Works matching DE "MEDIUM spiny neurons"

Results: 107

Optimized AAV capsids for basal ganglia diseases show robust potency and distribution.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60000-3

By:

Leib, D. E.;
Chen, Y. H.;
Tecedor, L.;
Ranum, P. T.;
Keiser, M. S.;
Lewandowski, B. C.;
Carrell, E. M.;
Arora, S.;
Huerta-Ocampo, I.;
Lai, D.;
Fluta, C. M.;
Cheng, C.;
Liu, X.;
Davidson, B. L.

Publication type:

Article

Dynamics of striatal action selection and reinforcement learning.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101747

By:

Lindsey, Jack W.;
Markowitz, Jeffrey;
Gillis, Winthrop F.;
Datta, Sandeep R.;
Litwin-Kumar, Ashok

Publication type:

Article

Radiation dosimetry of [11C]TZ1964B as determined by whole-body PET imaging of nonhuman primates.

Published in:

EJNMMI Research, 2025, v. 15, n. 1, p. 1, doi. 10.1186/s13550-025-01221-x

By:

Maiti, Baijayanta;
Goldman, Noah L.;
Hamdi, Mahdjoub;
Lenox-Krug, Jason;
Karimi, Morvarid;
Moerlein, Stephen M.;
Laforest, Richard;
Huang, Tianyu;
Tu, Zhude;
Perlmutter, Joel S.;
Norris, Scott A.

Publication type:

Article

Dopamine Receptor D3 Induces Transient, mTORC1-Dependent Autophagy That Becomes Persistent, AMPK-Mediated, and Neuroprotective in Experimental Models of Huntington's Disease.

Published in:

Cells (2073-4409), 2025, v. 14, n. 9, p. 652, doi. 10.3390/cells14090652

By:

Luis-Ravelo, Diego;
Fumagallo-Reading, Felipe;
Febles-Casquero, Alejandro;
Lopez-Fernandez, Jonathan;
Marcellino, Daniel J.;
Gonzalez-Hernandez, Tomas

Publication type:

Article

Dopamine lesions alter the striatal encoding of single-limb gait.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.92821

By:

Long Yang;
Singla, Deepak;
Wu, Alexander K.;
Cross, Katy A.;
Masmanidis, Sotiris C.

Publication type:

Article

Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.81830

By:

Petroccione, Maurice A.;
D'Brant, Lianna Y.;
Affinnih, Nurat;
Wehrle, Patrick H.;
Todd, Gabrielle C.;
Zahid, Shergil;
Chesbro, Haley E.;
Tschang, Ian L.;
Scimemi, Annalisa

Publication type:

Article

Retinoic acid-mediated homeostatic plasticity in the nucleus accumbens core contributes to incubation of cocaine craving.

Published in:

Psychopharmacology, 2024, v. 241, n. 10, p. 1983, doi. 10.1007/s00213-024-06612-x

By:

Wunsch, Amanda M.;
Hwang, Eun-Kyung;
Funke, Jonathan R.;
Baker, Raines;
Moutier, Alana;
Milovanovic, Mike;
Green, Thomas A.;
Wolf, Marina E.

Publication type:

Article

Corrigendum: Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum.

Published in:: Frontiers in Molecular Neuroscience, 2023, v. 16, p. 1, doi. 10.3389/fnmol.2023.1162275
Publication type:: Article

Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum.

Published in:

Frontiers in Molecular Neuroscience, 2023, v. 16, p. 1, doi. 10.3389/fnmol.2023.1107355

By:

Shu-yi Tan;
Jin-xiang Jiang;
Hui-xian Huang;
Xiu-ping Mo;
Jing-ru Feng;
Yu Chen;
Li Yang;
Cheng Long

Publication type:

Article

Role of 5-HT1A Receptor in Vilazodone-Mediated Suppression of L-DOPA-Induced Dyskinesia and Increased Responsiveness to Cortical Input in Striatal Medium Spiny Neurons in an Animal Model of Parkinson's Disease.

