Works about HEDGEHOG signaling proteins

Results: 1578

C.5 The generation of alternative transcripts as a method of regulating phosphorylation in Sonic Hedgehog (Shh) Subtype Medulloblastoma (MB).

Published in:

2025

By:

Ogawa, K;
Chahin, A;
Purzner, J;
Purzner, T

Publication type:

Abstract

C.2 Dexamethasone induced p57-mediated quiescence contributes to chemotherapy resistance in sonic hedgehog medulloblastoma.

Published in:

2025

By:

Sharma, A;
Purzner, J;
Purzner, T

Publication type:

Abstract

ALKAL1 gene silencing prevents colorectal cancer progression via suppressing Sonic Hedgehog (SHH) signaling pathway.

Published in:

Journal of Cancer, 2021, v. 12, n. 1, p. 150, doi. 10.7150/jca.46447

By:

Shasha Chen;
Bin Wang;
Xuekun Fu;
Yanfang Liang;
Xingxing Chai;
Ziyu Ye;
Ronggang Li;
Yaoming He;
Gang Kong;
Jiachun Lian;
Xiangyong Li;
Ting Chen;
Xin Zhang;
Xianxiu Qiu;
Xudong Tang;
Keyuan Zhou;
Bihua Lin;
Jincheng Zeng

Publication type:

Article

The P53<sup>N236S</sup> Mutation Plays a Regulatory Role in Osteosarcoma Metastasis Via the Cholesterol-Hedgehog Pathway.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2025, v. 59, n. 3, p. 375, doi. 10.33594/000000780

By:

Wang Lulin;
Liu Jiawei;
Zhang Shuojie;
Xie Xiaoli;
Wang Hui;
Jia Jing;
Dan Juhua

Publication type:

Article

Hedgehog pathway, cell cycle, and primary cilium.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02605-7

By:

Zhuang, Tenghan

Publication type:

Article

When G Protein‐Coupled Receptor Signaling Meets the Primary Cilium: Implications for Sonic Hedgehog Signaling.

Published in:

BioEssays, 2025, v. 47, n. 7, p. 1, doi. 10.1002/bies.70021

By:

Kim, Sung‐Eun

Publication type:

Article

G Protein‐Coupled Receptor Signal Intersection at the Primary Cilium.

Published in:

BioEssays, 2025, v. 47, n. 7, p. 1, doi. 10.1002/bies.70015

By:

Wang, Christina E.;
Ogden, Stacey K.

Publication type:

Article

Nuclear factor I-C regulates enamel and dentin formation via the Sonic hedgehog signaling pathway in mouse incisors.

Published in:

BMC Oral Health, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12903-025-06276-9

By:

Zhang, Rui;
Li, Ruiqi;
Huang, Xiaofeng

Publication type:

Article

A Hedgehog–Foxf axis coordinates dental follicle-derived alveolar bone formation.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61050-3

By:

Nagata, Mizuki;
Gadhvi, Gaurav T.;
Komori, Taishi;
Arai, Yuki;
Tsutsumi-Arai, Chiaki;
Chu, Angel Ka Yan;
Nye, Seth N.;
Yang, Yuntao;
Orikasa, Shion;
Takahashi, Akira;
Carlsson, Peter;
Zheng, W. Jim;
Welch, Joshua D.;
Ono, Noriaki;
Ono, Wanida

Publication type:

Article

Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson's disease–linked LRRK2-mutant mice.

Published in:

Science Signaling, 2025, v. 18, n. 893, p. 1, doi. 10.1126/scisignal.ads5761

By:

Jaimon, Ebsy;
Lin, Yu-En;
Tonelli, Francesca;
Antico, Odetta;
Alessi, Dario R.;
Pfeffer, Suzanne R.

Publication type:

Article

Advanced Basal Cell Carcinoma: A Narrative Review on Current Systemic Treatments and the Neoadjuvant Approach.

