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The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory.
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- Oncology Research, 2024, v. 32, n. 6, p. 1037, doi. 10.32604/or.2024.051112
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- Article
Accurate and comprehensive evaluation of O6‐methylguanine‐DNA methyltransferase promoter methylation by nanopore sequencing.
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- Neuropathology & Applied Neurobiology, 2024, v. 50, n. 3, p. 1, doi. 10.1111/nan.12984
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- Article
Immune cell infiltration and inflammatory landscape in primary brain tumours.
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- Journal of Translational Medicine, 2024, v. 22, p. 1, doi. 10.1186/s12967-024-05309-1
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- Article
Evaluation of the clinical use of MGMT methylation in extracellular vesicle-based liquid biopsy as a tool for glioblastoma patient management.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-62061-8
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- Article
Radiomics for predicting MGMT status in cerebral glioblastoma: comparison of different MRI sequences.
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- Journal of Radiation Research, 2024, v. 65, n. 3, p. 350, doi. 10.1093/jrr/rrae007
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- Article
Gene Expression Patterns Associated with Survival in Glioblastoma.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 7, p. 3668, doi. 10.3390/ijms25073668
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- Article
MGMT ProFWise: Unlocking a New Application for Combined Feature Selection and the Rank-Based Weighting Method to Link MGMT Methylation Status to Serum Protein Expression in Patients with Glioblastoma.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 7, p. 4082, doi. 10.3390/ijms25074082
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- Article
Clinical impact of IDH1 mutations and MGMT methylation in adult glioblastoma.
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- Egyptian Journal of Medical Human Genetics, 2024, v. 25, n. 1, p. 1, doi. 10.1186/s43042-024-00516-3
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- Article
Predominance of MGMT promoter methylation among Pakistani glioblastoma patients.
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- Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09363-2
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- Article
Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease.
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- NPJ Genomic Medicine, 2024, v. 9, n. 1, p. 1, doi. 10.1038/s41525-024-00395-y
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- Article
Unveiling the role of MGMT and DAPK hypermethylation in response to anti‐EGFR agents: Molecular insights for advancing HNSCC treatment.
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- Head & Neck, 2024, v. 46, n. 3, p. 461, doi. 10.1002/hed.27602
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- Article
MGMT unmethylation and high levels of CD47 and TIGIT indicate a poor prognosis in adult diffuse gliomas.
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- Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1323307
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- Article
Computational pathology-based weakly supervised prediction model for MGMT promoter methylation status in glioblastoma.
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- Frontiers in Neurology, 2024, p. 1, doi. 10.3389/fneur.2024.1345687
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- Article
Epigenetic modification and characterization of the MGMT promoter region using CRISPRoff in glioblastoma cells.
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- Frontiers in Oncology, 2024, p. 1, doi. 10.3389/fonc.2024.1342114
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- Article
Inhibition of O6‐methylguanine‐DNA‐methyltransferase (MGMT) by lomeguatrib reduces multiple myeloma cell viability and impairs DNA repair in MGMT‐proficient cells.
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- Chemical Biology & Drug Design, 2024, v. 103, n. 2, p. 1, doi. 10.1111/cbdd.14465
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- Article
IDH1‐mutated Crohn's disease‐associated small bowel adenocarcinomas: Distinctive pathological features and association with MGMT methylation and serrated‐type dysplasia.
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- Histopathology, 2024, v. 84, n. 3, p. 515, doi. 10.1111/his.15095
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- Article
Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma.
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- Journal of Neuro-Oncology, 2024, v. 166, n. 3, p. 419, doi. 10.1007/s11060-023-04535-9
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- Article
Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression.
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- Frontiers in Immunology, 2024, p. 01, doi. 10.3389/fimmu.2024.1328375
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- Article
Novel MGMT inhibitors increase the sensitivity of glioma MGMT-positive cells to treatment with alkylating agents in vitro.
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- Biopolymers & Cell, 2024, v. 40, n. 1, p. 47, doi. 10.7124/bc.000AAD
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- Article
Development of A Radiomic Model for MGMT Promoter Methylation Detection in Glioblastoma Using Conventional MRI.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 1, p. 138, doi. 10.3390/ijms25010138
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- Article
Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and Disease-Specific Survival in Isocitrate Dehydrogenase-Wildtype Grade 4 Glioblastoma.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 1, p. 612, doi. 10.3390/ijms25010612
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- Article
MGMT promoter methylation in 1p19q-intact gliomas.
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- Journal of Neuro-Oncology, 2024, v. 166, n. 1, p. 73, doi. 10.1007/s11060-023-04515-z
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- Article
dCas9/CRISPR-based methylation of O-6-methylguanine-DNA methyltransferase enhances chemosensitivity to temozolomide in malignant glioma.
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- Journal of Neuro-Oncology, 2024, v. 166, n. 1, p. 129, doi. 10.1007/s11060-023-04531-z
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- Article
Exploring MGMT methylation-driven structural connectivity changes in insular gliomas: a tractography and graph theoretical analysis.
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- Journal of Neuro-Oncology, 2024, v. 166, n. 1, p. 155, doi. 10.1007/s11060-023-04539-5
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- Article
Enhancing temozolomide antiglioma response by inhibiting O6-methylguanine-DNA methyltransferase with selected phytochemicals: in silico and in vitro approach.
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- 3 Biotech, 2023, v. 13, p. 1, doi. 10.1007/s13205-023-03821-7
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- Article
Genetic and epigenetic alterations in MGMT gene and correlation with concomitant chemoradiotherapy (CRT) in cervical cancer.
