Works matching DE "PHOSPHOINOSITIDE-dependent kinase-1"

Results: 163

PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury.

Published in:

PLoS Biology, 2014, v. 12, n. 11, p. 1, doi. 10.1371/journal.pbio.1001985

By:

Doherty, Johnna;
Sheehan, Amy E.;
Bradshaw, Rachel;
Fox, A. Nicole;
Lu, Tsai-Yi;
Freeman, Marc R.

Publication type:

Article

The HER2 Signaling Network in Breast Cancer-Like a Spider in its Web.

Published in:

Journal of Mammary Gland Biology & Neoplasia, 2014, v. 19, n. 3/4, p. 253, doi. 10.1007/s10911-014-9329-5

By:

Dittrich, A.;
Gautrey, H.;
Browell, D.;
Tyson-Capper, A.

Publication type:

Article

Mechanistic role of miR-375 in regulating PDPK1 to promote progression of small bowel neuroendocrine tumors: a silico analysis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02872-x

By:

Ren, Tao;
Zhou, Lu;
Li, Zhenlong;
Pan, Mingmei;
Han, Xueqiong

Publication type:

Article

Resveratrol inhibits the progression of oral squamouscell carcinoma through Norad/Igf2bp2/Pdk1 pathway and remodeling glucose metabolism reprogramming.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02363-z

By:

Zhang, Rongrong;
Guo, Jinjing;
Lin, Yicong

Publication type:

Article

Postnatal ontogeny of skeletal muscle protein synthesis in pigs<sup>2</sup>.

Published in:: Journal of Animal Science, 2008, v. 86, p. E13, doi. 10.2527/jas.2007-0419
Publication type:: Article

Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer’s Disease.

Published in:

Diseases, 2018, v. 6, n. 2, p. 28, doi. 10.3390/diseases6020028

By:

Matsuda, Satoru;
Nakagawa, Yukie;
Tsuji, Ai;
Kitagishi, Yasuko;
Nakanishi, Atsuko;
Murai, Toshiyuki

Publication type:

Article

The Arabidopsis DREB2 genetic pathway is constitutively repressed by basal phosphoinositide-dependent phospholipase C coupled to diacylglycerol kinase.

Published in:

Frontiers in Plant Science, 2013, v. 4, p. 1, doi. 10.3389/fpls.2013.00307

By:

Djafi, Nabila;
Vergnolle, Chantal;
Cantrel, Catherine;
Wietrzyñski, Wojciech;
Delage, Elise;
Cochet, Françoise;
Puyaubert, Juliette;
Soubigou-Taconnat, Ludivine;
Gey, Delphine;
Collin, Sylvie;
Balzergue, Sandrine;
Zachowski, Alain;
Ruelland, Eric

Publication type:

Article

Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide-3 kinase/protein kinase B signaling pathway.

Published in:

Molecular Medicine Reports, 2019, v. 19, n. 5, p. 4019

By:

Zhang, Daoming;
Wang, Aifu;
Feng, Jueping;
Zhang, Qi;
Liu, Linlin;
Ren, Hui

Publication type:

Article

Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway.

Published in:

Molecular Medicine Reports, 2018, v. 18, n. 2, p. 1582, doi. 10.3892/mmr.2018.9084

By:

Xu, Lin;
Jiang, Xuejun;
Wei, Fang;
Zhu, Hongling

Publication type:

Article

Overexpression of retinoblastoma‑binding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3‑kinase/protein kinase B pathway suppression.

