Works about ORGANIC cation transporters

Results: 504

Bioenergetics disruption, oxidative stress, and inflammation as underlying mechanisms of tramadol‐induced nephrotoxicity.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 9, p. 1, doi. 10.1002/jbt.23777

By:

Elmorsy, Ekramy M.;
Al Doghaither, Huda A.;
Al‐Ghafari, Ayat B.

Publication type:

Article

Interactions between cyazofamid and human drug transporters.

Published in:

Journal of Biochemical & Molecular Toxicology, 2020, v. 34, n. 4, p. 1, doi. 10.1002/jbt.22459

By:

Song, Im‐Sook;
Jeong, Hyeon‐Uk;
Choi, Min‐Koo;
Kwon, Mihwa;
Shin, Yongho;
Kim, Jeong Han;
Lee, Hye‐Suk

Publication type:

Article

Functional analysis of choline transporters in rheumatoid arthritis synovial fibroblasts.

Published in:

Modern Rheumatology, 2017, v. 27, n. 6, p. 995, doi. 10.1080/14397595.2017.1280118

By:

Masayuki Seki;
Yuiko Kawai;
Chikanao Ishii;
Tsuyoshi Yamanaka;
Masato Odawara;
Masato Inazu

Publication type:

Article

Hybrid Molecules of Benzylguanidine and the Alkylating Group of Melphalan: Synthesis and Effects on Neuroblastoma Cells.

Published in:

Journal of Clinical Medicine, 2023, v. 12, n. 13, p. 4469, doi. 10.3390/jcm12134469

By:

Bruchelt, Gernot;
Klose, Chihab;
Lischka, Matthias;
Brandes, Marietta;
Handgretinger, Rupert;
Brueckner, Reinhard

Publication type:

Article

Novel Clinical Updates in Uremia.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 13, p. 3791, doi. 10.3390/jcm11133791

By:

Clementi, Anna;
Virzì, Grazia Maria

Publication type:

Article

Exploring the Prebiotic Activities of Proanthocyanidins on a Platform Using the Three-Dimensionally (3D)-Cultured Organoids.

Published in:

Journal of Animal Science, 2023, v. 101, p. 355, doi. 10.1093/jas/skad281.421

By:

Lin Xi;
Feng Wang;
Cagle, Daisy;
Yue Zhu;
Odle, Jack;
Deyu Xie

Publication type:

Article

Polyamines protect boar sperm from oxidative stress in vitro.

Published in:

Journal of Animal Science, 2022, v. 100, n. 4, p. 1, doi. 10.1093/jas/skac069

By:

Li, Rongnan;
Wu, Xiaodong;
Zhu, Zhendong;
Lv, Yinghua;
Zheng, Yi;
Lu, Hongzhao;
Zhou, Kaifeng;
Wu, De;
Zeng, Wenxian;
Dong, Wuzi;
Zhang, Tao

Publication type:

Article

Effect of Erdafitinib on the Pharmacokinetics of Midazolam and Metformin in Patients With Advanced Solid Tumors Harboring FGFR Gene Alterations.

Published in:

Clinical Pharmacology in Drug Development, 2024, v. 13, n. 10, p. 1164, doi. 10.1002/cpdd.1445

By:

Zhu, Wei;
Baig, Mahadi;
Naini, Vahid;
De Meulder, Marc;
Akapame, Sydney;
De Zwart, Loeckie;
Haddish‐Berhane, Nahor;
Triantos, Spyros

Publication type:

Article

ACCP Abstract Booklet.

Published in:: Clinical Pharmacology in Drug Development, 2022, v. 11, p. 1, doi. 10.1002/cpdd.1151
Publication type:: Article

No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects.

Published in:

Clinical Pharmacology in Drug Development, 2019, v. 8, n. 6, p. 818, doi. 10.1002/cpdd.648

By:

Choi, Taylor;
Komirenko, Allison S.;
Riddle, Valerie;
Kim, Aryun;
Dhuria, Shyeilla V.

