Works matching DE "INVESTIGATIONAL drugs"

Results: 2212

Ethical Debate Continues Over Access to Investigational Cell- and Gene-Based Interventions.

Published in:: Medical Ethics Advisor, 2025, v. 41, n. 7, p. 1
Publication type:: Article

FDA Approves Tafasitamab-Cxix for Relapsed or Refractory Follicular Lymphoma.

Published in:: ONS Voice, 2025, p. N.PAG
Publication type:: Article

What Can We Learn from Patient Input at FDA Advisory Committee Meetings?

Published in:

Journal of Law, Medicine & Ethics, 2025, v. 53, n. 1, p. 145, doi. 10.1017/jme.2025.52

By:

Rand, Leah Z;
Eisenkraft Klein, Daniel

Publication type:

Article

In this Issue.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 118, n. 1, p. 9, doi. 10.1002/cpt.3710

By:

Gerding, Alethea

Publication type:

Article

Rationality over convenience: The CDSCO's regulatory ban on irrational antidiabetic fixed-dose combinations in India and its clinical-pharmacological imperatives.

Published in:

International Journal of Diabetes in Developing Countries, 2025, v. 45, n. 2, p. 261, doi. 10.1007/s13410-025-01501-1

By:

Samajdar, Shambo Samrat;
Joshi, Shashank R.;
Husain, Noor;
Bisht, Khushboo;
Venkatraman, Shravan;
Mukherjee, Shatavisa;
Chawla, Rajeev

Publication type:

Article

"Regression to the truth": lessons learned from negative IPF trials.

Published in:

Breathe, 2025, v. 21, n. 2, p. 1, doi. 10.1183/20734735.0260-2024

By:

Trachalaki, Athina;
Lindahl, Anna L.;
Petrarulo, Simone;
Margaritopoulos, George A.

Publication type:

Article

비만 약물치료의 최신지견.

Published in:

Journal of the Korean Medical Association / Taehan Uisa Hyophoe Chi, 2025, v. 68, n. 5, p. 321, doi. 10.5124/jkma.25.0058

By:

Nam, Ga Eun

Publication type:

Article

Predictors of response to intravenous immunoglobulin in patients with dermatomyositis: the ProDERM study Open Access.

Published in:

Rheumatology, 2025, v. 64, n. 6, p. 3767, doi. 10.1093/rheumatology/keaf070

By:

Charles-Schoeman, Christina;
Schessl, Joachim;
Bata-Csörgő, Zsuzsanna;
Dimachkie, Mazen M;
Griger, Zoltan;
Moiseev, Sergey;
Oddis, Chester V;
Schiopu, Elena;
Vencovský, Jiri;
Clodi, Elisabeth;
Levine, Todd;
Aggarwal, Rohit

Publication type:

Article

Promising Drugs Targeting Specific Mechanisms of Deregulation in T Cell Lineage Acute Lymphoblastic Leukemia.

Published in:

Oncology & Therapy, 2025, v. 13, n. 2, p. 325, doi. 10.1007/s40487-025-00339-1

By:

Thomas, Xavier

Publication type:

Article

Tapentadol – nowy opioid o unikalnym, podwójnym mechanizmie działania i szerokich możliwościach zastosowania – przegląd danych klinicznych.

Published in:

Pain Research / Ból, 2025, v. 26, n. 1, p. 26, doi. 10.5604/01.3001.0055.0947

By:

Zajączkowska, Renata;
Wordliczek, Jerzy;
Kocot-Kępska, Magdalena

Publication type:

Article

Therapeutic potential of zinc <sup>64</sup>Zn aspartate for obesity management: impact on oxidative stress, lipid metabolism, pancreas and liver in high-calorie diet model.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1543166

By:

Temnik, Max;
Gurin, Sergey;
Balakin, Alexandr;
Byshovets, Roman;
Kalmukova, Olesia;
Vovk, Tetiana;
Halenova, Tetiana;
Raksha, Nataliia;
Falalyeyeva, Tetyana;
Savchuk, Olexiy

Publication type:

Article

Outcomes in Patients with Non-Small-Cell Lung Cancer with Brain Metastases: A Real-World Data Study from a Resource-Limited Country.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1603, doi. 10.3390/cancers17101603

By:

Randjelovic, Nevena;
Petronijevic, Marina;
Calamac, Marina;
Peulic, Marija;
Filipovic, Biljana;
Mutavdzic, Vladan;
Djuric, Aleksandar;
Rankovic, Teodora;
Bugarcic, Milos;
Canak, Ivana;
Mikov, Jelena;
Igrutinovic, Nebojsa;
Novak, Stela;
Marjanovic, Marko;
Perovic, Jelena;
Urosevic, Teodora;
Cufer, Tanja

Publication type:

Article

Pertuzumab and Its Accelerated Approval: Evolving Treatment Paradigms and New Challenges in the Management of HER2-Positive Breast Cancer.

