Works matching DE "LETHAL mutations"

Results: 375

Simultaneous Disruption of Both Polyubiquitin Genes Affects Proteasome Function and Decreases Cellular Proliferation.

Published in:

Cell Biochemistry & Biophysics, 2020, v. 78, n. 3, p. 321, doi. 10.1007/s12013-020-00933-2

By:

Park, Chul-Woo;
Bae, Jin-Sil;
Ryu, Kwon-Yul

Publication type:

Article

The V <sub> f </sub> gene for scab resistance in apple is linked to sub-lethal genes.

Published in:

Euphytica, 2006, v. 151, n. 1, p. 123, doi. 10.1007/s10681-005-9082-3

By:

Gao, Z. S.;
van de Weg, W. E.

Publication type:

Article

Fast and efficient generation of a full-length balancer chromosome by a single Cre/loxP recombination event.

Published in:

Mammalian Genome, 2022, v. 33, n. 1, p. 169, doi. 10.1007/s00335-021-09897-x

By:

Ju, Cunxiang;
Zhang, Mingkun;
Guan, Min;
Li, Song;
Zhang, Yuxi;
Zhao, Jing;
Gao, Xiang

Publication type:

Article

Screening of 383 unrelated patients affected with Menkes disease and finding of 57 gross deletions in ATP7A(Communicated by Henrik Dahl).

Published in:

Human Mutation, 2003, v. 22, n. 6, p. 457, doi. 10.1002/humu.10287

By:

Zeynep Tümer;
Lisbeth Birk Møller;
Nina Horn

Publication type:

Article

Structural Bases for the Fitness Cost of the Antibiotic-Resistance and Lethal Mutations at Position 1408 of 16S rRNA.

Published in:

Molecules, 2020, v. 25, n. 1, p. 159, doi. 10.3390/molecules25010159

By:

Kondo, Jiro;
Koganei, Mai;
Vicens, Quentin

Publication type:

Article

Lethal Territorial Aggression in a White-Handed Gibbon.

Published in:

American Journal of Primatology, 1993, v. 31, n. 4, p. 311, doi. 10.1002/ajp.1350310407

By:

Palombit, Ryne A.

Publication type:

Article

Use of haplotypes to identify regions harbouring lethal recessive variants in pigs.

Published in:

Genetics Selection Evolution, 2017, v. 49, p. 1, doi. 10.1186/s12711-017-0332-3

By:

Howard, David M.;
Pong-Wong, Ricardo;
Knap, Pieter W.;
Woolliams, John A.

Publication type:

Article

NSF4SL: negative-sample-free contrastive learning for ranking synthetic lethal partner genes in human cancers.

Published in:

Bioinformatics, 2022, v. 38, p. ii13, doi. 10.1093/bioinformatics/btac462

By:

Wang, Shike;
Feng, Yimiao;
Liu, Xin;
Liu, Yong;
Wu, Min;
Zheng, Jie

Publication type:

Article

Fast-SL: an efficient algorithm to identify synthetic lethal sets in metabolic networks.

Published in:

Bioinformatics, 2015, v. 31, n. 20, p. 3299, doi. 10.1093/bioinformatics/btv352

By:

Pratapa, Aditya;
Balachandran, Shankar;
Raman, Karthik

Publication type:

Article

A method for detecting and identifying the lethal environmental factor on a dominant macrobenthos and its application to Lake Shinji, Japan.

Published in:

Marine Biology, 1990, v. 107, n. 3, p. 479, doi. 10.1007/BF01313432

By:

Yamamuro, M.;
Nakamura, M.;
Nishimura, M.

Publication type:

Article

Non-coding RNA: Structure and function for lncRNAs.

Published in:

Nature Reviews Genetics, 2013, v. 14, n. 9, p. 598, doi. 10.1038/nrg3561

By:

Flintoft, Louisa

Publication type:

Article

Structural localization of pathogenic mutations in the central nucleotide-binding domain (NBD) of nucleotide-binding oligomerization domain-2 (NOD2) protein and their inference in inflammatory disorders.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2021, v. 40, n. 12, p. 1198, doi. 10.1080/15257770.2021.1986719

By:

P., Raghuraman;
Ramireddy, Sriroopreddy;
Chakraborty, Sulagno;
Mukherjee, Sayani;
J., Sreeshma;
C., Sudandiradoss

Publication type:

Article

Mosquito control: A review on the past, present and future strategies.

