Works matching DE "HISTONE deacetylase inhibitors"

Results: 1863

The anticancer effects of HDAC inhibitors require the immune system.

Published in:

OncoImmunology, 2014, v. 3, n. 1, p. N.PAG, doi. 10.4161/onci.27414

By:

West, Alison C;
Smyth, Mark J;
Johnstone, Ricky W

Publication type:

Article

HDAC inhibitors and their potential applications to glioblastoma therapy.

Published in:

OncoImmunology, 2013, v. 2, n. 8, p. 1, doi. 10.4161/onci.25219

By:

Adamopoulou, Eleni;
Naumann, Ulrike

Publication type:

Article

Interrogation of macrophage-related prognostic signatures reveals a potential immune-mediated therapy strategy by histone deacetylase inhibition in glioma.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1554845

By:

Wang, Xisen;
Wang, Xuya;
Chen, Lei;
Ding, Haozhe;
Fan, Jikang;
Liang, Jianshen;
Zhang, Yu;
Li, Yiming;
Zhang, Yiming;
Yu, Shengping;
Zhang, Chen;
Li, Yaohua;
Li, Tao;
Yang, Xuejun

Publication type:

Article

Early growth response 1 as a key regulator of PD-L1 expression and immune evasion in extranodal NK/T-cell lymphoma.

Published in:

Blood Cancer Journal, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41408-025-01313-w

By:

Lee, Ji Yun;
Kim, Kui-Jin;
Park, Woochan;
Seo, Jeongmin;
Kang, Minsu;
Jung, Eun Hee;
Kim, Sang-A;
Suh, Koung Jin;
Kim, Ji-Won;
Kim, Se Hyun;
Lee, Jeong-Ok;
Kim, Jin Won;
Kim, Yu Jung;
Lee, Keun-Wook;
Kim, Jee Hyun;
Bang, Soo-Mee;
Kim, Tae Min;
Paik, Jin Ho

Publication type:

Article

Histone hyperacetylation disrupts spermatogonial stem cells homeostasis and impairs spermiogenesis.

Published in:

Stem Cell Research & Therapy, 2025, v. 16, n. 1, p. 1, doi. 10.1186/s13287-025-04385-4

By:

Ou, Xiangying;
Yang, Juan;
Du, Guihua;
Yang, Linfeng;
Zhong, Rong;
Long, Fei;
Huang, Haocong;
Zeng, Huihong;
Shao, Lijian

Publication type:

Article

Epigenetic Drivers of Atrial Fibrillation: Mechanisms, Biomarkers, and Therapeutic Targets.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5253, doi. 10.3390/ijms26115253

By:

Karakasis, Paschalis;
Theofilis, Panagiotis;
Milaras, Nikias;
Vlachakis, Panayotis K.;
Patoulias, Dimitrios;
Karamitsos, Theodoros;
Antoniadis, Antonios P.;
Fragakis, Nikolaos

Publication type:

Article

ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas.

Published in:

PLoS Genetics, 2025, v. 21, n. 6, p. 1, doi. 10.1371/journal.pgen.1011726

By:

Paasch, Thea Petersen;
Jarlstad Olesen, Morten Tobias;
García-Rodríguez, Juan Luis;
Assmus, Adrienne M.;
Fenton, Robert A.;
Kjems, Jørgen;
Hager, Henrik;
Kristensen, Lasse Sommer

Publication type:

Article

Reversing Epigenetic Dysregulation in Neurodegenerative Diseases: Mechanistic and Therapeutic Considerations.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4929, doi. 10.3390/ijms26104929

By:

Olawade, David B.;
Rashad, Intishar;
Egbon, Eghosasere;
Teke, Jennifer;
Ovsepian, Saak Victor;
Boussios, Stergios

Publication type:

Article

Simulated Microgravity-Induced Alterations in PDAC Cells: A Potential Role for Trichostatin A in Restoring Cellular Phenotype.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4758, doi. 10.3390/ijms26104758

By:

Pagano, Corinna Anais;
Masini, Maria Angela;
Sabbatini, Maurizio;
Gribaudo, Giorgia;
Manfredi, Marcello;
Caprì, Flavia Giusy;
Bonetto, Valentina;
Magnelli, Valeria;
Donadelli, Massimo;
Corino, Roberto;
Belay, Masho Hilawie;
Robotti, Elisa;
Marengo, Emilio

Publication type:

Article

Safety, pharmacokinetics, and efficacy of abexinostat, an novel histone deacetylase inhibitor, in Chinese patients with relapsed/refractory B cell non-Hodgkin lymphoma: a Phase 1 study.

