Works matching DE "NUCLEUS pulposus"

Results: 1382

DDX1 methylation mediated MATR3 splicing regulates intervertebral disc degeneration by initiating chromatin reprogramming.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61486-7

By:

Zhu, Dingchao;
Liang, Huaizhen;
Tong, Bide;
Du, Zhi;
Li, Gaocai;
Zhang, Weifeng;
Wu, Di;
Zhou, Xingyu;
Lei, Jie;
Zhang, Xiaoguang;
Ma, Liang;
Wang, Bingjin;
Feng, Xiaobo;
Wang, Kun;
Tan, Lei;
Song, Yu;
Yang, Cao

Publication type:

Article

Optimized hydrogel viscoelasticity and interlocking patch repair enhance compressive range of motion in injured discs and prevent re-herniation under physiological load in an Ex Vivo model.

Published in:

European Spine Journal, 2025, v. 34, n. 6, p. 2301, doi. 10.1007/s00586-025-08820-1

By:

Menghini, Danilo;
Ongini, Esteban;
Devan, Jan;
Bitterli, Pamela;
D'Este, Matteo;
Distler, Oliver;
Farshad, Mazda;
Grad, Sibylle;
Snedeker, Jess;
Dudli, Stefan

Publication type:

Article

Effects of GDF6 on active protein synthesis by cells of degenerated intervertebral disc.

Published in:

European Spine Journal, 2025, v. 34, n. 6, p. 2066, doi. 10.1007/s00586-025-08715-1

By:

Tam, Vivian;
Chopra, Neha;
Sima, Stone;
Chen, Peikai;
Sharma, Rakesh;
Chan, Danny;
Diwan, Ashish

Publication type:

Article

Impact of Body Weight on Intervertebral Disc: A Finite Element Analysis of Lumbar Spine Total Disc Replacement.

Published in:

Journal of Mechanical Engineering (1823-5514), 2025, v. 22, n. 2, p. 97, doi. 10.24191/jmeche.v22i2.6180

By:

Zahari, Siti Nurfaezah;
Abd Latif, Mohd Juzaila;
Zakaria, Mohamad Shukri;
Akiah, Masni Azian;
Quang, Nguyen Ho;
Abdul Kadir, Mohammed Rafiq

Publication type:

Article

BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00623-8

By:

Yu, Xiao-Jun;
Wang, Ying-Guang;
Lu, Rui;
Guo, Xin-Zhen;
Qu, Yun-Kun;
Wang, Shan-Xi;
Xu, Hao-Ran;
Kang, Hao;
You, Hong-Bo;
Xu, Yong

Publication type:

Article

CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00351-x

By:

Cheng, Xiaoqiang;
Lin, Jiayi;
Chen, Zhanghuan;
Mao, Yubo;
Wu, Xiexin;
Xu, Congxin;
Du, Jiacheng;
Dong, Zhongchen;
Yang, Huilin;
Zhou, Feng;
Geng, Dechun

Publication type:

Article

Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00368-2

By:

Shan, Liang;
Xu, Ximing;
Zhang, Jing;
Cai, Peng;
Gao, Han;
Lu, Yingjie;
Shi, Jiangang;
Guo, Yinlong;
Su, Yue

Publication type:

Article

Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00355-7

By:

Yuan, Xiaoqiu;
Li, Tiefeng;
Shi, Lei;
Miao, Jinhao;
Guo, Yongfei;
Chen, Yu

Publication type:

Article

Endoplasmic reticulum stress‐mediated autophagy alleviates lipopolysaccharide‐induced nucleus pulposus cell pyroptosis by inhibiting CHOP signaling in vitro.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 1, p. 1, doi. 10.1002/jbt.23523

By:

Chen, Lu;
Zhu, Lei;
Shi, Hang;
Xie, Zhi‐Yang;
Jiang, Zan‐Li;
Xu, Zheng‐Yuan;
Zhang, Zi‐Jian;
Wu, Xiao‐Tao

Publication type:

Article

Advanced glycation end products induce nucleus pulposus cell apoptosis by upregulating TXNIP via inhibiting glycolysis pathway in intervertebral disc degeneration.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 1, p. 1, doi. 10.1002/jbt.23515

By:

Chen, Fei;
Sheng, Xiaoping;
Sun, Haobo;
Guo, Qunfeng;
Wang, Haibin;
Wu, Lecheng;
Ni, Bin;
Yang, Jun

Publication type:

Article

Degenerative changes of lumbar spine and their clinical implications in patients with axial spondyloarthritis.