Publication type:

Article

Evaluation of the potential interaction between tofacitinib and drugs that undergo renal tubular secretion using metformin, an in vivo marker of renal organic cation transporter 2.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 499, doi. 10.1002/cpdd.120

By:

Klamerus, Karen J.;
Alvey, Christine;
Li, Lei;
Feng, Bo;
Wang, Rong;
Kaplan, Irina;
Shi, Haihong;
Dowty, Martin E.;
Krishnaswami, Sriram

Publication type:

Article

Molecular pharmacokinetic mechanism of JBP485 against aristolochic acid I (AAI) -induced nephrotoxicity.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1577942

By:

Wang, Chong;
Jin, Huan;
Wang, Changyuan;
Wu, Jingjing;
Meng, Qiang;
Zhong, Ming;
Sun, Huijun;
Wei, Yuheng;
Gao, Ge;
Kaku, Taiichi;
Huo, Xiaokui;
Liu, Kexin

Publication type:

Article

Acute hypobaric hypoxia attenuates the anti-fatigue effects of pitolisant by downregulating the expression of organic cation transporter 1 and P-glycoprotein.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1564174

By:

Zhao, Gang;
Li, Yajuan;
Liu, Mengyuan;
Chang, Wei;
Shen, Hui;
Xue, Junhui;
Liu, Fengzhou

Publication type:

Article

Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1466394

By:

Chávez-Arreola, Oscar I.;
Lazalde, Brissia;
López-López, Marisol;
Ortega-Vázquez, Alberto;
Torres-Salazar, Quitzia L.

Publication type:

Article

Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1466394

By:

Chávez-Arreola, Oscar I.;
Lazalde, Brissia;
López-López, Marisol;
Ortega-Vázquez, Alberto;
Torres-Salazar, Quitzia L.

Publication type:

Article

Antimicrobial peptide CC34 attenuates intestinal inflammation via downregulation of the NF-κB signaling pathway.

Published in:

3 Biotech, 2021, v. 11, n. 9, p. 1, doi. 10.1007/s13205-021-02948-9

By:

Dong, Liqiang;
Yang, Huan;
Wang, Zhao;
Jiang, Ning;
Zhang, Aizhong

Publication type:

Article

A dense convolutional neural network for hyperspectral image classification.

Published in:

Remote Sensing Letters, 2019, v. 10, n. 1, p. 59, doi. 10.1080/2150704X.2018.1526424

By:

Zhi, Lu;
Yu, Xuchu;
Liu, Bing;
Wei, Xiangpo

Publication type:

Article

Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters.

Published in:

Viruses (1999-4915), 2021, v. 13, n. 8, p. 1566, doi. 10.3390/v13081566

By:

Bleasby, Kelly;
Houle, Robert;
Hafey, Michael;
Lin, Meihong;
Guo, Jingjing;
Lu, Bing;
Sanchez, Rosa I.;
Fillgrove, Kerry L.

Publication type:

Article

Amino acid-responsive Crohn's disease: a case study.

Published in:

Clinical & Experimental Gastroenterology, 2010, v. 3, p. 171, doi. 10.2147/CEG.S15340

By:

Stein, Alvin;
Hinz, Marty;
Uncini, Thomas

Publication type:

Article

SLC22A1 rs622342 Polymorphism Predicts Insulin Resistance Improvement in Patients with Type 2 Diabetes Mellitus Treated with Metformin: A Cross-Sectional Study.

Published in:

International Journal of Endocrinology, 2020, p. 1, doi. 10.1155/2020/2975898

By:

Wu, Kunrong;
Li, Xiaoli;
Xu, Yuedong;
Zhang, Xiaoqian;
Guan, Ziwan;
Zhang, Shufang;
Li, Yan

Publication type:

Article

Metal ions effect on L‐carnitine activity: A new research direction with a possible mitigating effect of dietary cellulose.

