Works matching DE "MITOGEN-activated protein kinase kinase"

Results: 310

Targeted Therapy for Complex Lymphatic Anomalies in Patients with Noonan Syndrome and Related Disorders.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6126, doi. 10.3390/ijms26136126

By:

Leenders, Erika K. S. M.;
van den Brink, Vera C.;
Kleimeier, Lotte E. R.;
Woutersen, Danielle T. J.;
Coppens, Catelijne H.;
den Hertog, Jeroen;
Klein, Willemijn M.;
Rinne, Tuula;
Vrancken, Sabine L.;
de Wildt, Saskia N.;
Draaisma, Jos M. T.;
Fuijkschot, Joris

Publication type:

Article

Interferon regulatory factor 8 induces intrinsic functional changes in mature neutrophils Open Access.

Published in:

Journal of Leukocyte Biology, 2025, v. 117, n. 6, p. 1, doi. 10.1093/jleuko/qiaf078

By:

Polmann, Laura;
Grimm, Janna Carina;
Roth, Johannes;
Barczyk-Kahlert, Katarzyna

Publication type:

Article

Insertion of transposon in the vicinity of SSK2 confers enhanced tolerance to furfural in Saccharomyces cerevisiae.

Published in:

Applied Microbiology & Biotechnology, 2012, v. 95, n. 2, p. 531, doi. 10.1007/s00253-012-4022-3

By:

Kim, Hyun-Soo;
Kim, Na-Rae;
Kim, Wankee;
Choi, Wonja

Publication type:

Article

Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 10, p. 1724, doi. 10.3390/jcm8101724

By:

Li, Jiun Yi;
Chen, Ray Jade;
Huang, Li Ting;
Lee, Tzu Yin;
Lu, Wan Jung;
Lin, Kuan Hung

Publication type:

Article

Metabolic Profiling of Fermented Products of the Ethanolic Extract of Acanthopanax sessiliflorus Fruit and Evaluation of Its Immune Enhancement Effect in RAW 264.7 Macrophages and BV2 Microglia.

Published in:

Antioxidants, 2025, v. 14, n. 4, p. 397, doi. 10.3390/antiox14040397

By:

Kim, Kwan-Woo;
Choi, Bo-Ram;
Shin, Woo-Cheol;
Jang, Jin-Kyu;
Lee, Young-Seob;
Yoon, Dahye;
Lee, Dae Young

Publication type:

Article

Zoletil promotes apoptosis in BV-2 microglial cells via induction of oxidative stress and neural inflammation.

Published in:

Toxicology Research, 2022, v. 11, n. 1, p. 134, doi. 10.1093/toxres/tfab115

By:

Kim, Gyun Moo;
Lee, Chan;
Jang, Tae Chang

Publication type:

Article

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK.

Published in:

ChemistryOpen, 2015, v. 4, n. 1, p. 56, doi. 10.1002/open.201402076

By:

Vinh, Natalie B.;
Devine, Shane M.;
Munoz, Lenka;
Ryan, Renae M.;
Wang, Bing H.;
Krum, Henry;
Chalmers, David K.;
Simpson, Jamie S.;
Scammells, Peter J.

Publication type:

Article

Relative Bioavailability of Pediatric Oral Solution and Tablet Formulations of Trametinib in Adult Patients With Solid Tumors.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 287, doi. 10.1002/cpdd.152

By:

Cox, Donna S.;
Allred, Alicia;
Zhou, YanYan;
Infante, Jeffrey R.;
Gordon, Michael S.;
Bendell, Johanna;
Jones, Suzanne;
Burris, Howard;
Orford, Keith

Publication type:

Article

MK2 drives progression of pancreas and colon cancers by suppressing CD8+ T cell cytotoxic function and is a potential immunotherapy target.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1212100

By:

Jacenik, Damian;
Lebish, Eric J.;
Beswick, Ellen J.

Publication type:

Article

Salt-induced subcellular kinase relocation and seedling susceptibility caused by overexpression of Medicago SIMKK in Arabidopsis.