Published in:

BMC Cancer, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12885-025-14370-y

By:

Gui, Lin;
Xie, Zucheng;
Qin, Yan;
Liu, Peng;
Yang, Jianliang;
Chen, Xinrui;
Li, Zhenyu;
Tao, Ran;
Shi, Yuankai

Publication type:

Article

HDAC4: an emerging target in diabetes mellitus and diabetic complications.

Published in:

European Journal of Medical Research, 2025, v. 30, n. 1, p. 1, doi. 10.1186/s40001-025-02697-y

By:

Lin, Yiqi;
Li, Yuetong;
Ke, Caiying;
Jin, Ying;
Lao, Wanwen;
Wu, Yiling;
Liu, Yang;
Kong, Xinyi;
Qiao, Jie;
Zhai, Aixia;
Bi, Changlong

Publication type:

Article

Viral infection: Coaxing HIV out of hiding.

Published in:

Nature Reviews Microbiology, 2012, v. 10, n. 9, p. 596, doi. 10.1038/nrmicro2861

By:

Jermy, Andrew

Publication type:

Article

Manipulating histone acetylation leads to antitumor effects in hemangiosarcoma cells.

Published in:

Veterinary & Comparative Oncology, 2022, v. 20, n. 4, p. 805, doi. 10.1111/vco.12840

By:

Suzuki, Tamami;
Aoshima, Keisuke;
Yamazaki, Jumpei;
Kobayashi, Atsushi;
Kimura, Takashi

Publication type:

Article

Bioorthogonal Drug Release from Nanometric Micelles in Living Cells.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 43, p. 1, doi. 10.1002/chem.202301359

By:

Madegard, Léa;
Girard, Melissa;
Yaw, Benjamin Riss;
Porte, Karine;
Audisio, Davide;
Papot, Sébastien;
Taran, Frédéric

Publication type:

Article

PEGylated Poly‐HDACi: A Designer Polyprodrug from Optimized Drug Units**.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 4, p. 1, doi. 10.1002/chem.202103114

By:

Han, Jinghua;
Wang, Da‐Yuan;
Wang, Qiuyu;
Meng, Li;
Luo, Zihan;
Li, Jing;
Kang, Yanke;
Lv, Wenhui;
Huang, Qingqing;
Wang, Peng George;
Wang, Yajie;
Shen, Jie;
Wang, Yanming

Publication type:

Article

Syntheses of Thailandepsin B Pseudo‐Natural Products: Access to New Highly Potent HDAC Inhibitors via Late‐Stage Modification.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 69, p. 16241, doi. 10.1002/chem.202002449

By:

Brosowsky, Jana;
Lutterbeck, Monika;
Liebich, Amelie;
Keller, Manfred;
Herp, Daniel;
Vogelmann, Anja;
Jung, Manfred;
Breit, Bernhard

Publication type:

Article

In-Bead Screening of Hydroxamic Acids for the Identification of HDAC Inhibitors.

Published in:

Angewandte Chemie, 2016, v. 128, n. 14, p. 4548, doi. 10.1002/ange.201511308

By:

Qvortrup, Katrine;
Nielsen, Thomas E.

Publication type:

Article

Copper-Catalyzed 1,2-Addition of α-Carbonyl Iodides to Alkynes.

Published in:

Angewandte Chemie, 2015, v. 127, n. 4, p. 1323, doi. 10.1002/ange.201410279

By:

Xu, Tao;
Hu, Xile

Publication type:

Article

Evaluation of safety, pharmacokinetics, and efficacy of vorinostat, a histone deacetylase inhibitor, in the treatment of gastrointestinal (GI) cancer in a phase I clinical trial.

Published in:

International Journal of Clinical Oncology, 2013, v. 18, n. 1, p. 87, doi. 10.1007/s10147-011-0348-6

By:

Doi, Toshihiko;
Hamaguchi, Tetsuya;
Shirao, Kuniaki;
Chin, Kensho;
Hatake, Kiyohiko;
Noguchi, Kazuo;
Otsuki, Tetsuya;
Mehta, Anish;
Ohtsu, Atsushi

Publication type:

Article

Histone deacetylase‐based dual targeted inhibition in multiple myeloma.

Published in:

Medicinal Research Reviews, 2023, v. 43, n. 6, p. 2177, doi. 10.1002/med.21972

By:

Ferro, Angelica;
Pantazaka, Evangelia;
Athanassopoulos, Constantinos M.;
Cuendet, Muriel

Publication type:

Article

Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities.

