Works matching DE "HUNTINGTIN protein"

Results: 653

The Possibility of Developing a Neutralizing Agent to Curb the Effects of Huntington's Disease.

Published in:

International Journal of High School Research, 2025, v. 7, n. 5, p. 78, doi. 10.36838/v7i5.11

By:

Besta, Ram Sumedh

Publication type:

Article

Recovery of Lysosomal Acidification and Autophagy Flux by Attapulgite Nanorods: Therapeutic Potential for Lysosomal Disorders.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 728, doi. 10.3390/biom15050728

By:

Hao, Yuanjing;
Fan, Xinru;
Huang, Xiaodan;
Li, Zhaoying;
Jing, Zhiyuan;
Zhang, Guilong;
Xu, Yuxue;
Zhang, Na;
Wei, Pengfei

Publication type:

Article

Targeting Pathogenic DNA and RNA Repeats: A Conceptual Therapeutic Way for Repeat Expansion Diseases.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 54, p. 1, doi. 10.1002/chem.202201749

By:

Guo, Pei;
Han, Da

Publication type:

Article

One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington's Disease.

Published in:

Angewandte Chemie, 2014, v. 126, n. 7, p. 1959, doi. 10.1002/ange.201307510

By:

Ansaloni, Annalisa;
Wang, Zhe ‐ Ming;
Jeong, Jae Sun;
Ruggeri, Francesco Simone;
Dietler, Giovanni;
Lashuel, Hilal A.

Publication type:

Article

Domain interactions reveal auto-inhibition of the deubiquitinating enzyme USP19 and its activation by HSP90 in the modulation of huntingtin aggregation.

Published in:

Biochemical Journal, 2020, v. 477, n. 21, p. 4295, doi. 10.1042/BCJ20200536

By:

Wei Xue;
Shu-Xian Zhang;
Wen-Tian He;
Jun-Ye Hong;
Lei-Lei Jiang;
Hong-Yu Hu

Publication type:

Article

Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02460-z

By:

Pei, Sen;
Swayne, Theresa C.;
Morris, Jeffrey F.;
Emtage, Lesley

Publication type:

Article

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02360-2

By:

Galaz-Montoya, Jesús G.;
Shahmoradian, Sarah H.;
Shen, Koning;
Frydman, Judith;
Chiu, Wah

Publication type:

Article

Therapeutics: Targeting huntingtin through morpholino oligomers.

Published in:

Nature Reviews Genetics, 2014, v. 15, n. 9, p. 572, doi. 10.1038/nrg3804

By:

Burgess, Darren J.

Publication type:

Article

The neurogenetics of Drosophila : the Ganetzky legacy.

Published in:

Journal of Neurogenetics, 2016, v. 30, n. 3/4, p. 149, doi. 10.1080/01677063.2016.1254629

By:

O'Connor-Giles, Kate M.;
Zhang, Bing;
Simpson, Julie H.;
Wu, Chun-Fang

Publication type:

Article

Characterization of axonal transport defects in Drosophila Huntingtin mutants.

Published in:

Journal of Neurogenetics, 2016, v. 30, n. 3/4, p. 212, doi. 10.1080/01677063.2016.1202950

By:

Weiss, Kurt R.;
Littleton, J. Troy

Publication type:

Article

Exploring the Genetic Underpinnings of Brain and Behavioral Disorders.

Published in:

Journal of Neurogenetics, 2014, v. 28, n. 1/2, p. 1, doi. 10.3109/01677063.2014.908875

By:

Yao, Wei-Dong;
Wu, Chun-Fang

Publication type:

Article

Neurolipid systems: A new target for the treatment of dementia.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2024, v. 135, n. 3, p. 225, doi. 10.1111/bcpt.14059

By:

Pereira‐Castelo, Gorka;
Bengoetxea de Tena, Iker;
Martínez‐Gardeazabal, Jonatan;
Moreno‐Rodríguez, Marta;
de San Román, Estibaliz González;
Manuel, Iván;
Rodríguez‐Puertas, Rafael

Publication type:

Article

A systems-level 'misunderstanding': the plasma metabolome in Huntington's disease.

