Works about PHOSPHATIDYLINOSITOL 3-kinases

Results: 2464

Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury.

Published in:

Autophagy, 2025, v. 21, n. 7, p. 1473, doi. 10.1080/15548627.2025.2471633

By:

Xu, Lei;
Ye, Yangfan;
Gu, Wei;
Xu, Xiao;
Chen, Nuo;
Zhang, Liuchao;
Cai, Wanzhi;
Hu, Jingming;
Wang, Tian;
Chao, Honglu;
Tu, Yiming;
Ji, Jing

Publication type:

Article

Mammalian nucleophagy: process and function.

Published in:

Autophagy, 2025, v. 21, n. 7, p. 1396, doi. 10.1080/15548627.2025.2455158

By:

Ji, Fujian;
Dai, Enyong;
Kang, Rui;
Klionsky, Daniel J.;
Liu, Tong;
Hu, Yu;
Tang, Daolin;
Zhu, Kun

Publication type:

Article

Genomic and immunological profiling reveals novel prognostic biomarkers for limited-stage small cell lung cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02925-1

By:

Li, Ye;
Ma, Xiaolong;
Wan, Zhiyi;
Bao, Pengfei;
Zhang, Enli;
Liu, Lihua;
Jiao, Shunchang;
Sun, Shengjie

Publication type:

Article

Auranofin amplifies schisandrin A-induced apoptosis through ROS generation and inhibiting the PI3K/Akt pathway in hepatocellular carcinoma.

Published in:

Asian Pacific Journal of Tropical Biomedicine, 2025, v. 15, n. 6, p. 239, doi. 10.4103/apjtb.apjtb_83_25

By:

Hwangbo, Hyun;
Ji, Seon Yeong;
Kim, Min Yeong;
Hong, Su Hyun;
Kim, Sung Ok;
Kim, Gi-Young;
Choi, Yung Hyun

Publication type:

Article

IFNα signaling through PKC-θ is essential for antitumor NK cell function.

Published in:

OncoImmunology, 2014, v. 3, n. 8, p. N.PAG, doi. 10.4161/21624011.2014.948705

By:

Comet, Natalia R;
Aguiló, Juan Ignacio;
Rathoré, Moeez G;
Catalán, Elena;
Garaude, Johan;
Uzé, Gilles;
Naval, Javier;
Pardo, Julián;
Villalba, Martín;
Anel, Alberto

Publication type:

Article

Polymorphic GT dinucleotide repeat in the PIK3CA gene and risk of colorectal cancer.

Published in:

Cancer Biomarkers, 2015, v. 15, n. 4, p. 397, doi. 10.3233/CBM-150487

By:

Parsafar, Soha;
Hematti, Simin;
Ghorbani, Fateme;
Safari, Forousan;
Tavassoli, Manoochehr

Publication type:

Article

Juvenile hormone interacts with insulin and potentiates the ERK signaling pathway for female reproduction in locusts.

Published in:

Entomologia Generalis, 2025, v. 45, n. 2, p. 547, doi. 10.1127/entomologia/2025/3055

By:

Li, Lunjie;
Yang, Libin;
Yu, Guangze;
Guo, Mingfang;
Liu, Lijun;
Xu, Mengru;
Fu, Xiaoyan;
Zhang, Lin-Jie;
Jing, Yu-Pu

Publication type:

Article

circSLC39A8 by sponging hsa-miR-11181-5p and direct binding to PIK3CA mRNA promotes retinoblastoma proliferation.

Published in:

Journal of Cancer, 2025, v. 16, n. 8, p. 2434, doi. 10.7150/jca.99599

By:

Jian Gong;
Zicheng Song;
Jiandong Pan;
Xiangwei Huang;
Xiaofen Feng;
Qian Li

Publication type:

Article

Overexpression of BPIFB4 Alleviates COPD Inflammatory Damage by Inhibiting M1 Macrophage Activation via the PI3K/AKT Pathway.