Published in:

Medicinal Research Reviews, 2020, v. 40, n. 6, p. 2177, doi. 10.1002/med.21701

By:

Rodrigues, Daniel A.;
Pinheiro, Pedro de S. M.;
Sagrillo, Fernanda S.;
Bolognesi, Maria L.;
Fraga, Carlos A. M.

Publication type:

Article

Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease.

Published in:

Experimental Brain Research, 2012, v. 221, n. 3, p. 287, doi. 10.1007/s00221-012-3172-y

By:

Vadnal, J.;
Houston, S.;
Bhatta, S.;
Freeman, E.;
McDonough, J.

Publication type:

Article

Tissue transglutaminase (TG2) is involved in the resistance of cancer cells to the histone deacetylase (HDAC) inhibitor vorinostat.

Published in:

Amino Acids, 2017, v. 49, n. 3, p. 517, doi. 10.1007/s00726-016-2338-5

By:

Carbone, Carmine;
Di Gennaro, Elena;
Piro, Geny;
Milone, Maria;
Pucci, Biagio;
Caraglia, Michele;
Budillon, Alfredo

Publication type:

Article

Design and synthesis of mono and bicyclic tetrapeptides thioester as potent inhibitor of histone deacetylases.

Published in:

Amino Acids, 2014, v. 46, n. 10, p. 2435, doi. 10.1007/s00726-014-1800-5

By:

Hoque, Md.;
Islam, Md.;
Kato, Tamaki;
Nishino, Norikazu;
Ito, Akihiro;
Yoshida, Minoru

Publication type:

Article

Cyclic tetrapeptides with -SS- bridging between amino acid side chains for potent histone deacetylases' inhibition.

Published in:

Amino Acids, 2013, v. 45, n. 4, p. 835, doi. 10.1007/s00726-013-1527-8

By:

Arai, Toru;
Ashraful Hoque, Md.;
Nishino, Norikazu;
Kim, Hyun-Jung;
Ito, Akihiro;
Yoshida, Minoru

Publication type:

Article

Evaluation of functional groups on amino acids in cyclic tetrapeptides in histone deacetylase inhibition.

Published in:

Amino Acids, 2012, v. 42, n. 6, p. 2103, doi. 10.1007/s00726-011-0947-6

By:

Islam, Md.;
Bhuiyan, Mohammed;
Nsiama, Tienabe;
Oishi, Naoto;
Kato, Tamaki;
Nishino, Norikazu;
Ito, Akihiro;
Yoshida, Minoru

Publication type:

Article

Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis.

Published in:

Bioinformatics, 2014, v. 30, n. 17, p. i497, doi. 10.1093/bioinformatics/btu456

By:

Khan, Suleiman A.;
Virtanen, Seppo;
Kallioniemi, Olli P.;
Wennerberg, Krister;
Poso, Antti;
Kaski, Samuel

Publication type:

Article

Anticancer Identification and Molecular Docking of Cowanol from Garcinia fusca Against Histone Deacetylase Domains.

Published in:

Trends in Sciences, 2024, v. 21, n. 8, p. 1, doi. 10.48048/tis.2024.7807

By:

Punpai, Sakdiphong;
Saenkham, Audchara;
Boonsri, Pornthip;
Choowongkomon, Kiattawee;
Suksamrarn, Sunit;
Tanechpongtamb, Wanlaya

Publication type:

Article

HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell‐Based Model of Charcot‐Marie‐Tooth Disease (Type 2D).

Published in:

Advanced Biology, 2022, v. 6, n. 2, p. 1, doi. 10.1002/adbi.202101308

By:

Smith, Alec S.T.;
Kim, Jong Hyun;
Chun, Changho;
Gharai, Ava;
Moon, Hyo Won;
Kim, Eun Young;
Nam, Soo Hyun;
Ha, Nina;
Song, Ju Young;
Chung, Ki Wha;
Doo, Hyun Myung;
Hesson, Jennifer;
Mathieu, Julie;
Bothwell, Mark;
Choi, Byung‐Ok;
Kim, Deok‐Ho

Publication type:

Article

Karcinom plic střední linie NUT – molekulární profilování tří případů a literární přehled perspektiv pro precizní onkologii.

Published in:

Studia Pneumologica et Phthiseologica, 2023, v. 82, n. 3, p. 85

By:

Pešek, M.;
Polívka, J.;
L., Boudová.;
Martínek, P.;
Vaněček, T.;
Baxa, J.;
Mukenšnabl, P.;
Růžičková-Kirchnerová, O.;
Michal, M.

