Works matching DE "INSULIN agonists"

Results: 54

Structure-Guided Design of Selective Epac1 and Epac2 Agonists.

Published in:

PLoS Biology, 2015, v. 13, n. 1, p. 1, doi. 10.1371/journal.pbio.1002038

By:

Schwede, Frank;
Bertinetti, Daniela;
Langerijs, Carianne N.;
Hadders, Michael A.;
Wienk, Hans;
Ellenbroek, Johanne H.;
de Koning, Eelco J. P.;
Bos, Johannes L.;
Herberg, Friedrich W.;
Genieser, Hans-Gottfried;
Janssen, Richard A. J.;
Rehmann, Holger

Publication type:

Article

Pharmacological postconditioning of the rabbit heart with non-selective, A1, A2A and A3 adenosine receptor agonists.

Published in:

Journal of Pharmacy & Pharmacology, 2014, v. 66, n. 8, p. 1140, doi. 10.1111/jphp.12238

By:

Bibli, Sophia‐Iris;
Iliodromitis, Efstathios K.;
Lambertucci, Catia;
Zoga, Anastasia;
Lougiakis, Nikolaos;
Dagres, Nikolaos;
Volpini, Rosaria;
Dal Ben, Diego;
Kremastinos, Dimitrios Th.;
Tsantili Kakoulidou, Anna;
Cristalli, Gloria;
Andreadou, Ioanna

Publication type:

Article

Inverse association of PPARγ agonists use and high grade glioma development.

Published in:

Journal of Neuro-Oncology, 2010, v. 100, n. 2, p. 233, doi. 10.1007/s11060-010-0185-x

By:

Grommes, Christian;
Conway, Devon;
Alshekhlee, Amer;
Barnholtz-Sloan, Jill

Publication type:

Article

Safety, tolerability, and nonglycemic effects of incretin-based therapies.

Published in:

Journal of Family Practice, 2010, v. 59, p. S20

By:

Keith Campbell, R.;
Cobble, Michael E.;
Reid, Timothy S.;
Shomali, Mansur E.

Publication type:

Article

HOW TO IMPLEMENT INCRETIN THERAPY.

Published in:

Journal of Family Practice, 2008, v. 57, p. S26

By:

Cobble, Michael E.

Publication type:

Article

AN OVERVIEW OF INCRETIN CLINICAL TRIALS.

Published in:

Journal of Family Practice, 2008, v. 57, p. S10

By:

Garber, Alan J.;
Spann, Stephen J.

Publication type:

Article

THE INSULIN IMMUNOASSAY AFTER 50 YEARS.

Published in:

Perspectives in Biology & Medicine, 2009, v. 52, n. 3, p. 343, doi. 10.1353/pbm.0.0091

By:

BLUMENTHAL, STANLEY

Publication type:

Article

Identification of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists using molecular modeling method.

Published in:

Journal of Computer-Aided Molecular Design, 2014, v. 28, n. 11, p. 1143, doi. 10.1007/s10822-014-9791-6

By:

Wong, Fiona;
Sethi, Gautam;
Kumar, Alan;
Gee, Veronica;
Yap, Chun;
Ramachandran, Lalitha

Publication type:

Article

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.

Published in:

Nature, 2013, v. 503, n. 7477, p. 493, doi. 10.1038/nature12656

By:

Okada-Iwabu, Miki;
Yamauchi, Toshimasa;
Iwabu, Masato;
Honma, Teruki;
Hamagami, Ken-ichi;
Matsuda, Koichi;
Yamaguchi, Mamiko;
Tanabe, Hiroaki;
Kimura-Someya, Tomomi;
Shirouzu, Mikako;
Ogata, Hitomi;
Tokuyama, Kumpei;
Ueki, Kohjiro;
Nagano, Tetsuo;
Tanaka, Akiko;
Yokoyama, Shigeyuki;
Kadowaki, Takashi

Publication type:

Article

The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome.