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- Journal of Cancer Research & Clinical Oncology, 2023, v. 149, n. 16, p. 15159, doi. 10.1007/s00432-023-05305-w
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- Publication type:
- Article
Enhancing temozolomide antiglioma response by inhibiting O6-methylguanine-DNA methyltransferase with selected phytochemicals: in silico and in vitro approach.
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- 3 Biotech, 2023, v. 13, n. 12, p. 1, doi. 10.1007/s13205-023-03821-7
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- Article
Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results.
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- Acta Neuropathologica Communications, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40478-023-01680-0
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- Article
BTDNet: A Multi-Modal Approach for Brain Tumor Radiogenomic Classification.
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- Applied Sciences (2076-3417), 2023, v. 13, n. 21, p. 11984, doi. 10.3390/app132111984
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- Article
Epigenetic Activation of TUSC3 Sensitizes Glioblastoma to Temozolomide Independent of MGMT Promoter Methylation Status.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 20, p. 15179, doi. 10.3390/ijms242015179
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- Article
Racial and socioeconomic disparities in glioblastoma outcomes: A single‐center, retrospective cohort study.
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- Cancer (0008543X), 2023, v. 129, n. 19, p. 3010, doi. 10.1002/cncr.34881
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- Article
Prediction of Ki-67 labeling index, ATRX mutation, and MGMT promoter methylation status in IDH-mutant astrocytoma by morphological MRI, SWI, DWI, and DSC-PWI.
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- European Radiology, 2023, v. 33, n. 10, p. 7003, doi. 10.1007/s00330-023-09695-w
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- Article
MGMT Methylation Is Associated with Human Papillomavirus Infection in Cervical Dysplasia: A Longitudinal Study.
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- Journal of Clinical Medicine, 2023, v. 12, n. 19, p. 6188, doi. 10.3390/jcm12196188
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- Article
Metformin use is associated with longer survival in glioblastoma patients with MGMT gene silencing.
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- Journal of Neuro-Oncology, 2023, v. 165, n. 1, p. 209, doi. 10.1007/s11060-023-04485-2
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- Article
Undetected pseudoprogressions in the CeTeG/NOA-09 trial: hints from postprogression survival and MRI analyses.
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- Journal of Neuro-Oncology, 2023, v. 164, n. 3, p. 607, doi. 10.1007/s11060-023-04444-x
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- Article
Effect of tumor genetics, pathology, and location on fMRI of language reorganization in brain tumor patients.
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- European Radiology, 2023, v. 33, n. 9, p. 6069, doi. 10.1007/s00330-023-09610-3
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- Article
Apparent Diffusion Coefficient as Imaging Biomarker for Identifying IDH Mutation, 1p19q Codeletion, and MGMT Promoter Methylation Status in Patients With Glioma.
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- Journal of Magnetic Resonance Imaging, 2023, v. 58, n. 3, p. 732, doi. 10.1002/jmri.28589
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- Article
Editorial for "Apparent Diffusion Coefficient as Imaging Biomarker for Identifying IDH Mutation, 1p19q Codeletion, and MGMT Promoter Methylation Status in Patients With Glioma".
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- 2023
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- Publication type:
- Editorial
MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value.
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- Acta Neuropathologica Communications, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40478-023-01622-w
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- Article
胶质瘤中MGMT甲基化状态及其临床意义的 回顾性研究.
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- China Oncology, 2023, v. 33, n. 8, p. 740, doi. 10.19401/j.cnki.1007-3639.2023.08.003
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- Article
Epigenetic alterations in glioblastomas: Diagnostic, prognostic and therapeutic relevance.
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- International Journal of Cancer, 2023, v. 153, n. 3, p. 476, doi. 10.1002/ijc.34381
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- Article
Quantitative analysis of MGMT promoter methylation status changes by pyrosequencing in recurrent glioblastoma.
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- Neuropathology, 2023, v. 43, n. 4, p. 306, doi. 10.1111/neup.12887
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- Article
QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency.
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- Pharmaceutics, 2023, v. 15, n. 8, p. 2170, doi. 10.3390/pharmaceutics15082170
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- Article
CDC42--A promising immune-related target in glioma.
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- Frontiers in Neuroscience, 2023, p. 1, doi. 10.3389/fnins.2023.1192766
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- Article
ERCC1 and MGMT Methylation as a Predictive Marker of Relapse and FOLFOX Response in Colorectal Cancer Patients from South Tunisia.
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- Genes, 2023, v. 14, n. 7, p. 1467, doi. 10.3390/genes14071467
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- Article
Glioma diagnosis and comprehensive management during COVID-19 pandemic: A proposed algorithm.
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- Journal of Neurosciences in Rural Practice, 2023, v. 14, n. 3, p. 395, doi. 10.25259/JNRP_45_2022
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- Article
Prediction of O-6-methylguanine-DNA methyltransferase and overall survival of the patients suffering from glioblastoma using MRI-based hybrid radiomics signatures in machine and deep learning framework.
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- Neural Computing & Applications, 2023, v. 35, n. 18, p. 13647, doi. 10.1007/s00521-023-08405-3
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- Article
The Impact of O6-Methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation on the Outcomes of Patients with Leiomyosarcoma Treated with Dacarbazine.
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- Cells (2073-4409), 2023, v. 12, n. 12, p. 1635, doi. 10.3390/cells12121635
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- Article
Association between MGMT Enhancer Methylation and MGMT Promoter Methylation, MGMT Protein Expression, and Overall Survival in Glioblastoma.
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- Cells (2073-4409), 2023, v. 12, n. 12, p. 1639, doi. 10.3390/cells12121639
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- Article
Less Severe Lipopolysaccharide-Induced Inflammation in Conditional mgmt -Deleted Mice with LysM-Cre System: The Loss of DNA Repair in Macrophages.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 12, p. 10139, doi. 10.3390/ijms241210139
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- Article