Works about HISTONE demethylases

Results: 421

REIMAGINE: A central nervous system basket trial showing safety and efficacy of vafidemstat on aggression in different psychiatric disorders.

Published in:

Psychiatry & Clinical Neurosciences, 2025, v. 79, n. 5, p. 257, doi. 10.1111/pcn.13800

By:

Ferrer, Marc;
Richarte, Vanesa;
Gisbert, Laura;
Xaus, Jordi;
Gutierrez, Sonia;
Arevalo, Maria Isabel;
Ropacki, Michael;
Bullock, Roger;
Buesa, Carlos;
Ramos‐Quiroga, Josep Antoni

Publication type:

Article

Front Cover: Origins of Catalysis in Non‐Heme Fe(II)/2‐Oxoglutarate‐Dependent Histone Lysine Demethylase KDM4A with Differently Methylated Histone H3 Peptides (Chem. Eur. J. 3/2025).

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 3, p. 1, doi. 10.1002/chem.202580301

By:

Devadas, Sudheesh;
Thomas, Midhun George;
Rifayee, Simahudeen Bathir Jaber Sathik;
Varada, Bhargav;
White, Walter;
Sommer, Ethan;
Campbell, Kylin;
Schofield, Christopher J.;
Christov, Christo Z.

Publication type:

Article

Origins of Catalysis in Non‐Heme Fe(II)/2‐Oxoglutarate‐Dependent Histone Lysine Demethylase KDM4A with Differently Methylated Histone H3 Peptides.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 3, p. 1, doi. 10.1002/chem.202403989

By:

Devadas, Sudheesh;
Thomas, Midhun George;
Rifayee, Simahudeen Bathir Jaber Sathik;
Varada, Bhargav;
White, Walter;
Sommer, Ethan;
Campbell, Kylin;
Schofield, Christopher J.;
Christov, Christo Z.

Publication type:

Article

Cover Feature: Catalysis by KDM6 Histone Demethylases – A Synergy between the Non‐Heme Iron(II) Center, Second Coordination Sphere, and Long‐Range Interactions (Chem. Eur. J. 51/2023).

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 51, p. 1, doi. 10.1002/chem.202302510

By:

Rifayee, Simahudeen Bathir Jaber Sathik;
Chaturvedi, Shobhit S.;
Warner, Cait;
Wildey, Jon;
White, Walter;
Thompson, Martin;
Schofield, Christopher J.;
Christov, Christo Z.

Publication type:

Article

Catalysis by KDM6 Histone Demethylases – A Synergy between the Non‐Heme Iron(II) Center, Second Coordination Sphere, and Long‐Range Interactions.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 51, p. 1, doi. 10.1002/chem.202301305

By:

Rifayee, Simahudeen Bathir Jaber Sathik;
Chaturvedi, Shobhit S.;
Warner, Cait;
Wildey, Jon;
White, Walter;
Thompson, Martin;
Schofield, Christopher J.;
Christov, Christo Z.

Publication type:

Article

Perspectives for epigenetic editing in crops.

Published in:

Transgenic Research, 2021, v. 30, n. 4, p. 381, doi. 10.1007/s11248-021-00252-z

By:

Selma, S.;
Orzáez, D.

Publication type:

Article

The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis.

Published in:

Communications Chemistry, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42004-019-0210-8

By:

Al Temimi, Abbas H. K.;
Amatdjais-Groenen, Helene I. V.;
Reddy, Y. Vijayendar;
Blaauw, Richard H.;
Guo, Hong;
Qian, Ping;
Mecinović, Jasmin

Publication type:

Article

KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid accumulation in pancreatic ductal adenocarcinoma.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02020-4

By:

Wang, Yumin;
Liu, Shiqian;
Wang, Yan;
Li, Baibei;
Liang, Jiaming;
Chen, Yu;
Tang, Bo;
Yu, Shuiping;
Wang, Hongquan

Publication type:

Article

α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cells.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01805-x

By:

Xiang, Kexu;
Kunin, Mikhail;
Larafa, Safa;
Busch, Maike;
Dünker, Nicole;
Jendrossek, Verena;
Matschke, Johann

Publication type:

Article

KDM4C silencing inhibits cell migration and enhances radiosensitivity by inducing CXCL2 transcription in hepatocellular carcinoma.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01418-w

By:

Zeng, Zhen;
Li, Zixuan;
Xue, Jun;
Xue, Huichan;
Liu, Zhiwei;
Zhang, Wenxuan;
Liu, Hongli;
Xu, Shuangbing

Publication type:

Article

Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean.