Published in:

Gynecological Endocrinology, 2018, v. 34, n. 3, p. 217, doi. 10.1080/09513590.2017.1381680

By:

Rahmani, Elham;
Jamilian, Mehri;
Samimi, Mansooreh;
Zarezade Mehrizi, Maryam;
Aghadavod, Esmat;
Akbari, Elmira;
Tamtaji, Omid Reza;
Asemi, Zatollah

Publication type:

Article

A Highly Potent Insulin-mimetic Zinc(II) Complex with a Zn(S2O2) Coordination Mode: Bis(1,6-dimethyl-3-hydroxy-5-methoxy-2-pentyl-1,4-dihydropyridine-4-thionato)zinc(II).

Published in:

Chemistry Letters, 2005, v. 34, n. 5, p. 656, doi. 10.1246/cl.2005.656

By:

Adachi, Yusuke;
Yoshida, Jiro;
Kodera, Yukihiro;
Sakurai, Hiromu

Publication type:

Article

The use of incretin agents.

Published in:

Practice Nursing, 2009, v. 20, n. 4, p. 194, doi. 10.12968/pnur.2009.20.4.41209

By:

Aye, Myint Myint;
Jennings, Paul

Publication type:

Article

Amino acid ingestion and glucose metabolism-A review.

Published in:

IUBMB Life, 2010, v. 62, n. 9, p. 660, doi. 10.1002/iub.375

By:

Gannon, Mary C.;
Nuttall, Frank Q.

Publication type:

Article

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.

Published in:

Nature Medicine, 2014, v. 20, n. 8, p. 942, doi. 10.1038/nm.3614

By:

Oh, Da Young;
Walenta, Evelyn;
Akiyama, Taro E;
Lagakos, William S;
Lackey, Denise;
Pessentheiner, Ariane R;
Sasik, Roman;
Hah, Nasun;
Chi, Tyler J;
Cox, Jason M;
Powels, Mary Ann;
Di Salvo, Jerry;
Sinz, Christopher;
Watkins, Steven M;
Armando, Aaron M;
Chung, Heekyung;
Evans, Ronald M;
Quehenberger, Oswald;
McNelis, Joanne;
Bogner-Strauss, Juliane G

Publication type:

Article

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of JNJ-38431055, a Novel GPR119 Receptor Agonist and Potential Antidiabetes Agent, in Healthy Male Subjects.

Published in:

Clinical Pharmacology & Therapeutics, 2011, v. 90, n. 5, p. 685, doi. 10.1038/clpt.2011.169

By:

Katz, L B;
Gambale, J J;
Rothenberg, P L;
Vanapalli, S R;
Vaccaro, N;
Xi, L;
Polidori, D C;
Vets, E;
Sarich, T C;
Stein, P P

Publication type:

Article

Postprandial plasma glucose effects of once-weekly albiglutide for the treatment of type 2 diabetes.

Published in:

2016

By:

Matthews, Jessica E.;
Reinhardt, Rickey R.;
Carr, Molly C.

Publication type:

journal article

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.

Published in:

Nature, 2014, v. 513, n. 7516, p. 124, doi. 10.1038/nature13494

By:

Srivastava, Ankita;
Yano, Jason;
Hirozane, Yoshihiko;
Okada, Kengo;
Kefala, Georgia;
Snell, Gyorgy;
Lane, Weston;
Ivetac, Anthony;
Jennings, Andy;
Gruswitz, Franz;
Aertgeerts, Kathleen;
Nguyen, Jasmine

Publication type:

Article

Lead GPR40 agonist bites the dust.

Published in:: Nature Reviews Drug Discovery, 2014, v. 13, n. 2, p. 91, doi. 10.1038/nrd4246
Publication type:: Article

Metabolic disease: New opportunity for serotonin receptor agonists.

Published in:

Nature Reviews Drug Discovery, 2008, v. 7, n. 1, p. 17, doi. 10.1038/nrd2492

By:

Crunkhorn, Sarah

Publication type:

Article

Nitric Oxide Alters Human Microvascular Endothelial Cell Response to Cyclic Strain.

Published in:

Journal of Cardiovascular Pharmacology & Therapeutics, 1998, v. 3, n. 2, p. 135, doi. 10.1177/107424849800300206

By:

Upchurch Jr., Gilbert R.;
Leopold, Jane A.;
Welch, George N.;
Loscalzo, Joseph

Publication type:

Article

Cardiovascular effects of activation of central alpha7 and alpha4beta2 nAChRs: a role for vasopressin in anaesthetized rats.