Published in:

Lung (0341-2040), 2025, v. 203, n. 1, p. 1, doi. 10.1007/s00408-025-00824-4

By:

Xue, Lexin;
Xu, Jingran;
Gong, Hui;
Abudureheman, Zulipikaer;
ALimu, Ayiguli;
Chen, Yun;
Zheng, Aifang;
Gao, Liang;
Lu, Xiuqi;
Xie, Chengxin;
Li, Li

Publication type:

Article

Overcoming acquired immunotherapy resistance in non-small cell lung cancer using ginsenoside Rb1-loaded, peptide-enhanced exosome delivery systems.

Published in:

Journal of Nanobiotechnology, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12951-025-03456-1

By:

Jin, Xiangyuan;
Wuyun, Tanghesi;
Zhang, Yu;
Wang, Xiaohong;
Zhao, Ling

Publication type:

Article

AKT1 and CTNNB1 mutations as drivers of paclitaxel resistance in breast cancer cells.

Published in:

Oncology Letters, 2025, v. 30, n. 1, p. N.PAG, doi. 10.3892/ol.2025.15070

By:

Altiparmak-Ulbegi, Gulsum;
Hasbal-Celikok, Gozde;
Aksoy-Sagirli, Pinar

Publication type:

Article

Metabolomics combined with molecular docking and dynamics simulation to investigate the mechanism of action of Fibraurea recisa Pierre in the treatment of chronic urticaria.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1571819

By:

Xiao, Tian;
Tao, Jie;
Tan, Jiaoyang;
Zhao, Zhourong;
Yang, Liping;
Zhang, Chao;
Duan, Xiaohua

Publication type:

Article

Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.

Published in:

Molecular Medicine Reports, 2025, v. 32, n. 1, p. N.PAG, doi. 10.3892/mmr.2025.13544

By:

Wang, Haili;
Cheng, Guofang;
Zhang, Shuyuan;
Qu, Haibo;
Zhao, Xibo;
Yang, Ailing;
Sun, Xuejia;
Pan, Hua

Publication type:

Article

Dual Targeting of Pim and PI3 Kinases in Mature T‐Cell Lymphoma.

Published in:

European Journal of Haematology, 2025, v. 115, n. 1, p. 82, doi. 10.1111/ejh.14420

By:

Lohrberg, M.;
Heber, M.;
Ries, L.;
Markus, K.;
Ksionsko, N.;
Schmidt, N.;
Nothnick, G.;
Thielking, L.;
O'Neill, M.;
Martínéz‐González, S.;
Blanco‐Aparicio, C.;
Pastor, J.;
Cunningham, D.;
Koch, R.

Publication type:

Article

Polo样激酶4调控口腔鳞状细胞癌侵袭、增殖和凋亡的分子机制研究.

Published in:

China Oncology, 2025, v. 35, n. 4, p. 365, doi. 10.19401/j.cnki.1007-3639.2025.04.004

By:

秦欢;
王洁;
杨杰;
华英杰;
曲会娟;
冀洪海

Publication type:

Article

Recent advancements in biomarkers and molecular diagnostics in hormonal receptor‐positive breast cancer.

Published in:

Histopathology, 2025, v. 87, n. 1, p. 3, doi. 10.1111/his.15395

By:

Wang, Yihong;
Liu, Liu;
Graff, Stephanie L.;
Cheng, Liang

Publication type:

Article

Secondary Metabolites and Bioactivity of Alternaria sp., a Fungal Endophyte of Carum carvi.

Published in:

Chemistry of Natural Compounds, 2025, v. 61, n. 3, p. 533, doi. 10.1007/s10600-025-04693-4

By:

Guo, Wen-Lin;
Li, Shuo;
Yang, Zhong-Duo;
Ma, Ke-Zhen;
Chen, Jian-Guo;
Zhao, Tian-Kun;
Li, Yue;
Kim, Sa-Hyun

Publication type:

Article

17β-雌二醇对海马神经干细胞增殖和分化的影响及其机制.

Published in:

Journal of Jilin University (Medicine Edition), 2025, v. 51, n. 2, p. 317, doi. 10.13481/j.1671⁃587X.20250219

By:

杨英;
赵亮;
由涌;
许倩;
杨振军

Publication type:

Article

糖脂转运蛋白对胰腺癌 PANC-1 细胞增殖、迁移和侵袭的影响及其机制.