Published in:

Annals of Clinical & Translational Neurology, 2015, v. 2, n. 7, p. 756, doi. 10.1002/acn3.214

By:

Rosas, Herminia D.;
Doros, Gheorghe;
Bhasin, Swati;
Thomas, Beena;
Gevorkian, Sona;
Malarick, Keith;
Matson, Wayne;
Hersch, Steven M.

Publication type:

Article

Abnormally high HIP1 expression is associated with metastatic behaviors and poor prognosis in ESCC.

Published in:

Oncology Letters, 2021, v. 21, n. 2, p. 1, doi. 10.3892/ol.2020.12340

By:

YING SUN;
YONGAN ZHOU;
JINGHUA XIA;
MIAOMIAO WEN;
XUEJIAO WANG;
JIAO ZHANG;
YANNING ZHANG;
ZHIPEI ZHANG;
TAO JIANG

Publication type:

Article

Spatial Distribution of Intracellular Ion Concentrations in Aggregate‐Forming HeLa Cells Analyzed by μ‐XRF Imaging.

Published in:

ChemistryOpen, 2022, v. 11, n. 4, p. 1, doi. 10.1002/open.202200024

By:

Gräfenstein, Andreas;
Rumancev, Christoph;
Pollak, Roland;
Hämisch, Benjamin;
Galbierz, Vanessa;
Schroeder, Walter H.;
Garrevoet, Jan;
Falkenberg, Gerald;
Vöpel, Tobias;
Huber, Klaus;
Ebbinghaus, Simon;
Rosenhahn, Axel

Publication type:

Article

Lipidomics of Huntington's Disease: A Comprehensive Review of Current Status and Future Directions.

Published in:

Metabolites (2218-1989), 2025, v. 15, n. 1, p. 10, doi. 10.3390/metabo15010010

By:

Yilmaz, Ali;
Akyol, Sumeyya;
Ashrafi, Nadia;
Saiyed, Nazia;
Turkoglu, Onur;
Graham, Stewart F.

Publication type:

Article

Alteration of Autophagy and Glial Activity in Nilotinib-Treated Huntington's Disease Patients.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 12, p. 1225, doi. 10.3390/metabo12121225

By:

Anderson, Karen E.;
Stevenson, Max;
Varghese, Rency;
Hebron, Michaeline L.;
Koppel, Erin;
McCartin, Mara;
Kuprewicz, Robin;
Matar, Sara;
Ferrante, Dalila;
Moussa, Charbel

Publication type:

Article

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.585821

By:

Manjula, Ramu;
Anuja, Kumari;
Alcain, Francisco J.

Publication type:

Article

Insulin and Exendin-4 Reduced Mutated Huntingtin Accumulation in Neuronal Cells.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.00779

By:

Rea, Silvia;
Della-Morte, David;
Pacifici, Francesca;
Capuani, Barbara;
Pastore, Donatella;
Coppola, Andrea;
Arriga, Roberto;
Andreadi, Aikaterini;
Donadel, Giulia;
Di Daniele, Nicola;
Bellia, Alfonso;
Lauro, Davide

Publication type:

Article

Expression of Human Mutant Huntingtin Protein in Drosophila Hemocytes Impairs Immune Responses.

Published in:

Frontiers in Immunology, 2019, p. 1, doi. 10.3389/fimmu.2019.02405

By:

Lin, Yu-Hsien;
Maaroufi, Houda Ouns;
Ibrahim, Emad;
Kucerova, Lucie;
Zurovec, Michal

Publication type:

Article

Hunting cellular mechanisms underlying the spreading of misfolded protein pathology in the brain.

Published in:

2016

By:

Pecho‐Vrieseling, Eline

Publication type:

Editorial

Binding, internalization and fate of Huntingtin Exon1 fibrillar assemblies in mitotic and nonmitotic neuroblastoma cells.