Published in:

2008

By:

Moore, C.;
Wang, Y.;
Ramage, A. G.

Publication type:

journal article

Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPAR?-independent mechanism.

Published in:

Diabetologia, 2005, v. 48, n. 3, p. 586, doi. 10.1007/s00125-005-1672-z

By:

Artwohl, M.;
Fürnsinn, C.;
Waldhöusl, W.;
Hölzenbein, T.;
Rainer, G.;
Freudenthaler, A.;
Roden, M.;
Baumgartner-Parzer, S. M.

Publication type:

Article

Adsorption of Toll-Like Receptor 4 Agonist to Alum-Based Tetanus Toxoid Vaccine Dampens Pro-T Helper 2 Activities and Enhances Antibody Responses.

Published in:

2015

By:

Bortolatto, Juliana;
Mirotti, Luciana;
Rodriguez, Dunia;
Gomes, Eliane;
Russo, Momtchilo

Publication type:

journal article

Drug Watch.

Published in:: Formulary, 2000, v. 35, n. 7, p. 618
Publication type:: Article

Inhibin B plus LH vs Gn RH agonist test for distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism in boys.

Published in:

Clinical Endocrinology, 2015, v. 82, n. 1, p. 100, doi. 10.1111/cen.12613

By:

Binder, Gerhard;
Schweizer, Roland;
Blumenstock, Gunnar;
Braun, Regina

Publication type:

Article

Efficacy of DPP‐4 inhibitors, GLP‐1 analogues, and SGLT2 inhibitors as add‐ons to metformin monotherapy in T2DM patients: a model‐based meta‐analysis.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 2, p. 393, doi. 10.1111/bcp.13807

By:

Inoue, Hiroyuki;
Tamaki, Yoko;
Kashihara, Yushi;
Muraki, Shota;
Kakara, Makoto;
Hirota, Takeshi;
Ieiri, Ichiro

Publication type:

Article

CAP defines a second signalling pathway required for insulin-stimulated glucose transport.

Published in:: Nature, 2000, v. 407, n. 6801, p. 202, doi. 10.1038/35025089
Publication type:: Article

Effect of Rosiglitazone on Liver Structure and Function in Genetically Diabetic Akita Mice.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2013, v. 113, n. 5, p. 353, doi. 10.1111/bcpt.12104

By:

Hemmeryckx, Bianca;
Gaekens, Marijke;
Gallacher, David J.;
Lu, Hua Rong;
Lijnen, Henri Roger

Publication type:

Article

PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated iGF Axis.

Published in:

Frontiers in Endocrinology, 2017, v. 8, p. 1, doi. 10.3389/fendo.2017.00031

By:

Vella, Veronica;
Nicolosi, Maria Luisa;
Giuliano, Stefania;
Bellomo, Maria;
Belfiore, Antonino;
Malaguarnera, Roberta

Publication type:

Article

STIM2 enhances receptor-stimulated Ca2+ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions.

Published in:

Science Signaling, 2015, v. 8, n. 359, p. 1

By:

Hwei Ling Ong;
de Souza, Lorena Brito;
Xibao Liu;
Ambudkar, Indu S.;
Changyu Zheng;
Goldsmith, Corinne M.;
Kwong Tai Cheng;
Feske, Stefan

Publication type:

Article

Lorcaserin and adiposopathy: 5-HT2c agonism as a treatment for 'sick fat' and metabolic disease.

Published in:

Expert Review of Cardiovascular Therapy, 2009, v. 7, n. 7, p. 1429, doi. 10.1586/erc.09.123

By:

Bays, Harold E.

Publication type:

Article

Neuroprotective potential of adenosine A1 receptor partial agonists in experimental models of cerebral ischemia.

Published in:

Journal of Neurochemistry, 2019, v. 149, n. 2, p. 211, doi. 10.1111/jnc.14660

By:

Martire, Alberto;
Lambertucci, Catia;
Pepponi, Rita;
Ferrante, Antonella;
Benati, Nicholas;
Buccioni, Michela;
Dal Ben, Diego;
Marucci, Gabriella;
Klotz, Karl‐Norbert;
Volpini, Rosaria;
Popoli, Patrizia

Publication type:

Article

Effects of cannabinoids in Amyotrophic Lateral Sclerosis (ALS) murine models: a systematic review and meta‐analysis.

