Works matching DE "HIGH throughput screening (Drug development)"

Results: 3013

High-accuracy physical property prediction for pure organics via molecular representation learning: bridging data to discovery.

Published in:

NPJ Computational Materials, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41524-025-01720-4

By:

Ou, Qi;
Wang, Hongshuai;
Zhuang, Minyang;
Chen, Shangqian;
Liu, Lele;
Wang, Ning;
Gao, Zhifeng

Publication type:

Article

Highly parallel optimisation of chemical reactions through automation and machine intelligence.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61803-0

By:

Sin, Joshua W.;
Chau, Siu Lun;
Burwood, Ryan P.;
Püntener, Kurt;
Bigler, Raphael;
Schwaller, Philippe

Publication type:

Article

High-Fat Diet-Induced Diabetic Cardiomyopathy in Female Zebrafish: Cardiac Pathology and Functional Decline Mediated by Type 2 Diabetes.

Published in:

Nutrients, 2025, v. 18, n. 13, p. 2209, doi. 10.3390/nu17132209

By:

Huang, Shuaiwang;
Chen, Zhanglin;
Li, Haoming;
Zou, Yunyi;
Wang, Bihan;
Zhao, Wenjun;
Zheng, Lan;
Zhou, Zuoqiong;
Peng, Xiyang;
Tang, Changfa

Publication type:

Article

Discovery and Characterization of Novel Non-Hydroxamate HDAC11 Inhibitors.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 5950, doi. 10.3390/ijms26135950

By:

Kopranovic, Aleksandra;
Meyer-Almes, Franz-Josef

Publication type:

Article

Triggering AHR resolves TGF-β1 induced fibroblast activation and promotes AT1 cell regeneration in alveolar organoids.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08446-5

By:

Hagan, Andrew S.;
Williams, Scott;
Mathison, Casey J. N.;
Yan, Shanshan;
Nguyen, Bao;
Federe, Glenn C.;
Kuzu, Guray;
Siefert, Joseph C.;
Hampton, Janice;
Chichkov, Victor;
Whitney Barnes, S.;
King, Frederick J.;
Taylor, Brandon L.;
Walker, John R.;
Zhao, Rui;
Elliott, Jimmy;
Phillips, Dean P.;
Fang, Bin;
Decker, Rebekah S.

Publication type:

Article

The State of the Art on Chemical Databases and Libraries.

Published in:

Croatica Chemica Acta, 2025, v. 97, n. 4, p. 145, doi. 10.5562/cca4130

By:

Stepanić, Višnja;
Hršak, Dalibor;
Kobetić, Renata

Publication type:

Article

Utilizing small molecules to probe and harness the proteome by pooled protein tagging with ligandable domains.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1593844

By:

Larrimore, Katherine E.;
Serebrenik, Yevgeniy V.

Publication type:

Article

High-Throughput Quantification of Recrystallization Parameters for Alloy Development.

Published in:

Metallurgical & Materials Transactions. Part A, 2025, v. 56, n. 8, p. 3095, doi. 10.1007/s11661-025-07822-4

By:

Birchall, Finn;
Bishop, Catherine

Publication type:

Article

Target product profiles for new diagnostics to inform strongyloidiasis control programs.

Published in:

PLoS Neglected Tropical Diseases, 2025, v. 19, n. 7, p. 1, doi. 10.1371/journal.pntd.0012774

By:

Kazienga, Adama;
Coffeng, Luc E.;
Roose, Sara;
de Vlas, Sake J.;
Buonfrate, Dora;
Scarso, Salvatore;
Tamarozzi, Francesca;
Levecke, Bruno

Publication type:

Article

Genomic profiling of a collection of patient-derived xenografts and cell lines identified ixabepilone as an active drug against chemo-resistant osteosarcoma.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2025, v. 44, n. 1, p. 1, doi. 10.1186/s13046-025-03440-5

By:

Manara, Maria Cristina;
Bruzzese, Francesca;
Formentini, Laura;
Landuzzi, Lorena;
Pazzaglia, Laura;
Laginestra, Maria Antonella;
Carrabotta, Marianna;
Roca, Maria Serena;
Iannelli, Federica;
Grumetti, Laura;
Addi, Laura;
Parra, Alessandro;
Cristalli, Camilla;
Pasello, Michela;
Bavelloni, Alberto;
Carreras, Francesca;
Ruzzi, Francesca;
Bianchi, Giuseppe;
Gambarotti, Marco;
Righi, Alberto