Published in:

Oncology (08909091), 2014, v. 28, n. 3, p. 186

By:

O'SULLIVAN, CIARA C.;
CONNOLLY, ROISIN M.

Publication type:

Article

Neoadjuvant Pertuzumab: the Exception That Proves the Rule?

Published in:

Oncology (08909091), 2014, v. 28, n. 3, p. 197

By:

BURSTEIN, HAROLD J.

Publication type:

Article

Pertuzumab: Increasing the Options.

Published in:

Oncology (08909091), 2014, v. 28, n. 3, p. 199

By:

NUNES, RAQUEL;
SWAIN, SANDRA M.

Publication type:

Article

Two Paths Forward in Metastatic Castration-Resistant Prostate Cancer.

Published in:

Oncology (08909091), 2013, v. 27, n. 7, p. 638

By:

VOGELZANG, NICHOLAS J.

Publication type:

Article

Targeted Therapy in the Treatment of Castration-Resistant Prostate Cancer.

Published in:

Oncology (08909091), 2013, v. 27, n. 7, p. 620

By:

DERLETH, CHRISTINA L.;
YU, EVAN Y.

Publication type:

Article

The American Association for Cancer Research Annual Meeting.

Published in:: 2013
Publication type:: Proceeding

Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition.

Published in:

Medicinal Research Reviews, 2022, v. 42, n. 2, p. 744, doi. 10.1002/med.21862

By:

Macip, Guillem;
Garcia‐Segura, Pol;
Mestres‐Truyol, Júlia;
Saldivar‐Espinoza, Bryan;
Ojeda‐Montes, María José;
Gimeno, Aleix;
Cereto‐Massagué, Adrià;
Garcia‐Vallvé, Santiago;
Pujadas, Gerard

Publication type:

Article

Author response to: OSIN-D-24–00849 Comment on: A novel sequential treatment approach between denosumab and romosozumab in patients with severe osteoporosis.

Published in:

2024

By:

Kumar, Shejil;
Gild, Matti L.;
McDonald, Michelle M.;
Kim, Albert S.;
Clifton-Bligh, Roderick J.;
Girgis, Christian M.

Publication type:

Letter to the Editor

A novel sequential treatment approach between denosumab and romosozumab in patients with severe osteoporosis.

Published in:

Osteoporosis International, 2024, v. 35, n. 9, p. 1669, doi. 10.1007/s00198-024-07139-9

By:

Kumar, Shejil;
Gild, Matti L.;
McDonald, Michelle M.;
Kim, Albert S.;
Clifton-Bligh, Roderick J.;
Girgis, Christian M.

Publication type:

Article

The need for new acutely acting antimigraine drugs: moving safely outside acute medication overuse.

Published in:

Journal of Headache & Pain, 2019, v. 20, n. 1, p. 1, doi. 10.1186/s10194-019-1007-y

By:

van Hoogstraten, Willem Sebastiaan;
MaassenVanDenBrink, Antoinette

Publication type:

Article

Correction to: Therapeutic novelties in migraine: new drugs, new hope?

Published in:

Journal of Headache & Pain, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s10194-019-1013-0

By:

Do, Thien Phu;
Guo, Song;
Ashina, Messoud

Publication type:

Article

Therapeutic novelties in migraine: new drugs, new hope?

Published in:

Journal of Headache & Pain, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s10194-019-0974-3

By:

Do, Thien Phu;
Guo, Song;
Ashina, Messoud

Publication type:

Article

A review of an investigational drug retatrutide, a novel triple agonist agent for the treatment of obesity.

Published in:

European Journal of Clinical Pharmacology, 2024, v. 80, n. 5, p. 669, doi. 10.1007/s00228-024-03646-0

By:

Kaur, Manmeet;
Misra, Saurav

Publication type:

Article

Safety profile of COVID-19 drugs in a real clinical setting.

Published in:

European Journal of Clinical Pharmacology, 2022, v. 78, n. 5, p. 733, doi. 10.1007/s00228-021-03270-2

By:

Chiu, Mei Nee;
Bhardwaj, Maitry;
Sah, Sangeeta Pilkhwal

Publication type:

Article

Older participant perspectives on permanent study drug discontinuation in an ongoing primary prevention trial of statins.

Published in:

European Journal of Clinical Pharmacology, 2021, v. 77, n. 6, p. 841, doi. 10.1007/s00228-020-03073-x

By:

Zhou, Zhen;
Jose, Kim;
Curtis, Andrea J.;
Kost, Alissia;
Breslin, Monique;
Zoungas, Sophia;
Nelson, Mark R.