Published in:

Molecular Medicine Reports, 2018, v. 18, n. 2, p. 1571, doi. 10.3892/mmr.2018.9153

By:

Jin, Xiaoxi;
Jiang, Rui;
Xiang, Yongsheng;
Fan, Zhen;
Wu, Zhiwei;
Yang, Bo;
Yang, Lujun;
Wei, Shanshan;
Yang, Yan

Publication type:

Article

Long non‑coding RNA regulates hair follicle stem cell proliferation and differentiation through PI3K/AKT signal pathway.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 4, p. 5477, doi. 10.3892/mmr.2018.8546

By:

Cai, Bingjie;
Zheng, Yunpeng;
Ma, Shanshan;
Xing, Qu;
Wang, Xinxin;
Yang, Bo;
Yin, Guangwen;
Guan, Fangxia

Publication type:

Article

Phosphoinositide 3-kinase/Akt pathway is involved in pingyangmycin-induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 6, p. 8275, doi. 10.3892/mmr.2015.4447

By:

LI-XIA PENG;
PING ZHAO;
HONG-SHENG ZHAO;
ER PAN;
BIN-BIN YANG;
QIN LI

Publication type:

Article

Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 2, p. 3151, doi. 10.3892/mmr.2015.3683

By:

ZIXUN DAI;
PENGFEI LEI;
JIE XIE;
YIHE HU

Publication type:

Article

TLR2 Regulates Allergic Airway Inflammation and Autophagy Through PI3K/Akt Signaling Pathway.

Published in:

Inflammation, 2017, v. 40, n. 4, p. 1382, doi. 10.1007/s10753-017-0581-x

By:

Jiang, Xuqin;
Fang, Lei;
Wu, Huimei;
Mei, Xiaodong;
He, Fang;
Ding, Peishan;
Liu, Rongyu

Publication type:

Article

Angiotensin-(1-7): beyond the cardio-renal actions.

Published in:

Clinical Science, 2013, v. 124, n. 7, p. 423, doi. 10.1042/CS20120461

By:

PASSOS-SILVA, Danielle G.;
VERANO-BRAGA, Thiago;
SANTOS, Robson A. S.

Publication type:

Article

Discoidin Domain Receptor 2, a Potential Therapeutic Target in Lung Fibrosis.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2018, v. 59, n. 3, p. 277, doi. 10.1165/rcmb.2018-0161ed

By:

Borza, Corina M.;
Pozzi, Ambra;
Plosa, Erin J.

Publication type:

Article

Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat.

Published in:

Epilepsia (Series 4), 2012, v. 53, n. 3, p. 506, doi. 10.1111/j.1528-1167.2011.03384.x

By:

Zhang, Bo;
Wong, Michael

Publication type:

Article

Correction to: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.

Published in:

2019

By:

Xia, Xin;
Li, Xixi;
Li, Fanying;
Wu, Xujia;
Zhang, Maolei;
Zhou, Huangkai;
Huang, Nunu;
Yang, Xuesong;
Xiao, Feizhe;
Liu, Dawei;
Yang, Lixuan;
Zhang, Nu

Publication type:

Correction Notice

Correction: The AGC protein kinase UNICORN controls planar growth by attenuating PDK1 in Arabidopsis thaliana.

Published in:

2019

By:

Scholz, Sebastian;
Pleßmann, Janys;
Enugutti, Balaji;
Hüttl, Regina;
Wassmer, Katrin;
Schneitz, Kay

Publication type:

Correction Notice

Inhibitory effects of baicalin in the early stage of 3T3-L1 preadipocytes differentiation by down-regulation of PDK1/Akt phosphorylation.

Published in:

Molecular & Cellular Biochemistry, 2014, v. 385, n. 1/2, p. 257, doi. 10.1007/s11010-013-1834-0

By:

Kwak, Dong Hoon;
Lee, Ji-Hye;
Song, Kwang Hoon;
Ma, Jin Yeul

Publication type:

Article

Avian reovirus triggers autophagy in primary chicken fibroblast cells and Vero cells to promote virus production.

Published in:

Archives of Virology, 2012, v. 157, n. 4, p. 661, doi. 10.1007/s00705-012-1226-x

By:

Meng, Songshu;
Jiang, Ke;
Zhang, Xiaorong;
Zhang, Miao;
Zhou, Zhizhi;
Hu, Maozhi;
Yang, Rui;
Sun, Chenli;
Wu, Yantao

Publication type:

Article

Cerebral insulin, insulin signaling pathway, and brain angiogenesis.

