Works about PERFORINS

Results: 355

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin.

Published in:

PLoS Biology, 2015, v. 13, n. 2, p. 1, doi. 10.1371/journal.pbio.1002049

By:

Lukoyanova, Natalya;
Kondos, Stephanie C.;
Farabella, Irene;
Law, Ruby H. P.;
Reboul, Cyril F.;
Caradoc-Davies, Tom T.;
Spicer, Bradley A.;
Kleifeld, Oded;
Traore, Daouda A. K.;
Ekkel, Susan M.;
Voskoboinik, Ilia;
Trapani, Joseph A.;
Hatfaludi, Tamas;
Oliver, Katherine;
Hotze, Eileen M.;
Tweten, Rodney K.;
Whisstock, James C.;
Topf, Maya;
Saibil, Helen R.;
Dunstone, Michelle A.

Publication type:

Article

CD8 T cell-derived perforin regulates macrophage-mediated inflammation in a murine model of gout.

Published in:

Clinical Rheumatology, 2024, v. 43, n. 6, p. 2027, doi. 10.1007/s10067-024-06964-x

By:

Wang, Tianqi;
Zhang, Chunpan;
Zhou, Mingzhu;
Zhou, Hang;
Zhang, Xia;
Liu, Huilan;
Bai, Mingxin;
Xu, Yuetong;
Yang, Fan;
Zhu, Fengyunzhi;
Hao, Qiyuan;
Zhang, Tong;
Song, Shuju;
Qi, Haiyu;
Liu, Yanying

Publication type:

Article

Role of cytolytic impairment of natural killer and natural killer T-cell populations in rheumatoid arthritis.

Published in:

Clinical Rheumatology, 2014, v. 33, n. 8, p. 1067, doi. 10.1007/s10067-014-2641-z

By:

Aggarwal, Ashish;
Sharma, Aman;
Bhatnagar, Archana

Publication type:

Article

Fungal aegerolysin-like proteins: distribution, activities, and applications.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 2, p. 601, doi. 10.1007/s00253-014-6239-9

By:

Novak, Maruša;
Kraševec, Nada;
Skočaj, Matej;
Maček, Peter;
Anderluh, Gregor;
Sepčić, Kristina

Publication type:

Article

Current State of the Art and Prospects of T Cell-Redirecting Bispecific Antibodies in Multiple Myeloma.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 19, p. 4593, doi. 10.3390/jcm10194593

By:

Hosny, Mashhour;
Verkleij, Christie P. M.;
van der Schans, Jort;
Frerichs, Kristine A.;
Mutis, Tuna;
Zweegman, Sonja;
van de Donk, Niels W. C. J.

Publication type:

Article

Differential Effects of Stimulatory Factors on Natural Killer Cell Activities of Young and Aged Mice.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2012, v. 67, n. 9, p. 947, doi. 10.1093/gerona/gls079

By:

Nogusa, Shoko;
Murasko, Donna M.;
Gardner, Elizabeth M.

Publication type:

Article

Histologic and Immunohistochemical Patterns in Lymphomatoid Papulosis: A Systematic Review of Published Cases.

Published in:

Dermatopathology, 2025, v. 12, n. 1, p. 1, doi. 10.3390/dermatopathology12010006

By:

Fricke, Torben;
Kempf, Werner;
Schön, Michael P.;
Mitteldorf, Christina

Publication type:

Article

High Dimensionality Reduction and Immune Phenotyping of Natural Killer and Invariant Natural Killer Cells in Latent Tuberculosis-Diabetes Comorbidity.

Published in:

2022

By:

Kathamuthu, Gokul Raj;
Kumar, Nathella Pavan;
Moideen, Kadar;
Menon, Pradeep A.;
Babu, Subash

Publication type:

journal article

Antidepressant-like activity of adhyperforin, a novel constituent of Hypericum perforatum L.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep05632

By:

Jingwei Tian;
Fangxi Zhang;
Jucan Cheng;
Shuren Guo;
Pinglan Liu;
Hongbo Wang

Publication type:

Article

Sudocetaxel Zendusortide (TH1902) triggers the cGAS/ STING pathway and potentiates anti-PD-L1 immune-mediated tumor cell killing.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1355945

By:

Demeule, Michel;
Currie, Jean-Christophe;
Charfi, Cyndia;
Zgheib, Alain;
Cousineau, Isabelle;
Lullier, Véronique;
liveau, Richard Bé;
Marsolais, Christian;
Annabi, Borhane