Published in:

Plants (2223-7747), 2022, v. 11, n. 11, p. 1398, doi. 10.3390/plants11111398

By:

Liu, Mengshi;
Jiang, Jiacan;
Han, Yapeng;
Shi, Mengying;
Li, Xianli;
Wang, Yingxiang;
Dong, Zhicheng;
Yang, Cunyi

Publication type:

Article

Evolutionary History and Functional Diversification of the JmjC Domain-Containing Histone Demethylase Gene Family in Plants.

Published in:

Plants (2223-7747), 2022, v. 11, n. 8, p. N.PAG, doi. 10.3390/plants11081041

By:

Ma, Shifeng;
Zhang, Zhiqiang;
Long, Yingqiang;
Huo, Wenqi;
Zhang, Yuzhi;
Yang, Xiaoqing;
Zhang, Jie;
Li, Xinyang;
Du, Qiying;
Liu, Wei;
Yang, Daigang;
Ma, Xiongfeng

Publication type:

Article

Genome-Wide Identification of Histone Modification Gene Families in the Model Legume Medicago truncatula and Their Expression Analysis in Nodules.

Published in:

Plants (2223-7747), 2022, v. 11, n. 3, p. 322, doi. 10.3390/plants11030322

By:

Lopez, Loredana;
Perrella, Giorgio;
Calderini, Ornella;
Porceddu, Andrea;
Panara, Francesco

Publication type:

Article

Identification, Evolution, and Expression Profiling of Histone Lysine Methylation Moderators in Brassica rapa.

Published in:

Plants (2223-7747), 2019, v. 8, n. 12, p. 526, doi. 10.3390/plants8120526

By:

Liu, Gaofeng;
Khan, Nadeem;
Ma, Xiaoqing;
Hou, Xilin

Publication type:

Article

Histone Methylation Is Required for Virulence, Conidiation, and Multi-Stress Resistance of Alternaria alternata.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.924476

By:

Meng, Shuai;
Huang, Suya;
Liu, Jinhua;
Gai, Yunpeng;
Li, Min;
Duan, Shuo;
Zhang, Shuting;
Sun, Xuepeng;
Yang, Qi;
Wang, Yuchun;
Xu, Kai;
Ma, Haijie

Publication type:

Article

Insulin Signaling and Insulin Resistance Facilitate Trained Immunity in Macrophages Through Metabolic and Epigenetic Changes.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01330

By:

Ieronymaki, Eleftheria;
Daskalaki, Maria G.;
Lyroni, Konstantina;
Tsatsanis, Christos

Publication type:

Article

Comparative de novo transcriptome analysis of male and female Sea buckthorn.

Published in:

3 Biotech, 2018, v. 8, n. 2, p. 0, doi. 10.1007/s13205-018-1122-5

By:

Bansal, Ankush;
Salaria, Mehul;
Sharma, Tashil;
Stobdan, Tsering;
Kant, Anil

Publication type:

Article

The landscape and therapeutic relevance of cancer-associated transcript fusions.

Published in:

Oncogene, 2015, v. 34, n. 37, p. 4845, doi. 10.1038/onc.2014.406

By:

Yoshihara, K;
Wang, Q;
Torres-Garcia, W;
Zheng, S;
Vegesna, R;
Kim, H;
Verhaak, R G W

Publication type:

Article

PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer.

