Works about HISTONE deacetylase

Results: 3665

Transcriptional repression of autophagy and lysosome biogenesis.

Published in:

Autophagy, 2025, v. 21, n. 6, p. 1379, doi. 10.1080/15548627.2025.2465404

By:

Kim, Jaebeom;
Yu, Young Suk;
Kim, Keun Il;
Baek, Sung Hee

Publication type:

Article

Exploring the potential of Gonolobus condurango as a histone deacetylase inhibitor in triple-negative breast cancer cell lines: in vitro study.

Published in:

BMC Complementary Medicine & Therapies, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12906-025-04896-w

By:

Vajen, Beate;
Schäffer, Vera;
Eilers, Marlies;
Schlegelberger, Brigitte;
Skawran, Britta

Publication type:

Article

Chidamide, a Histone Deacetylase Inhibitor, Combined With R‐GemOx in Relapsed/Refractory Diffuse Large B‐Cell Lymphoma (TRUST): A Multicenter, Single‐Arm, Phase 2 Trial.

Published in:

Cancer Medicine, 2025, v. 14, n. 9, p. 1, doi. 10.1002/cam4.70919

By:

Zou, Qihua;
Zhang, Yuchen;
Zhou, Hui;
Lai, Yulin;
Cao, Yi;
Li, Zhiming;
Su, Ning;
Li, Wenyu;
Huang, Huiqiang;
Liu, Panpan;
Ye, Xu;
Wu, Yudan;
Tan, Huo;
Zheng, Runhui;
Wu, Bingyi;
Yang, Hui;
Zhong, Liye;
Lu, Yuhong;
Liang, Yang;
Sun, Peng

Publication type:

Article

Elevated HDAC4 Expression Is Associated with Reduced T-Cell Inflamed Tumor Microenvironment Gene Signatures and Immune Checkpoint Inhibitor Effectiveness in Melanoma †.

Published in:

Cancers, 2025, v. 17, n. 9, p. 1518, doi. 10.3390/cancers17091518

By:

Alamoudi, Mariam K.;
Alsaleh, Abdulmonem A.;
Thyagarajan, Anita;
Alkholifi, Faisal K.;
Raza, Muhammad Liaquat;
Sahu, Ravi P.

Publication type:

Article

Current Treatment of Uveal Melanoma.

Published in:

Cancers, 2025, v. 17, n. 9, p. 1403, doi. 10.3390/cancers17091403

By:

Hanratty, Katie;
Finegan, Gráinne;
Rochfort, Keith D.;
Kennedy, Susan

Publication type:

Article

Inhibition of histone deacetylase 6 activity mitigates neurological impairment and post-hemorrhagic hydrocephalus after intraventricular hemorrhage by modulating pyroptosis and autophagy pathways.

Published in:

Fluids & Barriers of the CNS, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12987-025-00658-5

By:

Wang, Hao-Xiang;
Deng, Zi-Ang;
Li, Yuan-You;
Li, Jun;
Chen, Ya-Xing;
Zhao, Yan-Jie;
Huang, Ke-Ru;
Tian, Wei-Ning;
Tong, Ai-Ping;
Zhou, Liang-Xue

Publication type:

Article

FEA对PRV体内外感染诱导免疫细胞组蛋白乙酰化修饰的调节作用.

Published in:

Feed Research, 2025, v. 48, n. 4, p. 56, doi. 10.13557/j.cnki.issn1002-2813.2025.04.011

By:

余小丽;
袁海峰;
黄昌巧;
蒋丽群;
李艳华;
胡效东;
任春芝;
胡庭俊

Publication type:

Article

Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination.

Published in:

Journal of Pathology, 2025, v. 266, n. 2, p. 217, doi. 10.1002/path.6419

By:

Yao, Jiayu;
Sun, Xiaoou;
Chen, Yousheng;
Xu, Xuan;
Feng, Junxiao;
Zhang, Mingming;
Liu, Xiangdong;
Shi, Xingjuan

Publication type:

Article

Regulation of Dendritic Cell Function by RFX5 through Interaction with HDAC2 and Its Mechanism in Pediatric Asthma.

Published in:

Biocell, 2025, v. 49, n. 4, p. 701, doi. 10.32604/biocell.2025.061289

By:

Wu, Yahui;
Dai, Tiansheng;
Qin, Jingwen;
Guo, Jian;
Fan, Jitao;
Mei, Jun;
Li, Xiaoli;
Liu, Fang

Publication type:

Article

Obacunone acts as a histone deacetylase 1 inhibitor to limit p38MAPK signaling and alleviate osteoarthritis progression.