Publication type:

Article

Epigenetic Regulation and Therapeutic Potential of Gasdermin Genes in Colorectal Adenocarcinoma.

Published in:

Experimed, 2023, v. 13, n. 3, p. 218, doi. 10.26650/experimed.1374173

By:

Caldiran, Feyzanur;
Senol, Rumeysa;
Cacan, Ercan

Publication type:

Article

The Impact of Simultaneous Epigenetic and Epitranscriptomic Intervention in Breast Cancer Cells.

Published in:

Istanbul Gelisim University Journal of Health Sciences / İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, 2024, n. 23, p. 505, doi. 10.38079/igusabder.1469350

By:

YANAR, Sevinç;
DEVECİ ÖZKAN, Asuman;
BAL ALBAYRAK, Merve Gülşen;
BETTS, Zeynep

Publication type:

Article

HER3 targeting augments the efficacy of panobinostat in claudin-low triple-negative breast cancer cells.

Published in:

NPJ Precision Oncology, 2023, v. 7, n. 1, p. 1, doi. 10.1038/s41698-023-00422-8

By:

Lyu, Hui;
Hou, Defu;
Liu, Hao;
Ruan, Sanbao;
Tan, Congcong;
Wu, Jiande;
Hicks, Chindo;
Liu, Bolin

Publication type:

Article

Tackling FGFR3-driven bladder cancer with a promising synergistic FGFR/HDAC targeted therapy.

Published in:

NPJ Precision Oncology, 2023, v. 7, n. 1, p. 1, doi. 10.1038/s41698-023-00417-5

By:

Wang, Zechen;
Muthusamy, Viswanathan;
Petrylak, Daniel P.;
Anderson, Karen S.

Publication type:

Article

LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02741-7

By:

Li, Mengxing;
Viswanadhapalli, Suryavathi;
Santhamma, Bindu;
Pratap, Uday P.;
Luo, Yiliao;
Liu, Junhao;
Altwegg, Kristin A.;
Tang, Weiwei;
Liu, Zexuan;
Li, Xiaonan;
Ebrahimi, Behnam;
Yan, Hui;
Zou, Yi;
Konda, Swapna;
Sareddy, Gangadhara R.;
Xu, Zhenming;
Chen, Yidong;
Rao, Manjeet K.;
Brenner, Andrew J.;
Kaklamani, Virginia G.

Publication type:

Article

Identification of potential chemical compounds enhancing generation of enucleated cells from immortalized human erythroid cell lines.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02202-1

By:

Soboleva, Svetlana;
Kurita, Ryo;
Ek, Fredrik;
Åkerstrand, Hugo;
Silvério-Alves, Rita;
Olsson, Roger;
Nakamura, Yukio;
Miharada, Kenichi

Publication type:

Article

Thyroid Hormone–mediated Histone Modification Protects Cortical Neurons From the Toxic Effects of Hypoxic Injury.

Published in:

Journal of the Endocrine Society, 2022, v. 6, n. 11, p. 1, doi. 10.1210/jendso/bvac139

By:

Abe, Kiyomi;
Li, Jianrong;
Liu, Yan Yun;
Brent, Gregory A

Publication type:

Article

Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands.

Published in:

Science Immunology, 2016, v. 1, n. 4, p. 1, doi. 10.1126/sciimmunol.aah4609

By:

Sanford, James A.;
Ling-Juan Zhang;
Williams, Michael R.;
Gangoiti, Jon A.;
Chun-Ming Huang;
Gallo, Richard L.

Publication type:

Article

Implication for Cancer Stem Cells in Solid Cancer Chemo-Resistance: Promising Therapeutic Strategies Based on the Use of HDAC Inhibitors.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 10, p. 912, doi. 10.3390/jcm8070912

By:

Roca, Maria Serena;
Di Gennaro, Elena;
Budillon, Alfredo

Publication type:

Article

Implication for Cancer Stem Cells in Solid Cancer Chemo-Resistance: Promising Therapeutic Strategies Based on the Use of HDAC Inhibitors.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 7, p. 912, doi. 10.3390/jcm8070912

By:

Roca, Maria Serena;
Di Gennaro, Elena;
Budillon, Alfredo

Publication type:

Article

Individualised Multimodal Treatment Strategies for Anaplastic and Poorly Differentiated Thyroid Cancer.