Published in:

Aquaculture Research, 2022, v. 53, n. 17, p. 5846, doi. 10.1111/are.16107

By:

Tjale, Phillip M.;
Ghonimy, Abdallah;
Zhang, Dong M.;
Wang, Qiu J.;
Chen, Yu K.;
Ma, Yue;
Guo, Zhi X.;
Zhao, Yun L.;
Farouk, Mohammed Hamdy

Publication type:

Article

Antituberculosis potential of borrelidin derivatives: An in silico molecular docking and molecular dynamic approach.

Published in:

Thai Journal of Pharmaceutical Sciences, 2025, v. 49, n. 1, p. 1

By:

Ernawati, Teni;
Ramadhan, Donny;
Hermawan, Faris;
Wulyoadi, Sasmito;
Marwoto, Bambang;
Wibisana, Ahmad;
Srijanto, Bambang

Publication type:

Article

Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain.

Published in:

PLoS ONE, 2022, v. 17, n. 5, p. 1, doi. 10.1371/journal.pone.0266559

By:

Shaheen, Abida;
Alam, Syed Mahboob;
Azam, Fahad;
Saleem, Salman Ahmad;
Khan, Moosa;
Hasan, Syed Saud;
Liaquat, Afrose

Publication type:

Article

Influence of Pectin Structural Properties on Interactions with Divalent Cations and Its Associated Functionalities.

Published in:

Comprehensive Reviews in Food Science & Food Safety, 2018, v. 17, n. 6, p. 1576, doi. 10.1111/1541-4337.12394

By:

Celus, Miete;
Kyomugasho, Clare;
Loey, Ann M.;
Grauwet, Tara;
Hendrickx, Marc E.

Publication type:

Article

Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice.

Published in:

Brain Structure & Function, 2017, v. 222, n. 4, p. 1913, doi. 10.1007/s00429-016-1315-9

By:

Gasser, Paul;
Hurley, Matthew;
Chan, June;
Pickel, Virginia

Publication type:

Article

The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake.

Published in:

Bioinorganic Chemistry & Applications, 2022, v. 2022, p. 1, doi. 10.1155/2022/3698391

By:

Gabano, Elisabetta;
Zanellato, Ilaria;
Pinton, Giulia;
Moro, Laura;
Ravera, Mauro;
Osella, Domenico

Publication type:

Article

Effects of Cimetidine and Dolutegravir on the Endogenous Drug–Drug Interaction Biomarkers for Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Protein 1 in Healthy Volunteers.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 2, p. 523, doi. 10.1002/cpt.3482

By:

Koishikawa, Tomoki;
Fujiwara, Kaku;
Taskar, Kunal;
Zamek‐Gliszczynski, Maciej J.;
Yoshida, Kenta;
Chu, Xiaoyan;
Hirabayashi, Hideki;
Mao, Jialin;
Rockich, Kevin;
Takashima, Tadayuki;
Yamaura, Yoshiyuki;
Lai, Yurong;
Tomoda, Yukana;
Kito, Tomoko;
Maeda, Kazuya;
Furihata, Kenichi;
Sugiyama, Yuichi;
Kusuhara, Hiroyuki

Publication type:

Article

New Biomarkers for Renal Transporter‐Mediated Drug–Drug Interactions: Metabolomic Effects of Cimetidine, Probenecid, Verapamil, and Rifampin in Humans.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 1, p. 130, doi. 10.1002/cpt.3414

By:

Gessner, Arne;
König, Jörg;
Wenisch, Pia;
Heinrich, Markus R.;
Stopfer, Peter;
Fromm, Martin F.;
Müller, Fabian

Publication type:

Article

How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 1, p. 225, doi. 10.1002/cpt.3276

By:

Shuklinova, Olha;
Neuhoff, Sibylle;
Polak, Sebastian

Publication type:

Article

In This Issue.

Published in:: Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 5, p. 941, doi. 10.1002/cpt.3042
Publication type:: Article

A Metabolomic Analysis of Sensitivity and Specificity of 23 Previously Proposed Biomarkers for Renal Transporter‐Mediated Drug‐Drug Interactions.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 5, p. 1058, doi. 10.1002/cpt.3017

By:

Gessner, Arne;
Müller, Fabian;
Wenisch, Pia;
Heinrich, Markus R.;
König, Jörg;
Stopfer, Peter;
Fromm, Martin F.