Published in:

Clinical Rheumatology, 2023, v. 42, n. 1, p. 111, doi. 10.1007/s10067-022-06321-w

By:

Kilic, Gamze;
Senol, Serkan;
Baspinar, Sevgi;
Kilic, Erkan;
Ozgocmen, Salih

Publication type:

Article

Age-dependent microstructural changes of the intervertebral disc: a validation of proteoglycan-sensitive spectral CT.

Published in:

European Radiology, 2021, v. 31, n. 12, p. 9390, doi. 10.1007/s00330-021-08028-z

By:

Pohlan, Julian;
Stelbrink, Carsten;
Pumberger, Matthias;
Deppe, Dominik;
Schömig, Friederike;
Hecht, Nils;
Göhler, Friedemann;
Hamm, Bernd;
Diekhoff, Torsten

Publication type:

Article

Clinical implementation of accelerated T2 mapping: Quantitative magnetic resonance imaging as a biomarker for annular tear and lumbar disc herniation.

Published in:

European Radiology, 2021, v. 31, n. 6, p. 3590, doi. 10.1007/s00330-020-07538-6

By:

Raudner, Marcus;
Schreiner, Markus M.;
Hilbert, Tom;
Kober, Tobias;
Weber, Michael;
Szelényi, Anna;
Windhager, Reinhard;
Juras, Vladimir;
Trattnig, Siegfried

Publication type:

Article

Lentivirus-shRNA Mediated Prolyl Hydroxylase 2 Knockdown Increases HIF-1α and Inhibits Nucleus Pulposus Cells Degeneration.

Published in:

Cells Tissues Organs, 2023, v. 212, n. 2, p. 185, doi. 10.1159/000520795

By:

Chen, Qi;
Shi, Fangfang;
Yang, Chen;
Mao, Guangfeng;
Zhou, Chunguang;
Liu, Limin;
Yang, Xi;
Song, Yueming

Publication type:

Article

Overexpression of miR-150 Inhibits the NF-κB Signal Pathway in Intervertebral Disc Degeneration through Targeting P2X7.

Published in:

Cells Tissues Organs, 2019, v. 207, n. 3-4, p. 165, doi. 10.1159/000503281

By:

Zhang, Yan;
Zhang, Yi-Shu;
Li, Xiao-Juan;
Huang, Chao-Rong;
Yu, Hui-Jin;
Yang, Xiao-Xia;
Wang, Bin-Xiong

Publication type:

Article

The Effect of Adenosine on Extracellular Matrix Production in Porcine Intervertebral Disc Cells.

Published in:

Cells Tissues Organs, 2018, v. 206, n. 1/2, p. 73, doi. 10.1159/000496186

By:

Yin, Xue;
Gonzales, Silvia;
Sha, Somya;
Levene, Howard;
Huang, Chun-Yuh

Publication type:

Article

The Influence of Hyperosmolarity in the Intervertebral Disc on the Proliferation and Chondrogenic Differentiation of Nucleus Pulposus-Derived Mesenchymal Stem Cells.

Published in:

Cells Tissues Organs, 2018, v. 205, n. 3, p. 178, doi. 10.1159/000490760

By:

Li, Hao;
Wang, Jingkai;
Li, Fangcai;
Chen, Gang;
Chen, Qixin

Publication type:

Article

A Novel Organ Culture Model of Mouse Intervertebral Disc Tissues.

