Works matching DE "LIGAND-gated ion channels"

Results: 317

Reduction of the Ca2+ permeability of ligand-gated ion channels as a strategy against excitotoxicity.

Published in:

Frontiers in Cellular Neuroscience, 2025, p. 1, doi. 10.3389/fncel.2025.1617006

By:

D'Andrea, Tiziano;
Fucile, Sergio

Publication type:

Article

De novo transcriptome sequencing of the northern fowl mite, Ornithonyssus sylviarum, shed light on parasitiform poultry mites evolution and its chemoreceptor repertoires.

Published in:

Parasitology Research, 2022, v. 121, n. 2, p. 521, doi. 10.1007/s00436-022-07432-8

By:

Bhowmick, Biswajit;
Chen, Huaqing;
Lozano-Fernandez, Jesus;
Vizueta, Joel;
Ignell, Rickard;
Han, Qian

Publication type:

Article

Synthetic Methods for the Preparation of Conformationally Restricted Analogues of Nicotine.

Published in:

Molecules, 2021, v. 26, n. 24, p. 7544, doi. 10.3390/molecules26247544

By:

Panda, Biswajit;
Albano, Gianluigi

Publication type:

Article

Pursuing High-Resolution Structures of Nicotinic Acetylcholine Receptors: Lessons Learned from Five Decades.

Published in:

Molecules, 2021, v. 26, n. 19, p. 5753, doi. 10.3390/molecules26195753

By:

Delgado-Vélez, Manuel;
Quesada, Orestes;
Villalobos-Santos, Juan C.;
Maldonado-Hernández, Rafael;
Asmar-Rovira, Guillermo;
Stevens, Raymond C.;
Lasalde-Dominicci, José Antonio

Publication type:

Article

Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease.

Published in:

Molecules, 2020, v. 25, n. 21, p. 5186, doi. 10.3390/molecules25215186

By:

Silvestro, Serena;
Schepici, Giovanni;
Bramanti, Placido;
Mazzon, Emanuela;
Cardona, Francesca

Publication type:

Article

Minimal Structural Changes Determine Full and Partial Nicotinic Receptor Agonist Activity for Nicotine Analogues.

Published in:

Molecules, 2019, v. 24, n. 15, p. 2684, doi. 10.3390/molecules24152684

By:

Gonzalez-Gutierrez, Juan Pablo;
Hodar, Martin;
Viscarra, Franco;
Paillali, Pablo;
Guerra-Díaz, Nicolás;
Pessoa-Mahana, Hernán;
Hernández-Morantes, Juan José;
Pérez-Sánchez, Horacio;
Bermúdez, Isabel;
Reyes-Parada, Miguel;
Iturriaga-Vásquez, Patricio

Publication type:

Article

Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06223-4

By:

Iguchi, Yoshio;
Fukabori, Ryoji;
Kato, Shigeki;
Takahashi, Kazumi;
Eifuku, Satoshi;
Maejima, Yuko;
Shimomura, Kenju;
Mizuma, Hiroshi;
Mawatari, Aya;
Doi, Hisashi;
Cui, Yilong;
Onoe, Hirotaka;
Hikishima, Keigo;
Osanai, Makoto;
Nishijo, Takuma;
Momiyama, Toshihiko;
Benton, Richard;
Kobayashi, Kazuto

Publication type:

Article

Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.81613

By:

Martí-Solans, Josep;
Børve, Aina;
Bump, Paul;
Hejnol, Andreas;
Lynagh, Timothy

Publication type:

Article

Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.79148

By:

Ivica, Josip;
Hongtao Zhu;
Lape, Remigijus;
Gouaux, Eric;
Sivilotti, Lucia G.

Publication type:

Article

Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.74322

By:

Korona, Dagmara;
Dirnberger, Benedict;
Giachello, Carlo N. G.;
Queiroz, Rayner M. L.;
Popovic, Rebeka;
Müller, Karin H.;
Minde, David-Paul;
Deery, Michael J.;
Johnson, Glynnis;
Firth, Lucy C.;
Earley, Fergus G.;
Russell, Steven;
Lilley, Kathryn S.

Publication type:

Article

P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian _-cell failure.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.75132

By:

Marcheva, Biliana;
Weidemann, Benjamin J.;
Akihiko Taguchi;
Perelis, Mark;
Ramsey, Kathryn Moynihan;
Newman, Marsha V.;
Yumiko Kobayashi;
Chiaki Omura;
Fox, Jocelyn E. Manning;
Haopeng Lin;
Macdonald, Patrick E.;
Bass, Joseph

Publication type:

Article

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.