Published in:

Oncogene, 2015, v. 34, n. 22, p. 2897, doi. 10.1038/onc.2014.219

By:

Lee, K-H;
Park, J-W;
Sung, H-S;
Choi, Y-J;
Kim, W H;
Lee, H S;
Chung, H-J;
Shin, H-W;
Cho, C-H;
Kim, T-Y;
Li, S-H;
Youn, H-D;
Kim, S J;
Chun, Y-S

Publication type:

Article

The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma.

Published in:

Oncogene, 2015, v. 34, n. 2, p. 257, doi. 10.1038/onc.2013.541

By:

Parrish, J K;
Sechler, M;
Winn, R A;
Jedlicka, P

Publication type:

Article

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45902-y

By:

Kim, Yong Yean;
Gryder, Berkley E.;
Sinniah, Ranuka;
Peach, Megan L.;
Shern, Jack F.;
Abdelmaksoud, Abdalla;
Pomella, Silvia;
Woldemichael, Girma M.;
Stanton, Benjamin Z.;
Milewski, David;
Barchi Jr., Joseph J.;
Schneekloth Jr, John S.;
Chari, Raj;
Kowalczyk, Joshua T.;
Shenoy, Shilpa R.;
Evans, Jason R.;
Song, Young K.;
Wang, Chaoyu;
Wen, Xinyu;
Chou, Hsien-Chao

Publication type:

Article

Pharmacological targeting of KDM6A and KDM6B, as a novel therapeutic strategy for treating craniosynostosis in Saethre-Chotzen syndrome.

Published in:

Stem Cell Research & Therapy, 2020, v. 11, n. 1, p. 1, doi. 10.1186/s13287-020-02051-5

By:

Pribadi, Clara;
Camp, Esther;
Cakouros, Dimitrios;
Anderson, Peter;
Glackin, Carlotta;
Gronthos, Stan

Publication type:

Article

Association of ORCA/LRWD1 with repressive histone methyl transferases mediates heterochromatin organization.

Published in:

Nucleus (1949-1034), 2015, v. 6, n. 6, p. 435, doi. 10.1080/19491034.2015.1102814

By:

Giri, Sumanprava;
Prasanth, Supriya G

Publication type:

Article

The Jumonji family: past, present and future of histone demethylases in cancer.

Published in:

Biomolecular Concepts, 2014, v. 5, n. 3, p. 209, doi. 10.1515/bmc-2014-0010

By:

Franci, Gianluigi;
Ciotta, Alfonso;
Altucci, Lucia

Publication type:

Article

The emerging roles for histone demethylases in the modulation of signaling pathways.

Published in:

Biomolecular Concepts, 2013, v. 4, n. 1, p. 13, doi. 10.1515/bmc-2012-0031

By:

Di Stefano, Luisa;
Dyson, Nicholas J.

Publication type:

Article

Ribosomal S6 kinase (RSK) plays a critical role in DNA damage response via the phosphorylation of histone lysine demethylase KDM4B.

Published in:

Breast Cancer Research, 2024, v. 26, n. 1, p. 1, doi. 10.1186/s13058-024-01901-x

By:

Wu, Wenwen;
Zhu, Jing;
Nihira, Naoe Taira;
Togashi, Yukiko;
Goda, Atsushi;
Koike, Junki;
Yamaguchi, Kiyoshi;
Furukawa, Yoichi;
Tomita, Takuya;
Saeki, Yasushi;
Johmura, Yoshikazu;
Nakanishi, Makoto;
Miyoshi, Yasuo;
Ohta, Tomohiko

Publication type:

Article

Sleep and Neurochemical Modulation by DZNep and GSK-J1: Potential Link With Histone Methylation Status.

Published in:

Frontiers in Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnins.2019.00237

By:

Murillo-Rodríguez, Eric;
Arankowsky-Sandoval, Gloria;
Barros, Jorge Aparecido;
Rocha, Nuno Barbosa;
Yamamoto, Tetsuya;
Machado, Sérgio;
Budde, Henning;
Telles-Correia, Diogo;
Monteiro, Diogo;
Cid, Luis;
Veras, André Barciela

Publication type:

Article

The role of PHF8 and TLR4 in osteogenic differentiation of periodontal ligament cells in inflammatory environment.

