Works matching DE "NICASTRIN"

Results: 31

Haploinsufficiency caused by a nonsense mutation in NCSTN underlying hidradenitis suppurativa in a Chinese family.

Published in:

Clinical & Experimental Dermatology, 2015, v. 40, n. 8, p. 916, doi. 10.1111/ced.12724

By:

Yang, J.‐q.;
Wu, X.‐j.;
Dou, T.‐t.;
Jiao, T.;
Chen, X.‐b.;
Min, M.;
Cai, S.‐q.;
Zheng, M.

Publication type:

Article

An atomic structure of human γ-secretase.

Published in:

Nature, 2015, v. 525, n. 7568, p. 212, doi. 10.1038/nature14892

By:

Bai, Xiao-chen;
Yan, Chuangye;
Yang, Guanghui;
Lu, Peilong;
Ma, Dan;
Sun, Linfeng;
Zhou, Rui;
Scheres, Sjors H. W.;
Shi, Yigong

Publication type:

Article

Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061299

By:

Stemmer, Nina;
Strekalova, Elena;
Djogo, Nevena;
Plöger, Frank;
Loers, Gabriele;
Lutz, David;
Buck, Friedrich;
Michalak, Marek;
Schachner, Melitta;
Kleene, Ralf

Publication type:

Article

Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways.

Published in:

PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0037111

By:

Jung-Soon Mo;
Ji-Hye Yoon;
Ji-Ae Hong;
Mi-Yeon Kim;
Eun-Jung Ann;
Ji-Seon Ahn;
Su- Man Kim;
Hyeong-Jin Baek;
Florian Lang;
Eui-Ju Choi;
Hee-Sae Park

Publication type:

Article

Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0028179

By:

Tong Li;
Yue-Ming Li;
Ahn, Kwangwook;
Price, Donald L.;
Sisodia, Sangram S.;
Wong, Philip C.

Publication type:

Article

eep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimer's Disease.

Published in:

PLoS ONE, 2011, v. 6, n. 2, p. 1, doi. 10.1371/journal.pone.0017298

By:

Lupton, Michelle K.;
Proitsi, Petroula;
Danillidou, Makrina;
Tsolaki, Magda;
Hamilton, Gillian;
Wroe, Richard;
Pritchard, Megan;
Lord, Kathryn;
Martin, Belinda M.;
Kloszewska, Iwona;
Soininen, Hilkka;
Mecocci, Patrizia;
Vellas, Bruno;
Harold, Denise;
Hollingworth, Paul;
Lovestone, Simon;
Powell, John F.

Publication type:

Article

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β<sub>42/40</sub> Ratio.

Published in:: PLoS ONE, 2009, v. 4, n. 11, p. 1, doi. 10.1371/journal.pone.0007893
Publication type:: Article

An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.

Published in:

Genetics, 2017, v. 206, n. 3, p. 1479, doi. 10.1534/genetics.116.196881

By:

Jongkyun Kang;
Sarah Shin;
Perrimon, Norbert;
Jie Shen

Publication type:

Article

Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1−/− phenotype and forms complexes with wildtype PS1 and nicastrin.

Published in:

Scientific Reports, 2015, p. 17042, doi. 10.1038/srep17042

By:

Brautigam, Hannah;
Moreno, Cesar L.;
Steele, John W.;
Bogush, Alexey;
Dickstein, Dara L.;
Kwok, John B.J.;
Schofield, Peter R.;
Thinakaran, Gopal;
Mathews, Paul M.;
Hof, Patrick R.;
Gandy, Sam;
Ehrlich, Michelle E.

Publication type:

Article

Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin.

Published in:

PLoS ONE, 2017, v. 12, n. 11, p. 1, doi. 10.1371/journal.pone.0188605

By:

Dursun, Erdinç;
Gezen-Ak, Duygu

Publication type:

Article

Effects of lipids on the activity and structural dynamics of gamma secretase: A study using coarse-grained molecular dynamics simulations.

Published in:

ChemPhysMater, 2024, v. 3, n. 3, p. 303, doi. 10.1016/j.chphma.2024.03.005

By:

Sajjad, Ahmad;
Jinfei Mei;
Chuanbo Wang;
Hongqi Ai

Publication type:

Article

Structural biology of presenilin 1 complexes.