Publication type:

Article

Blockade of PD-1 and LAG-3 expression on CD8+ T cells promotes the tumoricidal effects of CD8+ T cells.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1265255

By:

Jiajia Ma;
Shufang Yan;
Ying Zhao;
Huifang Yan;
Qian Zhang;
Xinxia Li

Publication type:

Article

Cytotoxic innate intraepithelial lymphocytes control early stages of Cryptosporidium infection.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1229406

By:

Hariss, Fatima;
Delbeke, Marie;
Guyot, Karine;
Zarnitzky, Pauline;
Ezzedine, Mohamad;
Certad, Gabriela;
Meresse, Bertrand

Publication type:

Article

Alterations of natural killer cells activatory molecules phenotype and function in mothers of ASD children: a pilot study.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1190925

By:

Saresella, Marina;
Marventano, Ivana;
Piancone, Federica;
Bolognesi, Elisabetta;
Hernis, Ambra;
Zanzottera, Milena;
La Rosa, Francesca;
Agliardi, Cristina;
Giraldo, Stefano;
Chiappedi, Matteo;
Guerini, Franca Rosa;
Clerici, Mario

Publication type:

Article

Surface plasmon resonance and microscale thermophoresis approaches for determining the affinity of perforin for calcium ions.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1181020

By:

Naneh, Omar;
Kozorog, Mirijam;
Merzel, Franci;
Gilbert, Robert;
Anderluh, Gregor

Publication type:

Article

Characterization of the humoral and cellular immunity induced by a recombinant BCG vaccine for the respiratory syncytial virus in healthy adults.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1215893

By:

Pacheco, Gaspar A.;
Andrade, Catalina A.;
Gálvez, Nicolás M. S.;
Vázquez, Yaneisi;
Rodríguez-Guilarte, Linmar;
Abarca, Katia;
González, Pablo A.;
Bueno, Susan M.;
Kalergis, Alexis M.

Publication type:

Article

A D-peptide-based oral nanotherapeutic modulates the PD-1/PD-L1 interaction for tumor immunotherapy.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1228581

By:

Dan Liu;
Jingmei Wang;
Weiming You;
Fang Ma;
Qi Sun;
Junjun She;
Wangxiao He;
Guang Yang

Publication type:

Article

Acute lymphoblastic leukemia-derived exosome inhibits cytotoxicity of natural killer cells by TGF-β signaling pathway.

Published in:

3 Biotech, 2021, v. 11, n. 7, p. 1, doi. 10.1007/s13205-021-02817-5

By:

Yu, Huijun;
Huang, Tingting;
Wang, Daming;
Chen, Lei;
Lan, Xi;
Liu, Xintong;
Chen, Keyan;
He, Haihong;
Li, Shaobo;
Zhou, Yiwen;
Xie, Jiansheng

Publication type:

Article

Acute lymphoblastic leukemia-derived exosome inhibits cytotoxicity of natural killer cells by TGF-β signaling pathway.

Published in:

3 Biotech, 2021, v. 11, n. 7, p. 1, doi. 10.1007/s13205-021-02817-5

By:

Yu, Huijun;
Huang, Tingting;
Wang, Daming;
Chen, Lei;
Lan, Xi;
Liu, Xintong;
Chen, Keyan;
He, Haihong;
Li, Shaobo;
Zhou, Yiwen;
Xie, Jiansheng

Publication type:

Article

Cytotoxic granules in distinct subsets of cutaneous lupus erythematosus.

Published in:

Clinical & Experimental Dermatology, 2014, v. 39, n. 7, p. 835, doi. 10.1111/ced.12428

By:

Fogagnolo, L.;
Soares, T. C. B.;
Senna, C. G.;
Souza, E. M.;
Blotta, M. H. S. L.;
Cintra, M. L.

Publication type:

Article

Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease.

Published in:

Cell & Bioscience, 2021, v. 11, n. 1, p. 1, doi. 10.1186/s13578-021-00664-8

By:

Zhang, Yujue;
Fan, Yuanyuan;
He, Wei;
Han, Yi;
Bao, Huarui;
Yang, Renjun;
Wang, Bingbing;
Kong, Derun;
Wang, Hua

Publication type:

Article

Dysfunctional Senescent Herpes Simplex Virus-Specific CD57 + CD8 + T Cells Are Associated with Symptomatic Recurrent Ocular Herpes in Humans.