Published in:

Journal of Experimental Botany, 2014, v. 65, n. 9, p. 2335, doi. 10.1093/jxb/eru115

By:

Ovečka, Miroslav;
Takáč, Tomáš;
Komis, George;
Vadovič, Pavol;
Bekešová, Slávka;
Doskočilová, Anna;
Smékalová, Veronika;
Luptovčiak, Ivan;
Šamajová, Olga;
Schweighofer, Alois;
Meskiene, Irute;
Jonak, Claudia;
Křenek, Pavel;
Lichtscheidl, Irene;
Škultéty, Ľudovít;
Hirt, Heribert;
Šamaj, Jozef

Publication type:

Article

Arabidopsis thaliana mitogen-activated protein kinase 6 is involved in seed formation and modulation of primary and lateral root development.

Published in:

Journal of Experimental Botany, 2014, v. 65, n. 1, p. 169, doi. 10.1093/jxb/ert368

By:

López-Bucio, J. S.;
Dubrovsky, J. G.;
Raya-González, J.;
Ugartechea-Chirino, Y.;
López-Bucio, J.;
de Luna-Valdez, L. A.;
Ramos-Vega, M.;
León, P.;
Guevara-García, A. A.

Publication type:

Article

Kinase-mediated orchestration of NADPH oxidase in plant immunity.

Published in:

Briefings in Functional Genomics, 2015, v. 14, n. 4, p. 253, doi. 10.1093/bfgp/elv004

By:

Hiroaki Adachi;
Hirofumi Yoshioka

Publication type:

Article

Functional studies of transcription factors involved in plant defenses in the genomics era.

Published in:

Briefings in Functional Genomics, 2015, v. 14, n. 4, p. 260, doi. 10.1093/bfgp/elv011

By:

Eunyoung Seo;
Doil Choi

Publication type:

Article

Ubiquitin-specific protease 8 ameliorates lipopolysaccharide-induced spleen injury via suppression of NF-κB and MAPK signaling pathways.

Published in:

Molecular Medicine Reports, 2022, v. 26, n. 6, p. N.PAG, doi. 10.3892/mmr.2022.12887

By:

Bi, Wei;
Zhang, Jiawei;
Zeng, Zhaohao;
Zhou, Ruiyi;
Zhao, Jiayi;
Yan, Wei;
Wang, Lu;
Li, Xiaoting;
Zhu, Lihong

Publication type:

Article

MEK inhibitor enhanced the antitumor effect of oxaliplatin and 5-fluorouracil in MEK1 Q56P-mutant colorectal cancer cells.

Published in:

Molecular Medicine Reports, 2019, v. 19, n. 2, p. 1092

By:

Jing, Changwen;
Li, Huizi;
Du, Yuanyuan;
Cao, Haixia;
Liu, Siwen;
Wang, Zhuo;
Ma, Rong;
Feng, Jifeng;
Wu, Jianzhong

Publication type:

Article

Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis.

Published in:

Molecular Medicine Reports, 2018, v. 18, n. 2, p. 1263, doi. 10.3892/mmr.2018.9136

By:

Wang, Zhe;
Han, Yudi;
Zhang, Zhaoqing;
Jia, Cunfeng;
Zhao, Qiang;
Song, Wei;
Chen, Tao;
Zhang, Yifan;
Wang, Xiuhui

Publication type:

Article

Electroacupuncture serum inhibits TNF‑α‑mediated chondrocyte inflammation via the Ras‑Raf‑MEK1/2‑ERK1/2 signaling pathway.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 5, p. 5807, doi. 10.3892/mmr.2017.7366

By:

HOUHUANG CHEN;
XIANG SHAO;
CHUNSONG ZHENG;
XIHAI LI;
LI LI;
XIN XU;
XIUE HONG;
MINGXIA WU

Publication type:

Article

Aloin promotes A549 cell apoptosis via the reactive oxygen species‑mitogen activated protein kinase signaling pathway and p53 phosphorylation.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 5, p. 5759, doi. 10.3892/mmr.2017.7379

By:

LI WAN;
LIN ZHANG;
KAI FAN;
JIANJUN WANG

Publication type:

Article

Toxic proteins from Croton tiglium L. exert a proinflammatory effect by inducing release of proinflammatory cytokines and activating the p38-MAPK signaling pathway.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 1, p. 631, doi. 10.3892/mmr.2017.6617

By:

Liping Liu;
Hongli Yu;
Hao Wu;
Xiaolin Yang;
Yaozong Pan;
Yeqing Chen;
Kuilong Wang;
Wei Wang;
Wenying Zhang;
Yangping Jin;
Chengchao Zhang;
Ai Jiang;
Chunyan Xia

Publication type:

Article

Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 1, p. 63, doi. 10.3892/mmr.2017.6563

By:

Pengfei Ba;
Xiaoyu Duan;
Guo Fu;
Shuyan Lv;
Pishan Yang;
Qinfeng Sun

Publication type:

Article

Prognostic role of TPL2 in early‑stage non‑small cell lung cancer.