Published in:

Journal of the National Science Foundation of Sri Lanka, 2022, v. 50, p. 277, doi. 10.4038/jnsfsr.v50i0.11244

By:

Karunaratne, S. H. P. P.;
Surendran, S. N.

Publication type:

Article

Ingestion of antagomir or agomir of microRNA results in physiological changes and high mortality in Frankliniella occidentalis.

Published in:

Entomologia Generalis, 2023, v. 43, n. 1, p. 109, doi. 10.1127/entomologia/2023/1758

By:

Sung Jin Kim;
Jong Hyeok Lee;
Ju Hyeon Kim;
Yoon, Kyungjae Andrew;
Si Hyeock Lee

Publication type:

Article

RNA interference-mediated silencing of ecdysone receptor (EcR) gene causes lethal and sublethal effects on melon aphid, Aphis gossypii.

Published in:

Entomologia Generalis, 2022, v. 42, n. 5, p. 791, doi. 10.1127/entomologia/2022/1434

By:

Ullah, Farman;
Gul, Hina;
Tariq, Kaleem;
Hafeez, Muhammad;
Desneux, Nicolas;
Xiwu Gao;
Dunlun Song

Publication type:

Article

Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.71154

By:

Dicks, Amanda R.;
Maksaev, Grigory I.;
Harissa, Zainab;
Savadipour, Alireza;
Tang, Ruhang;
Steward, Nancy;
Liedtke, Wolfgang;
Nichols, Colin G.;
Chia-Lung Wu;
Guilak, Farshid

Publication type:

Article

Epistatic selection on a selfish Segregation Distorter supergene - drive, recombination, and genetic load.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.78981

By:

Navarro-Dominguez, Beatriz;
Ching-Ho Chang;
Brand, Cara L.;
Muirhead, Christina A.;
Presgraves, Daven C.;
Larracuente, Amanda M.

Publication type:

Article

Determinants of the lethality of climate-related disasters in the Caribbean Community (CARICOM): a cross-country analysis.

Published in:

Scientific Reports, 2015, p. 11972, doi. 10.1038/srep11972

By:

Andrewin, Aisha N.;
Rodriguez-Llanes, Jose M.;
Guha-Sapir, Debarati

Publication type:

Article

Corrigendum: Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations.

Published in:

Scientific Reports, 2015, p. 11167, doi. 10.1038/srep11167

By:

Sardanyés, Josep;
Simó, Carles;
Martínez, Regina;
Solé, Ricard V.;
Elena, Santiago F.

Publication type:

Article

Novel approaches for generating and manipulating diploid strains of Chlamydomonas reinhardtii.

Published in:

Algae, 2019, v. 34, n. 1, p. 35, doi. 10.4490/algae.2019.34.2.25

By:

Kariyawasam, Thamali;
Sunjoo Joo;
Goodenough, Ursula;
Jae-Hyeok Lee

Publication type:

Article

New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development.

Published in:

Life (2075-1729), 2022, v. 12, n. 8, p. 1285, doi. 10.3390/life12081285

By:

Aizezi, Yalikunjiang;
Xie, Yinpeng;
Guo, Hongwei;
Jiang, Kai

Publication type:

Article

Synthetic lethality in cancer: a protocol for scoping review of gene interactions from synthetic lethal screens and functional studies.

Published in:

Systematic Reviews, 2025, v. 14, n. 1, p. 1, doi. 10.1186/s13643-025-02814-2

By:

Chauhan, Raashi;
Damerla, Rama Rao;
Dhyani, Vijay Shree

Publication type:

Article

QTL mapping of inbreeding-related cold sensitivity and conditional lethality in Drosophila melanogaster.