Published in:

Journal of Neurochemistry, 2019, v. 149, n. 2, p. 284, doi. 10.1111/jnc.14639

By:

Urbi, Berzenn;
Owusu, Maame Amma;
Hughes, Ian;
Katz, Matthew;
Broadley, Simon;
Sabet, Arman

Publication type:

Article

A population-specific diabetogenic haplotype HLA-A2,Cw1,B56,DR4,DQ8 is associated with high birthweight in Finnish diabetic families.

Published in:

Genes & Immunity, 2008, v. 9, n. 3, p. 207, doi. 10.1038/gene.2008.3

By:

Järvinen, T. M.;
Harjutsalo, V.;
Kinnunen, L.;
Miettinen, M. E.;
Tuomilehto-Wolf, E.;
Tuomilehto, J.

Publication type:

Article

Identifying Good Responders to Glucose Lowering Therapy in Type 2 Diabetes: Implications for Stratified Medicine.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0111235

By:

Jones, Angus G.;
Shields, Beverley M.;
Hyde, Christopher J.;
Henley, William E.;
Hattersley, Andrew T.

Publication type:

Article

Prescribing of long-acting beta-2-agonists/inhaled corticosteroids after the SMART trial.

Published in:

BMC Pulmonary Medicine, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12890-015-0051-x

By:

Rottenkolber, Marietta;
Fischer, Rainald;
Ibáñez, Luisa;
Fortuny, Joan;
Reynolds, Robert;
Amelio, Justyna;
Gerlach, Roman;
Tauscher, Martin;
Thürmann, Petra;
Hasford, Joerg;
Schmiedl, Sven

Publication type:

Article

Newly Synthesized Oleylgingerol and Oleylshogaol Activate TRPV1 Ion Channels.

Published in:

Bioscience, Biotechnology & Biochemistry, 2007, v. 71, n. 9, p. 2304, doi. 10.1271/bbb.70187

By:

Morita, Akihito;
Iwasaki, Yusaku;
Kobata, Kenji;
Yokogoshi, Hidehiko;
Watanabe, Tatsuo

Publication type:

Article

Long-term safety and efficacy of fasiglifam (TAK-875), a G-protein-coupled receptor 40 agonist, as monotherapy and combination therapy in Japanese patients with type 2 diabetes: a 52-week open-label phase III study.

Published in:

Diabetes, Obesity & Metabolism, 2016, v. 18, n. 9, p. 925, doi. 10.1111/dom.12693

By:

Kaku, K.;
Enya, K.;
Nakaya, R.;
Ohira, T.;
Matsuno, R.

Publication type:

Article

A Network Meta-Analysis Comparing Semaglutide Once-Weekly with Other GLP-1 Receptor Agonists in Japanese Patients with Type 2 Diabetes.

Published in:

Diabetes Therapy, 2018, v. 9, n. 3, p. 973, doi. 10.1007/s13300-018-0397-1

By:

Webb, Neil;
Orme, Michelle;
Witkowski, Michal;
Nakanishi, Rie;
Langer, Jakob

Publication type:

Article

Effectiveness of Liraglutide and Lixisenatide in the Treatment of Type 2 Diabetes: Real-World Evidence from The Health Improvement Network (THIN) Database in the United Kingdom.

Published in:

Diabetes Therapy, 2017, v. 8, n. 2, p. 417, doi. 10.1007/s13300-017-0241-z

By:

Feher, Michael;
Vega-Hernandez, Gabriela;
Mocevic, Emina;
Buysse, Brian;
Myland, Melissa;
Power, Geraldine;
Nystrup Husemoen, Lise;
Kim, Joseph;
Witte, Daniel

Publication type:

Article

Influencia de la grasa de la dieta en el metabolismo glucídico de mujeres obesas con el genotipo Pro12Pro en el gen PPARgama2.