Published in:

Molecules, 2021, v. 26, n. 19, p. 5790, doi. 10.3390/molecules26195790

By:

Altwal, Feras;
Padovan-Neto, Fernando E.;
Ritger, Alexandra;
Steiner, Heinz;
West, Anthony R.

Publication type:

Article

Decreased FAK activity and focal adhesion dynamics impair proper neurite formation of medium spiny neurons in Huntington's disease.

Published in:

Acta Neuropathologica, 2022, v. 144, n. 3, p. 521, doi. 10.1007/s00401-022-02462-z

By:

Lee, Hae Nim;
Hyeon, Seung Jae;
Kim, Heejung;
Sim, Kyoung Mi;
Kim, Yunha;
Ju, Jeongmin;
Lee, Junghee;
Wang, Yingxiao;
Ryu, Hoon;
Seong, Jihye

Publication type:

Article

The difficulty to model Huntington's disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-85656-x

By:

Le Cann, Kim;
Foerster, Alec;
Rösseler, Corinna;
Erickson, Andelain;
Hautvast, Petra;
Giesselmann, Sebastian;
Pensold, Daniel;
Kurth, Ingo;
Rothermel, Markus;
Mattis, Virginia B.;
Zimmer-Bensch, Geraldine;
von Hörsten, Stephan;
Denecke, Bernd;
Clarner, Tim;
Meents, Jannis;
Lampert, Angelika

Publication type:

Article

IRL790 modulated striatal D1 neurons synaptic plasticity ameliorating levodopa-induced dyskinesia in mouse.

Published in:

Frontiers in Aging Neuroscience, 2024, p. 1, doi. 10.3389/fnagi.2024.1401991

By:

Xiaofei Wang;
Wangming Zhang

Publication type:

Article

Sex differences in membrane properties and cellular excitability of dopamine D1 receptor-expressing neurons within the shell of the nucleus accumbens of pre- and mid-adolescent mice.

Published in:

Biology of Sex Differences, 2024, v. 15, n. 1, p. 1, doi. 10.1186/s13293-024-00631-1

By:

Aziz, Heather C.;
Mangieri, Regina A.

Publication type:

Article

Metabotropic glutamate type 5 receptor binding availability during dextroamphetamine sensitization in mice and humans.

Published in:

Journal of Psychiatry & Neuroscience, 2021, v. 46, n. 1, p. E1, doi. 10.1503/jpn.190162

By:

Smart, Kelly;
Atsuko Nagano-Saito;
Milella, Michele S.;
Yae Sakae, Diana;
Favier, Mathieu;
Vigneault, Erika;
Louie, Leanne;
Hamilton, Alison;
Ferguson, Stephen S. G.;
Rosa-Neto, Pedro;
Narayanan, Sridar;
El Mestikawy, Salah;
Leyton, Marco;
Benkelfat, Chawki

Publication type:

Article

Segregation and Crosstalk of D1 Receptor-Mediated Activation of ERK in Striatal Medium Spiny Neurons upon Acute Administration of Psychostimulants.

Published in:

PLoS Computational Biology, 2014, v. 10, n. 1, p. 1, doi. 10.1371/journal.pcbi.1003445

By:

Gutierrez-Arenas, Omar;
Eriksson, Olivia;
Hellgren Kotaleski, Jeanette

Publication type:

Article

Optimal Balance of the Striatal Medium Spiny Neuron Network.

Published in:

PLoS Computational Biology, 2013, v. 9, n. 4, p. 1, doi. 10.1371/journal.pcbi.1002954

By:

Ponzi, Adam;
Wickens, Jeffery R.