Published in:

Journal of Evolutionary Biology, 2008, v. 21, n. 5, p. 1236, doi. 10.1111/j.1420-9101.2008.01572.x

By:

Vermeulen, C. J.;
Bijlsma, R.;
Loeschcke, V.

Publication type:

Article

Depigmented hypertrichosis following Blaschko’s lines associated with cerebral and ocular malformations: a new neurocutaneous, autosomal lethal gene syndrome from the group of epidermal naevus syndromes?

Published in:

British Journal of Dermatology, 2000, v. 142, n. 6, p. 1204, doi. 10.1046/j.1365-2133.2000.03551.x

By:

Schauder, S.;
Hanefeld, F.;
Noske, U.M.;
Zoll, B.

Publication type:

Article

The ability to induce heat shock transcription factor-regulated genes in response to lethal heat stress is associated with thermotolerance in tomato cultivars.

Published in:

Frontiers in Plant Science, 2023, p. 1, doi. 10.3389/fpls.2023.1269964

By:

Junya Mizoi;
Daisuke Todaka;
Tomohiro Imatomi;
Satoshi Kidokoro;
Tetsuya Sakurai;
Ken-Suke Kodaira;
Hidehito Takayama;
Kazuo Shinozaki;
Kazuko Yamaguchi-Shinozaki

Publication type:

Article

Novel Mutations Within Collagen Alpha1(I) and Alpha2(I) Ligand-Binding Sites, Broadening the Spectrum of Osteogenesis Imperfecta – Current Insights Into Collagen Type I Lethal Regions.

Published in:

Frontiers in Genetics, 2021, v. 12, p. 1, doi. 10.3389/fgene.2021.692978

By:

Sałacińska, Kinga;
Pinkier, Iwona;
Rutkowska, Lena;
Chlebna-Sokół, Danuta;
Jakubowska-Pietkiewicz, Elżbieta;
Michałus, Izabela;
Kępczyński, Łukasz;
Salachna, Dominik;
Jamsheer, Aleksander;
Bukowska-Olech, Ewelina;
Jaszczuk, Ilona;
Jakubowski, Lucjusz;
Gach, Agnieszka

Publication type:

Article

Involvement of DNA Repair Genes and System of Radiation-Induced Activation of Transposons in Formation of Transgenerational Effects.

Published in:

Frontiers in Genetics, 2020, v. 11, p. N.PAG, doi. 10.3389/fgene.2020.596947

By:

Yushkova, Elena

Publication type:

Article

A Newly Observed Mutation of the ABCA3 Gene Causing Lethal Respiratory Failure of a Full-Term Newborn: A Case Report.

Published in:

Frontiers in Genetics, 2020, v. 11, p. N.PAG, doi. 10.3389/fgene.2020.568303

By:

Jouza, Martin;
Jimramovsky, Tomas;
Sloukova, Eva;
Pecl, Jakub;
Seehofnerova, Anna;
Jezova, Marta;
Urik, Milan;
Kunovsky, Lumir;
Slaba, Katerina;
Stourac, Petr;
Klincova, Martina;
Hubacek, Jaroslav A.;
Jabandziev, Petr

Publication type:

Article

Influence of Dominance and Drift on Lethal Mutations in Human Populations.

Published in:

Frontiers in Genetics, 2020, p. 1, doi. 10.3389/fgene.2020.00267

By:

Waxman, David;
Overall, Andrew D. J.

Publication type:

Article

Sifilografía: A History of the Writerly Pox in the Eighteenth-Century Hispanic World by Juan Carlos González Espitia (review).

Published in:

Eighteenth-Century Studies, 2023, v. 56, n. 4, p. 644, doi. 10.1353/ecs.2023.a900671

By:

Deanda-Camacho, Elena

Publication type:

Article

Polyglycylation domain of β-tubulin maintains axonemal architecture and affects cytokinesis in Tetrahymena.

Published in:

Nature Cell Biology, 2002, v. 4, n. 3, p. 256, doi. 10.1038/ncb764

By:

Thazhath, Rupal;
Liu, Chengbao;
Gaertig, Jacek

Publication type:

Article

Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia.