Published in:

Cells Tissues Organs, 2016, v. 201, n. 1, p. 38, doi. 10.1159/000439268

By:

Yan, Zhengjian;
Yin, Liangjun;
Wang, Zhongliang;
Ye, Jixing;
Zhang, Zhonglin;
Li, Ruifang;
Denduluri, Sahitya K.;
Wang, Jing;
Wei, Qiang;
Zhao, Lianggong;
Lu, Shun;
Wang, Xin;
Tang, Shengli;
Shi, Lewis L.;
Lee, Michael J.;
He, Tong-Chuan;
Deng, Zhong-Liang

Publication type:

Article

ATF1 and miR-27b-3p drive intervertebral disc degeneration through the PPARG/NF-κB signaling axis.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08186-6

By:

Guo, Wei;
Mu, Kun;
Geng, Jing-Chao;
Xing, Hai-Yang;
Dong, Yu;
Liu, Wen-Dong;
Wang, Shuan-Chi;
Shi, Jia-Xiao;
Xing, Bao-Rui;
Zhao, Jian-Yong;
Li, Xiao-Ming

Publication type:

Article

PLGA/BK microspheres targeting the bradykinin signaling pathway as a therapeutic strategy to delay intervertebral disc degeneration.

Published in:

Communications Biology, 2024, p. 1, doi. 10.1038/s42003-024-07196-0

By:

Qiu, Xiaoming;
Zhang, Yizhi;
Wei, Ziyan;
Luo, Zhangbin;
Wang, Zhuanping;
Kang, Xuewen

Publication type:

Article

Microgravity and Radiation Effects on Astronaut Intervertebral Disc Health.

Published in:

Aerospace Medicine & Human Performance, 2021, v. 92, n. 5, p. 342, doi. 10.3357/AMHP.5713.2021

By:

Smith, Karenna;
Mercuri, Jeremy

Publication type:

Article

The Survival of Human Intervertebral Disc Nucleus Pulposus Cells under Oxidative Stress Relies on the Autophagy Triggered by Delphinidin.

Published in:

Antioxidants, 2024, v. 13, n. 7, p. 759, doi. 10.3390/antiox13070759

By:

Bahar, Md Entaz;
Hwang, Jin Seok;
Lai, Trang Huyen;
Byun, June-Ho;
Kim, Dong-Hee;
Kim, Deok Ryong

Publication type:

Article

Integrated bulk and single-cell RNA sequencing to identify potential biomarkers in intervertebral disc degeneration.

Published in:

European Journal of Medical Research, 2025, v. 30, n. 1, p. 1, doi. 10.1186/s40001-025-02346-4

By:

Fan, Chunyang;
Xu, Wei;
Li, Xuefeng;
Wang, Jiale;
He, Wei;
Shen, Meng;
Hua, Di;
Zhang, Yao;
Gu, Ye;
Wu, Xiexing;
Mao, Haiqing

Publication type:

Article

A<sub>2A</sub>R regulate inflammation through PKA/NF-κB signaling pathways in intervertebral disc degeneration.

Published in:

European Journal of Medical Research, 2024, v. 29, n. 1, p. 1, doi. 10.1186/s40001-024-02028-7

By:

Liu, Weijun;
Li, Qingbo;
Fang, Weizhi;
Cai, Lei;
Wang, Zhengkun;
Kou, Bowen;
Zhou, Chuankun;
Zhou, Yichi;
Yao, Zhi;
Wei, Mengcheng;
Zhang, Shishuang

Publication type:

Article

Correction.

Published in:: 2021
Publication type:: Correction Notice

Sinapine thiocyanate alleviates intervertebral disc degeneration by not regulating JAK1/STAT3/NLRP3 signal pathway.

Published in:

Advances in Clinical & Experimental Medicine, 2024, v. 33, n. 9, p. 965, doi. 10.17219/acem/174508

By:

Pengfei Yu;
Zhijia Ma;
Hong;
Jintao Liu;
Hongwei Li

Publication type:

Article

Increased local miR-21 expressions are linked with clinical severity in lumbar disc herniation patients with sciatic pain.

Published in:

Advances in Clinical & Experimental Medicine, 2022, v. 31, n. 7, p. 723, doi. 10.17219/acem/146968

By:

Zhen-Fei Zou;
Jing-Pei He;
Yan-Lian Chen;
Hai-Lin Chen

Publication type:

Article

In vivo delivery of MMP3-shRNA and Sox9 lentivirus cocktail enhances matrix synthesis to prevent lumbar disc degeneration.