Published in:

2016

By:

Zeng, Yi;
Zhang, Le;
Hu, Zhiping

Publication type:

journal article

Silencing PDK1 limits hypoxia-induced pulmonary arterial hypertension in mice via the Akt/p70S6K signaling pathway.

Published in:

Experimental & Therapeutic Medicine, 2019, v. 18, n. 1, p. 699, doi. 10.3892/etm.2019.7627

By:

Di, Ruomin;
Yang, Zhongzhou;
Xu, Peng;
Xu, Yingjia

Publication type:

Article

miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis.

Published in:

Experimental & Therapeutic Medicine, 2018, v. 15, n. 1, p. 1119, doi. 10.3892/etm.2017.5444

By:

Sun, Wencai;
Li, Yintai;
Wei, Suizhuan

Publication type:

Article

Indole-3-carbinol inhibits nasopharyngeal carcinoma cell growth in vivo and in vitro through inhibition of the PI3K/Akt pathway.

Published in:

Experimental & Therapeutic Medicine, 2014, v. 8, n. 1, p. 207, doi. 10.3892/etm.2014.1696

By:

CHENG-GANG MAO;
ZE-ZHANG TAO;
ZHE CHEN;
CHEN CHEN;
SHI-MING CHEN;
LI-JIA WAN

Publication type:

Article

Akt inhibitor MK-2206 enhances the effect of cisplatin in gastric cancer cells.

Published in:

Biomedical Reports, 2016, v. 4, n. 3, p. 365, doi. 10.3892/br.2016.594

By:

KAIXIONG TAO;
YUPING YIN;
QIAN SHEN;
YING CHEN;
RUIDONG LI;
WEILONG CHANG;
JIE BAI;
WEIZHEN LIU;
LIANG SHI;
PENG ZHANG

Publication type:

Article

Disruption of Autophagic Flux and Treatment with the PDPK1 Inhibitor GSK2334470 Synergistically Inhibit Renal Cell Carcinoma Pathogenesis.

Published in:

Journal of Cancer, 2024, v. 15, n. 5, p. 1429, doi. 10.7150/jca.92521

By:

Wei Zhou;
Ji Huang;
Chuansheng Huang;
Gongxian Wang;
Xinhua Tu

Publication type:

Article

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23833-2

By:

Yin, Shasha;
Liu, Liu;
Brobbey, Charles;
Palanisamy, Viswanathan;
Ball, Lauren E.;
Olsen, Shaun K.;
Ostrowski, Michael C.;
Gan, Wenjian

Publication type:

Article

The role of phosphoinositide 3-kinase subunits in chronic thyroiditis.

Published in:

Thyroid Research, 2012, v. 5, n. 1, p. 22, doi. 10.1186/1756-6614-5-22

By:

Wojciechowska-Durczynska, Katarzyna;
Krawczyk-Rusiecka, Kinga;
Cyniak-Magierska, Anna;
Zygmunt, Arkadiusz;
Sporny, Stanisław;
Lewinski, Andrzej

Publication type:

Article

LncRNA TP73-AS1 promoted the progression of lung adenocarcinoma via PI3K/AKT pathway.

Published in:

Bioscience Reports, 2019, v. 39, n. 1, p. 1, doi. 10.1042/BSR20180999

By:

Chunfeng Liu;
Lei Ren;
Jun Deng;
Songping Wang

Publication type:

Article

Immunohistochemical analysis of PDK1 expression in breast cancer.

Published in:

Diagnostic Pathology, 2014, v. 9, n. 1, p. 1, doi. 10.1186/1746-1596-9-82

By:

Arsenic, Ruza

Publication type:

Article

Definition of the binding mode of phosphoinositide 3-kinase α-selective inhibitor A-66S through molecular dynamics simulation.

Published in:

Journal of Molecular Modeling, 2014, v. 20, n. 4, p. 1, doi. 10.1007/s00894-014-2166-z

By:

Bian, Xiaoli;
Dong, Wangqing;
Zhao, Yang;
Sun, Rui;
Kong, Wanjun;
Li, Yiping

Publication type:

Article

Correction: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.