Published in:

Leukemia (08876924), 2015, v. 29, n. 3, p. 586, doi. 10.1038/leu.2014.245

By:

Eiring, A M;
Page, B D G;
Kraft, I L;
Mason, C C;
Vellore, N A;
Resetca, D;
Zabriskie, M S;
Zhang, T Y;
Khorashad, J S;
Engar, A J;
Reynolds, K R;
Anderson, D J;
Senina, A;
Pomicter, A D;
Arpin, C C;
Ahmad, S;
Heaton, W L;
Tantravahi, S K;
Todic, A;
Colaguori, R

Publication type:

Article

Tumor protein expression of the DNA repair gene BRCA1 and lethal prostate cancer.

Published in:

Carcinogenesis, 2020, v. 41, n. 7, p. 904, doi. 10.1093/carcin/bgaa061

By:

Stopsack, Konrad H;
Gerke, Travis;
Zareba, Piotr;
Pettersson, Andreas;
Chowdhury, Dipanjan;
Ebot, Ericka M;
Flavin, Richard;
Finn, Stephen;
Kantoff, Philip W;
Stampfer, Meir J;
Loda, Massimo;
Fiorentino, Michelangelo;
Mucci, Lorelei A

Publication type:

Article

A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae.

Published in:

Nature Communications, 2025, v. 16, p. 1, doi. 10.1038/s41467-024-55391-8

By:

Tolosana, Ignacio;
Willis, Katie;
Gribble, Matthew;
Phillimore, Lee;
Burt, Austin;
Nolan, Tony;
Crisanti, Andrea;
Bernardini, Federica

Publication type:

Article

Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54787-w

By:

Ona Chuquimarca, Samara Mishelle;
Beenstock, Jonah;
Daou, Salima;
Porat, Jennifer;
Keszei, Alexander F. A.;
Yin, Jay Z.;
Beschauner, Tobias;
Bayfield, Mark A.;
Mazhab-Jafari, Mohammad T.;
Sicheri, Frank

Publication type:

Article

Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50882-0

By:

Machour, Feras E.;
R. Abu-Zhayia, Enas;
Kamar, Joyce;
Barisaac, Alma Sophia;
Simon, Itamar;
Ayoub, Nabieh

Publication type:

Article

Evidence for a Syncytial Origin of Eukaryotes from Ancestral State Reconstruction.

Published in:

Genome Biology & Evolution, 2021, v. 13, n. 7, p. 1, doi. 10.1093/gbe/evab096

By:

Skejo, Josip;
Garg, Sriram G;
Gould, Sven B;
Hendriksen, Michael;
Tria, Fernando D K;
Bremer, Nico;
Franjević, Damjan;
Blackstone, Neil W;
Martin, William F

Publication type:

Article

Female-Specific Flightless (fsRIDL) Phenotype for Control of Aedes albopictus.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 7, p. 1, doi. 10.1371/journal.pntd.0001724

By:

Labbé, Geneviève M. C.;
Scaife, Sarah;
Morgan, Siân A.;
Curtis, Zoë H.;
Alphey, Luke

Publication type:

Article

Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2024, v. 43, n. 1, p. 1, doi. 10.1186/s13046-024-03168-8

By:

Chen, Wei;
Yang, Kai-Bin;
Zhang, Yuan-Zhe;
Lin, Zai-Shan;
Chen, Jin-Wei;
Qi, Si-Fan;
Wu, Chen-Fei;
Feng, Gong-Kan;
Yang, Da-Jun;
Chen, Ming;
Zhu, Xiao-Feng;
Li, Xuan

Publication type:

Article

Initiation-specific alleles of the Cdc45 helicase-activating protein.

Published in:

PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0214426

By:

Rios-Morales, Ramon Y.;
Chan, Sze Ham;
Bell, Stephen P.

Publication type:

Article

Edition of TFAM gene by CRISPR/Cas9 technology in bovine model.

