Works matching DE "MOLECULAR pharmacology"

Results: 778

Expression characteristics and biological significance of exosome-related genes in lung cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03173-z

By:

Zhong, Qixiang;
Zhao, Yujie

Publication type:

Article

Machine learning modeling and analysis of prognostic hub genes in cervical adenocarcinoma: a multi target therapy for enhancement in immunosurveillance.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02834-3

By:

Abbasi, Madiha Jabeen;
Abbasi, Rashid;
Wu, ShuPeng;
Heyat, Md Belal Bin;
Xianfeng, Ding;
Jia, Huijie;
Zheng, Aiwen

Publication type:

Article

基于网络药理学和实验验证探讨健脾养肝汤治疗自身免疫性肝炎的作用机制.

Published in:

Evaluation & Analysis of Drug-Use in Hospitals of China / Zhongguo Yiyuan Yongyao Pingjia yu Fenxi, 2025, v. 25, n. 6, p. 679, doi. 10.14009/j.issn.1672-2124.2025.06.008

By:

于盈盈;
杨润萌;
张亚;
包一珺;
吕文良;
朱丹

Publication type:

Article

Wuda Granule Alleviates DSS-Induced Colitis in Mice by Inhibiting Inflammation, Protecting Intestinal Barrier and Reducing Oxidative Stress Through Nrf2/Keap1/HO-1 Pathway.

Published in:

Journal of Inflammation Research, 2025, v. 18, p. 7301, doi. 10.2147/JIR.S519483

By:

Wang, Tao;
Ou, Yanghui;
Xiong, Wenjun;
Luo, Lijie;
Xu, Yihua;
Chen, Guojian;
Peng, Yaohui;
Chen, Yan;
Zeng, Haiping;
Yu, Yang;
Tang, Haipeng;
Yao, Hongliang;
Wang, Wei

Publication type:

Article

Investigating the Role and Underlying Mechanisms of 18β-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-γ/NF-κB Signaling Pathway.

Published in:

Journal of Inflammation Research, 2025, v. 18, p. 7529, doi. 10.2147/JIR.S510949

By:

Zhu, Aijing;
Qiu, Qingqing;
Xu, Zhengguang;
Zhang, Qilian;
Sun, Fang;
Liu, Yanzhan;
Chen, Zeang;
Zhang, Yanan;
Yao, Jing

Publication type:

Article

Pharmacological mechanisms of carvacrol against hepatocellular carcinoma by network pharmacology and molecular docking.

Published in:

Technology & Health Care, 2025, v. 33, n. 4, p. 1850, doi. 10.1177/09287329241306192

By:

Liu, Lu;
Yu, Ping;
Zhao, Zhongwei;
Yang, Hongyuan;
Yu, Risheng

Publication type:

Article

The molecular basis of all-trans retinoic acid binding to the target genes involved in rheumatoid arthritis through network pharmacology and molecular docking.

Published in:

Clinical Rheumatology, 2025, v. 44, n. 7, p. 2621, doi. 10.1007/s10067-025-07482-0

By:

Zheng, Xi;
Ke, Xin;
Gao, Jie;
Zheng, Zhaohui;
Zhu, Ping

Publication type:

Article

Investigating the Anti-glioblastoma Potential of Alkaloids from the Solanaceae Family: A Multi-Targeted Approach Using Network Pharmacology and Molecular Modeling Approaches.

Published in:

Journal of Computational Biophysics & Chemistry, 2026, v. 25, n. 2, p. 167, doi. 10.1142/S2737416525500425

By:

Alamri, Abdulaziz;
Jabir, Nasimudeen R.;
Firoz, Chelapram K.;
Alsolami, Khadeejah;
Khan, Mohd Shahnawaz;
Alhashmi, Mohammad Hassan;
Tabrez, Shams

Publication type:

Article

The processed Sanguisorba officinalis L. triterpenoids prevent colon cancer through the TNF- α /NF-κB signaling pathway, combined with network pharmacology, molecular simulation dynamics and experimental verification.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1605326

By:

Gan, Chunli;
Mu, Yuanqiu;
Ali, Shah Syed Faizan;
Shi, Xuepeng;
Jiang, Shuang;
Wang, Zhengyang;
Wu, Xiaotian;
Wang, Xiaotong;
Wang, Zhibin;
Zhang, Shulu;
Feng, Zheng;
Yang, Chunjuan

Publication type:

Article

Exploring the mechanism of Synechococcus sp. XM-24 in gastric cancer treatment via network pharmacology and molecular docking.