Publication type:

Article

Identification of low-molecular compounds that inhibit envelope formation of hepatitis B virus.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10473-5

By:

Sato, Kosuke;
Inoue, Jun;
Ninomiya, Masashi;
Sano, Akitoshi;
Tsuruoka, Mio;
Onuki, Masazumi;
Sawahashi, Satoko;
Ouchi, Keishi;
Doi, Kotaro;
Watanabe, Kengo;
Masamune, Atsushi

Publication type:

Article

Identification of low-molecular compounds that inhibit envelope formation of hepatitis B virus.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10473-5

By:

Sato, Kosuke;
Inoue, Jun;
Ninomiya, Masashi;
Sano, Akitoshi;
Tsuruoka, Mio;
Onuki, Masazumi;
Sawahashi, Satoko;
Ouchi, Keishi;
Doi, Kotaro;
Watanabe, Kengo;
Masamune, Atsushi

Publication type:

Article

High-throughput LDI MS technology decodes the distinct metabolic landscape of prostate cancer in a large-scale cohort.

Published in:

Biomarker Research, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40364-025-00804-z

By:

Jiang, Xinrong;
Zhang, Chen;
Le, Jing;
Zhang, Jie;
Cao, Shuo;
Xu, Xinran;
Chen, Xiaoming;
Cheng, Sheng;
Yu, Haitao;
Jiang, Haofei;
Zang, Ruichen;
Wang, Kunyu;
Chen, Weiwu;
Fan, Haobo;
Wu, Jianmin;
Yu, Yanlan;
Ding, Guoqing

Publication type:

Article

Synergizing multimodal data and fingerprint space exploration for mechanism of action prediction Open Access.

Published in:

Bioinformatics, 2025, v. 41, n. 6, p. 1, doi. 10.1093/bioinformatics/btaf223

By:

Hu, Kaimiao;
Wei, Jianguo;
Sun, Changming;
Geng, Jie;
Wei, Leyi;
Dai, Qi;
Su, Ran

Publication type:

Article

Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.106844

By:

Han Zhou;
Tonglian Zhou;
Wenli Yu;
Liping Liu;
Yeonjin Ko;
Johnson, Kristen A.;
Wilson, Ian A.;
Schultz, Peter G.;
Bollong, Michael J.

Publication type:

Article

Improved doramectin production based on high-throughput screening and medium optimization in Streptomyces avermitilis.

Published in:

Preparative Biochemistry & Biotechnology, 2025, v. 55, n. 6, p. 696, doi. 10.1080/10826068.2024.2448181

By:

Wang, Yu;
He, Huan;
Li, Siqi;
Ren, Limei;
Li, Xiaobing;
Wang, Xiaoru

Publication type:

Article

Mapping cation-eutaxy ternary with a phenomenological model.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60739-9

By:

Won, Jongbum;
Kim, Taeyoung;
Lee, Minwoo;
Davies, Daniel W.;
Lee, Giyeok;
Walsh, Aron;
Soon, Aloysius;
Kim, Jong-Young;
Shim, Wooyoung

Publication type:

Article

The latest advances with natural products in drug discovery and opportunities for the future: a 2025 update.

Published in:

Expert Opinion on Drug Discovery, 2025, v. 20, n. 7, p. 827, doi. 10.1080/17460441.2025.2507382

By:

Xie, Shaowen;
Zhan, Fangyi;
Zhu, Jingjie;
Xu, Shengtao;
Xu, Jinyi

Publication type:

Article

State-of-the-art in high throughput organ-on-chip for biotechnology and pharmaceuticals.

Published in:

Clinical & Experimental Reproductive Medicine, 2025, v. 52, n. 2, p. 114, doi. 10.5653/cerm.2024.06954

By:

Song, Suk-Heung;
Jeong, Sehoon

Publication type:

Article

High yield purification of an isoleucine zipper-modified CD95 ligand for efficient cell apoptosis initiation and with biotin or DNA-oligomer binding domain to probe ligand functionalization effects.

Published in:

BMC Biotechnology, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12896-025-00986-2

By:

Shang, Xiaoyue;
Bartels, Nina;
Weck, Johann Moritz;
Suppmann, Sabine;
Basquin, Jérôme;
Thaventhiran, Gajen;
Heuer-Jungemann, Amelie;
Monzel, Cornelia

Publication type:

Article

The present and future of precision oncology and tumor-agnostic therapeutic approaches.