Published in:

Molecular Neurodegeneration, 2014, v. 9, n. 1, p. 1, doi. 10.1186/1750-1326-9-59

By:

Yi Li;
Bohm, Christopher;
Dodd, Roger;
Fusheng Chen;
Qamar, Seema;
Schmitt-Ulms, Gerold;
Fraser, Paul E.;
St George-Hyslop, Peter H.

Publication type:

Article

Mutations in the γ-Secretase Genes NCSTN, PSENEN, and PSEN1 Underlie Rare Forms of Hidradenitis Suppurativa (Acne Inversa).

Published in:

Journal of Investigative Dermatology, 2012, v. 132, n. 10, p. 2459, doi. 10.1038/jid.2012.162

By:

Pink, Andrew E;
Simpson, Michael A;
Desai, Nemesha;
Dafou, Dimitra;
Hills, Alison;
Mortimer, Peter;
Smith, Catherine H;
Trembath, Richard C;
Barker, Jonathan N W

Publication type:

Article

Nicastrin Mutations in French Families with Hidradenitis Suppurativa.

Published in:

Journal of Investigative Dermatology, 2012, v. 132, n. 6, p. 1728, doi. 10.1038/jid.2012.23

By:

Miskinyte, Snaigune;
Nassif, Aude;
Merabtene, Fatiha;
Ungeheuer, Marie-Noëlle;
Join-Lambert, Olivier;
Jais, Jean-Philippe;
Hovnanian, Alain

Publication type:

Article

Nicastrin is required for amyloid precursor protein ( APP) but not Notch processing, while anterior pharynx-defective 1 is dispensable for processing of both APP and Notch.

Published in:

Journal of Neurochemistry, 2016, v. 136, n. 6, p. 1246, doi. 10.1111/jnc.13518

By:

Hu, Chen;
Zeng, Linlin;
Li, Ting;
Meyer, Michael A.;
Cui, Mei‐Zhen;
Xu, Xuemin

Publication type:

Article

In this Issue.

Published in:: 2015
Publication type:: Editorial

Akt1 phosphorylates Nicastrin to regulate its protein stability and activity.

Published in:

Journal of Neurochemistry, 2015, v. 134, n. 5, p. 799, doi. 10.1111/jnc.13173

By:

Jo, Eun‐Hye;
Ahn, Ji‐Seon;
Mo, Jung‐Soon;
Yoon, Ji‐Hye;
Ann, Eun‐Jung;
Baek, Hyeong‐Jin;
Lee, Hye‐Jin;
Kim, Seol‐Hee;
Kim, Mi‐Yeon;
Park, Hee‐Sae

Publication type:

Article

Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies.

Published in:

Journal of Neurochemistry, 2014, v. 131, n. 1, p. 94, doi. 10.1111/jnc.12772

By:

Holmes, Oliver;
Paturi, Swetha;
Wolfe, Michael S.;
Selkoe, Dennis J.

Publication type:

Article

Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment.

Published in:

Journal of Neurochemistry, 2012, v. 123, n. 5, p. 837, doi. 10.1111/jnc.12016

By:

Mao, Guozhang;
Cui, Mei-Zhen;
Li, Tong;
Jin, Yipeng;
Xu, Xuemin

Publication type:

Article

Nicastrin and Notch4 drive endocrine therapy resistance and epithelial-mesenchymal transition in MCF7 breast cancer cells.

Published in:

Breast Cancer Research, 2014, v. 16, n. 3, p. 1, doi. 10.1186/bcr3675

By:

Lombardo, Ylenia;
Faronato, Monica;
Filipovic, Aleksandra;
Vircillo, Valentina;
Magnani, Luca;
Coombes, R. Charles

Publication type:

Article

A novel nicastrin mutation in a large Chinese family with hidradenitis suppurativa.

Published in:

British Journal of Dermatology, 2013, v. 168, n. 5, p. 1141, doi. 10.1111/bjd.12135

By:

Jiao, T.;
Dong, H.;
Jin, L.;
Wang, S.;
Wang, J.

Publication type:

Article

A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa.

Published in:

British Journal of Dermatology, 2013, v. 168, n. 1, p. 206, doi. 10.1111/j.1365-2133.2012.11174.x

By:

Nomura, Y.;
Nomura, T.;
Sakai, K.;
Sasaki, K.;
Ohguchi, Y.;
Mizuno, O.;
Hata, H.;
Aoyagi, S.;
Abe, R.;
Itaya, Y.;
Akiyama, M.;
Shimizu, H.