Published in:

Advances in Clinical & Experimental Medicine, 2020, v. 29, n. 6, p. 639, doi. 10.17219/acem/121509

By:

Zheng Zhao;
Siyuan Li;
Hui Huang;
Jing Fang;
Huawei Wei;
Yongming Xi

Publication type:

Article

Tratamentul conservator al herniei cervicale la câini: importanṭa respectării procedurilor - Un studiu de caz.

Published in:

Veterinary Drug / Medicamentul Veterinar, 2019, v. 13, n. 2, p. 35

By:

Bulai, Anca;
Crivineanu, Maria;
Alexandru, Diana Mihaela

Publication type:

Article

1,25(OH)₂D₃ inhibits ferroptosis in nucleus pulposus cells via VDR signaling to mitigate lumbar intervertebral disc degeneration.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-92405-x

By:

Li, Qiang;
Peng, Jing;
Ding, Fan

Publication type:

Article

1,25(OH)₂D₃ inhibits ferroptosis in nucleus pulposus cells via VDR signaling to mitigate lumbar intervertebral disc degeneration.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-92405-x

By:

Li, Qiang;
Peng, Jing;
Ding, Fan

Publication type:

Article

Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-90909-0

By:

Tang, Xiaokai;
Zhong, Junlong;
Luo, Hao;
Zhou, Faxin;
Wang, Lixia;
Lin, Sijian;
Xiong, Jiachao;
Lv, Hao;
Zhou, Zhenhai;
Yu, Honggui;
Cao, Kai

Publication type:

Article

SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep07456

By:

Wei Jiang;
Xuemei Zhang;
Jie Hao;
Jieliang Shen;
Ji Fang;
Wen Dong;
Dawu Wang;
Xiaojun Zhang;
Wei Shui;
Yi Luo;
Liangbo Lin;
Quanhe Qiu;
Bin Liu;
Zhenming Hu

Publication type:

Article

Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells.

Published in:

BMC Pharmacology & Toxicology, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s40360-022-00633-y

By:

Chen, Weisin;
Yasen, Miersalijiang;
Wang, Hanquan;
Zhuang, Chenyang;
Wang, Zixiang;
Lu, Shunyi;
Jiang, Libo;
Lin, Hong

Publication type:

Article

Region-specific mitophagy in nucleus pulposus, annulus fibrosus, and cartilage endplate of intervertebral disc degeneration: mechanisms and therapeutic strategies.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1579507

By:

Feng, Chaoqun;
Hu, Ziang;
Zhao, Min;
Leng, Chuan;
Li, Guangye;
Yang, Fei;
Fan, Xiaohong

Publication type:

Article

Region-specific mitophagy in nucleus pulposus, annulus fibrosus, and cartilage endplate of intervertebral disc degeneration: mechanisms and therapeutic strategies.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1579507

By:

Feng, Chaoqun;
Hu, Ziang;
Zhao, Min;
Leng, Chuan;
Li, Guangye;
Yang, Fei;
Fan, Xiaohong

Publication type:

Article

Silk fibroin–collagen hydrogel loaded with IGF1-CESCs attenuates intervertebral disk degeneration by accelerating annulus fibrosus healing in rats.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1552174

By:

Tian, Zhiqiang;
Shen, Zigang;
Chen, Hong;
Zhao, Ping

Publication type:

Article

Homoplantaginin exerts therapeutic effects on intervertebral disc degeneration by alleviating TNF-α-induced nucleus pulposus cell senescence and inflammation.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1526107

By:

Guo, Jiadong;
Zhang, Pu;
Yang, Xiao;
Wang, Xin;
Cao, Xiankun;
Zhao, Jie

Publication type:

Article

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1501725

By:

Zhu, Zaishi;
Huang, Zeling;
Zhang, Chaofeng;
Xu, Bo;
Chen, Hua;
Pei, Shuai;
Zhang, Baofei;
Jie, Lishi;
Shi, Xiaoqing;
Liu, Yujiang;
Li, Yuwei;
Shen, Xiaofeng

Publication type:

Article

From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration.