Published in:

Viruses (1999-4915), 2025, v. 17, n. 5, p. 606, doi. 10.3390/v17050606

By:

Chentoufi, Aziz A.;
Khan, Arif A.;
Srivastava, Ruchi;
Karan, Sweta;
Lekbach, Yassir;
Vahed, Hawa;
BenMohamed, Lbachir

Publication type:

Article

Modified-Live Feline Calicivirus Vaccination Elicits Cellular Immunity against a Current Feline Calicivirus Field Strain in an Experimental Feline Challenge Study.

Published in:

Viruses (1999-4915), 2021, v. 13, n. 9, p. 1736, doi. 10.3390/v13091736

By:

Spiri, Andrea M.;
Novacco, Marilisa;
Meli, Marina L.;
Stirn, Martina;
Riond, Barbara;
Fogle, Jonathan E.;
Boretti, Felicitas S.;
Herbert, Imogen;
Hosie, Margaret J.;
Hofmann-Lehmann, Regina

Publication type:

Article

Insight into the Lytic Functions of the Lactococcal Prophage TP712.

Published in:

Viruses (1999-4915), 2019, v. 11, n. 10, p. 881, doi. 10.3390/v11100881

By:

Escobedo, Susana;
Campelo, Ana Belén;
Wegmann, Udo;
García, Pilar;
Rodríguez, Ana;
Martínez, Beatriz

Publication type:

Article

Increased Cytotoxic CD4+ T Cells with Reduced Cytotoxic Gene Profile Expression in Cytomegalovirus Reactivated Kidney Transplant Patients.

Published in:

Iranian Journal of Allergy, Asthma & Immunology, 2024, v. 23, n. 6, p. 662, doi. 10.18502/ijaai.v23i6.17376

By:

Hassanzadeh, Yashgin;
Yaghobi, Ramin;
Pakzad, Parviz;
Geramizadeh, Bita

Publication type:

Article

NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression.

Published in:

Age (0161-9152), 2015, v. 37, n. 1, p. 1, doi. 10.1007/s11357-015-9748-2

By:

Duggal, Niharika Arora;
Upton, Jane;
Phillips, Anna C.;
Hampson, Peter;
Lord, Janet M.

Publication type:

Article

Bacteriophage-encoded protein utilization in bacterial ghost production: a mini-review.

Published in:

World Journal of Microbiology & Biotechnology, 2024, v. 40, n. 9, p. 1, doi. 10.1007/s11274-024-04091-y

By:

Xuan, Guanhua;
Qiu, Dongdong;
Wang, Yinfeng;
Wang, Jingxue;
Lin, Hong

Publication type:

Article

Antigen Dependently Activated Cluster of Differentiation 8-Positive T Cells Cause Perforin-Mediated Neurotoxicity in Experimental Stroke.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 50, p. 16784, doi. 10.1523/JNEUROSCI.1867-14.2014

By:

Mracsko, Eva;
Liesz, Arthur;
Stojanovic, Ana;
Lou, Wilson Pak-Kin;
Osswald, Matthias;
Wei Zhou;
Karcher, Simone;
Winkler, Frank;
Martin-Villalba, Ana;
Cerwenka, Adelheid;
Veltkamp, Roland

Publication type:

Article

Impaired T-bet-pSTAT1α and perforin-mediated immune responses in the tumoral region of lung adenocarcinoma.

Published in:

2015

By:

Andreev, Katerina;
Denis Iulian Trufa, I;
Siegemund, Raphaela;
Rieker, Ralf;
Hartmann, Arndt;
Schmidt, Joachim;
Sirbu, Horia;
Finotto, Susetta;
Trufa, I Denis Iulian;
Trufa, Denis Iulian

Publication type:

journal article

Open questions: Missing pieces from the immunological jigsaw puzzle.

Published in:

2013

By:

Griffiths, Gillian M.

Publication type:

Opinion

Cytotoxic CD4+ T-cells specific for EBV capsid antigen BORF1 are maintained in long-term latently infected healthy donors.

Published in:

PLoS Pathogens, 2021, v. 17, n. 12, p. 1, doi. 10.1371/journal.ppat.1010137

By:

Dowell, Alexander C.;
Haigh, Tracey A.;
Ryan, Gordon B.;
Turner, James E.;
Long, Heather M.;
Taylor, Graham S.