Publication type:

Article

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.

Published in:

Oncogene, 2012, v. 31, n. 6, p. 787, doi. 10.1038/onc.2011.265

By:

Hayashi, I;
Takatori, S;
Urano, Y;
Miyake, Y;
Takagi, J;
Sakata-Yanagimoto, M;
Iwanari, H;
Osawa, S;
Morohashi, Y;
Li, T;
Wong, P C;
Chiba, S;
Kodama, T;
Hamakubo, T;
Tomita, T;
Iwatsubo, T

Publication type:

Article

Analysis of nicastrin gene phylogeny and expression in zebrafish.

Published in:

Development Genes & Evolution, 2015, v. 225, n. 3, p. 171, doi. 10.1007/s00427-015-0500-9

By:

Lim, Anne;
Moussavi Nik, Seyyed;
Ebrahimie, Esmaeil;
Lardelli, Michael

Publication type:

Article

Three-dimensional structure of human γ-secretase.

Published in:

Nature, 2014, v. 512, n. 7513, p. 166, doi. 10.1038/nature13567

By:

Lu, Peilong;
Bai, Xiao-chen;
Ma, Dan;
Xie, Tian;
Yan, Chuangye;
Sun, Linfeng;
Yang, Guanghui;
Zhao, Yanyu;
Zhou, Rui;
Scheres, Sjors H. W.;
Shi, Yigong

Publication type:

Article

NCSTN mutations in hidradenitis suppurativa/acne inversa do not influence cytokine production by peripheral blood mononuclear cells.

Published in:

British Journal of Dermatology, 2017, v. 176, n. 1, p. 277, doi. 10.1111/bjd.15076

By:

Xu, H.;
He, Y.;
Hui, Y.;
Xiao, X.;
Zhang, X.;
Li, C.;
Wang, B.

Publication type:

Article

Beyond the tip of the iceberg: the role of phosphoinositide 3-kinase/ AKT in acne inversa/hidradenitis suppurativa.

Published in:

British Journal of Dermatology, 2016, v. 174, n. 3, p. 484, doi. 10.1111/bjd.14349

By:

Frew, J.W.

Publication type:

Article

Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase/ AKT signalling pathways.

Published in:

British Journal of Dermatology, 2016, v. 174, n. 3, p. 522, doi. 10.1111/bjd.14223

By:

Xiao, X.;
He, Y.;
Li, C.;
Zhang, X.;
Xu, H.;
Wang, B.

Publication type:

Article

First nicastrin mutation in PASH (pyoderma gangrenosum, acne and suppurative hidradenitis) syndrome.

Published in:

British Journal of Dermatology, 2015, v. 173, n. 2, p. 610, doi. 10.1111/bjd.13668

By:

Duchatelet, S.;
Miskinyte, S.;
Join‐Lambert, O.;
Ungeheuer, M.‐N.;
Francès, C.;
Nassif, A.;
Hovnanian, A.

Publication type:

Article

OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.

Published in:

Cellular & Molecular Life Sciences, 2014, v. 71, n. 13, p. 2561, doi. 10.1007/s00018-013-1515-x

By:

Han, Jonghee;
Jung, Sunmin;
Jang, Jiyeon;
Kam, Tae-In;
Choi, Hyunwoo;
Kim, Byung-Ju;
Nah, Jihoon;
Jo, Dong-Gyu;
Nakagawa, Toshiyuki;
Nishimura, Masaki;
Jung, Yong-Keun

Publication type:

Article

Oxidized Docosahexaenoic Acid Species and Lipid Peroxidation Products Increase Amyloidogenic Amyloid Precursor Protein Processing.

Published in:

Neurodegenerative Diseases, 2016, v. 16, n. 1/2, p. 44, doi. 10.1159/000440839

By:

Grimm, Marcus O.W.;
Haupenthal, Viola J.;
Mett, Janine;
Stahlmann, Christoph P.;
Blümel, Tamara;
Mylonas, Nadine T.;
Endres, Kristina;
Grimm, Heike S.;
Hartmann, Tobias

Publication type:

Article