Published in:

2022

By:

Xia, Xin;
Li, Xixi;
Li, Fanying;
Wu, Xujia;
Zhang, Maolei;
Zhou, Huangkai;
Huang, Nunu;
Yang, Xuesong;
Xiao, Feizhe;
Liu, Dawei;
Yang, Lixuan;
Zhang, Nu

Publication type:

Correction Notice

Phase I safety and pharmacokinetic dose-escalation study of pilaralisib polymorph E, a phosphoinositide 3-kinase inhibitor in tablet formulation, in patients with solid tumors or lymphoma.

Published in:

2016

By:

Bechter, Oliver;
Dumez, Herlinde;
Costermans, Jo;
Punie, Kevin;
Hsu, Karl;
Dedieu, Jean-François;
Ghuysen, Anne-Frédérique;
Francesconi, Elisa;
Sharma, Jyoti;
Liu, Li;
Schöffski, Patrick;
Bechter, Oliver E;
Dedieu, Jean-François;
Ghuysen, Anne-Frédérique;
Schöffski, Patrick

Publication type:

journal article

Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma.

Published in:

Cancer Chemotherapy & Pharmacology, 2015, v. 75, n. 3, p. 595, doi. 10.1007/s00280-014-2639-x

By:

Joshi, Shweta;
Singh, Alok;
Durden, Donald

Publication type:

Article

An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.

Published in:

Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 4, p. 867, doi. 10.1007/s00280-013-2078-0

By:

De, Pradip;
Dey, Nandini;
Terakedis, Breanne;
Bergsagel, P.;
Li, Zhi;
Mahadevan, Daruka;
Garlich, Joseph;
Trudel, Suzanne;
Makale, Milan;
Durden, Donald

Publication type:

Article

The effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in redox changes and PI3K/Akt/CREB.

Published in:

Immunopharmacology & Immunotoxicology, 2012, v. 34, n. 5, p. 810, doi. 10.3109/08923973.2012.657799

By:

Seo, Min Su;
Choi, Eun Mi

Publication type:

Article

The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 361, doi. 10.1080/14756366.2018.1553167

By:

Xu, Xinyuan;
Chen, Yingyi;
Fu, Qiang;
Ni, Duan;
Zhang, Jian;
Li, Xiaolong;
Lu, Shaoyong

Publication type:

Article

Inflammatory compound lipopolysaccharide promotes the survival of GM‐CSF cultured dendritic cell via PI3 kinase‐dependent upregulation of Bcl‐x.

Published in:

Immunology & Cell Biology, 2018, v. 96, n. 9, p. 912, doi. 10.1111/imcb.12051

By:

Chen, Shun;
Li, Xinchen;
Zhang, Wenjie;
Zi, Mengting;
Xu, Yuekang

Publication type:

Article

Class-Switch Recombination (CSR)/Hyper-IgM (HIGM) Syndromes and Phosphoinositide 3-Kinase (PI3K) Defects.

Published in:

Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.02172

By:

Jhamnani, Rekha D.;
Nunes-Santos, Cristiane J.;
Bergerson, Jenna;
Rosenzweig, Sergio D.

Publication type:

Article

Efficacy, safety, pharmacokinetics and pharmacodynamics of SAR245409 (voxtalisib, XL765), an orally administered phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor: a phase 1 expansion cohort in patients with relapsed or refractory lymphoma

Published in:

Leukemia & Lymphoma, 2015, v. 56, n. 6, p. 1763, doi. 10.3109/10428194.2014.974040

By:

Papadopoulos, Kyriakos P.;
Egile, Coumaran;
Ruiz-Soto, Rodrigo;
Jiang, Jason;
Shi, Weiliang;
Bentzien, Frauke;
Rasco, Drew;
Abrisqueta, Pau;
Vose, Julie M.;
Tabernero, Josep

Publication type:

Article

PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma.

Published in:

PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0150836

By:

Singh, Alok R.;
Joshi, Shweta;
Zulcic, Muamera;
Alcaraz, Michael;
Garlich, Joseph R.;
Morales, Guillermo A.;
Cho, Yoon J.;
Bao, Lei;
Levy, Michael L.;
Newbury, Robert;
Malicki, Denise;
Messer, Karen;
Crawford, John;
Durden, Donald L.