Published in:

Journal of Orthopaedic Surgery & Research, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13018-025-05804-1

By:

Gao, Yong;
Wang, Ke;
Shi, Chao;
Gao, Yang;
Kong, De-Qian

Publication type:

Article

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4.

Published in:

FEBS Open Bio, 2025, v. 15, n. 5, p. 726, doi. 10.1002/2211-5463.13965

By:

Huang, Jingrui;
Xu, Yukun;
Li, Yujia;
Pang, Yiming;
Ding, Xueting;
Zhou, Raorao;
Liang, Dan;
Che, Xianda;
Zhang, Yuanyu;
Wang, Chunfang;
Li, Wenjin;
Li, Pengcui

Publication type:

Article

Current Status of Healthy Human Skin Models: Can Histone Deacetylase Inhibitors Potentially Improve the Present Replacement Models?

Published in:

Skin Pharmacology & Physiology, 2013, v. 27, n. 1, p. 36, doi. 10.1159/000351363

By:

Lemper, M.;
Snykers, S.;
Vanhaecke, T.;
De Paepe, K.;
Rogiers, V.

Publication type:

Article

Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1.

Published in:

2015

By:

Wang, Shiwen;
Jiang, Bowen;
Zhang, Tengfei;
Liu, Lixia;
Wang, Yi;
Wang, Yiping;
Chen, Xiufei;
Lin, Huaipeng;
Zhou, Lisha;
Xia, Yukun;
Chen, Leilei;
Yang, Chen;
Xiong, Yue;
Ye, Dan;
Guan, Kun-Liang

Publication type:

Correction Notice

Epigenetic Reprogramming of the Type III Interferon Response Potentiates Antiviral Activity and Suppresses Tumor Growth.

Published in:

PLoS Biology, 2014, v. 12, n. 1, p. 1, doi. 10.1371/journal.pbio.1001758

By:

Ding, Siyuan;
Khoury-Hanold, William;
Iwasaki, Akiko;
Robek, Michael D.

Publication type:

Article

An HDAC in the Cytoplasm, not the Nucleus, Plays a Pathogenic Role in Huntington's Disease.

Published in:

PLoS Biology, 2013, v. 11, n. 11, p. 1, doi. 10.1371/journal.pbio.1001718

By:

Robinson, Richard

Publication type:

Article

HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration.

Published in:

PLoS Biology, 2013, v. 11, n. 11, p. 1, doi. 10.1371/journal.pbio.1001717

By:

Mielcarek, Michal;
Landles, Christian;
Weiss, Andreas;
Bradaia, Amyaouch;
Seredenina, Tamara;
Inuabasi, Linda;
Osborne, Georgina F.;
Wadel, Kristian;
Touller, Chrystelle;
Butler, Rachel;
Robertson, Janette;
Franklin, Sophie A.;
Smith, Donna L.;
Park, Larry;
Marks, Paul A.;
Wanker, Erich E.;
Olson, Eric N.;
Luthi-Carter, Ruth;
van der Putten, Herman;
Beaumont, Vahri

Publication type:

Article

Photoperiodic Regulation of Flowering Time through Periodic Histone Deacetylation of the Florigen Gene FT.

Published in:

PLoS Biology, 2013, v. 11, n. 9, p. 1, doi. 10.1371/journal.pbio.1001649

By:

Gu, Xiaofeng;
Wang, Yizhong;
He, Yuehui

Publication type:

Article

Deacetylation Ensures Timely Regulation of Flowering.

Published in:

PLoS Biology, 2013, v. 11, n. 9, p. 1, doi. 10.1371/journal.pbio.1001646

By:

Coombs, Amy

Publication type:

Article

The ING1a Tumor Suppressor Regulates Endocytosis to Induce Cellular Senescence Via the Rb-E2F Pathway.

Published in:

PLoS Biology, 2013, v. 11, n. 3, p. 1, doi. 10.1371/journal.pbio.1001502

By:

Rajarajacholan, Uma Karthika;
Thalappilly, Subhash;
Riabowol, Karl

Publication type:

Article

Enzyme Inhibitor May Offer Dual Protection against Brain Disease.