Published in:

PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0213376

By:

de Oliveira, Vanessa Cristina;
Moreira, Gabriel Sassarão Alves;
Bressan, Fabiana Fernandes;
Gomes Mariano Junior, Clésio;
Roballo, Kelly Cristine Santos;
Charpentier, Marine;
Concordet, Jean-Paul;
Meirelles, Flávio Vieira;
Ambrósio, Carlos Eduardo

Publication type:

Article

Effects of a blood-free mosquito diet on fitness and gonotrophic cycle parameters of laboratory reared Anopheles gambiae sensu stricto.

Published in:

Parasites & Vectors, 2024, v. 17, n. 1, p. 1, doi. 10.1186/s13071-024-06345-y

By:

Mosi, Faith Allan;
Rutha, Isaack;
Velez, Rita;
Swai, Johnson Kyeba;
Mlacha, Yeromin P.;
Marques, Joana;
Silveira, Henrique;
Tarimo, Brian B.

Publication type:

Article

Low susceptibility of NC/Nga mice to the lipopolysaccharide-mediated lethality with d-galactosamine sensitization and the involvement of fewer natural killer T cells.

Published in:

Innate Immunity, 2012, v. 18, n. 1, p. 35, doi. 10.1177/1753425910390400

By:

Koide, Naoki;
Morikawa, Akiko;
Odkhuu, Erdenezaya;
Haque, Abedul;
Badamtseren, Battuvshin;
Naiki, Yoshikazu;
Komatsu, Takayuki;
Yoshida, Tomoaki;
Yokochi, Takashi

Publication type:

Article

Lethal and repellent effects of transfluthrin and metofluthrin used in portable blowers for personal protection against Ochlerotatus togoi and Aedes albopictus (Diptera: Culicidae).

Published in:

Entomological Research, 2007, v. 37, n. 3, p. 173, doi. 10.1111/j.1748-5967.2007.00109.x

By:

Dong-Kyu Lee

Publication type:

Article

Developmental genetics of the mouse t-complex.

Published in:

Genes & Genetic Systems, 2014, v. 89, n. 3, p. 109, doi. 10.1266/ggs.89.109

By:

Michihiko Sugimoto

Publication type:

Article

Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma.

Published in:

PLoS Pathogens, 2023, v. 19, n. 7, p. 1, doi. 10.1371/journal.ppat.1011543

By:

Paredes-Santos, Tatiana C.;
Bitew, Mebratu A.;
Swale, Christopher;
Rodriguez, Felipe;
Krishnamurthy, Shruthi;
Wang, Yifan;
Maru, Parag;
Sangaré, Lamba Omar;
Saeij, Jeroen P. J.

Publication type:

Article

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation.

Published in:

PLoS Genetics, 2021, v. 17, n. 10, p. 1, doi. 10.1371/journal.pgen.1009740

By:

Fuchs, Silke;
Garrood, William T.;
Beber, Anna;
Hammond, Andrew;
Galizi, Roberto;
Gribble, Matthew;
Morselli, Giulia;
Hui, Tin-Yu J.;
Willis, Katie;
Kranjc, Nace;
Burt, Austin;
Crisanti, Andrea;
Nolan, Tony

Publication type:

Article

Radiobiological features in offspring of natural populations of Drosophila melanogaster after Chernobyl accident.

Published in:: Environmental & Molecular Mutagenesis, 2022, v. 63, n. 2, p. 84, doi. 10.1002/em.22476
Publication type:: Article

Transgenerational effects in offspring of chronically irradiated populations of Drosophila melanogaster after the Chernobyl accident.

Published in:

Environmental & Molecular Mutagenesis, 2021, v. 62, n. 1, p. 39, doi. 10.1002/em.22416

By:

Yushkova, Elena;
Bashlykova, Ludmila

Publication type:

Article

Overlapping deletions spanning the proximal two-thirds of the mouse t complex.

Published in:

Mammalian Genome, 2003, v. 14, n. 12, p. 817, doi. 10.1007/s00335-003-2298-4

By:

Bergstrom, David E.;
Bergstrom, Rebecca A.;
Munroe, Robert J.;
Lee, Barbara K.;
Browning, Victoria L.;
You, Yun;
Eicher, Eva M.;
Schimenti, John C.

Publication type:

Article