Publication type:

Article

ABHD6 loss-of-function in mesoaccumbens postsynaptic but not presynaptic neurons prevents diet-induced obesity in male mice.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54819-5

By:

Lau, David;
Tobin, Stephanie;
Pribiag, Horia;
Nakajima, Shingo;
Fisette, Alexandre;
Matthys, Dominique;
Franco Flores, Anna Kristyna;
Peyot, Marie-Line;
Murthy Madiraju, S. R.;
Prentki, Marc;
Stellwagen, David;
Alquier, Thierry;
Fulton, Stephanie

Publication type:

Article

Single-cell transcriptomics unveils molecular signatures of neuronal vulnerability in a mouse model of prion disease that overlap with Alzheimer's disease.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54579-2

By:

Slota, Jessy A.;
Lamoureux, Lise;
Frost, Kathy L.;
Sajesh, Babu V.;
Booth, Stephanie A.

Publication type:

Article

NPAS4 supports cocaine-conditioned cues in rodents by controlling the cell type-specific activation balance in the nucleus accumbens.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50099-1

By:

Hughes, Brandon W.;
Huebschman, Jessica L.;
Tsvetkov, Evgeny;
Siemsen, Benjamin M.;
Snyder, Kirsten K.;
Akiki, Rose Marie;
Wood, Daniel J.;
Penrod, Rachel D.;
Scofield, Michael D.;
Berto, Stefano;
Taniguchi, Makoto;
Cowan, Christopher W.

Publication type:

Article

Editorial: ASICs: structure, function, and pharmacology, part II.

Published in:

Frontiers in Physiology, 2024, p. 1, doi. 10.3389/fphys.2024.1390239

By:

Soto, Enrique;
Askwith, Candice

Publication type:

Article

Levodopa-Induced Dyskinesia Is Related to Indirect Pathway Medium Spiny Neuron Excitotoxicity: A Hypothesis Based on an Unexpected Finding.

Published in:

Parkinson's Disease (20420080), 2016, p. 1, doi. 10.1155/2016/6461907

By:

Ivanova, Svetlana A.;
Loonen, Anton J. M.

Publication type:

Article

Early developmental changes in GABAA receptor expression in nucleus accumbens medium spiny neurons.

Published in:

Frontiers in Neuroscience, 2024, p. 1, doi. 10.3389/fnins.2024.1445162

By:

Wang, Ziyi;
Folorunso, Oluwarotimi O.;
Morris, Kiely;
Berretta, Sabina;
Engin, Elif

Publication type:

Article

Hyperactive mTORC1 in striatum dysregulates dopamine receptor expression and odor preference behavior.

Published in:

Frontiers in Neuroscience, 2024, p. 1, doi. 10.3389/fnins.2024.1461178

By:

Lin Chen;
Ryo Saito;
Shoko Noda-Narita;
Hidetoshi Kassai;
Atsu Aiba

Publication type:

Article

The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex.

Published in:

Frontiers in Neuroscience, 2024, p. 1, doi. 10.3389/fnins.2024.1403402

By:

Islam, K. Ushna S.;
Blaess, Sandra

Publication type:

Article

Preserved VPS13A distribution and expression in Huntington's disease: divergent mechanisms of action for similar movement disorders?

Published in:

Frontiers in Neuroscience, 2024, p. 1, doi. 10.3389/fnins.2024.1394478

By:

García-García, Esther;
Carreras-Caballé, Maria;
Coll-Manzano, Albert;
Ramón-Lainez, Alba;
Besa-Selva, Gisela;
Pérez-Navarro, Esther;
Malagelada, Cristina;
Alberch, Jordi;
Masana, Mercè;
Rodríguez, Manuel J.

Publication type:

Article

C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types.

Published in:

Frontiers in Neuroscience, 2024, p. 1, doi. 10.3389/fnins.2024.1258996

By:

Broce, Iris J.;
Sirkis, Daniel W.;
Nillo, Ryan M.;
Bonham, Luke W.;
Lee, Suzee E.;
Miller, Bruce L.;
Castruita, Patricia A.;
Sturm, Virginia E.;
Sugrue, Leo S.;
Desikan, Rahul S.;
Yokoyama, Jennifer S.