Publication type:

Article

Regulatory characteristics and pivotal study design of US Food and Drug Administration approval of drugs for major vs. minor cancer.

Published in:

European Journal of Clinical Pharmacology, 2019, v. 75, n. 9, p. 1193, doi. 10.1007/s00228-019-02695-0

By:

Yamashita, Kenji;
Kaneko, Masayuki;
Narukawa, Mamoru

Publication type:

Article

The misleading use of the term pragmatic in pre-licensing medicine trials.

Published in:

2019

By:

Dal-Ré, Rafael

Publication type:

Editorial

The patient’s safety and access to experimental drugs after the termination of clinical trials: regulations and trends.

Published in:

European Journal of Clinical Pharmacology, 2018, v. 74, n. 8, p. 1001, doi. 10.1007/s00228-018-2474-9

By:

da Silva, Ricardo Eccard;
Amato, Angélica Amorim;
Sousa, Thiago do Rego;
de Carvalho, Marta Rodrigues;
Novaes, Maria Rita Carvalho Garbi

Publication type:

Article

Pharmacokinetics and immunogenicity of T0001, a newly developed anti-TNFα fusion protein, in healthy volunteers.

Published in:

European Journal of Clinical Pharmacology, 2017, v. 73, n. 9, p. 1095, doi. 10.1007/s00228-017-2280-9

By:

Wang, Yitong;
Liu, Chang;
Chen, Shi;
Wang, Wei;
Dong, Lihou;
Wang, Qian;
Wang, Yan;
Zhao, Libo;
Zang, Yannan;
Xie, Zhenwei;
Liu, Yang;
Liu, Yanjun;
Song, Haifeng;
Li, Zhanguo;
Fang, Yi

Publication type:

Article

Application challenges of the new EU Clinical Trials Regulation.

Published in:

European Journal of Clinical Pharmacology, 2017, v. 73, n. 7, p. 795, doi. 10.1007/s00228-017-2267-6

By:

Gefenas, Eugenijus;
Cekanauskaite, Asta;
Lekstutiene, Jurate;
Lukaseviciene, Vilma

Publication type:

Article

Six-year activity on approval of compassionate use of medicines by the Ethics Committee of the University Hospital of Bologna (Italy): time to update rules and recommendations.

Published in:

European Journal of Clinical Pharmacology, 2017, v. 73, n. 4, p. 479, doi. 10.1007/s00228-016-2186-y

By:

Montanaro, Nicola;
Melis, Mauro;
Proni, Stefania;
Chiabrando, Giacomo;
Motola, Domenico

Publication type:

Article

Who is a 'healthy subject'?-consensus results on pivotal eligibility criteria for clinical trials.

Published in:

European Journal of Clinical Pharmacology, 2017, v. 73, n. 4, p. 409, doi. 10.1007/s00228-016-2189-8

By:

Breithaupt-Groegler, Kerstin;
Coch, Christoph;
Coenen, Martin;
Donath, Frank;
Erb-Zohar, Katharina;
Francke, Klaus;
Goehler, Karin;
Iovino, Mario;
Kammerer, Klaus;
Mikus, Gerd;
Rengelshausen, Jens;
Sourgens, Hildegard;
Schinzel, Reinhard;
Sudhop, Thomas;
Wensing, Georg

Publication type:

Article

An analysis of marketing authorisation applications via the mutual recognition and decentralised procedures in Europe.

Published in:

European Journal of Clinical Pharmacology, 2015, v. 71, n. 10, p. 1237, doi. 10.1007/s00228-015-1904-1

By:

Ebbers, Hans;
Langedijk, Joris;
Bouvy, Jacoline;
Hoekman, Jarno;
Boon, Wouter;
Jong, Jean;
Bruin, Marie

Publication type:

Article

Potential use of NOACs in developing countries: pros and cons.

Published in:

European Journal of Clinical Pharmacology, 2014, v. 70, n. 7, p. 817, doi. 10.1007/s00228-014-1693-y

By:

Bista, Durga;
Chalmers, Leanne;
Bereznicki, Luke;
Peterson, Gregory

Publication type:

Article

Novel drug targets in clinical development for heart failure.

Published in:

European Journal of Clinical Pharmacology, 2014, v. 70, n. 7, p. 765, doi. 10.1007/s00228-014-1671-4

By:

George, Melvin;
Rajaram, Muthukumar;
Shanmugam, Elangovan;
VijayaKumar, Thangavel

Publication type:

Article

Investigation of combined CYP3A4 inductive/inhibitory properties by studying statin interactions: a model study with the renin inhibitor ACT-178882.