Published in:

Neuropathology & Applied Neurobiology, 2016, v. 42, n. 2, p. 137, doi. 10.1111/nan.12258

By:

Ruiz‐Arlandis, G.;
Pieri, L.;
Bousset, L.;
Melki, R.

Publication type:

Article

Beyond CAG Repeats: The Multifaceted Role of Genetics in Huntington Disease.

Published in:

Genes, 2024, v. 15, n. 6, p. 807, doi. 10.3390/genes15060807

By:

Pengo, Marta;
Squitieri, Ferdinando

Publication type:

Article

Integrative Analysis Unveils the Correlation of Aminoacyl-tRNA Biosynthesis Metabolites with the Methylation of the SEPSECS Gene in Huntington's Disease Brain Tissue.

Published in:

Genes, 2023, v. 14, n. 9, p. 1752, doi. 10.3390/genes14091752

By:

Vishweswaraiah, Sangeetha;
Yilmaz, Ali;
Saiyed, Nazia;
Khalid, Abdullah;
Koladiya, Purvesh R.;
Pan, Xiaobei;
Macias, Shirin;
Robinson, Andrew C.;
Mann, David;
Green, Brian D.;
Kerševičiūte, Ieva;
Gordevičius, Juozas;
Radhakrishna, Uppala;
Graham, Stewart F.

Publication type:

Article

Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington's Disease.

Published in:

Genes, 2022, v. 13, n. 11, p. 2017, doi. 10.3390/genes13112017

By:

Pellegrini, Miguel;
Bergonzoni, Guendalina;
Perrone, Federica;
Squitieri, Ferdinando;
Biagioli, Marta

Publication type:

Article

Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats.

Published in:

Genes, 2022, v. 13, n. 5, p. 800, doi. 10.3390/genes13050800

By:

Belkozhayev, Ayaz;
Niyazova, Raigul;
Wilson, Cornelia;
Jainakbayev, Nurlan;
Pyrkova, Anna;
Ashirbekov, Yeldar;
Akimniyazova, Aigul;
Sharipov, Kamalidin;
Ivashchenko, Anatoliy

Publication type:

Article

An Overview of Alternative Splicing Defects Implicated in Myotonic Dystrophy Type I.

Published in:

Genes, 2020, v. 11, n. 9, p. 1109, doi. 10.3390/genes11091109

By:

López-Martínez, Andrea;
Soblechero-Martín, Patricia;
de-la-Puente-Ovejero, Laura;
Nogales-Gadea, Gisela;
Arechavala-Gomeza, Virginia

Publication type:

Article

Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4.

Published in:

Genes, 2019, v. 10, n. 8, p. 615, doi. 10.3390/genes10080615

By:

Zhao, Yun;
Li, Chunjin;
Zhou, Xu

Publication type:

Article

A Study of a Geographical Cluster of Huntington's Disease in a Brazilian Town of Zona da Mata, Minas Gerais State.

Published in:

European Neurology, 2015, v. 74, n. 1/2, p. 62, doi. 10.1159/000434630

By:

agostinho, Luciana de andrade;
da Silva, Iane dos Santos;
Maia, Lorena agostini;
azevedo, Mariana de almeida;
Faria, Távia Muniz Ribeiro de Oliveira;
apolinario, Thays andrade;
Pereira, Simão Pedro;
Reis, Rafael de Lima;
dos Santos, Suely Rodrigues;
Paiva, Carmen Lúcia antão

Publication type:

Article

Meso scale discovery-based assays for the detection of aggregated huntingtin.

Published in:

PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0213521

By:

Reindl, Wolfgang;
Baldo, Barbara;
Schulz, Jana;
Janack, Isabell;
Lindner, Ilka;
Kleinschmidt, Markus;
Sedaghat, Yalda;
Thiede, Christina;
Tillack, Karsten;
Schmidt, Christina;
Cardaun, Isabell;
Schwagarus, Tom;
Herrmann, Frank;
Hotze, Madlen;
Osborne, Georgina F.;
Herrmann, Simone;
Weiss, Andreas;
Zerbinatti, Celina;
Bates, Gillian P.;
Bard, Jonathan

Publication type:

Article

Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes.