Published in:

Molecular Medicine Reports, 2017, v. 15, n. 6, p. 3451, doi. 10.3892/mmr.2017.6430

By:

BOLDRINI, LAURA;
GIORDANO, MIRELLA;
SERVADIO, ADELE;
NICCOLI, CRISTINA;
BERTOGLIO, PIETRO;
LUCCHI, MARCO;
MUSSI, ALFREDO;
FONTANINI, GABRIELLA;
MELFI, FRANCA

Publication type:

Article

Expression of MMPs is dependent on the activity of mitogen-activated protein kinase in chondrosarcoma.

Published in:

Molecular Medicine Reports, 2017, v. 15, n. 2, p. 915, doi. 10.3892/mmr.2016.6077

By:

Min Yao;
Xiaomei Wang;
Yufeng Zhao;
Xiaomeng Wang;
Feng Gao

Publication type:

Article

Endothelial lipase is upregulated by interleukin-6 partly via the p38 MAPK and p65 NF-κB signaling pathways.

Published in:

Molecular Medicine Reports, 2016, v. 14, n. 3, p. 1979, doi. 10.3892/mmr.2016.5457

By:

XIN YUE;
MINGHUI WU;
HONG JIANG;
JING HAO;
QINGHAO ZHAO;
QING ZHU;
GAOWA SAREN;
YUN ZHANG;
XIAOLI ZHANG

Publication type:

Article

Aspirin inhibits osteoclastogenesis by suppressing the activation of NF-κB and MAPKs in RANKL-induced RAW264.7 cells.

Published in:

Molecular Medicine Reports, 2016, v. 14, n. 3, p. 1957, doi. 10.3892/mmr.2016.5456

By:

YAN-PING ZENG;
CHAO YANG;
YUAN LI;
YONG FAN;
HONG-JUN YANG;
BIN LIU;
HONG-XUN SANG

Publication type:

Article

Pyropia yezoensis glycoprotein regulates antioxidant status and prevents hepatotoxicity in a rat model of D-galactosamine/lipopolysaccharide-induced acute liver failure.

Published in:

Molecular Medicine Reports, 2016, v. 13, n. 4, p. 3110, doi. 10.3892/mmr.2016.4932

By:

JEONG-WOOK CHOI;
IN-HYE KIM;
YOUNG-MIN KIM;
MIN-KYEONG LEE;
TAEK-JEONG NAM

Publication type:

Article

Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells.

Published in:

Molecular Medicine Reports, 2016, v. 13, n. 2, p. 1570, doi. 10.3892/mmr.2015.4715

By:

RUINIAN ZHENG;
ZHIJIAN YOU;
JUN JIA;
SHUNHUAN LIN;
SHUAI HAN;
AIXUE LIU;
HUIDONG LONG;
SENMING WANG

Publication type:

Article

Restoration of adiponectin expression via the ERK pathway in TNFα-treated 3T3-L1 adipocytes.

Published in:

Molecular Medicine Reports, 2014, v. 10, n. 2, p. 905, doi. 10.3892/mmr.2014.2278

By:

EUGENE CHANG;
JUNG MOOK CHOI;
WON JUN KIM;
EUN-JUNG RHEE;
KI WON OH;
WON-YOUNG LEE;
SE EUN PARK;
SUNG WOO PARK;
CHEOL-YOUNG PARK

Publication type:

Article

Protective effects of the SEPS1 gene on lipopolysaccharide-induced sepsis.

Published in:

Molecular Medicine Reports, 2014, v. 9, n. 5, p. 1869, doi. 10.3892/mmr.2014.1991

By:

LEI HE;
BIN WANG;
YUAN YAO;
MAOSHENG SU;
HUANXIAN MA;
NING JIA

Publication type:

Article

Effect of Yang He Decoction on Treatment of Bone Tuberculosis via Phosphoinositide 3-Kinases/Protein Kinase B and Mitogen-Activated Protein Kinase Signaling Pathways.

