Works matching DE "PHOSPHOINOSITIDE-dependent kinase-1"
Results: 160
Up-Regulation of the Inwardly Rectifying K Channel Kir2.1 (KCNJ2) by Protein Kinase B (PKB/Akt) and PIKfyve.
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- Journal of Membrane Biology, 2013, v. 246, n. 3, p. 189, doi. 10.1007/s00232-012-9520-9
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- Article
Postnatal ontogeny of skeletal muscle protein synthesis in pigs<sup>2</sup>.
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- Journal of Animal Science, 2008, v. 86, p. E13, doi. 10.2527/jas.2007-0419
- Publication type:
- Article
The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 361, doi. 10.1080/14756366.2018.1553167
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- Article
Cerebral insulin, insulin signaling pathway, and brain angiogenesis.
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- 2016
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- Publication type:
- journal article
Disruption of Autophagic Flux and Treatment with the PDPK1 Inhibitor GSK2334470 Synergistically Inhibit Renal Cell Carcinoma Pathogenesis.
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- Journal of Cancer, 2024, v. 15, n. 5, p. 1429, doi. 10.7150/jca.92521
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- Article
Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition.
- Published in:
- 2016
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- Publication type:
- journal article
TLR2 Regulates Allergic Airway Inflammation and Autophagy Through PI3K/Akt Signaling Pathway.
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- Inflammation, 2017, v. 40, n. 4, p. 1382, doi. 10.1007/s10753-017-0581-x
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- Publication type:
- Article
miR-138 inhibits proliferation by targeting 3-phosphoinositide-dependent protein kinase-1 in non-small cell lung cancer cells.
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- Clinical Respiratory Journal, 2015, v. 9, n. 1, p. 27, doi. 10.1111/crj.12100
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- Article
Correction: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.
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- 2022
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- Correction Notice
NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro.
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- Acta Pharmacologica Sinica, 2013, v. 34, n. 5, p. 681, doi. 10.1038/aps.2013.22
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- Article
Correction: The AGC protein kinase UNICORN controls planar growth by attenuating PDK1 in Arabidopsis thaliana.
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- 2019
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- Publication type:
- Correction Notice
Co-expression of the RPS6KB1 and PDPK1 genes for production of activated p70S6K1 using bac-to-bac baculovirus expression system.
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- Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-024-10136-0
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- Publication type:
- Article
The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na<sup>+</sup>/K<sup>+</sup>-ATPase.
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- Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09451-3
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- Publication type:
- Article
AKT/GSK-3β signaling is altered through downregulation of mTOR during cerebral Ischemia/Reperfusion injury.
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- Molecular Biology Reports, 2022, v. 49, n. 5, p. 3955, doi. 10.1007/s11033-022-07247-x
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- Publication type:
- Article
Metabolic remodeling of cardiomyocytes identified in phosphoinositide-dependent kinase 1-deficient mice.
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- Biochemical Journal, 2019, v. 476, n. 13, p. 1943, doi. 10.1042/BCJ20190105
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- Publication type:
- Article
Antioxidant Effects of Hydrogen Sulfide on Left Ventricular Remodeling in Smoking Rats Are Mediated via PI3K/Akt-Dependent Activation of Nrf2.
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- Toxicological Sciences, 2015, v. 144, n. 1, p. 197, doi. 10.1093/toxsci/kfu272
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- Article
Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity.
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- Journal of Cell Biology, 2017, v. 216, n. 8, p. 2551, doi. 10.1083/jcb.201612042
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- Publication type:
- Article
AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.
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- Journal of Cell Biology, 2015, v. 211, n. 3, p. 619, doi. 10.1083/jcb.201503113
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- Publication type:
- Article
Silencing PDK1 limits hypoxia-induced pulmonary arterial hypertension in mice via the Akt/p70S6K signaling pathway.
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- Experimental & Therapeutic Medicine, 2019, v. 18, n. 1, p. 699, doi. 10.3892/etm.2019.7627
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- Publication type:
- Article
miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis.
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- Experimental & Therapeutic Medicine, 2018, v. 15, n. 1, p. 1119, doi. 10.3892/etm.2017.5444
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- Publication type:
- Article
Indole-3-carbinol inhibits nasopharyngeal carcinoma cell growth in vivo and in vitro through inhibition of the PI3K/Akt pathway.
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- Experimental & Therapeutic Medicine, 2014, v. 8, n. 1, p. 207, doi. 10.3892/etm.2014.1696
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- Publication type:
- Article
Akt inhibitor MK-2206 enhances the effect of cisplatin in gastric cancer cells.
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- Biomedical Reports, 2016, v. 4, n. 3, p. 365, doi. 10.3892/br.2016.594
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- Publication type:
- Article
Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development.
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- Physiological Reports, 2016, v. 4, n. 11, p. n/a, doi. 10.14814/phy2.12812
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- Publication type:
- Article
A Complex Interplay of Anionic Phospholipid Binding Regulates 3′-Phosphoinositide-Dependent-Kinase-1 Homodimer Activation.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-50742-8
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- Publication type:
- Article
The Arabidopsis DREB2 genetic pathway is constitutively repressed by basal phosphoinositide-dependent phospholipase C coupled to diacylglycerol kinase.
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- Frontiers in Plant Science, 2013, v. 4, p. 1, doi. 10.3389/fpls.2013.00307
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- Publication type:
- Article
Class-Switch Recombination (CSR)/Hyper-IgM (HIGM) Syndromes and Phosphoinositide 3-Kinase (PI3K) Defects.
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- Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.02172
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- Publication type:
- Article
Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides.