Publication type:

Article

Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.

Published in:

PLoS ONE, 2016, v. 11, n. 2, p. 1, doi. 10.1371/journal.pone.0148730

By:

Yueh, Alexander E.;
Payne, Susan N.;
Leystra, Alyssa A.;
Van De Hey, Dana R.;
Foley, Tyler M.;
Pasch, Cheri A.;
Clipson, Linda;
Matkowskyj, Kristina A.;
Deming, Dustin A.

Publication type:

Article

Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis.

Published in:

Cardiovascular Research, 2017, v. 113, n. 8, p. 938, doi. 10.1093/cvr/cvx052

By:

Garikipati, Venkata N. S.;
Verma, Suresh K.;
Jolardarashi, Darukeshwara;
Zhongjian Cheng;
Ibetti, Jessica;
Cimini, Maria;
Yan Tang;
Khan, Mohsin;
Yujia Yue;
Benedict, Cindy;
Nickoloff, Emily;
Truongcao, May M.;
Gao, Erhe;
Krishnamurthy, Prasanna;
Goukassian, David A.;
Koch, Walter J.;
Kishore, Raj

Publication type:

Article

P359 Inhibition of phosphoinositide 3-kinase gamma protects against chemotherapy-induced heart failure.

Published in:

Cardiovascular Research, 2014, v. 103, n. suppl_1, p. S65, doi. 10.1093/cvr/cvu091.43

By:

Li, M;
Ghigo, A;
Cimino, J;
Franco, I;
Morello, F;
Hirsch, E

Publication type:

Article

PI3Kγ in hypertension: a novel therapeutic target controlling vascular myogenic tone and target organ damage.

Published in:

Cardiovascular Research, 2012, v. 95, n. 4, p. 403, doi. 10.1093/cvr/cvs166

By:

Carnevale, Daniela;
Lembo, Giuseppe

Publication type:

Article

Ligand-based Pharmacophore Modeling; Atom-based 3D-QSAR Analysis and Molecular Docking Studies of Phosphoinositide-Dependent Kinase-1 Inhibitors.

Published in:

Indian Journal of Pharmaceutical Sciences, 2012, v. 74, n. 2, p. 141

By:

KIRUBAKARAN, P.;
MUTHUSAMY, K.;
SINGH, K. H. D.;
NAGAMANI, S.

Publication type:

Article

De Novo Transcriptome Assembly and Analysis of Longevity Genes Using Subterranean Termite (Reticulitermes chinensis) Castes.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 13660, doi. 10.3390/ijms232113660

By:

Haroon;
Li, Yu-Xin;
Ye, Chen-Xu;
Su, Jian;
Nabi, Ghulam;
Su, Xiao-Hong;
Xing, Lian-Xi

Publication type:

Article

High Density Lipoprotein Protects Mesenchymal Stem Cells from Oxidative Stress-Induced Apoptosis via Activation of the PI3K/Akt Pathway and Suppression of Reactive Oxygen Species.

Published in:

International Journal of Molecular Sciences, 2012, v. 13, n. 12, p. 17104, doi. 10.3390/ijms131217104

By:

Jianfeng Xu;
Juying Qian;
Xinxing Xie;
Li Lin;
Yunzeng Zou;
Mingqiang Fu;
Zheyong Huang;
Guoping Zhang;
Yangang Su;
Junbo Ge

Publication type:

Article

NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro.

Published in:

Acta Pharmacologica Sinica, 2013, v. 34, n. 5, p. 681, doi. 10.1038/aps.2013.22

By:

Wang, Wen-juan;
Long, Lin-mei;
Yang, Neng;
Zhang, Qing-qing;
Ji, Wen-jun;
Zhao, Jiang-hu;
Qin, Zheng-hong;
Wang, Zhong;
Chen, Gang;
Liang, Zhong-qin

Publication type:

Article