Published in:

Scientific Reports, 2015, p. 8558, doi. 10.1038/srep08558

By:

Lynagh, Timothy;
Beech, Robin N.;
Lalande, Maryline J.;
Keller, Kevin;
Cromer, Brett A.;
Wolstenholme, Adrian J.;
Laube, Bodo

Publication type:

Article

Combined Neurotoxic Effects of Commercial Formulations of Pyrethroid (Deltamethrin) and Neonicotinoid (Imidacloprid) Pesticides on Adult Zebrafish (Danio rerio): Behavioral, Molecular, and Histopathological Analysis.

Published in:

Life (2075-1729), 2025, v. 15, n. 4, p. 538, doi. 10.3390/life15040538

By:

Petrovici, Adriana;
Savuța, Gheorghe;
Lucini, Carla;
Robea, Madalina-Andreea;
Solcan, Carmen

Publication type:

Article

Purinergic signaling: Diverse effects and therapeutic potential in cancer.

Published in:

Frontiers in Oncology, 2023, v. 13, p. 1, doi. 10.3389/fonc.2023.1058371

By:

Kaur, Jasmeet;
Dora, Sanchit

Publication type:

Article

Pyroptosis for osteoarthritis treatment: insights into cellular and molecular interactions inflammatory.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1556990

By:

Lin, Minghui;
Zhang, Cunxin;
Li, Haiming;
Li, Kang;
Gou, Shuao;
He, Xiao;
Lv, Chaoliang;
Gao, Kai

Publication type:

Article

Study, by use of coarse-grained models, of the functionally crucial residues and allosteric pathway of anesthetic regulation of the Gloeobacter violaceus ligand-gated ion channel.

Published in:

European Biophysics Journal, 2014, v. 43, n. 12, p. 623, doi. 10.1007/s00249-014-0992-7

By:

Li, Xing;
Xie, Fang;
Zhang, Jing;
Su, Ji

Publication type:

Article

Trapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor channels.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54538-x

By:

Gangwar, Shanti Pal;
Yelshanskaya, Maria V.;
Aktolun, Muhammed;
Yen, Laura Y.;
Newton, Thomas P.;
Strømgaard, Kristian;
Kurnikova, Maria G.;
Sobolevsky, Alexander I.

Publication type:

Article

Symmetry-adapted Markov state models of closing, opening, and desensitizing in α 7 nicotinic acetylcholine receptors.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53170-z

By:

Zhuang, Yuxuan;
Howard, Rebecca J.;
Lindahl, Erik

Publication type:

Article

Structural insights into the human P2X1 receptor and ligand interactions.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52776-7

By:

Bennetts, Felix M.;
Venugopal, Hariprasad;
Glukhova, Alisa;
Mobbs, Jesse I.;
Ventura, Sabatino;
Thal, David M.

Publication type:

Article

Finely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-51815-7

By:

Lin, Yi-Yu;
Lu, Yan;
Li, Chun-Yun;
Ma, Xue-Fei;
Shao, Miao-Qing;
Gao, Yu-Hao;
Zhang, Yu-Qing;
Jiang, Hai-Ning;
Liu, Yan;
Yang, Yang;
Huang, Li-Dong;
Cao, Peng;
Wang, Heng-Shan;
Wang, Jin;
Yu, Ye

Publication type:

Article

Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-47370-w

By:

Bharambe, Nikhil;
Li, Zhuowen;
Seiferth, David;
Balakrishna, Asha Manikkoth;
Biggin, Philip C.;
Basak, Sandip

Publication type:

Article

Anesthetic Potential of Herbal Plants.

Published in:

International Journal of Pharmacy & Life Sciences, 2020, v. 11, n. 7, p. 69

By:

Sontakke, Rupali;
Singhal, Rohit;
Jain, Neetesh Kumar

Publication type:

Article

Anesthetic Potential of Herbal Plants.

Published in:

International Journal of Pharmacy & Life Sciences, 2020, v. 11, n. 6, p. 69

By:

Sontakke, Rupali;
Singhal, Rohit;
Jain, Neetesh Kumar

Publication type:

Article

A Study on the Effect of Putrescine on MES and Chemical Induced Convulsions in Mice.

Published in:

International Journal of Pharmacy & Life Sciences, 2015, v. 6, n. 6, p. 4573

By:

Khan, Firdos;
Kukde, Deepshikha;
Zaveri, Purvi;
Mohsina, Sayyed;
Sharma, Vimukta

Publication type:

Article

Physiology of Non-Voltage-Gated Ion Channels.

Published in:

American Journal of Biomedical Sciences, 2021, v. 13, n. 4, p. 192, doi. 10.5099/aj210400192

By:

Toghan, Rana;
Abdel-Sater, Khaled A.