Published in:

PLoS Biology, 2012, v. 10, n. 2, p. 1, doi. 10.1371/journal.pbio.1001270

By:

Choi, Charles Q.

Publication type:

Article

Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions.

Published in:

PLoS Biology, 2012, v. 10, n. 2, p. 1, doi. 10.1371/journal.pbio.1001257

By:

Debacker, Kim;
Frizzell, Aisling;
Gleeson, Olive;
Kirkham-McCarthy, Lucy;
Mertz, Tony;
Lahue, Robert S.

Publication type:

Article

Recruitment of Cln3 Cyclin to Promoters Controls Cell Cycle Entry via Histone Deacetylase and Other Targets.

Published in:

PLoS Biology, 2009, v. 7, n. 9, p. 1, doi. 10.1371/journal.pbio.1000189

By:

Hongyin Wang;
Carey, Lucas B.;
Ying Cai;
Wijnen, Herman;
Futcher, Bruce

Publication type:

Article

Dual Regulation by Pairs of Cyclin-Dependent Protein Kinases and Histone Deacetylases Controls G1 Transcription in Budding Yeast.

Published in:

PLoS Biology, 2009, v. 7, n. 9, p. 1, doi. 10.1371/journal.pbio.1000188

By:

Dongqing Huang;
Kaluarachchi, Supipi;
van Dyk, Dewald;
Friesen, Helena;
Sopko, Richelle;
Wei Ye;
Bastajian, Nazareth;
Moffat, Jason;
Sassi, Holly;
Costanzo, Michael;
Andrews, Brenda J.

Publication type:

Article

For Some Genes, Acetylation/Deacetylation Cycling Is the Real Turn-On.

Published in:

PLoS Biology, 2005, v. 3, n. 12, p. e431, doi. 10.1371/journal.pbio.0030431

By:

Robinson, Richard

Publication type:

Article

HDAC3 Contributes to Ischemic Stroke by Regulating Interferon Pathway.

Published in:

Journal of Integrative Neuroscience, 2023, v. 22, n. 6, p. 1, doi. 10.31083/j.jin2206156

By:

Jiaxin Wang;
Mengmeng Yang;
Yang Chen;
Yankuo Liu;
Haoliang Zhang;
Ruijia Tian;
Wujie Zhao;
Hongrui Zhu;
Sheng Wang

Publication type:

Article

Investigation of non-hydroxamate scaffolds against HDAC6 inhibition: A pharmacophore modeling, molecular docking, and molecular dynamics simulation approach.

Published in:

Journal of Bioinformatics & Computational Biology, 2018, v. 16, n. 3, p. N.PAG, doi. 10.1142/S0219720018400152

By:

Zeb, Amir;
Park, Chanin;
Son, Minky;
Rampogu, Shailima;
Alam, Syed Ibrar;
Park, Seok Ju;
Lee, Keun Woo

Publication type:

Article

Introduction to Selected Papers from GIW2017.

Published in:

Journal of Bioinformatics & Computational Biology, 2018, v. 16, n. 3, p. N.PAG, doi. 10.1142/S0219720018020031

By:

Sael, Lee

Publication type:

Article

Studying the Cytotoxic Activity of Newly Designed and Synthesized HDAC Inhibitors Derivatives of Pentanoyl Anilide‐5‐Biguanide.

Published in:

Macromolecular Symposia, 2022, v. 401, n. 1, p. 1, doi. 10.1002/masy.202100346

By:

Sagheer, Othman Makki;
Mohammed, Mohammed Hassan;
Wadi, Jaafar S.;
Ibraheem, Zaid O.

Publication type:

Article

Development of Lysine Crotonyl‐Mimic Probe to Covalently Identify H3K27Cr Interacting Proteins.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 62, p. 1, doi. 10.1002/chem.202301624

By:

Guo, Xiaochun;
Wang, Yuena;
An, Yuhao;
Liu, Zhihong;
Liu, Jianbo;
Chen, Jiaxin;
Zhan, Mei‐miao;
Liang, Mingcha;
Hou, Zhanfeng;
Wan, Chuan;
Yin, Feng;
Wang, Rui;
Li, Zigang

Publication type:

Article

Identification and characterization of an acetyl esterase from Paenibacillus sp. XW-6-66 and its novel function in 7-aminocephalosporanic acid deacetylation.