Publication type:

Article

Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells.

Published in:

PLoS Pathogens, 2021, v. 17, n. 11, p. 1, doi. 10.1371/journal.ppat.1010034

By:

Adeniji, Opeyemi S.;
Kuri-Cervantes, Leticia;
Yu, Chenfei;
Xu, Ziyang;
Ho, Michelle;
Chew, Glen M.;
Shikuma, Cecilia;
Tomescu, Costin;
George, Ashley F.;
Roan, Nadia R.;
Ndhlovu, Lishomwa C.;
Liu, Qin;
Muthumani, Kar;
Weiner, David B.;
Betts, Michael R.;
Xiao, Han;
Abdel-Mohsen, Mohamed

Publication type:

Article

Granzyme B-dependent and perforin-independent DNA fragmentation in intestinal epithelial cells induced by anti-CD3 mAb-activated intra-epithelial lymphocytes.

Published in:

Cell & Tissue Research, 2013, v. 352, n. 2, p. 287, doi. 10.1007/s00441-012-1549-7

By:

Ogata, Masaki;
Ota, Yuta;
Matsutani, Takaji;
Nanno, Masanobu;
Suzuki, Ryuji;
Itoh, Tsunetoshi

Publication type:

Article

Single-Cell Analysis Reveals That CD47 mRNA Expression Correlates with Immune Cell Activation, Antiviral ISGs and Cytotoxicity.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2024, v. 58, n. 4, p. 322, doi. 10.33594/000000715

By:

Cham, Lamin B.;
Rosas-Umbert, Miriam;
Lin Lin;
Tolstrup, Martin;
Søgaard, Ole S.

Publication type:

Article

Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses.

Published in:

Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-1083-1

By:

Benitez, Asiel A.;
Khalil-Agüero, Sara;
Nandakumar, Anjali;
Gupta, Namita T.;
Zhang, Wen;
Atwal, Gurinder S.;
Murphy, Andrew J.;
Sleeman, Matthew A.;
Haxhinasto, Sokol

Publication type:

Article

Perforin is recaptured by natural killer cells following target cells stimulation for cytotoxicity.

Published in:

Cell Biology International, 2012, v. 36, n. 2, p. 223, doi. 10.1042/CBI20110242

By:

Wang, Lei;
Sun, Rulin;
Li, Pan;
Han, Yang;
Xiong, Ping;
Xu, Yong;
Fang, Min;
Tan, Zheng;
Zheng, Fang;
Gong, Feili

Publication type:

Article

The Functional Role and Prognostic Significance of TIM-3 Expression on NK Cells in the Diagnostic Bone Marrows in Acute Myeloid Leukemia.

Published in:

Biomedicines, 2024, v. 12, n. 12, p. 2717, doi. 10.3390/biomedicines12122717

By:

Sun, Kai;
Shi, Zong-Yan;
Xie, Dai-Hong;
Wang, Ya-Zhe;
Jiang, Hao;
Jiang, Qian;
Huang, Xiao-Jun;
Qin, Ya-Zhen

Publication type:

Article

Induction Therapies Determine the Distribution of Perforin and Granzyme B Transcripts in Kidney Transplant Recipients.

Published in:

Biomedicines, 2024, v. 12, n. 6, p. 1258, doi. 10.3390/biomedicines12061258

By:

Pipic, Dino;
Rasmussen, Marianne;
Saleh, Qais W.;
Tepel, Martin

Publication type:

Article

Functional Properties of CD8+ Lymphocytes in Patients with Pleural Plaque and Malignant Mesothelioma.

Published in:

Journal of Immunology Research, 2014, p. 1, doi. 10.1155/2014/670140

By:

Naoko Kumagai-Takei;
Yasumitsu Nishimura;
Megumi Maeda;
Hiroaki Hayashi;
Hidenori Matsuzaki;
Suni Lee;
Takumi Kishimoto;
Kazuya Fukuoka;
Takashi Nakano;
Takemi Otsuki

Publication type:

Article

Evidence of membranolytic targeting and intracellular citrullination in neutrophils isolated from patients with rheumatoid arthritis.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-66516-w

By:

Moadab, Fatemeh;
Wang, Xiaoxing;
Le, Ethan;
Gazitt, Tal;
Najjar, Rayan;
Nelson, J. Lee;
Joshua, Vijay;
Malmström, Vivianne;
Elkon, Keith;
Grönwall, Caroline;
Mustelin, Tomas

Publication type:

Article

Neutralizing IL-15 Inhibits Tissue-Damaging Immune Response in Ex Vivo Cultured Untreated Celiac Intestinal Mucosa.