Publication type:

Article

The Effect of Trimethoprim on Thiamine Absorption: A Transporter‐Mediated Drug‐Nutrient Interaction.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 2, p. 381, doi. 10.1002/cpt.2932

By:

Vora, Bianca;
Wen, Anita;
Yee, Sook Wah;
Trinh, Kim;
Azimi, Mina;
Green, Elizabeth A. E.;
Sirota, Marina;
Greenberg, Andrew S.;
Newman, John W.;
Giacomini, Kathleen M.

Publication type:

Article

3D Spheroid Primary Human Hepatocytes for Prediction of Cytochrome P450 and Drug Transporter Induction.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 6, p. 1284, doi. 10.1002/cpt.2887

By:

Järvinen, Erkka;
Hammer, Helen S.;
Pötz, Oliver;
Ingelman‐Sundberg, Magnus;
Stage, Tore Bjerregaard

Publication type:

Article

Biomarkers Come of Age in Clinical Pharmacology.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 5, p. 945, doi. 10.1002/cpt.2880

By:

Giacomini, Kathleen M.

Publication type:

Article

ASCPT News.

Published in:: 2023
Publication type:: Proceeding

Challenges and Opportunities for Improved Drug–Drug Interaction Predictions for Renal OCT2 and MATE1/2‐K Transporters.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 562, doi. 10.1002/cpt.2666

By:

Krishnan, Srinivasan;
Ramsden, Diane;
Ferguson, Douglas;
Stahl, Simone H.;
Wang, Joanne;
McGinnity, Dermot F.;
Hariparsad, Niresh

Publication type:

Article

Oral Glucose Tolerance Test: An Informative Endpoint or an Added Burden in Metformin Drug–Drug Interaction Studies?

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 453, doi. 10.1002/cpt.2650

By:

Dauki, Anees M.;
Hsueh, Chia‐Hsiang;
Cherala, Ganesh;
Othman, Ahmed A.

Publication type:

Article

Accelerating SLC Transporter Research: Streamlining Knowledge and Validated Tools.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 439, doi. 10.1002/cpt.2639

By:

Wiedmer, Tabea;
Ingles‐Prieto, Alvaro;
Goldmann, Ulrich;
Steppan, Claire M.;
Superti‐Furga, Giulio

Publication type:

Article

Renal Transporter‐Mediated Drug‐Biomarker Interactions of the Endogenous Substrates Creatinine and N1‐Methylnicotinamide: A PBPK Modeling Approach.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 687, doi. 10.1002/cpt.2636

By:

Türk, Denise;
Müller, Fabian;
Fromm, Martin F.;
Selzer, Dominik;
Dallmann, Robert;
Lehr, Thorsten

Publication type:

Article

Evaluation of the Effect of Abrocitinib on Drug Transporters by Integrated Use of Probe Drugs and Endogenous Biomarkers.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 665, doi. 10.1002/cpt.2594

By:

Vourvahis, Manoli;
Byon, Wonkyung;
Chang, Cheng;
Le, Vu;
Diehl, Annette;
Graham, Daniela;
Tripathy, Sakambari;
Raha, Nancy;
Luo, Lina;
Mathialagan, Sumathy;
Dowty, Martin;
Rodrigues, A. David;
Malhotra, Bimal

Publication type:

Article

Drug‐Drug Interactions Involving Renal OCT2/MATE Transporters: Clinical Risk Assessment May Require Endogenous Biomarker‐Informed Approach.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 4, p. 855, doi. 10.1002/cpt.2089

By:

Mathialagan, Sumathy;
Feng, Bo;
Rodrigues, A. David;
Varma, Manthena V. S.

Publication type:

Article

Keyword Index.