Published in:

Nutrición Hospitalaria, 2010, v. 25, n. 4, p. 622, doi. 10.3305/nh.2010.25.4.4468

By:

Kaippert, V. Chaia;
Rosado, E. Lopes;
Rosa, G.;
Oliveira, E. M. Morais;
Uehara, S. Kimi;
D'Andrea, C. Lima;
Nogueira, J.;
Lago, M. Fofano do

Publication type:

Article

Effect of transdermal nitroglycerin on glucose-stimulated insulin release in healthy male volunteers.

Published in:

European Journal of Clinical Investigation, 2000, v. 30, n. 1, p. 41, doi. 10.1046/j.1365-2362.2000.00588.x

By:

Kovacs;
Szilvassy;
Hegyi;
Nemeth;
Ferdinandy;
Tosaki;
Tosaki, Arpad

Publication type:

Article

Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets.

Published in:

Diabetes, 2010, v. 59, n. 12, p. 3099, doi. 10.2337/db10-0689

By:

Sloop, Kyle W.;
Willard, Francis S.;
Brenner, Martin B.;
Ficorilli, James;
Valasek, Kathleen;
Showalter, Aaron D.;
Farb, Thomas B.;
Cao, Julia X. C.;
Cox, Amy L.;
Michael, M. Dodson;
Sanfeliciano, Sonia Maria Gutierrez;
Tebbe, Mark J.;
Coghlan, Michael J.

Publication type:

Article

Selective Small-Molecule Agonists of G Protein-Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice.

Published in:

Diabetes, 2008, v. 57, n. 8, p. 2211, doi. 10.2337/db08-0130

By:

Tan, Carina P.;
Yue Feng;
Yun-Ping Zhou;
Eiermann, George J.;
Petrov, Aleksandr;
Zhou, Changyou;
Lin, Songnian;
Salituro, Gino;
Meinke, Peter;
Mosley, Ralph;
Akiyama, Taro E.;
Einstein, Monica;
Kumar, Sanjeev;
Berger, Joel P.;
Mills, Sander G.;
Thornberry, Nancy A.;
Lihu Yang;
Howard, Andrew D.

Publication type:

Article

Partial Resistance to Peroxisome Proliferator-Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism.

Published in:

Diabetes, 2008, v. 57, n. 8, p. 2012, doi. 10.2337/db08-0226

By:

Satapati, Santhosh;
He, TianTeng;
Inagaki, Takeshi;
Potthoff, Matthew;
Merritt, Matthew E.;
Esser, Victoria;
Mangelsdorf, David J.;
Kliewer, Steven A.;
Browning, Jeffrey D.;
Burgess, Shawn C.

Publication type:

Article

NEW AND NOVEL TREATMENTS FOR DIABETIC COMPLICATIONS.

Published in:: 2008
Publication type:: Abstract

Combination Therapy with Pparα and Pparγ Agonists in Type 2 Diabetes Blunts the Reduction in Intra-Organ Triglyceride Content Seen with Pparγ Monotherapy.

Published in:

Diabetes, 2007, v. 56, p. A163

By:

Balasubramanian, Ravikumar;
Gerrard, Jean;
English, Philip T.;
Firbank, Michael F.;
Taylor, Roy

Publication type:

Article

Ghrelin Agonist (TZP-101) Gastroprokinetic Action in Diabetic Patients with Gastroparesis: A Pilot Study.

Published in:

Diabetes, 2007, v. 56, p. A159

By:

Madsen, Jan Lysgård;
Madsbad, Sten;
Shaughnessy, Laura;
Jensen, Thorbjørn;
Pezzullo, John;
Kosutic, Gordana

Publication type:

Article

Pioglitazone Lowers the Intima-Media-Thickness (imt) in Patients with Type-2-Diabetes Mellitus.

Published in:

Diabetes, 2007, v. 56, p. A132

By:

Bierwirth, Ralph-Achim;
Merke, Jürgen;
Grünerbel, Arthur;
Hofmann, Christian;
Dietlein, Michael;
Franzen, Christine;
Karagiannis, Efstrathios;
Lübben, Georg

Publication type:

Article

Anti-Diabetic Effects of CVT-3619, Metformin and Pioglitazone Alone and Combined in ZDF Rats.

Published in:

Diabetes, 2007, v. 56, p. A132

By:

Dhalla, Arvinder K.;
Santikul, Melissa;
Smith, Michelle;
Belardinelli, Luiz

Publication type:

Article