Publication type:

Article

L-3,3’,5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors.

Published in:

PLoS ONE, 2019, v. 14, n. 10, p. 1, doi. 10.1371/journal.pone.0223272

By:

Moffett, Steven X.;
Klein, Eric A.;
Brannigan, Grace;
Martin, Joseph V.

Publication type:

Article

Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives.

Published in:

PLoS ONE, 2019, v. 14, n. 8, p. 1, doi. 10.1371/journal.pone.0221132

By:

Qneibi, Mohammad;
Hamed, Othman;
Natsheh, Abdel-Razzak;
Fares, Oswa;
Jaradat, Nidal;
Emwas, Nour;
AbuHasan, Qais;
Al-Kerm, Rana;
Al-Kerm, Rola

Publication type:

Article

遗传性癫癎与药物精准治疗的研究进展.

Published in:

Chinese Journal of Contemporary Pediatrics, 2017, v. 19, n. 10, p. 1118, doi. 10.7499/j.issn.1008-8830.2017.10.017

By:

吕格;
综述;
韩蕴丽;
审校

Publication type:

Article

A narrative review of autophagy in migraine.

Published in:

2025

By:

Huang, Yanan;
Li, Hongyan;
Yu, Qijun;
Pan, Yonghui

Publication type:

Literature Review

Bee venom acupuncture therapy ameliorates neuroinflammatory alterations in a pilocarpine-induced epilepticus model.

Published in:

Metabolic Brain Disease, 2021, v. 36, n. 7, p. 2047, doi. 10.1007/s11011-021-00766-9

By:

Abd El-Hameed, Abeer Mohamed;
Abuelsaad, Abdelaziz S. A.;
Khalil, Abdelwahab

Publication type:

Article

Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids.

Published in:

Neurochemical Research, 2016, v. 41, n. 3, p. 476, doi. 10.1007/s11064-015-1619-9

By:

Johnston, Graham

Publication type:

Article

Non-competitive Inhibition of Nicotinic Acetylcholine Receptors by Ladybird Beetle Alkaloids.

Published in:

Neurochemical Research, 2015, v. 40, n. 10, p. 2078, doi. 10.1007/s11064-014-1466-0

By:

Leong, Ron;
Xing, Hong;
Braekman, Jean-Claude;
Kem, William

Publication type:

Article

Analysis of γ-Aminobutyric Acid (GABA) Type A Receptor Subtypes Using Isosteric and Allosteric Ligands.

Published in:

Neurochemical Research, 2014, v. 39, n. 10, p. 1924, doi. 10.1007/s11064-014-1382-3

By:

Olsen, Richard

Publication type:

Article

Crystallization scale purification of α7 nicotinic acetylcholine receptor from mammalian cells using a BacMam expression system.

Published in:

Acta Pharmacologica Sinica, 2015, v. 36, n. 8, p. 1013, doi. 10.1038/aps.2015.34

By:

Cheng, Hao;
Fan, Chen;
Zhang, Si-wei;
Wu, Zhong-shan;
Cui, Zhi-cheng;
Melcher, Karsten;
Zhang, Cheng-hai;
Jiang, Yi;
Cong, Yao;
Xu, H Eric

Publication type:

Article

Nicotinic acetylcholine receptor modulator insecticides act on diverse receptor subtypes with distinct subunit compositions.

Published in:

PLoS Genetics, 2022, v. 18, n. 1, p. 1, doi. 10.1371/journal.pgen.1009920

By:

Lu, Wanjun;
Liu, Zhihan;
Fan, Xinyu;
Zhang, Xinzhong;
Qiao, Xiaomu;
Huang, Jia

Publication type:

Article

A simplified protocol for the automated production of 2‐[18F]fluoro‐3‐[2‐((S)‐3‐pyrrolinyl)methoxy]pyridine ([18F]nifene) on an IBA Synthera® module.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2024, v. 67, n. 1, p. 31, doi. 10.1002/jlcr.4071

By:

Bhuiyan, Mohammed;
Souris, Jeffrey;
Kucharski, Anna;
Freifelder, Richard;
Mukherjee, Jogeshwar;
Chen, Chin‐Tu

Publication type:

Article

Ensemble-Based Virtual Screening Led to the Discovery of Novel Lead Molecules as Potential NMBAs.

Published in:

Molecules, 2024, v. 29, n. 9, p. 1955, doi. 10.3390/molecules29091955

By:

Zhang, Yi;
Ge, Gonghui;
Xu, Xiangyang;
Wu, Jinhui

Publication type:

Article

Pharmacophore Mapping Combined with dbCICA Reveal New Structural Features for the Development of Novel Ligands Targeting α4β2 and α7 Nicotinic Acetylcholine Receptors.