Published in:

Journal of Personalized Medicine, 2025, v. 15, n. 6, p. 226, doi. 10.3390/jpm15060226

By:

Paradisi, Andrea;
Mannino, Maria;
Brunetti, Francesco;
Bocchino, Enrico;
Di Stefani, Alessandro;
Peris, Ketty

Publication type:

Article

The Prognostic Value of the Hedgehog Signaling Pathway in Ovarian Cancer.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5888, doi. 10.3390/ijms26125888

By:

Salman, Noor D.;
Hanker, Lars C.;
Győrffy, Balázs;
Bartha, Áron;
Proppe, Louisa;
Götte, Martin

Publication type:

Article

Downregulation of S6 Kinase and Hedgehog–Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5721, doi. 10.3390/ijms26125721

By:

Kebenko, Maxim;
Zhuang, Ruimeng;
Hoffer, Konstantin;
Worthmann, Anna;
Horn, Stefan;
Kriegs, Malte;
Vorwerk, Jan;
von Bubnoff, Nikolas;
Khandanpour, Cyrus;
Gebauer, Niklas;
Gorantla, Sivahari Prasad;
Fiedler, Walter;
Bokemeyer, Carsten;
Jücker, Manfred

Publication type:

Article

ZIC1 transcription factor overexpression in segmental bone defects is associated with brown adipogenic and osteogenic differentiation.

Published in:

Stem Cells, 2025, v. 43, n. 6, p. 1, doi. 10.1093/stmcls/sxaf013

By:

Thottappillil, Neelima;
Li, Zhao;
Xing, Xin;
Arondekar, Shreya;
Zhu, Manyu;
Cherief, Masnsen;
Qin, Qizhi;
Zhou, Myles;
Archer, Mary;
Broderick, Kristen;
Pèault, Bruno;
Lee, Min;
James, Aaron W

Publication type:

Article

Integration of Shallow Gradients of Shh and Netrin-1 Guides Commissural Axons.

Published in:

PLoS Biology, 2015, v. 13, n. 3, p. 1, doi. 10.1371/journal.pbio.1002119

By:

Sloan, Tyler F. W.;
Qasaimeh, Mohammad A.;
Juncker, David;
Yam, Patricia T.;
Charron, Frédéric

Publication type:

Article

Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover.

Published in:

PLoS Biology, 2013, v. 11, n. 11, p. 1, doi. 10.1371/journal.pbio.1001721

By:

Huang, Shoujun;
Zhang, Zhao;
Zhang, Chunxia;
Lv, Xiangdong;
Zheng, Xiudeng;
Chen, Zhenping;
Sun, Liwei;
Wang, Hailong;
Zhu, Yuanxiang;
Zhang, Jing;
Yang, Shuyan;
Lu, Yi;
Sun, Qinmiao;
Tao, Yi;
Liu, Feng;
Zhao, Yun;
Chen, Dahua

Publication type:

Article

Sonic Hedgehog Promotes Tumor Cell Survival by Inhibiting CDON Pro-Apoptotic Activity.

Published in:

PLoS Biology, 2013, v. 11, n. 8, p. 1, doi. 10.1371/journal.pbio.1001623

By:

Delloye-Bourgeois, Céline;
Gibert, Benjamin;
Rama, Nicolas;
Delcros, Jean-Guy;
Gadot, Nicolas;
Scoazec, Jean-Yves;
Krauss, Robert;
Bernet, Agnès;
Mehlen, Patrick

Publication type:

Article

Secretion and Signaling Activities of Lipoprotein- Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals.

Published in:

PLoS Biology, 2013, v. 11, n. 3, p. 1, doi. 10.1371/journal.pbio.1001505

By:

Palm, Wilhelm;
Swierczynska, Marta M.;
Kumari, Veena;
Ehrhart-Bornstein, Monika;
Bornstein, Stefan R.;
Suzanne Eaton, Suzanne Eaton

Publication type:

Article

Hedgehog Signaling Acts with the Temporal Cascade to Promote Neuroblast Cell Cycle Exit.

Published in:

PLoS Biology, 2013, v. 11, n. 2, p. 1, doi. 10.1371/journal.pbio.1001494

By:

Phing Chian Chai;
Zhong Liu;
William Chia;
Yu Cai

Publication type:

Article

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog.

Published in:

PLoS Biology, 2010, v. 8, n. 6, p. 1, doi. 10.1371/journal.pbio.1000382

By:

Dessaud, Eric;
Ribes, Vanessa;
Balaskas, Nikolaos;
Lin Lin Yang;
Pierani, Alessandra;
Kicheva, Anna;
Novitch, Bennett G.;
Briscoe, James;
Sasai, Noriaki

Publication type:

Article

Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion.

Published in:

PLoS Biology, 2006, v. 4, n. 8, p. e232, doi. 10.1371/journal.pbio.0040232

By:

Bijlsma, Maarten F.;
Spek, C. Arnold;
Zivkovic, Danica;
van de Water, Sandra;
Rezaee, Farhad;
Peppelenbosch, Maikel P.