Published in:

PLoS ONE, 2025, v. 20, n. 7, p. 1, doi. 10.1371/journal.pone.0326664

By:

Li, Jiayi;
Ma, Yamei;
Guo, Longzhi;
Liu, Junhong;
Li, Lin

Publication type:

Article

Histamine H<sub>3</sub> receptor: an emerging target for cancer therapy?

Published in:

Inflammation Research, 2025, v. 74, n. 1, p. 1, doi. 10.1007/s00011-025-02054-z

By:

Lauretta, Paolo;
Martinez Vivot, Rocio;
Velazco, Agueda;
Medina, Vanina A.

Publication type:

Article

Dr. Morley Donald Hollenberg. An extraordinary scientist, teacher and mentor.

Published in:

2025

By:

Oikonomopoulou, Katerina;
Diamandis, Eleftherios P.

Publication type:

Letter

Terpinen-4-ol Targets HIF-1α/TGF-β1/TNF-α Axis to Attenuate Ethanol-Induced Hepatotoxicity: Network Pharmacology and In Vitro Validation.

Published in:

Medicina (1010660X), 2025, v. 61, n. 6, p. 1048, doi. 10.3390/medicina61061048

By:

Alsahli, Tariq G.;
Khalid, Maryam;
Malik, Muhammad Nasir Hayat;
Alshammari, Saud O.

Publication type:

Article

Anti‐Osteoporosis Activity of Lycopene Through ESR1: Network Pharmacology, Molecular Docking, Imaging Technology, and Experimental Validation.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 6, p. 1, doi. 10.1111/cbdd.70135

By:

Zhao, Benqian;
Chen, Lulu;
Wang, Wei;
Xu, Weinan;
Xu, Bing

Publication type:

Article

Khellin Mitigates Cisplatin-Induced Renal Injury by Targeting Oxidative Stress, Inflammation, and Apoptosis: Integration of Network Pharmacology, Molecular Docking, and Preclinical Validation.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 836, doi. 10.3390/ph18060836

By:

Sharawi, Zeina W.;
Abass, Shimaa A.;
Zubair, Manal A.;
Hegazy, Rabab A.;
Farrag, Foad A.;
Hamdi, Abdelrahman;
El-Magd, Mohammed A.;
Elgazar, Abdullah A.

Publication type:

Article

Systematic analysis on the mechanism of Zhizi-Bopi decoction against hepatitis B via network pharmacology and molecular docking.

Published in:

Biotechnology Letters, 2023, v. 45, n. 4, p. 463, doi. 10.1007/s10529-023-03359-x

By:

Zhang, He;
Xu, Zhouyi;
Gao, Haojun;
Zhang, Qinyuan

Publication type:

Article

Therapeutic Potential of Methylindoline Derivative in Ameliorating Cadmium‐Induced Nephritis Experimented in Zebrafish Model.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 6, p. 1, doi. 10.1002/jbt.70312

By:

Nayak, S. P. Ramya Ranjan;
Herold, Aveeda;
Shiny, Marapatla;
Vedula, Girija Sastry;
Soundharrajan, Ilavenil;
Almutairi, Bader O.;
Namasivayam, S. Karthick Raja;
Kumaradoss, Kathiravan Muthu;
Arockiaraj, Jesu

Publication type:

Article

Network pharmacology and molecular docking analysis on the mechanism of Cordyceps militaris polysaccharide regulating immunity through TLR4/TNF‐α pathwayss.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 6, p. 1, doi. 10.1002/jbt.23345

By:

Pei, Hongyan;
He, Zhongmei;
Chen, Weijia;
Zhao, Yan;
Li, Jianming;
Wang, Ruibing;
Zong, Ying;
Du, Rui

Publication type:

Article

Ergothioneine attenuates varicocele‐induced testicular damage by upregulating HSP90AA1 in rats.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 4, p. 1, doi. 10.1002/jbt.23301

By:

Chen, Qi;
Zhou, Ranran;
Yang, Cheng;
Jiang, Qijun;
Yuan, Haoyu;
Qiu, Xin;
Tian, Hu;
Zhou, Junhao;
Liu, Cundong

Publication type:

Article

Network pharmacology and molecular docking integrated strategy to investigate the pharmacological mechanism of palmatine in Alzheimer's disease.