Published in:

PLoS ONE, 2019, v. 14, n. 2, p. 1, doi. 10.1371/journal.pone.0212337

By:

Tousley, Adelaide;
Iuliano, Maria;
Weisman, Elizabeth;
Sapp, Ellen;
Richardson, Heather;
Vodicka, Petr;
Alexander, Jonathan;
Aronin, Neil;
DiFiglia, Marian;
Kegel-Gleason, Kimberly B.

Publication type:

Article

Introducing an expanded CAG tract into the huntingtin gene causes a wide spectrum of ultrastructural defects in cultured human cells.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0204735

By:

Morozova, Ksenia N.;
Suldina, Lyubov A.;
Malankhanova, Tuyana B.;
Grigor’eva, Elena V.;
Zakian, Suren M.;
Kiseleva, Elena;
Malakhova, Anastasia A.

Publication type:

Article

Does arterial hypertension influence the onset of Huntington's disease?

Published in:

PLoS ONE, 2018, v. 13, n. 5, p. 1, doi. 10.1371/journal.pone.0197975

By:

Valcárcel-Ocete, Leire;
Fullaondo, Asier;
Alkorta-Aranburu, Gorka;
García-Barcina, María;
Roos, Raymund A. C.;
Hjermind, Lena E.;
Saft, Carsten;
Frontali, Marina;
Reilmann, Ralf;
Rickards, Hugh;
null, null;
Zubiaga, Ana M.;
Aguirre, Ana

Publication type:

Article

BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates.

Published in:

PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0192289

By:

Manfré, Giuseppe;
Novati, Arianna;
Faccini, Ilaria;
Rossetti, Andrea C.;
Bosch, Kari;
Molteni, Raffaella;
Riva, Marco A.;
Van der Harst, Johanneke E.;
Nguyen, Huu Phuc;
Homberg, Judith R.

Publication type:

Article

Uncovering the Significance of STEP61 in Alzheimer's Disease: Structure, Substrates, and Interactome.

Published in:

Cellular & Molecular Neurobiology, 2023, v. 43, n. 7, p. 3099, doi. 10.1007/s10571-023-01364-2

By:

Bagwe, Pritam V.;
Deshpande, Radni D.;
Juhasz, Gabor;
Sathaye, Sadhana;
Joshi, Shreerang V.

Publication type:

Article

A Progressive Loss of phosphoSer138-Profilin Aligns with Symptomatic Course in the R6/2 Mouse Model of Huntington's Disease: Possible Sex-Dependent Signaling.

Published in:

Cellular & Molecular Neurobiology, 2022, v. 42, n. 3, p. 871, doi. 10.1007/s10571-020-00984-2

By:

Baharani, Akanksha;
Wei, Zelan;
Roesler, William J.;
Mousseau, Darrell D.

Publication type:

Article

The Role of Extracellular Matrix Components in the Spreading of Pathological Protein Aggregates.

Published in:

Frontiers in Cellular Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fncel.2022.844211

By:

Moretto, Edoardo;
Stuart, Skye;
Surana, Sunaina;
Vargas, Jose Norberto S.;
Schiavo, Giampietro

Publication type:

Article

Detection of ubiquitinated huntingtin species in intracellular aggregates.

Published in:

Frontiers in Molecular Neuroscience, 2015, v. 8, p. 1, doi. 10.3389/fnmol.2015.00001

By:

Juenemann, Katrin;
Wiemhoefer, Anne;
Reits, Eric A.

Publication type:

Article

Down-regulation of miR-9* in the peripheral leukocytes of Huntington's disease patients.

Published in:

2017

By:

Kuo-Hsuan Chang;
Yih-Ru Wu;
Chiung-Mei Chen;
Chang, Kuo-Hsuan;
Wu, Yih-Ru;
Chen, Chiung-Mei

Publication type:

journal article

Mild cognitive impairment in Huntington's disease: challenges and outlooks.