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- Frontiers in Aging Neuroscience, 2018, p. 1, doi. 10.3389/fnagi.2017.00435
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- Publication type:
- Article
Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla.
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- Stem Cell Research & Therapy, 2018, v. 9, n. 1, p. N.PAG, doi. 10.1186/s13287-018-1077-9
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- Publication type:
- Article
LncRNA TP73-AS1 promoted the progression of lung adenocarcinoma via PI3K/AKT pathway.
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- Bioscience Reports, 2019, v. 39, n. 1, p. 1, doi. 10.1042/BSR20180999
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- Publication type:
- Article
Tetramethylpyrazine Analogue CXC195 Ameliorates Cerebral Ischemia-reperfusion Injury by Regulating Endothelial Nitric Oxide Synthase Phosphorylation Via PI3K/Akt Signaling.
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- Neurochemical Research, 2015, v. 40, n. 3, p. 446, doi. 10.1007/s11064-014-1485-x
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- Publication type:
- Article
Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis.
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- Cardiovascular Research, 2017, v. 113, n. 8, p. 938, doi. 10.1093/cvr/cvx052
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- Publication type:
- Article
P359 Inhibition of phosphoinositide 3-kinase gamma protects against chemotherapy-induced heart failure.
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- Cardiovascular Research, 2014, v. 103, n. suppl_1, p. S65, doi. 10.1093/cvr/cvu091.43
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- Publication type:
- Article
PKCη/Rdx-driven Phosphorylation of PDK1: A Novel Mechanism Promoting Cancer Cell Survival and Permissiveness for Parvovirus-induced Lysis.
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- PLoS Pathogens, 2015, v. 11, n. 3, p. 1, doi. 10.1371/journal.ppat.1004703
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- Publication type:
- Article
Inhibitory effects of baicalin in the early stage of 3T3-L1 preadipocytes differentiation by down-regulation of PDK1/Akt phosphorylation.
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- Molecular & Cellular Biochemistry, 2014, v. 385, n. 1/2, p. 257, doi. 10.1007/s11010-013-1834-0
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- Article
Perspective on novel proteins encoded by circular RNAs in glioblastoma.
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- Cancer Biology & Medicine, 2022, v. 19, n. 3, p. 278, doi. 10.20892/j.issn.2095-3941.2021.0678
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- Publication type:
- Article
A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.
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- BJU International, 2012, v. 110, n. 11c, p. E1237, doi. 10.1111/j.1464-410X.2012.11569.x
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- Publication type:
- Article
Phosphoinositide 3-kinase: friend and foe in cardiovascular disease.
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- Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00169
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- Publication type:
- Article
Phosphoinositide Diversity, Distribution, and Effector Function: Stepping Out of the Box.
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- BioEssays, 2017, v. 39, n. 12, p. n/a, doi. 10.1002/bies.201700121
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- Publication type:
- Article
Correlation of PDK1 expression with clinicopathologic features and prognosis of hepatocellular carcinoma.
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- OncoTargets & Therapy, 2016, v. 9, p. 5597, doi. 10.2147/OTT.S110646
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- Publication type:
- Article
Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.
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- Science Signaling, 2018, v. 11, n. 521, p. 1, doi. 10.1126/scisignal.aao3810
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- Publication type:
- Article
Primordial follicle activation in the ovary of Ames dwarf mice.
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- Journal of Ovarian Research, 2014, v. 7, n. 1, p. 1, doi. 10.1186/s13048-014-0120-4
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- Publication type:
- Article
Autophagy and 3-Phosphoinositide-Dependent Kinase 1 (PDK1)-Related Kinome in Pagetic Osteoclasts.
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- Journal of Bone & Mineral Research, 2016, v. 31, n. 7, p. 1334, doi. 10.1002/jbmr.2806
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- Publication type:
- Article
Ligand-based Pharmacophore Modeling; Atom-based 3D-QSAR Analysis and Molecular Docking Studies of Phosphoinositide-Dependent Kinase-1 Inhibitors.
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- Indian Journal of Pharmaceutical Sciences, 2012, v. 74, n. 2, p. 141
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- Publication type:
- Article
Epigenetic repression of miR-375 is the dominant mechanism for constitutive activation of the PDPK1/ RPS6 KA3 signalling axis in multiple myeloma.
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- British Journal of Haematology, 2017, v. 178, n. 4, p. 534, doi. 10.1111/bjh.14707
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- Publication type:
- Article
The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling.
- Published in:
- Cancer Cell International, 2020, v. 20, n. 1, p. 1, doi. 10.1186/s12935-020-01177-z
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- Publication type:
- Article
PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury.
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- PLoS Biology, 2014, v. 12, n. 11, p. 1, doi. 10.1371/journal.pbio.1001985
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- Publication type:
- Article
The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation.
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- Basic Research in Cardiology, 2012, v. 107, n. 5, p. 1, doi. 10.1007/s00395-012-0281-5
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- Publication type:
- Article
Avian reovirus triggers autophagy in primary chicken fibroblast cells and Vero cells to promote virus production.
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- Archives of Virology, 2012, v. 157, n. 4, p. 661, doi. 10.1007/s00705-012-1226-x
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- Publication type:
- Article
FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21<sup>Cip1/Waf1</sup>.
- Published in:
- Biochemical Journal, 2015, v. 469, n. 2, p. 289, doi. 10.1042/BJ20140831
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- Publication type:
- Article
The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling.
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- Biochemical Journal, 2014, v. 464, n. 3, p. 439, doi. 10.1042/BJ20131461
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- Publication type:
- Article