Publication type:

Article

Histamine H3 receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats.

Published in:

Canadian Journal of Physiology & Pharmacology, 2025, v. 103, n. 4, p. 134, doi. 10.1139/cjpp-2024-0240

By:

González-Sandoval, Carolina;
Godínez-Ramos, Isabel;
Arias-Montaño, José-Antonio;
Barral, Jaime

Publication type:

Article

Selective Expression of a Dominant-Negative Type la PKA Regulatory Subunit in Striatal Medium Spiny Neurons Impairs Gene Expression and Leads to Reduced Feeding and Locomotor Activity.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 14, p. 4896, doi. 10.1523/JNEUROSCI.3460-13.2014

By:

Linghai Yang;
Gilbert, Merle L.;
Ruimao Zheng;
McKnight, G. Stanley

Publication type:

Article

ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 47, p. 18381, doi. 10.1523/JNEUROSCI.1875-13.2013

By:

Lobo, Mary Kay;
Zaman, Samir;
Damez-Werno, Diane M.;
Koo, Ja Wook;
Bagot, Rosemary C.;
DiNieri, Jennifer A.;
Nugent, Alexandria;
Finkel, Eric;
Chaudhury, Dipesh;
Chandra, Ramesh;
Riberio, Efrain;
Rabkin, Jacqui;
Mouzon, Ezekiell;
Cachope, Roger;
Cheer, Joseph F.;
Han, Ming-Hu;
Dietz, David M.;
Self, David W.;
Hurd, Yasmin L.;
Vialou, Vincent

Publication type:

Article

Dopamine D2 Receptors Regulate Collateral Inhibition between Striatal Medium Spiny Neurons.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 35, p. 14075, doi. 10.1523/JNEUROSCI.0692-13.2013

By:

Lalchandani, Rupa R.;
van der Goes, Marie-Sophie;
Partridge, John G.;
Vicini, Stefano

Publication type:

Article

Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning.

Published in:

Journal of Neurochemistry, 2024, v. 168, n. 3, p. 312, doi. 10.1111/jnc.16063

By:

Deseyve, Catarina;
Domingues, Ana Verónica;
Carvalho, Tawan T. A.;
Armada, Gisela;
Correia, Raquel;
Vieitas‐Gaspar, Natacha;
Wezik, Marcelina;
Pinto, Luísa;
Sousa, Nuno;
Coimbra, Bárbara;
Rodrigues, Ana João;
Soares‐Cunha, Carina

Publication type:

Article

Dopamine transmission in the tail striatum: Regional variation and contribution of dopamine clearance mechanisms.

Published in:

Journal of Neurochemistry, 2024, v. 168, n. 3, p. 251, doi. 10.1111/jnc.16052

By:

Riley, Bronwyn;
Gould, Emily;
Lloyd, Jordan;
Hallum, Luke E.;
Vlajkovic, Srdjan;
Todd, Kathryn;
Freestone, Peter S.

Publication type:

Article

LRTM2 AND ITS POTENTIAL BINDING PARTNERS: INSIGHTS INTO THEIR ROLES IN STRIATAL MEDIUM SPINY NEURONS.

Published in:

International Journal of Neuropsychopharmacology, 2025, v. 28, p. i278, doi. 10.1093/ijnp/pyae059.492

By:

Misato Ichise;
Minoru Hatayama;
Jun Aruga

Publication type:

Article

A brief exposure to toluene vapor alters the intrinsic excitability of D2 medium spiny neurons in the rat ventral striatum.

Published in:

Frontiers in Neuroscience, 2023, p. 1, doi. 10.3389/fnins.2023.1235866

By:

Okas, Michael;
Kastner, Abigail;
Gioia, Dominic;
Woodward, John J.

Publication type:

Article

Cofilin linked to GluN2B subunits of NMDA receptors is required for behavioral sensitization by changing the dendritic spines of neurons in the caudate and putamen after repeated nicotine exposure.