Published in:

2021

By:

Liu, Zhao;
He, Yiheng;
Xu, Chenrong;
Li, Jianjia;
Zeng, Shuguang;
Yang, Xi;
Han, Qianqian

Publication type:

journal article

The role of histone demethylases in cancer therapy

Published in:

Molecular Oncology, 2012, v. 6, n. 6, p. 683, doi. 10.1016/j.molonc.2012.07.004

By:

Hoffmann, Inga;
Roatsch, Martin;
Schmitt, Martin L.;
Carlino, Luca;
Pippel, Martin;
Sippl, Wolfgang;
Jung, Manfred

Publication type:

Article

Abstracts.

Published in:: Journal of Pathology, 2023, v. 261, p. S1, doi. 10.1002/path.6237
Publication type:: Article

Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b.

Published in:

Cell Research, 2013, v. 23, n. 2, p. 225, doi. 10.1038/cr.2012.177

By:

Zhang, Qi;
Qi, Shankang;
Xu, Mingchu;
Yu, Lin;
Tao, Ye;
Deng, Zengqin;
Wu, Wei;
Li, Jiwen;
Chen, Zhongzhou;
Wong, Jiemin

Publication type:

Article

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.

Published in:

Cell Research, 2013, v. 23, n. 1, p. 122, doi. 10.1038/cr.2012.119

By:

Jiang, Wei;
Wang, Jinzhao;
Zhang, Yi

Publication type:

Article

HOTAIR: a key regulator in gynecologic cancers.

Published in:

Cancer Cell International, 2017, v. 17, p. 1, doi. 10.1186/s12935-017-0434-6

By:

Jing Li;
Jing Wang;
Yan Zhong;
Ruixia Guo;
Danxia Chu;
Haifeng Qiu;
Zhongfu Yuan

Publication type:

Article

Genome-wide identification, classification, and expression analysis of the JmjC domain-containing histone demethylase gene family in birch.

Published in:

BMC Genomics, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s12864-021-08063-6

By:

Chen, Bowei;
Ali, Shahid;
Zhang, Xu;
Zhang, Yonglan;
Wang, Min;
Zhang, Qingzhu;
Xie, Linan

Publication type:

Article

Getting to the heart of the matter in cancer: Novel approaches to targeting cancer stem cells.

Published in:

Proceedings of the Japan Academy, Series A: Mathematical Sciences, 2017, v. 93, n. 3b, p. 146, doi. 10.2183/pjab.93.009

By:

Hugh COLVIN;
Masaki MORI

Publication type:

Article

JMJD3-regulated expression of IL-6 is involved in the proliferation and chemosensitivity of acute myeloid leukemia cells.

Published in:

Biological Chemistry, 2021, v. 402, n. 7, p. 815, doi. 10.1515/hsz-2020-0345

By:

Xu, Xiaojun;
Ye, Yongbin;
Wang, Xiaobo;
Lu, Bo;
Guo, Ziwen;
Wu, Shunjie

Publication type:

Article

Vitamin C promotes pluripotency of human induced pluripotent stem cells via the histone demethylase JARID1A.

Published in:

Biological Chemistry, 2016, v. 397, n. 11, p. 1205, doi. 10.1515/hsz-2016-0181

By:

Eid, Wassim;
Abdel-Rehim, Wafaa

Publication type:

Article

Lysine-specific histone demethylase LSD1 and the dynamic control of chromatin.

Published in:

Biological Chemistry, 2013, v. 394, n. 8, p. 1019, doi. 10.1515/hsz-2013-0119

By:

Rudolph, Thomas;
Beuch, Stefanie;
Reuter, Gunter

Publication type:

Article

A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 5, p. 370, doi. 10.1038/nsmb.3005

By:

Gonzalez, Inma;
Munita, Roberto;
Agirre, Eneritz;
Dittmer, Travis A;
Gysling, Katia;
Misteli, Tom;
Luco, Reini F

Publication type:

Article

Crystal-clear dynamics.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 9, p. 1025, doi. 10.1038/nsmb.2670

By:

Larochelle, Stéphane

Publication type:

Article

Spatial and temporal expression of histone demethylase, Kdm2a, during murine molar development.