Published in:

Journal of Clinical Medicine, 2018, v. 7, n. 5, p. 115, doi. 10.3390/jcm7050115

By:

Wächter, Sabine;
Wunderlich, Annette;
Roth, Silvia;
Mintziras, Ioannis;
Maurer, Elisabeth;
Hoffmann, Sebastian;
Verburg, Frederik A.;
Fellinger, Sebastian A.;
Holzer, Katharina;
Bartsch, Detlef K.;
Di Fazio, Pietro

Publication type:

Article

Combination of immunotherapy and histone deacetylase inhibitors in cancer treatment.

Published in:

Acta Universitatis Lodziensis Folia Biologica et Oecologica, 2021, v. 17, p. 13, doi. 10.18778/1730-2366.16.09

By:

ORZECHOWSKA, MONIKA

Publication type:

Article

Induction of Neurotrophic and Differentiation Factors in Neural Stem Cells by Valproic Acid.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2014, v. 115, n. 2, p. 216, doi. 10.1111/bcpt.12201

By:

Almutawaa, Walaa;
Kang, Na Hyea;
Pan, Yi;
Niles, Lennard P.

Publication type:

Article

New Epigenetic Modifier Inhibitors Enhance Microspore Embryogenesis in Bread Wheat.

Published in:

Plants (2223-7747), 2024, v. 13, n. 6, p. 772, doi. 10.3390/plants13060772

By:

Valero-Rubira, Isabel;
Vallés, María Pilar;
Echávarri, Begoña;
Fustero, Patricia;
Costar, María Asunción;
Castillo, Ana María

Publication type:

Article

Unraveling Epigenetic Changes in A. thaliana Calli: Impact of HDAC Inhibitors.

Published in:

Plants (2223-7747), 2023, v. 12, n. 24, p. 4177, doi. 10.3390/plants12244177

By:

Pírek, Pavlína;
Kryštofová, Karolína;
Kováčová, Ingrid;
Kromerová, Anna;
Zachová, Dagmar;
Helia, Ondřej;
Panzarová, Klára;
Fajkus, Jiří;
Zdráhal, Zbyněk;
Lochmanová, Gabriela;
Fojtová, Miloslava

Publication type:

Article

Histone Deacetylase Inhibitors Increase the Embryogenic Potential and Alter the Expression of Embryogenesis-Related and HDAC-Encoding Genes in Grapevine (Vitis vinifera L., cv. Mencía).

Published in:

Plants (2223-7747), 2021, v. 10, n. 6, p. 1164, doi. 10.3390/plants10061164

By:

Martínez, Óscar;
Arjones, Verónica;
González, María Victoria;
Rey, Manuel

Publication type:

Article

Trichostatin A Affects Developmental Reprogramming of Bread Wheat Microspores towards an Embryogenic Route.

Published in:

Plants (2223-7747), 2020, v. 9, n. 11, p. 1442, doi. 10.3390/plants9111442

By:

Castillo, Ana María;
Valero-Rubira, Isabel;
Burrell, María Ángela;
Allué, Sandra;
Costar, María Asunción;
Vallés, María Pilar

Publication type:

Article

Vorinostat in the acute neuroinflammatory form of X‐linked adrenoleukodystrophy.

Published in:

Annals of Clinical & Translational Neurology, 2020, v. 7, n. 5, p. 639, doi. 10.1002/acn3.51015

By:

Zierfuss, Bettina;
Weinhofer, Isabelle;
Kühl, Jörn‐Sven;
Köhler, Wolfgang;
Bley, Annette;
Zauner, Katharina;
Binder, Johannes;
Martinović, Ksenija;
Seiser, Christian;
Hertzberg, Christoph;
Kemp, Stephan;
Egger, Gerda;
Leitner, Gerda;
Bauer, Jan;
Wiesinger, Christoph;
Kunze, Markus;
Forss‐Petter, Sonja;
Berger, Johannes

Publication type:

Article

The promise and perils of HDAC inhibitors in neurodegeneration.

Published in:

Annals of Clinical & Translational Neurology, 2015, v. 2, n. 1, p. 79, doi. 10.1002/acn3.147

By:

Didonna, Alessandro;
Opal, Puneet

Publication type:

Article

Synergistic integration of histone deacetylase inhibitors apparently enhances the cytokine‐induced killer cell efficiency in multiple myeloma via the NKG2D pathway.

Published in:

Clinical & Translational Immunology, 2024, v. 13, n. 3, p. 1, doi. 10.1002/cti2.1500

By:

Pu, Jingjing;
Sharma, Amit;
Liu, Ting;
Hou, Jian;
Schmidt‐Wolf, Ingo GH

Publication type:

Article