Published in:

Biotechnology Letters, 2019, v. 41, n. 8/9, p. 1059, doi. 10.1007/s10529-019-02709-y

By:

Ding, Junmei;
Zhou, Yang;
Zhu, Hujie;
Deng, Ming;
Long, Liangchuan;
Yang, Yunjuan;
Wu, Qian;
Huang, Zunxi

Publication type:

Article

Copper oxide nanoparticles induce anticancer activity in A549 lung cancer cells by inhibition of histone deacetylase.

Published in:

Biotechnology Letters, 2018, v. 40, n. 2, p. 249, doi. 10.1007/s10529-017-2463-6

By:

Kalaiarasi, Arunachalam;
Sankar, Renu;
Anusha, Chidambaram;
Saravanan, Kandasamy;
Aarthy, Kalyanasundaram;
Karthic, Selvaraj;
Mathuram, Theodore lemuel;
Ravikumar, Vilwanathan

Publication type:

Article

Expression profile analysis of trichostatin A in human gastric cancer cells.

Published in:

Biotechnology Letters, 2002, v. 24, n. 5, p. 377, doi. 10.1023/A:1014512819978

By:

Hosoon Lee;
Seongeun Lee;
Myungin Bæk;
Hae-Yeong Kim;
Doo-Il Jeoung

Publication type:

Article

Alterations of the gene expression profile in renal cell carcinoma after treatment with the histone deacetylase-inhibitor valproic acid and interferon-alpha.

Published in:

World Journal of Urology, 2011, v. 29, n. 6, p. 779, doi. 10.1007/s00345-010-0582-y

By:

Juengel, E.;
Bhasin, M.;
Libermann, T.;
Barth, S.;
Michaelis, M.;
Cinatl, J.;
Jones, J.;
Hudak, L.;
Jonas, D.;
Blaheta, R.

Publication type:

Article

In vitro evaluation of the Aurora kinase inhibitor VX-680 for Hepatoblastoma.

Published in:

Pediatric Surgery International, 2012, v. 28, n. 6, p. 579, doi. 10.1007/s00383-012-3086-6

By:

Dewerth, Alexander;
Wonner, Timo;
Lieber, Justus;
Ellerkamp, Verena;
Warmann, Steven;
Fuchs, Jörg;
Armeanu-Ebinger, Sorin

Publication type:

Article

Sin3: a flexible regulator of global gene expression and genome stability.

Published in:

Current Genetics, 2005, v. 47, n. 1, p. 1, doi. 10.1007/s00294-004-0541-5

By:

Silverstein, Rebecca;
Ekwall, Karl

Publication type:

Article

Panobinostat, a histone deacetylase inhibitor, rescues the angiogenic potential of endothelial colony-forming cells in moyamoya disease.

Published in:

Child's Nervous System, 2019, v. 35, n. 5, p. 823, doi. 10.1007/s00381-019-04099-y

By:

Jangra, Anshika;
Choi, Seung Ah;
Koh, Eun Jung;
Moon, Youn Joo;
Wang, Kyu-Chang;
Phi, Ji Hoon;
Lee, Ji Yeoun;
Kim, Seung-Ki

Publication type:

Article

A randomized phase II study of two doses of vorinostat in combination with 5-FU/LV in patients with refractory colorectal cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 3, p. 743, doi. 10.1007/s00280-011-1762-1

By:

Fakih, M.;
Groman, A.;
McMahon, J.;
Wilding, G.;
Muindi, J.

Publication type:

Article

The effect of food on the bioavailability of panobinostat, an orally active pan-histone deacetylase inhibitor, in patients with advanced cancer.

Published in:

2012

By:

Shapiro, Geoffrey;
Frank, Richard;
Dandamudi, Uday;
Hengelage, Thomas;
Zhao, Lily;
Gazi, Lucien;
Porro, Maria;
Woo, Margaret;
Lewis, Lionel

Publication type:

Report

Methylseleninic acid inhibits HDAC activity in diffuse large B-cell lymphoma cell lines.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 3, p. 815, doi. 10.1007/s00280-011-1649-1

By:

Kassam, Shireen;
Goenaga-Infante, Heidi;
Maharaj, Lenushka;
Hiley, Crispin;
Juliger, Simone;
Joel, Simon

Publication type:

Article

Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor.