Published in:

Natural Product Communications, 2022, v. 17, n. 3, p. 1, doi. 10.1177/1934578X221075080

By:

Zhang, Qiang;
Ma, Wanli;
Wang, Qing;
Gao, Hua;
Sun, Jianmin

Publication type:

Article

PTEN regulates IGF-1R-mediated therapy resistance in melanoma.

Published in:

Pigment Cell & Melanoma Research, 2015, v. 28, n. 5, p. 572, doi. 10.1111/pcmr.12390

By:

Wang, Jun;
Sinnberg, Tobias;
Niessner, Heike;
Dölker, Rebecca;
Sauer, Birgit;
Kempf, Wolfgang E.;
Meier, Friedegund;
Leslie, Nick;
Schittek, Birgit

Publication type:

Article

Resistance to MAPK inhibition: come see(c) AMPed up melanoma.

Published in:

Pigment Cell & Melanoma Research, 2014, v. 27, n. 3, p. 323, doi. 10.1111/pcmr.12230

By:

Rodríguez, Carlos I.;
Setaluri, Vijayasaradhi

Publication type:

Article

Cudraflavanone B Isolated from the Root Bark of Cudrania tricuspidata Alleviates Lipopolysaccharide-Induced Inflammatory Responses by Downregulating NF-κB and ERK MAPK Signaling Pathways in RAW264.7 Macrophages and BV2 Microglia.

Published in:

Inflammation, 2021, v. 44, n. 1, p. 104, doi. 10.1007/s10753-020-01312-y

By:

Ko, Wonmin;
Kim, Kwan-Woo;
Quang, Tran Hong;
Yoon, Chi-Su;
Kim, Nayeon;
Lee, Hwan;
Kim, Sam-Cheol;
Woo, Eun-Rhan;
Kim, Youn-Chul;
Oh, Hyuncheol;
Lee, Dong-Sung

Publication type:

Article

Mechanism of Shenxiong-Xinmaikang Decoction in Treating Stable Angina Pectoris based on Network Pharmacology and Molecular Docking.

Published in:

Indian Journal of Pharmaceutical Sciences, 2024, v. 86, n. 4, p. 1388, doi. 10.36468/pharmaceutical-sciences.1404

By:

YANCHEN DONG;
YONGZHEN LIANG;
JINNAN MO;
YUQING CAI;
DONGHUI LIANG

Publication type:

Article

Effect of MST1 on Invasion and Migration of Colon Cancer through Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signal Pathway.

Published in:

Indian Journal of Pharmaceutical Sciences, 2023, v. 85, n. 6, p. 1648, doi. 10.36468/pharmaceutical-sciences.1219

By:

XU WENMIN;
TAN JINGYU;
LUO HANYI

Publication type:

Article

The Crosstalk between MicroRNA-196a and Annexin-A1: A Potential Mechanism for Oral Squamous Cell Carcinoma Progression.

Published in:

Indian Journal of Pharmaceutical Sciences, 2022, v. 84, p. 144

By:

DUAN, M. L.;
DU, X. M.

Publication type:

Article

Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Impairs Synaptic Plasticity and Hippocampal-Dependent Memory.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 8, p. 2348, doi. 10.1523/JNEUROSCI.3825-15.2016

By:

Rahman, Nor Zaihana Abdul;
Greenwood, Sam M.;
Brett, Ros R.;
Tossell, Kyoko;
Ungless, Mark A.;
Plevin, Robin;
Bushell, Trevor J.

Publication type:

Article

Role of ERK1/2 MAPK Signaling in the Maintenance of Myelin and Axonal Integrity in the Adult CNS.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 48, p. 16031, doi. 10.1523/JNEUROSCI.3360-14.2014

By:

Ishii, Akihiro;
Furusho, Miki;
Dupree, Jeffrey L.;
Bansal, Rashmi

Publication type:

Article

Notch Signaling Regulates Differentiation and Steroidogenesis in Female Mouse Ovarian Granulosa Cells.