Publication type:

Article

The you Gene Encodes an EGF-CUB Protein Essential for Hedgehog Signaling in Zebrafish.

Published in:

PLoS Biology, 2005, v. 3, n. 1, p. 1, doi. 10.1371/journal.pbio.0030066

By:

Woods, Ian G;
Talbot, William S

Publication type:

Article

Rational Design of Polymeric Hybrid Micelles with Highly Tunable Properties to Co-Deliver MicroRNA-34a and Vismodegib for Melanoma Therapy.

Published in:

Advanced Functional Materials, 2015, v. 25, n. 48, p. 7457, doi. 10.1002/adfm.201503115

By:

Li, Hanmei;
Fu, Yao;
Zhang, Ting;
Li, Yanping;
Hong, Xiaoyu;
Jiang, Jiayu;
Gong, Tao;
Zhang, Zhirong;
Sun, Xun

Publication type:

Article

Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma.

Published in:

Journal of Neuro-Oncology, 2013, v. 115, n. 2, p. 161, doi. 10.1007/s11060-013-1216-1

By:

Hayden Gephart, Melanie;
Su, YouRong;
Bandara, Samuel;
Tsai, Feng-Chiao;
Hong, Jennifer;
Conley, Nicholas;
Rayburn, Helen;
Milenkovic, Ljiljana;
Meyer, Tobias;
Scott, Matthew

Publication type:

Article

Sex and hedgehog: roles of genes in the hedgehog signaling pathway in mammalian sexual differentiation.

Published in:

Chromosome Research, 2012, v. 20, n. 1, p. 247, doi. 10.1007/s10577-011-9254-z

By:

Franco, Heather;
Yao, Humphrey

Publication type:

Article

Hesperetin derivative decreases CCl<sub>4</sub>‐induced hepatic fibrosis by Ptch1‐dependent mechanisms.

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 10, p. 1, doi. 10.1002/jbt.23149

By:

Zhu, Sai;
Chen, Xin;
Chen, Si‐Yu;
Wang, Ao;
Wu, Sha;
Wu, Yuan‐Yuan;
Cheng, Miao;
Xu, Jin‐Jin;
Li, Xiao‐Feng;
Huang, Cheng;
Li, Jun

Publication type:

Article

Biomarkers for predicting the response of esophageal squamous cell carcinoma to neoadjuvant chemoradiation therapy.

Published in:

Surgery Today, 2014, v. 44, n. 3, p. 421, doi. 10.1007/s00595-013-0580-y

By:

Okumura, Hiroshi;
Uchikado, Yasuto;
Setoyama, Tetsuro;
Matsumoto, Masataka;
Owaki, Tetsuhiro;
Ishigami, Sumiya;
Natsugoe, Shoji

Publication type:

Article

Accelerated intestinal epithelial cell turnover after bowel resection in a rat is correlated with inhibited hedgehog signaling cascade.

Published in:

2016

By:

Sukhotnik, I.;
Dorfman, T.;
Halabi, Salim;
Pollak, Y.;
Kreizman Shefer, H.;
Coran, A.;
Berkowitz, D.;
Coran, A G

Publication type:

journal article

Hedgehog signal inhibitors suppress the invasion of human rhabdomyosarcoma cells.

Published in:

Pediatric Surgery International, 2013, v. 29, n. 11, p. 1153, doi. 10.1007/s00383-013-3369-6

By:

Oue, Takaharu;
Uehara, Shuichiro;
Yamanaka, Hiroaki;
Nomura, Motonari;
Usui, Noriaki

Publication type:

Article

Sonic hedgehog gene expression in nitrofen induced hypoplastic lungs in mice.

Published in:

2009

By:

Sato, Hideaki;
Murphy, Paula;
Hajduk, Piotr;
Takayasu, Hajime;
Kitagawa, Hiroaki;
Puri, Prem

Publication type:

journal article

Sonic hedgehog expression in the development of hindgut in ETU-exposed fetal rats.

Published in:

2006

By:

Mandhan, Parkash;
Beasley, Spencer;
Hale, Tracy;
Ellmers, Leigh;
Roake, Justin;
Sullivan, Michael

Publication type:

journal article

Sonic hedgehog hepatocellular adenoma: magnetic resonance imaging features and correlation with histology.