Published in:: Clinical Pharmacology & Therapeutics, 2021, v. 109, p. S96, doi. 10.1002/cpt.2168
Publication type:: Article

Quantitative Proteomics and Mechanistic Modeling of Transporter‐Mediated Disposition in Nonalcoholic Fatty Liver Disease.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 5, p. 1128, doi. 10.1002/cpt.1699

By:

Vildhede, Anna;
Kimoto, Emi;
Pelis, Ryan M.;
Rodrigues, A. David;
Varma, Manthena V.S.

Publication type:

Article

Next Challenge From the Variance in Individual Physiologically‐Based Pharmacokinetic Model‐Predicted to Observed Morphine Concentration in Critically Ill Neonates.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 2, p. 319, doi. 10.1002/cpt.1607

By:

Emoto, Chie;
Hahn, David;
Euteneuer, Joshua C.;
Mizuno, Tomoyuki;
Vinks, Alexander A.;
Fukuda, Tsuyoshi

Publication type:

Article

Variability and Heritability of Thiamine Pharmacokinetics With Focus on OCT1 Effects on Membrane Transport and Pharmacokinetics in Humans.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 3, p. 628, doi. 10.1002/cpt.1666

By:

Jensen, Ole;
Matthaei, Johannes;
Blome, Felix;
Schwab, Matthias;
Tzvetkov, Mladen V.;
Brockmöller, Jürgen

Publication type:

Article

Sorafenib Activity and Disposition in Liver Cancer Does Not Depend on Organic Cation Transporter 1.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 227, doi. 10.1002/cpt.1588

By:

Chen, Mingqing;
Neul, Claudia;
Schaeffeler, Elke;
Frisch, Franziska;
Winter, Stefan;
Schwab, Matthias;
Koepsell, Hermann;
Hu, Shuiying;
Laufer, Stefan;
Baker, Sharyn D.;
Sparreboom, Alex;
Nies, Anne T.

Publication type:

Article

A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization.

Published in:

Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 5, p. 1083, doi. 10.1002/cpt.1516

By:

Cheung, Kit Wun Kathy;
Groen, Bianca D.;
Spaans, Edwin;
Borselen, Marjolein D.;
Bruijn, Adrianus C.J.M.;
Simons‐Oosterhuis, Ytje;
Tibboel, Dick;
Samsom, Janneke N.;
Verdijk, Robert M.;
Smeets, Bart;
Zhang, Lei;
Huang, Shiew‐Mei;
Giacomini, Kathleen M.;
Wildt, Saskia N.

Publication type:

Article

Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy.

Published in:

PLoS Genetics, 2019, v. 15, n. 5, p. 1, doi. 10.1371/journal.pgen.1007687

By:

Vázquez-Arreguín, Karina;
Bensard, Claire;
Schell, John C.;
Swanson, Eric;
Chen, Xinjian;
Rutter, Jared;
Tantin, Dean

Publication type:

Article

Fast and Durable Intraoperative Near‐infrared Imaging of Ovarian Cancer Using Ultrabright Squaraine Fluorophores.

Published in:

Angewandte Chemie, 2022, v. 134, n. 17, p. 1, doi. 10.1002/ange.202117330

By:

Fukuda, Takeshi;
Yokomizo, Shinya;
Casa, Stefanie;
Monaco, Hailey;
Manganiello, Sophia;
Wang, Haoran;
Lv, Xiangmin;
Ulumben, Amy Daniel;
Yang, Chengeng;
Kang, Min‐Woong;
Inoue, Kazumasa;
Fukushi, Masahiro;
Sumi, Toshiyuki;
Wang, Cheng;
Kang, Homan;
Bao, Kai;
Henary, Maged;
Kashiwagi, Satoshi;
Soo Choi, Hak

Publication type:

Article

Redox Stability Controls the Cellular Uptake and Activity of Ruthenium‐Based Inhibitors of the Mitochondrial Calcium Uniporter (MCU).

Published in:

Angewandte Chemie, 2020, v. 132, n. 16, p. 6544, doi. 10.1002/ange.202000247

By:

Woods, Joshua J.;
Lovett, James;
Lai, Barry;
Harris, Hugh H.;
Wilson, Justin J.

Publication type:

Article