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 11, p. 1, doi. 10.1002/jbt.23200

By:

Pei, Hongyan;
Zeng, Jianning;
Chen, Weijia;
He, Zhongmei;
Du, Rui

Publication type:

Article

Exploring the molecular mechanism of Tripterygium Wilfordii Hook F in treating systemic lupus erythematosus via network pharmacology and molecular docking: Tripterygium Wilfordii Hook F in treating systemic lupus erythematosus: Yanggang Hong et al.

Published in:

Clinical Rheumatology, 2025, v. 44, n. 4, p. 1549, doi. 10.1007/s10067-025-07311-4

By:

Hong, Yanggang;
Wang, Deqi;
Qian, Hengrong;
Jiang, Xiaoyang;
Wang, Yi;
Liang, Xinyue;
Gao, Sheng;
Hua, Chunyan

Publication type:

Article

Understanding Molecular Mechanisms Behind the Anti-Inflammatory Effects of Machilus macrantha (Gulmavu) by Network Pharmacology and Molecular Modeling Approach.

Published in:

Journal of Computational Biophysics & Chemistry, 2025, v. 24, n. 8, p. 985, doi. 10.1142/S2737416525500061

By:

Mukhopadhyay, Nabarun;
Sen, Sibu;
Kumar, Ashish;
Sandbhor, Rujuta;
Dikundwar, Amol G.;
Kaki, Venkata Rao

Publication type:

Article

Insights into Molecular Mechanism of Nicotine Addiction Based on Network Pharmacology and Molecular Docking Strategy.

Published in:

Journal of Computational Biophysics & Chemistry, 2024, v. 23, n. 1, p. 35, doi. 10.1142/S2737416523500497

By:

Zhang, Sen;
Zhao, Yuhang;
Chang, Zewen;
Chen, Huan;
Hou, Hongwei

Publication type:

Article

Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation, Angiogenesis, and Tissue Remodeling.

Published in:

Gels (2310-2861), 2025, v. 11, n. 2, p. 104, doi. 10.3390/gels11020104

By:

Ran, Fei;
Mu, Kailang;
Zhou, Lingli;
Peng, Leqiang;
Liu, Gang;
Liu, Yuchen;
Pang, Yuxin;
Feng, Guo;
Guo, Changmao;
Wang, Tianjian;
Luo, Qiumei

Publication type:

Article

乌头汤及其配伍对抗类风湿性关节炎的机制.

Published in:

Journal of Jilin University (Science Edition) / Jilin Daxue Xuebao (Lixue Ban), 2025, v. 63, n. 1, p. 191, doi. 10.13413/j.cnki.jdxblxb.2024468

By:

姜永新;
刘凯丰;
胡成祥;
李婉南;
韩葳葳

Publication type:

Article

网络药理学和分子对接技术研究桑黄类真菌对疾病的潜在作用机制.

Published in:

Mycosystema, 2023, v. 42, n. 1, p. 365, doi. 10.13346/j.mycosystema.220373

By:

楚建芝;
郑娜;
崔琪;
李满鑫;
李寅;
伍国超;
程显好;
张蕊

Publication type:

Article

基于网络药理学和分子对接技术探讨冬虫夏草治疗肾纤维化的潜在作用机制.

Published in:

Mycosystema, 2021, v. 40, n. 11, p. 2995, doi. 10.13346/j.mycosystema.210227

By:

范卫锋;
邹园生;
李文佳;
李皓翔;
汪小东;
梅全喜;
钱正明

Publication type:

Article

5-Fluorouracil in Combination with Calcium Carbonate Nanoparticles Loaded with Antioxidant Thymoquinone against Colon Cancer: Synergistically Therapeutic Potential and Underlying Molecular Mechanism.