Published in:

Journal of Neural Transmission, 2024, v. 131, n. 4, p. 289, doi. 10.1007/s00702-024-02744-8

By:

Jellinger, Kurt A.

Publication type:

Article

FGF2 and dual agonist of NCAM and FGF receptor 1, Enreptin, rescue neurite outgrowth loss in hippocampal neurons expressing mutated huntingtin proteins.

Published in:

Journal of Neural Transmission, 2019, v. 126, n. 11, p. 1493, doi. 10.1007/s00702-019-02073-1

By:

Ilieva, Mirolyuba;
Nielsen, Troels T.;
Michel, Tanja;
Pankratova, Stanislava

Publication type:

Article

MAP2 Splicing is Altered in Huntington's Disease.

Published in:

Brain Pathology, 2017, v. 27, n. 2, p. 181, doi. 10.1111/bpa.12387

By:

Cabrera, Jorge Rubén;
Lucas, José J.

Publication type:

Article

RNA toxicity induced by expanded CAG repeats in Huntington's disease.

Published in:

Brain Pathology, 2016, v. 26, n. 6, p. 779, doi. 10.1111/bpa.12427

By:

Martí, Eulàlia

Publication type:

Article

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.

Published in:

Nature Medicine, 2014, v. 20, n. 5, p. 536, doi. 10.1038/nm.3514

By:

Wang, Nan;
Gray, Michelle;
Lu, Xiao-Hong;
Cantle, Jeffrey P;
Holley, Sandra M;
Greiner, Erin;
Gu, Xiaofeng;
Shirasaki, Dyna;
Cepeda, Carlos;
Li, Yuqing;
Dong, Hongwei;
Levine, Michael S;
Yang, X William

Publication type:

Article

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.

Published in:

Nature Medicine, 2013, v. 19, n. 8, p. 1030, doi. 10.1038/nm.3246

By:

Marco, Sonia;
Giralt, Albert;
Petrovic, Milos M;
Pouladi, Mahmoud A;
Martínez-Turrillas, Rebeca;
Martínez-Hernández, José;
Kaltenbach, Linda S;
Torres-Peraza, Jesús;
Graham, Rona K;
Watanabe, Masahiko;
Luján, Rafael;
Nakanishi, Nobuki;
Lipton, Stuart A;
Lo, Donald C;
Hayden, Michael R;
Alberch, Jordi;
Wesseling, John F;
Pérez-Otaño, Isabel

Publication type:

Article

Huntington's disease: easing the NMDAR traffic jam.

Published in:

Nature Medicine, 2013, v. 19, n. 8, p. 971, doi. 10.1038/nm.3283

By:

Daggett, Anthony;
Yang, X William

Publication type:

Article

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.

Published in:

Nature Medicine, 2012, v. 18, n. 1, p. 159, doi. 10.1038/nm.2559

By:

Jeong, Hyunkyung;
Cohen, Dena E;
Cui, Libin;
Supinski, Andrea;
Savas, Jeffrey N;
Mazzulli, Joseph R;
Yates, John R;
Bordone, Laura;
Guarente, Leonard;
Krainc, Dimitri

Publication type:

Article

Endothelial Dysfunction in Huntington's Disease: Pathophysiology and Therapeutic Implications.

Published in:

2025

By:

Hu, Ning;
Chen, Zihao;
Zhao, Xinyue;
Peng, Xin;
Wu, Yimeng;
Yang, Kai;
Sun, Taolei

Publication type:

Literature Review

Multimer Detection System: A Universal Assay System for Differentiating Protein Oligomers from Monomers.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 3, p. 1199, doi. 10.3390/ijms26031199

By:

Jamerlan, Angelo Moscoso;
Shim, Kyu Hwan;
Sharma, Niti;
An, Seong Soo A.

Publication type:

Article

Dimerization of Polyglutamine within the PRIME20 Model using Stochastic Approximation Monte Carlo.

Published in:

Macromolecular Theory & Simulations, 2023, v. 32, n. 5, p. 1, doi. 10.1002/mats.202200075

By:

Lauer, Christian;
Paul, Wolfgang

Publication type:

Article