang, Jingyi;
Li, Meng;
Xu, Feng;
Wang, Ao;
Lei, Yang;
Zhu, Guoping

Publication type:

Article

Ginkgolide B inhibits hydrogen peroxide-induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells.

Published in:

Molecular Medicine Reports, 2020, v. 22, n. 1, p. 310, doi. 10.3892/mmr.2020.11099

By:

Liu, Jin;
Wu, Peng;
Xu, Zhihui;
Zhang, Jun;
Liu, Jiabao;
Yang, Zhijian

Publication type:

Article

Adipose-derived mesenchymal stem cells ameliorate dibutyltin dichloride-induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway.

Published in:

Molecular Medicine Reports, 2020, v. 21, n. 4, p. 1833, doi. 10.3892/mmr.2020.10995

By:

Xu, Xiangxiang;
Yu, Huajun;
Sun, Linxiao;
Zheng, Chenlei;
Shan, Yunfeng;
Zhou, Zhenxu;
Wang, Cheng;
Chen, Bicheng

Publication type:

Article

Levobupivacaine inhibits proliferation and promotes apoptosis of breast cancer cells by suppressing the PI3K/Akt/mTOR signalling pathway.

Published in:

BMC Research Notes, 2020, v. 13, p. 1, doi. 10.1186/s13104-020-05191-2

By:

Kwakye, Akosua Kotaa;
Kampo, Sylvanus;
Lv, Jiaxin;
Ramzan, Muhammad Noman;
Richard, Seidu A.;
Falagán, Aglais Arredondo;
Agudogo, Jerry;
Atito-Narh, Evans;
Yan, Qiu;
Wen, Qing-Ping

Publication type:

Article

芒果苷通过 PI3K/Akt/mTOR 通路抑制缺氧缺血性脑损伤大鼠神经细胞凋亡及炎症反应.

Published in:

Progress in Modern Biomedicine, 2020, v. 20, n. 11, p. 1820, doi. 10.13241/j.cnki.pmb.2020.10.005

By:

党双双;
易甫;
武锋;
陈伟;
李敬霞

Publication type:

Article