Published in:

Antioxidants, 2024, v. 13, n. 9, p. 1030, doi. 10.3390/antiox13091030

By:

Deng, Xi;
Yang, Zhongming;
Chan, Kim Wei;
Ismail, Norsharina;
Abu Bakar, Md Zuki

Publication type:

Article

Vitamin C: Rationale for Its Use in Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS).

Published in:

Antioxidants, 2024, v. 13, n. 1, p. 95, doi. 10.3390/antiox13010095

By:

Fowler III, Alpha A.

Publication type:

Article

Potential Targets and Mechanisms of Jiedu Quyu Ziyin Decoction for Treating SLE-GIOP: Based on Network Pharmacology and Molecular Docking.

Published in:

Journal of Immunology Research, 2023, p. 1, doi. 10.1155/2023/8942415

By:

Li, Jie;
Chang, Run-yu;
Chen, Lin-feng;
Qian, Su-hai;
Wang, Rong-yun;
Lan, Ji-le;
Huang, Lin;
Ding, Xing-hong

Publication type:

Article

Network pharmacology and molecular docking analysis on Shenfu Qiangxin indicate mTOR is a potential target to treat heart failure.

Published in:

European Journal of Medical Research, 2024, v. 29, n. 1, p. 1, doi. 10.1186/s40001-024-01732-8

By:

Zou, Peilin;
Li, Jiajun;
Zhang, Yucong;
Qian, Zonghao;
Nie, Hao;
Yang, Ni;
Zhang, Le;
Lin, Li;
Peng, Dewei;
Zhang, Cuntai

Publication type:

Article

Identification of the mechanisms underlying per- and polyfluoroalkyl substance-induced hippocampal neurotoxicity as determined by network pharmacology and molecular docking analyses.

Published in:

Toxicology Research, 2023, v. 12, n. 6, p. 1126, doi. 10.1093/toxres/tfad104

By:

Li, Shirui;
Gao, Zhihui;
Zhong, Meihan;
Bi, Haoran;
Li, Jianan

Publication type:

Article

Gene editing, metabolomics, network pharmacology strategies to explore terpenoid content and anti-TMV activity in NtSPS1 knockout Nicotiana tabacum.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-98745-y

By:

Dai, Jia-Meng;
Zhang, Jian-Duo;
Liu, Xin;
Zhang, Ling-Fang;
Wang, Jin;
Xu, Yong;
Yang, Guang-Yu;
Li, Jing;
Chen, Ming-Li;
Hu, Qiu-Fen

Publication type:

Article

Studying the efficacy of JBOL volatile components in idiopathic pulmonary fibrosis (IPF) using GC-MS and network pharmacology.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-97374-9

By:

Zhang, Aijun;
Kong, Linghui;
Li, Tong;
Shi, Lei;
Jiang, Juanjuan;
Li, Ping;
Li, Honglin;
Han, Xinru;
Li, Jian;
Feng, Shuai;
Li, Feng;
Meng, Zhaoqing

Publication type:

Article

Mechanism of dracorhodin in accelerating diabetic foot ulcer healing via the Nrf2 pathway, a network pharmacology, molecular docking and experimental validation.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-97831-5

By:

Tang, Guangjun;
Wang, Ying;
Deng, Pin;
Wu, Junde;
Lu, Zhongwen;
Zhu, Ruizheng;
Guo, Hui;
Zhang, Yunhui;
Mo, Xingjie;
Chen, Zhaojun

Publication type:

Article

Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-90209-7

By:

Lara, César O.;
Burgos, Carlos F.;
Fariña-Oliva, Katherine;
Marileo, Ana M.;
Martín, Victoria P. San;
Flaig, David;
Soto-Ortega, Paul;
Contreras, Omayra V.;
Sazo, Anggelo;
Gaete-Riquelme, Krishna;
Corradi, Jeremías;
Muñoz-Montesino, Carola;
Fuentealba, Jorge;
Castro, Patricio A.;
Aguayo, Luis G.;
Bouzat, Cecilia;
Moraga-Cid, Gustavo;
Yévenes, Gonzalo E.

Publication type:

Article

Metabolic profiles and potential antioxidant mechanisms of hawk tea.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-88160-8

By:

Jiang, Sixia;
Zhang, Hong;
Song, Ya;
Xiao, Mingji;
Hu, Hao;
Yu, Shirui;
Xie, Feng

Publication type:

Article

Network Pharmacology and Molecular Mechanism of Traditional Indonesian Medicine in Hypertension Treatment.