Published in:

Cells (2073-4409), 2025, v. 14, n. 3, p. 234, doi. 10.3390/cells14030234

By:

Rotondi Aufiero, Vera;
Iacomino, Giuseppe;
De Chiara, Giovanni;
Picariello, Errico;
Iaquinto, Gaetano;
Troncone, Riccardo;
Mazzarella, Giuseppe

Publication type:

Article

Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature.

Published in:

Cells (2073-4409), 2023, v. 12, n. 3, p. 449, doi. 10.3390/cells12030449

By:

Ręka, Gabriela;
Stefaniak, Martyna;
Lejman, Monika

Publication type:

Article

T-Bet Deficiency Attenuates Bile Duct Injury in Experimental Biliary Atresia.

Published in:

Cells (2073-4409), 2021, v. 10, n. 12, p. 3461, doi. 10.3390/cells10123461

By:

Mohanty, Sujit K.;
Donnelly, Bryan;
Temple, Haley;
Bondoc, Alexander;
McNeal, Monica;
Tiao, Greg

Publication type:

Article

Tumor Lactic Acidosis: Protecting Tumor by Inhibiting Cytotoxic Activity Through Motility Arrest and Bioenergetic Silencing.

Published in:

Frontiers in Oncology, 2020, v. 10, p. N.PAG, doi. 10.3389/fonc.2020.589434

By:

Fischbeck, Angelika J.;
Ruehland, Svenja;
Ettinger, Andreas;
Paetzold, Kerstin;
Masouris, Ilias;
Noessner, Elfriede;
Mendler, Anna N.

Publication type:

Article

Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection.

Published in:

Frontiers in Immunology, 2016, p. 1, doi. 10.3389/fimmu.2016.00133

By:

Arapović, Maja;
Popović, Branka;
Krmpotić, Astrid;
Jonjić, Stipan;
Arapović, Jurica;
Brizić, Ilija;
Jurković, Slaven;
Jordan, Stefan

Publication type:

Article

The Differentiation and Protective Function of Cytolytic CD4 T Cells in influenza infection.

Published in:

Frontiers in Immunology, 2016, p. 1, doi. 10.3389/fimmu.2016.00093

By:

Brown, Deborah M.;
Lampe, Anna T.;
Workman, Aspen M.

Publication type:

Article

Cloning CTL-specific genes (and now for something completely differential).

Published in:

Frontiers in Immunology, 2014, v. 5, p. 1, doi. 10.3389/fimmu.2014.00509

By:

Bleackley, R. Chris

Publication type:

Article

Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function.

Published in:

Frontiers in Immunology, 2013, v. 4, p. 1, doi. 10.3389/fimmu.2013.00441

By:

Trapani, Joseph A.;
Voskoboinik, Ilia

Publication type:

Article

CD8αα expression marks terminally differentiated human CD8+ T cells expanded in chronic viral infection.

Published in:

Frontiers in Immunology, 2013, v. 4, p. 1, doi. 10.3389/fimmu.2013.00223

By:

Walker, L. J.;
Marrinan, E.;
Muenchhoff, M.;
Ferguson, J.;
Kloverpris, H.;
Cheroutre, H.;
Barnes, E.;
Goulder, P.;
Klenerman, Paul

Publication type:

Article

Immunohistochemical expression of perforin in adult systemic lupus erythematosus associated macrophage activation syndrome: Clinicohematological correlation and literature review.

Published in:

Lupus, 2024, v. 33, n. 1, p. 26, doi. 10.1177/09612033231221414

By:

Velayutham, Bakialakshmi;
Padhi, Somanath;
Devi, Sujata;
Patra, Susama;
Panigrahi, Chinmayee;
Ramasubbu, Mathan Kumar;
Kumar, Rajesh;
Raheman, Samiur

Publication type:

Article

Exosomal miR-552-5p Regulates the Role of NK Cells in EMT of Gastric Cancer via the PD-1/PD-L1 Axis.

Published in:

Journal of Cancer, 2025, v. 16, n. 2, p. 406, doi. 10.7150/jca.102360

By:

Jingwen Qin;
Jinhua Yang;
Haopeng Cui;
Chunling Feng;
Aiqun Liu

Publication type:

Article