Published in:

European Journal of Clinical Pharmacology, 2014, v. 70, n. 6, p. 675, doi. 10.1007/s00228-014-1674-1

By:

Dingemanse, Jasper;
Nicolas, Laurent;
Bortel, Luc

Publication type:

Article

Assessment of interaction potential of AZD2066 using in vitro metabolism tools, physiologically based pharmacokinetic modelling and in vivo cocktail data.

Published in:

European Journal of Clinical Pharmacology, 2014, v. 70, n. 2, p. 167, doi. 10.1007/s00228-013-1603-8

By:

Nordmark, Anna;
Andersson, Anita;
Baranczewski, Pawel;
Wanag, Ewa;
Ståhle, Lars

Publication type:

Article

Pharmacokinetics of dolutegravir in HIV-seronegative subjects with severe renal impairment.

Published in:

European Journal of Clinical Pharmacology, 2014, v. 70, n. 1, p. 29, doi. 10.1007/s00228-013-1590-9

By:

Weller, Stephen;
Borland, Julie;
Chen, Shuguang;
Johnson, Mark;
Savina, Paul;
Wynne, Brian;
Wajima, Toshihiro;
Peppercorn, Amanda;
Piscitelli, Stephen

Publication type:

Article

Effects of vercirnon on the activity of CYP3A4, CYP2C19 and CYP2C8 enzymes and BCRP and OATP1B1 transporters using probe substrates.

Published in:

European Journal of Clinical Pharmacology, 2014, v. 70, n. 1, p. 37, doi. 10.1007/s00228-013-1592-7

By:

Haberer, Lynda;
McSherry, Iain;
Cargill, Anna;
McCarthy, Linda

Publication type:

Article

Newer antipsychotics and upcoming molecules for schizophrenia.

Published in:

European Journal of Clinical Pharmacology, 2013, v. 69, n. 8, p. 1497, doi. 10.1007/s00228-013-1498-4

By:

George, Melvin;
Amrutheshwar, Radhika;
Rajkumar, Ravi;
Kattimani, Shivanand;
Dkhar, Steven

Publication type:

Article

Dose finding by concentration-response versus dose-response: a simulation-based comparison.

Published in:

European Journal of Clinical Pharmacology, 2013, v. 69, n. 7, p. 1391, doi. 10.1007/s00228-013-1474-z

By:

Berges, Alienor;
Chen, Chao

Publication type:

Article

A 1-year cross-sectional analysis of non-interventional post-marketing study protocols submitted to the German Federal Institute for Drugs and Medical Devices (BfArM).

Published in:

European Journal of Clinical Pharmacology, 2013, v. 69, n. 7, p. 1453, doi. 10.1007/s00228-013-1482-z

By:

Jeinsen, Beatrice;
Sudhop, Thomas

Publication type:

Article

Entry-into-humans study with a new direct renin inhibitor.

Published in:

European Journal of Clinical Pharmacology, 2012, v. 68, n. 9, p. 1257, doi. 10.1007/s00228-012-1253-2

By:

Nicolas, Laurent;
Gutierrez, Marcelo;
Binkert, Christoph;
Dingemanse, Jasper

Publication type:

Article

Pharmacokinetics and pharmacodynamics of the novel PAR-1 antagonist vorapaxar in patients with end-stage renal disease.

Published in:

European Journal of Clinical Pharmacology, 2012, v. 68, n. 7, p. 1049, doi. 10.1007/s00228-012-1217-6

By:

Kosoglou, Teddy;
Kraft, Walter;
Kumar, Bharath;
Statkevich, Paul;
Xuan, Fengjuan;
Ma, Lei;
Jennings, Lisa;
Schiller, James;
Langdon, Ronald;
Cutler, David

Publication type:

Article

Clinical trials during pregnancy: what has been done.

Published in:

European Journal of Clinical Pharmacology, 2012, v. 68, n. 5, p. 455, doi. 10.1007/s00228-011-1145-x

By:

Domínguez, Viviana;
Ramos, Nuria;
Torrents, Abiguei;
García, David;
Carné, Xavier

Publication type:

Article

Impact of proteostasis workload on sensitivity to proteasome inhibitors in multiple myeloma.

Published in:

Clinical & Experimental Medicine, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10238-025-01713-z

By:

Sedlacek, Jindrich

Publication type:

Article

Investigational Probiotic Drug Gains FDA Support for Phase 2 Obesity Trial.

Published in:

Patient Care (Online), 2025, p. N.PAG

By:

Jennings, Sydney

Publication type:

Article

Investigational Ketogenic Diet Pill BL-001 Shows Significant Weight Loss in Phase 1 Trial.

Published in:

Patient Care (Online), 2025, p. N.PAG

By:

Halsey, Grace

Publication type:

Article