Published in:

Behavioral & Brain Functions, 2024, v. 20, n. 1, p. 1, doi. 10.1186/s12993-024-00253-y

By:

Kim, Sunghyun;
Sohn, Sumin;
Choe, Eun Sang

Publication type:

Article

The effect of growth hormone on motor findings and dendrite morphology in an experimental Parkinson's disease model.

Published in:

Anatomical Science International, 2025, v. 100, n. 1, p. 79, doi. 10.1007/s12565-024-00790-6

By:

Kirazli, Ozlem;
Ozkan, Mazhar;
Verimli, Ural;
Gulhan, Rezzan;
Arman, Ahmet;
Sehirli, Umit Suleyman

Publication type:

Article

An Increase of Excitatory-to-Inhibitory Synaptic Balance in the Contralateral Cortico-Striatal Pathway Underlies Improved Stroke Recovery in BDNF Val66Met SNP Mice.

Published in:

Neurorehabilitation & Neural Repair, 2019, v. 33, n. 12, p. 989, doi. 10.1177/1545968319872997

By:

Qin, Luye;
Actor-Engel, Hannah S.;
Woo, Moon-Sook;
Shakil, Faariah;
Chen, Yi-Wen;
Cho, Sunghee;
Aoki, Chiye

Publication type:

Article

HIV-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum.

Published in:

PLoS ONE, 2017, v. 12, n. 11, p. 1, doi. 10.1371/journal.pone.0188404

By:

Javadi-Paydar, Mehrak;
Jr.Roscoe, Robert F.;
Denton, Adam R.;
Mactutus, Charles F.;
Booze, Rosemarie M.

Publication type:

Article

Internal Clocks, mGluR7 and Microtubules: A Primer for the Molecular Encoding of Target Durations in Cerebellar Purkinje Cells and Striatal Medium Spiny Neurons.

Published in:

Frontiers in Molecular Neuroscience, 2020, v. 12, p. 1, doi. 10.3389/fnmol.2019.00321

By:

Yousefzadeh, S. Aryana;
Hesslow, Germund;
Shumyatsky, Gleb P.;
Meck, Warren H.

Publication type:

Article

Restoring Compromised Cl- in D2 Neurons of a Huntington's Disease Mouse Model Rescues Motor Disability.

Published in:

Journal of Neuroscience, 2024, v. 44, n. 50, p. 1, doi. 10.1523/JNEUROSCI.0215-24.2024

By:

Serranilla, Melissa;
Pressey, Jessica C.;
Woodin, Melanie A.

Publication type:

Article

Differential Activation States of Direct Pathway Striatal Output Neurons during L-DOPA-Induced Dyskinesia Development.

Published in:

Journal of Neuroscience, 2024, v. 44, n. 26, p. 1, doi. 10.1523/JNEUROSCI.0050-24.2024

By:

Figge, David A.;
de Amaral Oliveira, Henrique;
Crim, Jack;
Cowell, Rita M.;
Standaert, David G.;
Eskow Jaunarajs, Karen L.

Publication type:

Article

Circuit-Wide Gene Network Analysis Reveals Sex-Specific Roles for Phosphodiesterase 1b in Cocaine Addiction.

Published in:

Journal of Neuroscience, 2024, v. 44, n. 23, p. 1, doi. 10.1523/JNEUROSCI.1327-23.2024

By:

Teague, Collin D.;
Markovic, Tamara;
Xianxiao Zhou;
Martinez-Rivera, Freddyson J.;
Minier-Toribio, Angelica;
Zinsmaier, Alexander;
Pulido, Nathalia V.;
Schmidt, Kyra H.;
Lucerne, Kelsey E.;
Godino, Arthur;
van der Zee, Yentl Y.;
Ramakrishnan, Aarthi;
Futamura, Rita;
Browne, Caleb J.;
Holt, Leanne M.;
Yun Young Yim;
Azizian, Corrine H.;
Walker, Deena M.;
Li Shen;
Yan Dong

Publication type:

Article

Multimodal Interrogation of Ventral Pallidum Projections Reveals Projection-Specific Signatures and Effects on Cocaine Reward.