Published in:

Oncologist, 2025, v. 30, n. 6, p. 1, doi. 10.1093/oncolo/oyaf152

By:

Shah, Nakul M;
Meric-Bernstam, Funda

Publication type:

Article

Establishment of a Sandwich ELISA for Detection of Pan-Merbecoviruses.

Published in:

Pathogens, 2025, v. 14, n. 6, p. 605, doi. 10.3390/pathogens14060605

By:

Li, Kaixin;
Katayama, Misa;
Ichikawa, Ayano;
Matsugo, Hiromichi;
Wakabayashi, Yuta;
Takenaka-Uema, Akiko;
Sekine, Wataru;
Horimoto, Taisuke;
Murakami, Shin

Publication type:

Article

A High-Throughput Inhibitor Screen Targeting CLAG3 Export and Membrane Insertion on Human Erythrocytes Infected with Malaria Parasites.

Published in:

Pathogens, 2025, v. 14, n. 6, p. 520, doi. 10.3390/pathogens14060520

By:

Shao, Jinfeng;
Chu, Jonathan;
Mohammad, Kashif;
Desai, Sanjay A.

Publication type:

Article

Bridging Ethnobotanical Knowledge and Multi-Omics Approaches for Plant-Derived Natural Product Discovery.

Published in:

Metabolites (2218-1989), 2025, v. 15, n. 6, p. 362, doi. 10.3390/metabo15060362

By:

Chele, Kekeletso H.;
Piater, Lizelle A.;
van der Hooft, Justin J. J.;
Tugizimana, Fidele

Publication type:

Article

Process Studies on the W-C-Ti System Using a High-Throughput Laser-Based Additive Manufacturing Approach.

Published in:

Metals (2075-4701), 2025, v. 15, n. 6, p. 664, doi. 10.3390/met15060664

By:

Schubert, Tim;
Malchus, Christiana;
Schurr, Julian;
Wengenmayr, Emanuel;
Bernthaler, Timo;
Schneider, Gerhard

Publication type:

Article

Improvement in Transient Agarose Spot (TAS) Cell Migration Assay: Microplate-Based Detection and Evaluation.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5584, doi. 10.3390/ijms26125584

By:

Veres-Székely, Apor;
Szász, Csenge;
Pap, Domonkos;
Bokrossy, Péter;
Lenzinger, Dorina;
Visnovitz, Tamás;
Mihály, Judith;
Pálmai, Marcell;
Varga, Zoltán;
Őrfi, László;
Szabó, Attila J.;
Vannay, Ádám;
Szebeni, Beáta

Publication type:

Article

Integrated analysis of CD30 detection methodologies and synergistic drug combinations for optimizing brentuximab vedotin therapy in lymphoma.

Published in:

Clinical & Experimental Medicine, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10238-025-01765-1

By:

Ye, Mingyu;
Wang, Tao;
Song, Zhiqiang;
Liu, Xuefei;
Liu, Ping;
Zhang, Ling;
Tang, Gusheng;
He, Miaoxia;
Liu, Na;
Yang, Jianmin

Publication type:

Article

Pretrained E(3)-equivariant message-passing neural networks with multi-level representations for organic molecule spectra prediction.

Published in:

NPJ Computational Materials, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41524-025-01698-z

By:

Xu, Yuzhi;
Bian, Daqian;
Ju, Cheng-Wei;
Zhao, Fanyu;
Xie, Pujun;
Wang, Yuanqing;
Hu, Wei;
Sun, Zhenrong;
Zhang, John Z. H.;
Zhu, Tong

Publication type:

Article

Flexible Concentration Gradient Droplet Generation via Partitioning–Recombination in a Shear Flow-Driven Multilayer Microfluidic Chip.

Published in:

Symmetry (20738994), 2025, v. 17, n. 6, p. 826, doi. 10.3390/sym17060826

By:

Yu, Linkai;
Feng, Qingyang;
Chen, Yifan;
Wu, Yongji;
Sun, Haizhen;
Yang, Hao;
Sun, Lining

Publication type:

Article

Discovery of Small Molecules Against Foot-and-Mouth Disease Virus Replication by Targeting 2C Helicase Activity.