Published in:

2011

By:

Hamberg, Paul;
Woo, Margaret;
Chen, Lin-Chi;
Verweij, Jaap;
Porro, Maria;
Zhao, Lily;
Li, Wenkui;
Biessen, Diane;
Sharma, Sunil;
Hengelage, Thomas;
Jonge, Maja

Publication type:

Report

The histone deacetylase inhibitor PXD101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer models.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 2, p. 389, doi. 10.1007/s00280-010-1495-6

By:

Na, Young-Soon;
Jung, Kyung-Ah;
Kim, Seung-Mi;
Hong, Yong;
Ryu, Min-Hee;
Jang, Se;
Moon, Dae;
Cho, Dong-Hyung;
Kim, Jin;
Lee, Jung;
Kim, Tae

Publication type:

Article

Prediction of human pharmacokinetics and tissue distribution of apicidin, a potent histone deacetylase inhibitor, by physiologically based pharmacokinetic modeling.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 2, p. 465, doi. 10.1007/s00280-010-1502-y

By:

Shin, Beom;
Bulitta, Jürgen;
Balthasar, Joseph;
Kim, Minki;
Choi, Yohan;
Yoo, Sun

Publication type:

Article

Antitumor effects of ( S)-HDAC42, a phenylbutyrate-derived histone deacetylase inhibitor, in multiple myeloma cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 2, p. 489, doi. 10.1007/s00280-010-1501-z

By:

Bai, Li-Yuan;
Omar, Hany;
Chiu, Chang-Fang;
Chi, Zeng-Pang;
Hu, Jing-Lan;
Weng, Jing-Ru

Publication type:

Article

Pharmacokinetic and pharmacodynamic properties of an oral formulation of the histone deacetylase inhibitor Belinostat (PXD101).

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 67, n. 6, p. 1273, doi. 10.1007/s00280-010-1419-5

By:

Steele, N.;
Plumb, J.;
Vidal, L.;
Tjørnelund, J.;
Knoblauch, P.;
Buhl-Jensen, P.;
Molife, R.;
Brown, R.;
de Bono, J.;
Evans, T.

Publication type:

Article

Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 67, n. 2, p. 439, doi. 10.1007/s00280-010-1344-7

By:

Yang, Cao;
Choy, Edwin;
Hornicek, Francis;
Wood, Kirkham;
Schwab, Joseph;
Liu, Xianzhe;
Mankin, Henry;
Duan, Zhenfeng

Publication type:

Article

The histone deacetylase inhibitor valproic acid sensitizes human and canine osteosarcoma to doxorubicin.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 67, n. 1, p. 83, doi. 10.1007/s00280-010-1287-z

By:

Wittenburg, Luke;
Bisson, Liam;
Rose, Barbara;
Korch, Christopher;
Thamm, Douglas

Publication type:

Article

The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances taxol-induced cell death in breast cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 6, p. 1131, doi. 10.1007/s00280-010-1455-1

By:

Yi-kang Shi;
Zhong-hua Li;
Xi-qian Han;
Ji-hu Yi;
Zhen-hua Wang;
Jing-li Hou;
Cong-ran Feng;
Qing-hong Fang;
Hui-hui Wang;
Peng-fei Zhang;
Feng-shan Wang;
Jie Shen;
Peng Wang

Publication type:

Article

Identification of type-specific anticancer histone deacetylase inhibitors: road to success.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 4, p. 625, doi. 10.1007/s00280-010-1324-y

By:

Noureen, Nighat;
Rashid, Hamid;
Kalsoom, Saima

Publication type:

Article

Plasma and cerebrospinal fluid pharmacokinetics of the histone deacetylase inhibitor, belinostat (PXD101), in non-human primates.

Published in:

Cancer Chemotherapy & Pharmacology, 2008, v. 62, n. 3, p. 433, doi. 10.1007/s00280-007-0622-5

By:

Warren, Katherine E.;
McCully, Cindy;
Dvinge, Henrik;
Tjørnelund, Jette;
Sehested, Maxwell;
Lichenstein, Henri S.;
Balis, Frank M.

Publication type:

Article

The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo.

Published in:

Cancer Chemotherapy & Pharmacology, 2007, v. 60, n. 2, p. 275, doi. 10.1007/s00280-006-0374-7

By:

Tumber, Anthony;
Collins, Laura S.;
Petersen, Kamille Dumong;
Thougaard, Annemette;
Christiansen, Sanne J.;
Dejligbjerg, Marielle;
Buhl Jensen, Peter;
Sehested, Maxwell;
Ritchie, James W. A.

Publication type:

Article