Published in:

Indonesian Journal of Pharmacy / Majalah Farmasi Indonesia, 2024, v. 35, n. 4, p. 712

By:

Setiani, Lusi Agus;
Saputri, Fadlina Chany;
Yanuar, Arry;
Mun'im, Abdul

Publication type:

Article

Editorial: Emerging trends in cardiac and skeletal muscle pharmacotherapy.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1619972

By:

Son, Young Hoon;
Vechetti, Ivan;
Coletta, Dawn Katrina

Publication type:

Article

Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of OATF against kidney stones.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1575270

By:

Dai, Sisi;
Fang, Qi;
Li, Hong-Yan;
Sun, Rui;
Zhang, Hui-Yong;
Wu, Wei

Publication type:

Article

The potential role and mechanism of Rhizoma Coptidis in prevention of diabetic encephalopathy: targeting sodium ion and channels.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1542015

By:

Cao, Ning;
Shou, Zhangxuan;
Wang, Mimi;
Wu, You;
Wang, Xuefeng

Publication type:

Article

Indirubin attenuates sepsis by targeting the EGFR/SRC/PI3K and NF-κB/MAPK signaling pathways in macrophages.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1542061

By:

Li, Yancen;
Wan, Chengyu;
Li, Fan;
Xin, Guang;
Wang, Tao;
Zhou, Qilong;
Wen, Tingyu;
Li, Shiyi;
Chen, Xiaoting;
Huang, Wen

Publication type:

Article

Exploring manzamine a: a promising anti-lung cancer agent from marine sponge Haliclona sp.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1525210

By:

Su, Min;
Zhu, Jie;
Bai, Luyuan;
Cao, Yu;
Wang, Shaohui

Publication type:

Article

β-lapachone suppresses carcinogenesis of cervical cancer via interaction with AKT1.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1509568

By:

Du, Pan;
Li, Yue;
Han, Anna;
Wang, Mengying;
Liu, Jiajing;
Piao, Yingshi;
Chen, Liyan

Publication type:

Article

Decoding nature: multi-target anti-inflammatory mechanisms of natural products in the TLR4/NF-κB pathway.

Published in:

2025

By:

Zhao, Yue;
Wu, Jiacai;
Liu, Xiaolan;
Chen, Xu;
Wang, Juan

Publication type:

Literature Review

Editorial: Systems pharmacology in the spotlight: trending technologies in network biology and drug discovery.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1535754

By:

Goel, Raghuveera Kumar;
Lukong, Kiven Erique;
Emili, Andrew

Publication type:

Article

Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1481091

By:

Wang, Chenxi;
Zhao, Xin;
Jiang, Jingjing;
Jia, Mengqi;
Shi, Wenqing;
Wu, Zhenghua;
Feng, Shiyu;
Fan, Guorong;
Lou, Yuefen

Publication type:

Article

Investigation on improving immunologic reconstitution insufficiency using DiwuYanggan capsules in AIDS patients.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1485719

By:

Ke, Jing Wen;
Chen, Yao;
Lei, En Ze;
Xiao, Ming Zhong;
Ni, Wei;
Huang, Fang;
Li, Han Min;
Jiang, Hong Lin;
Ruan, Lian Guo;
Liu, Jian Zhong

Publication type:

Article

Reduning alleviates sepsis-induced acute lung injury by reducing apoptosis of pulmonary microvascular endothelial cells.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1196350

By:

Ziyi Wang;
Zhe Guo;
Xuesong Wang;
Haiyan Liao;
Feng Chen;
Yuxin Liu;
Zhong Wang

Publication type:

Article

Elucidating the mechanism of Kuwanon G in treating diabetic encephalopathy through network pharmacology: A comprehensive study.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2025, v. 34, n. 3, p. 251, doi. 10.5246/jcps.2025.03.019

By:

Yuqian Zhang;
Haiying Niu;
Xiaowei Zhang;
Weiwei Xie;
Kaiyue Zhang;
Lantong Zhang;
Yiran Jin

Publication type:

Article