Published in:

Frontiers in Immunology, 2024, p. 01, doi. 10.3389/fimmu.2024.1355503

By:

Shuai Li;
Jinpeng Du;
Yunfei Huang;
Shenglong Gao;
Zhigang Zhao;
Zhen Chang;
Xuefang Zhang;
BaoRong He

Publication type:

Article

Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1251517

By:

Qunbo Meng;
Kaiwen Liu;
Zhenchuan Liu;
Jinbo Liu;
Ziyu Tian;
Shanshan Qin;
Jianlu Wei;
Lei Cheng

Publication type:

Article

Single-cell RNA-seq analysis reveals that immune cells induce human nucleus pulposus ossification and degeneration.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1224627

By:

Song Guo;
Meijun Yan;
Xinhua Li;
Shuya Zhang;
Zhong Liu;
Kewei Li;
Pengcheng Liu;
Yanbin Liu;
Guixin Sun;
Qiang Fu

Publication type:

Article

Corrigendum: The cGAS-STING pathway affects vertebral bone but does not promote intervertebral disc cell senescence or degeneration.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1201655

By:

Ottone, Olivia K.;
Kim, C. James;
Collins, John A.;
Risbud, Makarand V.

Publication type:

Article

Immune exposure: how macrophages interact with the nucleus pulposus.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1155746

By:

Peng Feng;
Ying Che;
Chunyu Gao;
Liguo Zhu;
Jinghua Gao;
Nam V. Vo

Publication type:

Article

Evaluation of preclinical efficacy of human umbilical cord mesenchymal stem cells in ankylosing spondylitis.

Published in:

Frontiers in Immunology, 2023, v. 14, p. 1, doi. 10.3389/fimmu.2023.1153927

By:

Danpeng Shen;
Zhiqiang Wang;
Hongwei Wang;
Hongyan Zhu;
Cuibao Jiang;
Fan Xie;
Hongpeng Zhang;
Qian Lv;
Qi Liu;
Nianmin Qi;
Hao Wang

Publication type:

Article

The Factors Associated With the Successful Outcomes of Percutaneous Disc Decompression in Patients With Lumbar Herniated Nucleus Pulposus.

Published in:

Annals of Rehabilitation Medicine, 2015, v. 39, n. 5, p. 735, doi. 10.5535/arm.2015.39.5.735

By:

Sang Heon Lee;
Yong Jin Jeong;
Nack Hwan Kim;
Hyeun Jun Park;
Hyun-Joon Yoo;
Soo Yung Jo

Publication type:

Article

Grape seed extract inhibits nucleus pulposus cell apoptosis and attenuates annular puncture induced intervertebral disc degeneration in rabbit model.

Published in:

Anatomy & Cell Biology, 2020, v. 53, n. 3, p. 313, doi. 10.5115/acb.20.047

By:

B., Ogunlade;
O. P., Fidelis;
S. A., Adelakun;
O. A., Adedotun

Publication type:

Article

An enzyme-proof glycan glue for extracellular matrix to ameliorate intervertebral disc degeneration.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-58946-5

By:

Liu, Yu;
Chao, Tzuwei;
Li, Yuwei;
Peng, Peng;
Ge, Gaoran;
Geng, Dechun;
Dong, Lei;
Wang, Chunming

Publication type:

Article

Evaluation of spine disorders using high contrast imaging of the cartilaginous endplate.

Published in:

Frontiers in Physiology, 2024, p. 1, doi. 10.3389/fphys.2024.1394189

By:

Athertya, Jiyo S.;
Statum, Sheronda;
Xiaojun Chen;
Du, Kevin;
Soo Hyun Shin;
Jerban, Saeed;
Chung, Christine B.;
Chang, Eric Y.;
Yajun Ma

Publication type:

Article

SPECT Imaging of Acute Disc Herniation by Targeting Integrin α5β1 in Rat Models.

Published in:

Frontiers in Neurology, 2022, v. 13, p. 1, doi. 10.3389/fneur.2022.782967

By:

Guan, Jian;
Yuan, Chenghua;
Tian, Xin;
Cheng, Lei;
Gao, Hannan;
Yao, Qingyu;
Wang, Xinyu;
Wu, Hao;
Chen, Zan;
Jian, Fengzeng

Publication type:

Article