Published in:

Viruses (1999-4915), 2025, v. 17, n. 6, p. 785, doi. 10.3390/v17060785

By:

Zhou, Saisai;
Mu, Suyu;
Yu, Shuqi;
Tian, Yang;
Lu, Sijia;
Li, Zhen;
Wu, Hao;
Zhao, Jiaying;
Chen, Huanchun;
Sun, Shiqi;
Song, Yunfeng

Publication type:

Article

基于网络药理学和分子对接技术探讨沙棘活性成分对非酒精性脂肪肝作用机制

Published in:

Chinese Nursing Research, 2023, v. 37, n. 16, p. 2853, doi. 10.12102/j.issn.1009-6493.2023.16.001

By:

高健;
吴胜男;
王晓静;
纪景馨;
张然;
程景民

Publication type:

Article

Preliminary study of HPV integration status on the occurrence and development of vaginal intraepithelial neoplasia.

Published in:

Journal of Obstetrics & Gynaecology Research, 2024, v. 50, n. 3, p. 478, doi. 10.1111/jog.15855

By:

Yuan, Shuning;
Qian, Cheng;
Zhang, Hailong;
Xing, Yan

Publication type:

Article

Development of a high‐throughput method based on thin‐film microextraction using a 96‐well plate system with a cork coating for the extraction of emerging contaminants in river water samples.

Published in:

Journal of Separation Science, 2018, v. 41, n. 3, p. 697, doi. 10.1002/jssc.201700774

By:

Morés, Lucas;
Dias, Adriana Neves;
Carasek, Eduardo

Publication type:

Article

Biomimetic Miniaturized Platform Able to Sustain Arrays of Liquid Droplets for High-Throughput Combinatorial Tests.

Published in:

Advanced Functional Materials, 2014, v. 24, n. 32, p. 5096, doi. 10.1002/adfm.201400503

By:

Neto, Ana I.;
Correia, Clara R.;
Custódio, Catarina A.;
Mano, João F.

Publication type:

Article

High Throughput Screening of Dynamic Silk-Elastin-Like Protein Biomaterials.

Published in:

Advanced Functional Materials, 2014, v. 24, n. 27, p. 4303, doi. 10.1002/adfm.201304106

By:

Wang, Qin;
Xia, Xiaoxia;
Huang, Wenwen;
Lin, Yinan;
Xu, Qiaobing;
Kaplan, David L.

Publication type:

Article

A single point mutation converts a glutaryl-7-aminocephalosporanic acid acylase into an N-acyl-homoserine lactone acylase.

Published in:

Biotechnology Letters, 2021, v. 43, n. 7, p. 1467, doi. 10.1007/s10529-021-03135-9

By:

Murugayah, Shereen A.;
Evans, Gary B.;
Tyndall, Joel D. A.;
Gerth, Monica L.

Publication type:

Article

Improved AP-3 production through combined ARTP mutagenesis, fermentation optimization, and subsequent genome shuffling.

Published in:

Biotechnology Letters, 2021, v. 43, n. 6, p. 1143, doi. 10.1007/s10529-020-03034-5

By:

Li, Juan;
Guo, Siyu;
Hua, Qiang;
Hu, Fengxian

Publication type:

Article

Combined in silico and in vitro approaches to identify P‐glycoprotein‐inhibiting pesticides.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 1, p. 1, doi. 10.1002/jbt.23588

By:

Guéniche, Nelly;
Lakehal, Zeineb;
Habauzit, Denis;
Bruyère, Arnaud;
Fardel, Olivier;
Le Hégarat, Ludovic;
Huguet, Antoine

Publication type:

Article

Using multiple cognitive task analysis methods for supervisory control interface design in high-throughput biological screening processes.

Published in:

Cognition, Technology & Work, 2006, v. 8, n. 4, p. 237, doi. 10.1007/s10111-006-0029-9

By:

Kaber, D. B.;
Segall, N.;
Green, R. S.;
Entzian, K.;
Junginger, S.

Publication type:

Article

A Fluorogenic Substrate for Quinoline Reduction: Pnictogen‐Bonding Catalysis in Aqueous Systems.

Published in:

Helvetica Chimica Acta, 2024, v. 107, n. 5, p. 1, doi. 10.1002/hlca.202400015

By:

Renno, Giacomo;
Zhang, Qing‐Xia;
Frontera, Antonio;
Sakai, Naomi;
Matile, Stefan

Publication type:

Article

Engineering Host–Guest Interactions in Organic Framework Materials for Drug Delivery.