Published in:

Journal of Jilin University (Medicine Edition), 2025, v. 51, n. 2, p. 284, doi. 10.13481/j.1671⁃587X.20250202

By:

卢梦云;
韩语诚;
胡溢洪;
何旻蕙;
张艳群;
邹先琼

Publication type:

Article

黄芩苷通过PI3K/AKT/eNOS通路保护脑微出血大鼠神经损伤.

Published in:

Tianjin Medical Journal, 2025, v. 53, n. 5, p. 468, doi. 10.11958/20250606.

By:

钟文闻;
邹正寿;
向庆伟

Publication type:

Article

Downregulation of PHLDA2 promotes apoptosis and autophagy in endometrial cancer cells while inhibiting their proliferation and metastasis.

Published in:

European Journal of Gynaecological Oncology, 2025, v. 46, n. 5, p. 107, doi. 10.22514/ejgo.2025.071

By:

Meiping Guo;
Zhiying Wang;
Meiyan Lin

Publication type:

Article

Curcumin enhances breast cancer cell death by suppressing PD-L1 expression.

Published in:

European Journal of Gynaecological Oncology, 2025, v. 46, n. 5, p. 60, doi. 10.22514/ejgo.2025.066

By:

Mingjian Ding;
Xinya Dai;
Xiaojun Liu;
Liang Zhang;
Guozhong Cui

Publication type:

Article

Humanized patient-derived xenograft mouse model bearing ovarian clear cell carcinoma.

Published in:

Journal of Gynecologic Oncology, 2025, v. 36, n. 3, p. 1, doi. 10.3802/jgo.2025.36.e40

By:

Zhen Yuan;
Huimei Zhou;
Dongyan Cao;
Jiaxin Yang;
Qian Liu

Publication type:

Article

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 6, p. 679, doi. 10.1038/nsmb.2570

By:

Honigmann, Alf;
van den Bogaart, Geert;
Iraheta, Emilio;
Risselada, H Jelger;
Milovanovic, Dragomir;
Mueller, Veronika;
Müllar, Stefan;
Diederichsen, Ulf;
Fasshauer, Dirk;
Grubmüller, Helmut;
Hell, Stefan W;
Eggeling, Christian;
Kühnel, Karin;
Jahn, Reinhard

Publication type:

Article

Differential expression of follicular fluid exosomal microRNA in women with diminished ovarian reserve.

Published in:

Journal of Assisted Reproduction & Genetics, 2024, v. 41, n. 4, p. 1087, doi. 10.1007/s10815-024-03037-5

By:

Xie, Ying;
Chen, Juan;
Liu, Kailu;
Huang, Jingyu;
Zeng, Yaqiong;
Gao, Mengya;
Qian, Yu;
Liu, Li;
Tan, Yong;
Nie, Xiaowei

Publication type:

Article

Lithiation of a Silyl Ether: Formation of an ortho-Fries Hydroxyketone.

Published in:

Angewandte Chemie, 2014, v. 126, n. 34, p. 9172, doi. 10.1002/ange.201404495

By:

Lo, Hong ‐ Jay;
Lin, Chin ‐ Yin;
Tseng, Mei ‐ Chun;
Chein, Rong ‐ Jie

Publication type:

Article

IL-8 and PI3K pathway influence the susceptibility of TRAIL-sensitive colorectal cancer cells to TRAIL-induced cell death.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09895-7

By:

Jong, Kelly Xue Jing;
Mohamed, Elsa Haniffah Mejia;
Syafruddin, Saiful Effendi;
Faruqu, Farid Nazer;
Vellasamy, Kumutha Malar;
Ibrahim, Kamariah;
Ibrahim, Zaridatul Aini

Publication type:

Article

Inhibition of phosphoinositide 3-kinase activity attenuates neutrophilic airway inflammation and inhibits pyrin domain-containing 3 inflammasome activation in an ovalbumin-lipopolysaccharide-induced asthma murine model.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09360-5

By:

Li, Qun;
Jiang, Guiyun;
Lv, Yunxiang

Publication type:

Article

An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators.

Published in:

Medicinal Research Reviews, 2024, v. 44, n. 5, p. 2331, doi. 10.1002/med.22044

By:

Hao, Wanting;
Luo, Dongdong;
Jiang, Yuqi;
Wan, Shengbiao;
Li, Xiaoyang

Publication type:

Article

Recent insights in the PI3K/Akt pathway as a promising therapeutic target in combination with EGFR‐targeting agents to treat head and neck squamous cell carcinoma.