Published in:

Journal of Neuroscience, 2024, v. 44, n. 18, p. 1, doi. 10.1523/JNEUROSCI.1469-23.2024

By:

Bernat, Nimrod;
Campbell, Rianne R.;
Hyungwoo Nam;
Basu, Mahashweta;
Odesser, Tal;
Elyasaf, Gal;
Engeln, Michel;
Chandra, Ramesh;
Golden, Shana;
Ament, Seth;
Lobo, Mary Kay;
Kupchik, Yonatan M.

Publication type:

Article

Tmod2 Is a Regulator of Cocaine Responses through Control of Striatal and Cortical Excitability and Drug-Induced Plasticity.

Published in:

Journal of Neuroscience, 2024, v. 44, n. 18, p. 1, doi. 10.1523/JNEUROSCI.1389-23.2024

By:

Mitra, Arojit;
Deats, Sean P.;
Dickson, Price E.;
Jiuhe Zhu;
Gardin, Justin;
Nieman, Brian J.;
Henkelman, R. Mark;
Nien-Pei Tsai;
Chesler, Elissa J.;
Zhong-Wei Zhang;
Kumar, Vivek

Publication type:

Article

Ventral Subiculum Inputs to Nucleus Accumbens Medial Shell Preferentially Innervate D2R Medium Spiny Neurons and Contain Calcium Permeable AMPARs.

Published in:

Journal of Neuroscience, 2023, v. 43, n. 7, p. 1166, doi. 10.1523/JNEUROSCI.1907-22.2022

By:

Boxer, Emma E.;
Kim, JungMin;
Dunn, Brett;
Aoto, Jason

Publication type:

Article

Early TNF-Dependent Regulation of Excitatory and Inhibitory Synapses on Striatal Direct Pathway Medium Spiny Neurons in the YAC128 Mouse Model of Huntington’s Disease.

Published in:

Journal of Neuroscience, 2023, v. 43, n. 4, p. 672, doi. 10.1523/JNEUROSCI.1655-22.2022

By:

Chambon, Julien;
Komal, Pragya;
Lewitus, Gil M.;
Kemp, Gina M.;
Valade, Simone;
Adaïdi, Houaria;
Bistami, Noura Al;
Stellwagen, David

Publication type:

Article

Preserved Motility after Neonatal Dopaminergic Lesion Relates to Hyperexcitability of Direct Pathway Medium Spiny Neurons.

Published in:

Journal of Neuroscience, 2022, v. 42, n. 47, p. 8767, doi. 10.1523/JNEUROSCI.1992-21.2022

By:

Keifman, Ettel;
Coll, Camila;
Tubert, Cecilia;
Paz, Rodrigo M.;
Belforte, Juan E.;
Murer, Mario G.;
Braz, Barbara Y.

Publication type:

Article

BCL11B‐Related Dystonia: Further Evidence of an Emerging Cause of Childhood‐Onset Generalized Dystonia.

Published in:

Movement Disorders Clinical Practice, 2024, v. 11, n. 7, p. 897, doi. 10.1002/mdc3.14084

By:

Garone, Giacomo;
Capuano, Alessandro;
Amodio, Donato;
Nicita, Francesco;
Travaglini, Lorena;
Graziola, Federica;
De Benedictis, Alessandro;
Frascarelli, Flaminia;
Parisi, Pasquale;
Pizzi, Simone;
Tartaglia, Marco;
Marras, Carlo Efisio;
Niceta, Marcello

Publication type:

Article

Cell type specification and diversity in subpallial organoids.

Published in:

Frontiers in Genetics, 2024, p. 1, doi. 10.3389/fgene.2024.1440583

By:

Pavon, Narciso;
Yubing Sun;
ChangHui Pak

Publication type:

Article