Published in:

Molecules, 2022, v. 27, n. 23, p. 8236, doi. 10.3390/molecules27238236

By:

Batista, Victor S.;
Gonçalves, Adriano Marques;
Nascimento-Júnior, Nailton M.

Publication type:

Article

From cis -Lobeline to trans -Lobeline: Study on the Pharmacodynamics and Isomerization Factors.

Published in:

Molecules, 2022, v. 27, n. 19, p. 6253, doi. 10.3390/molecules27196253

By:

Xu, Huan-Hua;
Yang, Liang;
Tang, Ming-Xia;
Ye, An-Ping;
Tu, Bo-Dan;
Jiang, Zhen-Hong;
Yi, Jian-Feng

Publication type:

Article

Involvement of TRPV1 channel in the etiology of epilepsy.

Published in:

Journal of Cellular Neuroscience & Oxidative Stress, 2022, v. 14, p. 15

By:

ERBAKAN, Kaan

Publication type:

Article

Autoimmunity to glutamate receptor channels.

Published in:

Neurology & Clinical Neuroscience, 2024, v. 12, n. 3, p. 129, doi. 10.1111/ncn3.12650

By:

Kawachi, Izumi

Publication type:

Article

Movement Disorders in GRIA2‐Related Disorder – Expanding the Genetic Spectrum of Developmental Dyskinetic Encephalopathy.

Published in:

Movement Disorders Clinical Practice, 2023, v. 10, n. 8, p. 1222, doi. 10.1002/mdc3.13797

By:

Vijayaraghavan, Asish;
Urulangodi, Madhusoodanan;
Ajit Valaparambil, Karthika;
Sundaram, Soumya;
Krishnan, Syam

Publication type:

Article

Channels of Evolution: Unveiling Evolutionary Patterns in Diatom Ca 2+ Signalling.

Published in:

Plants (2223-7747), 2024, v. 13, n. 9, p. 1207, doi. 10.3390/plants13091207

By:

Murphy, Eleanor A.;
Kleiner, Friedrich H.;
Helliwell, Katherine E.;
Wheeler, Glen L.

Publication type:

Article

TPC1-Type Channels in Physcomitrium patens : Interaction between EF-Hands and Ca 2+.

Published in:

Plants (2223-7747), 2022, v. 11, n. 24, p. 3527, doi. 10.3390/plants11243527

By:

Mérida-Quesada, Franko;
Vergara-Valladares, Fernando;
Rubio-Meléndez, María Eugenia;
Hernández-Rojas, Naomí;
González-González, Angélica;
Michard, Erwan;
Navarro-Retamal, Carlos;
Dreyer, Ingo

Publication type:

Article

allosteric gating mechanism of the MthK channel.

Published in:

National Science Review, 2022, v. 9, n. 8, p. 1, doi. 10.1093/nsr/nwac072

By:

Guan, Fenghui;
Li, Tianyu;
Dong, Wei;
Guo, Rui;
Chai, Hao;
Chen, Zhiqiu;
Ren, Zhong;
Li, Yang;
Ye, Sheng

Publication type:

Article

Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.86016

By:

Bergh, Cathrine;
Rovšnik, Urška;
Howard, Rebecca;
Lindahl, Erik

Publication type:

Article

Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.86029

By:

De Gieter, Steven;
Gallagher, Casey I.;
Wijckmans, Eveline;
Pasini, Diletta;
Ulens, Chris;
Efremov, Rouslan G.

Publication type:

Article

Genetic polymorphisms in external apical root resorption and orthodontic tooth movements: A systematic review.

Published in:

Korean Journal of Orthodontics, 2024, v. 54, n. 5, p. 284, doi. 10.4041/kjod24.030

By:

Cabral de Ávila Andrade, Ana Luiza;
de Almeida Pinto, Yasmin Dias;
Barros Maia, Bernardo Emerenciano;
Dias Corrêa, Joice;
de Azevedo Miranda, Diogo;
Ricardo Manzi, Flávio;
de Abreu Lima, Izabella Lucas

Publication type:

Article

Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.

Published in:

Scientific Reports, 2015, p. 13833, doi. 10.1038/srep13833

By:

Chen, Qiang;
Kinde, Monica N.;
Arjunan, Palaniappa;
Wells, Marta M.;
Cohen, Aina E.;
Xu, Yan;
Tang, Pei

Publication type:

Article

Editorial: The GABAA receptor: a target of pharmacologically active molecules.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1440937

By:

Ernst, Margot;
Wei Lu;
Mattei, César

Publication type:

Article