Published in:

Medicinal Research Reviews, 2022, v. 42, n. 1, p. 112, doi. 10.1002/med.21806

By:

Zaryouh, Hannah;
De Pauw, Ines;
Baysal, Hasan;
Peeters, Marc;
Vermorken, Jan Baptist;
Lardon, Filip;
Wouters, An

Publication type:

Article

Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors.

Published in:

Medicinal Research Reviews, 2021, v. 41, n. 3, p. 1599, doi. 10.1002/med.21770

By:

Zhu, Jingyu;
Li, Kan;
Yu, Li;
Chen, Yun;
Cai, Yanfei;
Jin, Jian;
Hou, Tingjun

Publication type:

Article

MFGE8 mitigates brain injury in a rat model of SAH by maintaining vascular endothelial integrity via TIGβ5/PI3K/CXCL12 signaling.

Published in:

Experimental Brain Research, 2021, v. 239, n. 7, p. 2193, doi. 10.1007/s00221-021-06111-x

By:

Wang, Jikai;
Wang, Yiping;
Zuo, Yuchun;
Duan, Jiajia;
Pan, Aihua;
Li, Jian-Ming;
Yan, Xiao-Xin;
Liu, Fei

Publication type:

Article

Reduction of no-reflow and reperfusion injury with the synthetic 17β-aminoestrogen compound Prolame is associated with PI3K/Akt/eNOS signaling cascade.

Published in:

Basic Research in Cardiology, 2015, v. 110, n. 2, p. 1, doi. 10.1007/s00395-015-0464-y

By:

Hernández-Reséndiz, Sauri;
Palma-Flores, Carlos;
los Santos, Sergio;
Román-Anguiano, Nadia;
Flores, Mirthala;
Peña, Aurora;
Flores, Pedro;
Fernández-G, Juan;
Coral-Vázquez, Ramón;
Zazueta, Cecilia

Publication type:

Article

NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury.

Published in:

Basic Research in Cardiology, 2013, v. 108, n. 3, p. 1, doi. 10.1007/s00395-013-0341-5

By:

Sun, Zhongchan;
Tong, Guang;
Ma, Nan;
Li, Jianying;
Li, Xiujuan;
Li, Shuang;
Zhou, Jingyu;
Xiong, Lize;
Cao, Feng;
Yao, Libo;
Wang, Haichang;
Shen, Lan

Publication type:

Article

N-Acetylcysteine improves intestinal function in lipopolysaccharides-challenged piglets through multiple signaling pathways.

Published in:

Amino Acids, 2017, v. 49, n. 12, p. 1915, doi. 10.1007/s00726-017-2389-2

By:

Yi, Dan;
Hou, Yongqing;
Xiao, Hang;
Wang, Lei;
Zhang, Yue;
Chen, Hongbo;
Wu, Tao;
Ding, Binying;
Hu, Chien-An;
Wu, Guoyao

Publication type:

Article

Kynurenic acid inhibits colon cancer proliferation in vitro: effects on signaling pathways.

Published in:

Amino Acids, 2014, v. 46, n. 10, p. 2393, doi. 10.1007/s00726-014-1790-3

By:

Walczak, Katarzyna;
Turski, Waldemar;
Rajtar, Grażyna

Publication type:

Article

Retraction: Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

Published in:: Biochemical Journal, 2025, v. 482, n. 7, p. 363, doi. 10.1042/BJ20030577_RET
Publication type:: Article

ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.

Published in:

Biochemical Journal, 2024, v. 481, n. 23, p. 1787, doi. 10.1042/BCJ20240479

By:

Gong, Grace Q.;
Masson, Glenn R.;
Woo-Jeong Lee;
Dickson, James M. J.;
Kendall, Jackie D.;
Rathinaswamy, Manoj K.;
Buchanan, Christina M.;
Middleditch, Martin;
Owen, Brady M.;
Spicer, Julie A.;
Rewcastle, Gordon W.;
Denny, William A.;
Burke, John E.;
Shepherd, Peter R.;
Williams, Roger L.;
Flanagan, Jack U.