Published in:

Endocrinology, 2018, v. 159, n. 1, p. 184, doi. 10.1210/en.2017-00677

By:

Prasasya, Rexxi D;
Mayo, Kelly E

Publication type:

Article

LncPTSR Triggers Vascular Remodeling in Pulmonary Hypertension by Regulating [Ca2+]i in Pulmonary Arterial Smooth Muscle Cells.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2022, v. 66, n. 5, p. 524, doi. 10.1165/rcmb.2020-0480OC

By:

Liyu Deng;
Jidong Chen;
Bin Chen;
Ting Wang;
Lei Yang;
Jing Liao;
Junbo Yi;
Yuqin Chen;
Jian Wang;
Linneman, John;
Yanqin Niu;
Deming Gou

Publication type:

Article

ASK1ng to Delay the Progression of Pulmonary Fibrosis.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2022, v. 66, n. 5, p. 465, doi. 10.1165/rcmb.2022-0026ED

By:

Schuliga, Michael;
Madala, Satish K.

Publication type:

Article

RAS Mutations in Esophageal Squamous Papilloma.

Published in:

2024

By:

Sasaki, Eiichi;
Matsushita, Hirokazu;
Masago, Katsuhiro;
Hanai, Nobuhiro

Publication type:

Letter

Distal C‐terminus of Cav1.2 is indispensable for the chondrogenic differentiation of rat dental pulp stem cells.

Published in:

Cell Biology International, 2020, v. 44, n. 2, p. 512, doi. 10.1002/cbin.11251

By:

Ju, Yanqin;
Ren, Xudong;
Zhao, Shouliang

Publication type:

Article

Antifibrotic Effects of Pirfenidone in Rat Proximal Tubular Epithelial Cells.

Published in:

Renal Failure, 2012, v. 34, n. 10, p. 1309, doi. 10.3109/0886022X.2012.718955

By:

Takakura, Koji;
Tahara, Atsuo;
Sanagi, Masanao;
Itoh, Hiroyuki;
Tomura, Yuichi

Publication type:

Article

Effects of butyltins on mitogen-activated-protein kinase kinase kinase and Ras activity in human natural killer cells.

Published in:

Journal of Applied Toxicology, 2014, v. 34, n. 9, p. 1002, doi. 10.1002/jat.2921

By:

Celada, Lindsay J.;
Whalen, Margaret M.

Publication type:

Article

Inhibitory effects of tert-butylhydroquinone on osteoclast differentiation via up-regulation of heme oxygenase-1 and down-regulation of HMGB1 release and NFATc1 expression.

Published in:

Journal of Applied Toxicology, 2014, v. 34, n. 1, p. 49, doi. 10.1002/jat.2827

By:

Yamaguchi, Yu;
Sakai, Eiko;
Sakamoto, Hiroshi;
Fumimoto, Reiko;
Fukuma, Yutaka;
Nishishita, Kazuhisa;
Okamoto, Kuniaki;
Tsukuba, Takayuki

Publication type:

Article

Mini review-vanadium-induced neurotoxicity and possible targets.

Published in:

2020

By:

Jaiswal, Madhuri Ramji;
Kale, Pravin Popatrao

Publication type:

journal article

Tensile Overload Injures Human Alveolar Epithelial Cells through YAP/F-Actin/MAPK Signaling.

Published in:

Biomedicines, 2023, v. 11, n. 7, p. 1833, doi. 10.3390/biomedicines11071833

By:

He, Shan;
Liu, Ruihan;
Luo, Qing;
Song, Guanbin

Publication type:

Article

Schisandrin B attenuates pressure overload-induced cardiac remodeling in mice by inhibiting the MAPK signaling pathway.

Published in:

Experimental & Therapeutic Medicine, 2019, v. 18, n. 6, p. 4645, doi. 10.3892/etm.2019.8154

By:

Ai, Fen;
Guo, Qing-Hao;
Yu, Bo;
Li, Wei;
Guo, Xin;
Chen, Zhen

Publication type:

Article

Metformin protects against sevoflurane-induced neuronal apoptosis through the S1P1 and ERK signaling pathways.

Published in:

Experimental & Therapeutic Medicine, 2019, v. 17, n. 2, p. 1463

By:

Yue, Huiyu;
Hu, Bin;
Luo, Zhikai;
Liu, Mei

Publication type:

Article

Total flavonoids of Hedyotis diffusa Willd inhibit inflammatory responses in LPS-activated macrophages via suppression of the NF-B and MAPK signaling pathways.

Published in:

Experimental & Therapeutic Medicine, 2016, v. 11, n. 3, p. 1116, doi. 10.3892/etm.2015.2963

By:

YUNLONG CHEN;
YANYAN LIN;
YACHAN LI;
CANDONG LI

Publication type:

Article