Published in:

Helvetica Chimica Acta, 2023, v. 106, n. 6, p. 1, doi. 10.1002/hlca.202300013

By:

Ernst, Michelle;
Gryn'ova, Ganna

Publication type:

Article

Inhibition of Thiol‐Mediated Uptake with Irreversible Covalent Inhibitors.

Published in:

Helvetica Chimica Acta, 2021, v. 104, n. 8, p. 1, doi. 10.1002/hlca.202100085

By:

Lim, Bumhee;
Cheng, Yangyang;
Kato, Takehiro;
Pham, Anh‐Tuan;
Le Du, Eliott;
Mishra, Abhaya Kumar;
Grinhagena, Elija;
Moreau, Dimitri;
Sakai, Naomi;
Waser, Jerome;
Matile, Stefan

Publication type:

Article

Characterization and evolution of an activator-independent methanol dehydrogenase from Cupriavidus necator N-1.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 11, p. 4969, doi. 10.1007/s00253-016-7320-3

By:

Wu, Tung-Yun;
Chen, Chang-Ting;
Liu, Jessica;
Bogorad, Igor;
Damoiseaux, Robert;
Liao, James

Publication type:

Article

Combinatorial and high-throughput screening approaches for strain engineering.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 5, p. 2093, doi. 10.1007/s00253-015-6400-0

By:

Liu, Wenshan;
Jiang, Rongrong

Publication type:

Article

ABC transporters coupled with the elevated ergosterol contents contribute to the azole resistance and amphotericin B susceptibility.

Published in:

Applied Microbiology & Biotechnology, 2014, v. 98, n. 6, p. 2609, doi. 10.1007/s00253-013-5425-5

By:

Ren, Biao;
Dai, Huan-Qin;
Pei, Gang;
Tong, Yao-Jun;
Zhuo, Ying;
Yang, Na;
Su, Meng-Yi;
Huang, Pei;
Yang, Yu-Zhuo;
Zhang, Li-Xin

Publication type:

Article

An integrated high-throughput strategy for rapid screening of poly(γ-glutamic acid)-producing bacteria.

Published in:

Applied Microbiology & Biotechnology, 2013, v. 97, n. 5, p. 2163, doi. 10.1007/s00253-013-4717-0

By:

Zeng, Wei;
Lin, Yuanshan;
Qi, Zongxian;
He, Yangyang;
Wang, Dayun;
Chen, Guiguang;
Liang, Zhiqun

Publication type:

Article

Directed evolution of a highly active Yersinia mollaretii phytase.

Published in:

Applied Microbiology & Biotechnology, 2012, v. 95, n. 2, p. 405, doi. 10.1007/s00253-011-3756-7

By:

Shivange, Amol;
Serwe, Annegret;
Dennig, Alexander;
Roccatano, Danilo;
Haefner, Stefan;
Schwaneberg, Ulrich

Publication type:

Article

A high-throughput screening strategy for nitrile-hydrolyzing enzymes based on ferric hydroxamate spectrophotometry.

Published in:

Applied Microbiology & Biotechnology, 2011, v. 89, n. 3, p. 817, doi. 10.1007/s00253-010-2977-5

By:

Yu-Cai He;
Cui-Luan Ma;
Jian-He Xu;
Li Zhou

Publication type:

Article

α- and β-tubulin from Phytophthora capsici KACC 40483: molecular cloning, biochemical characterization, and antimicrotubule screening.

Published in:

Applied Microbiology & Biotechnology, 2009, v. 82, n. 3, p. 513, doi. 10.1007/s00253-008-1821-7

By:

Koo, Bon-Sung;
Park, Haechul;
Kalme, Satish;
Park, Hye-Yeon;
Han, Jin;
Yeo, Yun-Soo;
Yoon, Sang-Hong;
Kim, Soo-Jin;
Lee, Chang-Muk;
Yoon, Moon-Young

Publication type:

Article

Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Target.

Published in:

Cells Tissues Organs, 2022, v. 211, n. 2, p. 157, doi. 10.1159/000512218

By:

Jonckheere, Sven;
Adams, Jamie;
De Groote, Dominic;
Campbell, Kyra;
Berx, Geert;
Goossens, Steven

Publication type:

Article