Publication type:

Article

Michael D. Waterfield.

Published in:

Biochemical Journal, 2023, v. 480, n. 18, p. 1475, doi. 10.1042/BCJ20230368

By:

Downward, Julian;
Parker, Peter J.;
Vanhaesebroeck, Bart

Publication type:

Article

The choreography of protein kinase PDK1 and its diverse substrate dance partners.

Published in:

Biochemical Journal, 2023, v. 480, n. 19, p. 1503, doi. 10.1042/BCJ20220396

By:

Leroux, Alejandro E.;
Biondi, Ricardo M.

Publication type:

Article

The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase.

Published in:

Biochemical Journal, 2023, v. 480, n. 10, p. 729, doi. 10.1042/BCJ20220493

By:

Bardwell, A. Jane;
Paul, Madhuri;
Yoneda, Kiku C.;
Andrade-Ludeña, María D.;
Nguyen, Oanh T.;
Fruman, David A.;
Bardwell, Lee

Publication type:

Article

Phosphoinositide 3-kinases in platelets, thrombosis and therapeutics.

Published in:

Biochemical Journal, 2020, v. 477, n. 22, p. 4327, doi. 10.1042/BCJ20190402

By:

Ribes, Agnès;
Oprescu, Antoine;
Viaud, Julien;
Hnia, Karim;
Chicanne, Gaëtan;
Xuereb, Jean-Marie;
Severin, Sonia;
Gratacap, Marie-Pierre;
Payrastre, Bernard

Publication type:

Article

Fibroblast growth factors: properties, biosynthesis, biological functions, therapeutic applications and engineering.

Published in:

International Journal of Medical Biochemistry, 2024, v. 7, n. 2, p. 114, doi. 10.14744/ijmb.2024.16768

By:

Tiwari, Nitin;
Tiwari, Ashok;
Mehra, Lalita;
Ganguly, Arjun;
Darji, Kamlesh;
Pandit, Muzafar;
R., Rachana

Publication type:

Article

Advances and controversies in new techniques of breast pathology.

Published in:

China Oncology, 2025, v. 35, n. 3, p. 283, doi. 10.19401/j.cnki.1007-3639.2025.03.004

By:

ZHANG Yujia;
MA Li

Publication type:

Article

Precision diagnosis and treatment of breast cancer in the post-CDK4/6 inhibitor era.

Published in:

China Oncology, 2025, v. 35, n. 3, p. 273, doi. 10.19401/j.cnki.1007-3639.2025.03.003

By:

LI Bin;
TAO Zhonghua;
HU Xichun

Publication type:

Article

Effects of SEC14L1P1 on proliferation and migration of oral squamous cell carcinoma cells.

Published in:

China Oncology, 2025, v. 35, n. 3, p. 309, doi. 10.19401/j.cnki.1007-3639.2025.03.007

By:

ZHENG Wentian;
GONG Hui;
ZHANG Xinyue;
HAO Jiayi;
WANG Yajie;
JIANG Yingying

Publication type:

Article

Loss of miR-634 contributes to the formation FOXA1-positive triple negative breast cancer subtype.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01472-5

By:

Ren, Feng;
Rui, Xiaoping;
Xiao, Xianqiu

Publication type:

Article

IL-22 activates the PI3K-AKT pathway to promote colorectal cancer cell proliferation and metastasis.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01169-9

By:

Ruan, Hong-xun;
Qin, Xiao-ning;
Huang, Wei;
Lin, Lin

Publication type:

Article

Exploring PI3K Pathway Inhibitors for Acute Myeloid Leukemia: A Drug-Repurposing Approach.

Published in:

Experimed, 2023, v. 13, n. 3, p. 205, doi. 10.26650/experimed.1358971

By:

Ergun, Cansu;
Kiremitci, Buse Zeren;
Arslantas, Gizem;
Bozkurt, Busenur;
Duran, Gizem Ayna;
Kiraz, Yagmur

Publication type:

Article

Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00496-y

By:

Yip, Hon Yan Kelvin;
Shin, Sung-Young;
Chee, Annabel;
Ang, Ching-Seng;
Rossello, Fernando J.;
Wong, Lee Hwa;
Nguyen, Lan K.;
Papa, Antonella

Publication type:

Article