Published in:

Biotechnic & Histochemistry, 2016, v. 91, n. 2, p. 137, doi. 10.3109/10520295.2015.1106586

By:

Yi, Q;
Cao, Y;
Liu, OS;
Lu, YQ;
Wang, JS;
Wang, SL;
Yao, R;
Fan, ZP

Publication type:

Article

Histone Demethylase Gene PHF2 Is Mutated in Gastric and Colorectal Cancers.

Published in:

Pathology & Oncology Research, 2017, v. 23, n. 3, p. 471, doi. 10.1007/s12253-016-0130-1

By:

Lee, Joo;
Yoo, Nam;
Kim, Min;
Lee, Sug

Publication type:

Article

IDH1 Targeting as a New Potential Option for Intrahepatic Cholangiocarcinoma Treatment—Current State and Future Perspectives.

Published in:

Molecules, 2020, v. 25, n. 16, p. 3754, doi. 10.3390/molecules25163754

By:

Crispo, Fabiana;
Pietrafesa, Michele;
Condelli, Valentina;
Maddalena, Francesca;
Bruno, Giuseppina;
Piscazzi, Annamaria;
Sgambato, Alessandro;
Esposito, Franca;
Landriscina, Matteo

Publication type:

Article

Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B.

Published in:

Molecules, 2019, v. 24, n. 9, p. 1739, doi. 10.3390/molecules24091739

By:

Pippa, Simone;
Mannironi, Cecilia;
Licursi, Valerio;
Bombardi, Luca;
Colotti, Gianni;
Cundari, Enrico;
Mollica, Adriano;
Coluccia, Antonio;
Naccarato, Valentina;
La Regina, Giuseppe;
Silvestri, Romano;
Negri, Rodolfo;
Valente, Sergio;
Muñoz-Torrero, Diego

Publication type:

Article

Triple Combinations of Histone Lysine Demethylase Inhibitors with PARP1 Inhibitor–Olaparib and Cisplatin Lead to Enhanced Cytotoxic Effects in Head and Neck Cancer Cells.

Published in:

Biomedicines, 2024, v. 12, n. 6, p. 1359, doi. 10.3390/biomedicines12061359

By:

Dorna, Dawid;
Kleszcz, Robert;
Paluszczak, Jarosław

Publication type:

Article

IDH Mutations in Glioma: Double-Edged Sword in Clinical Applications?

Published in:

Biomedicines, 2021, v. 9, n. 7, p. 799, doi. 10.3390/biomedicines9070799

By:

Kayabolen, Alisan;
Yilmaz, Ebru;
Bagci-Onder, Tugba

Publication type:

Article

Expression ratio of histone demethylase KDM3A to protamine-1 mRNA is predictive of successful testicular sperm extraction in men with obstructive and non-obstructive azoospermia.

Published in:

Andrology, 2016, v. 4, n. 3, p. 492, doi. 10.1111/andr.12164

By:

Javadirad, S. M.;
Hojati, Z.;
Ghaedi, K.;
Nasr‐Esfahani, M. H.

Publication type:

Article

Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-81689-4

By:

Wright, Hollis;
Aylwin, Carlos F.;
Toro, Carlos A.;
Ojeda, Sergio R.;
Lomniczi, Alejandro

Publication type:

Article

Histone demethylase JMJD2B/KDM4B regulates transcriptional program via distinctive epigenetic targets and protein interactors for the maintenance of trophoblast stem cells.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-020-79601-7

By:

Mak, Kylie Hin-Man;
Lam, Yuk Man;
Ng, Ray Kit

Publication type:

Article

A bacterial enzyme may correct 2-HG accumulation in human cancers.

Published in:

Frontiers in Oncology, 2023, p. 1, doi. 10.3389/fonc.2023.1235191

By:

Yin, William J.

Publication type:

Article