Published in:

European Radiology, 2024, v. 34, n. 7, p. 4649, doi. 10.1007/s00330-023-10344-5

By:

Ducatel, Arnaud;
Trillaud, Hervé;
Reizine, Edouard;
Vilgrain, Valérie;
Sempoux, Christine;
Schmidt-Kobbe, Sabine;
Gouw, Annette S. H.;
de Haas, Robbert J;
Julien, Céline;
Paradis, Valérie;
Blanc, Jean-Frédéric;
Chiche, Laurence;
Balabaud, Charles;
Bioulac-Sage, Paulette;
Frulio, Nora

Publication type:

Article

Molecular characterization of common carp ( Cyprinus carpio) Sonic Hedgehog and discovery of its maternal expression.

Published in:

Development Genes & Evolution, 2007, v. 217, n. 4, p. 299, doi. 10.1007/s00427-007-0139-2

By:

Na Wang;
Yong-Hua Sun;
Jing Liu;
Ya-Ping Wang;
Zuo-Yan Zhu

Publication type:

Article

Hedgehog Signaling during Gut Formation in the Freshwater Leech, Helobdella austinensis.

Published in:

Cells Tissues Organs, 2025, v. 214, n. 3, p. 194, doi. 10.1159/000543782

By:

Medina-Jiménez, Brenda I.;
Kwak, Hee-Jin;
Aryal, Yam Prasad;
Lee, Chan-Jun;
Jeong, Geon-Hwi;
Pyo, In-Hyeok;
Park, Hyeonwoo;
Kim, Sangjune;
Park, Soon Cheol;
Cho, Sung-Jin

Publication type:

Article

Lack of Nuclear Localization of the Creb3l1 Transcription Factor Causes Defects in Caudal Fin Bifurcation in Zebrafish Danio rerio.

Published in:

Cells Tissues Organs, 2025, v. 214, n. 2, p. 77, doi. 10.1159/000540103

By:

VanWinkle, Peyton E.;
Wynn, Bridge;
Lee, Eunjoo;
Nawara, Tomasz J.;
Thomas, Holly;
Parant, John M.;
Alvarez, Cecilia;
Serra, Rosa;
Sztul, Elizabeth

Publication type:

Article

Meckel’s Cartilage Differentiation Is Dependent on Hedgehog Signaling.

Published in:

Cells Tissues Organs, 2005, v. 179, n. 4, p. 146, doi. 10.1159/000085950

By:

Melnick, Michael;
Witcher, Daniel;
Bringas, Jr., Pablo;
Carlsson, Peter;
Jaskoll, Tina

Publication type:

Article

Hedgehog signaling directs cell differentiation and plays a critical role in tendon enthesis healing.

Published in:

NPJ Regenerative Medicine, 2025, v. 10, n. 1, p. 1, doi. 10.1038/s41536-025-00392-4

By:

Fang, Fei;
Casserly, Matthew;
Robbins, Julia;
Thomopoulos, Stavros

Publication type:

Article

A murine model of large-scale bone regeneration reveals a selective requirement for Sonic Hedgehog.

Published in:

NPJ Regenerative Medicine, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41536-022-00225-8

By:

Serowoky, Maxwell A.;
Kuwahara, Stephanie T.;
Liu, Shuwan;
Vakhshori, Venus;
Lieberman, Jay R.;
Mariani, Francesca V.

Publication type:

Article

The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions.

Published in:

NPJ Regenerative Medicine, 2021, v. 6, n. 1, p. 1, doi. 10.1038/s41536-021-00120-8

By:

Di Luca, Mariana;
Fitzpatrick, Emma;
Burtenshaw, Denise;
Liu, Weimin;
Helt, Jay-Christian;
Hakimjavadi, Roya;
Corcoran, Eoin;
Gusti, Yusof;
Sheridan, Daniel;
Harman, Susan;
Lally, Catriona;
Redmond, Eileen M.;
Cahill, Paul A.

Publication type:

Article

Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus.

Published in:

Nature Immunology, 2006, v. 7, n. 4, p. 418, doi. 10.1038/ni1313

By:

El Andaloussi, Abdeljabar;
Graves, Stephanie;
Fanyong Meng;
Mandal, Malay;
Mashayekhi, Mona;
Aifantis, Iannis

Publication type:

Article

SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02260-4

By:

Bordin, Fabio;
Terriaca, Gloria;
Apostolico, Adriano;
Di Fiore, Annamaria;
Mir, Faranak Taj;
Bellardinelli, Sara;
Bufalieri, Francesca;
Bordone, Rosa;
Bellardinilli, Francesca;
Giannini, Giuseppe;
Canettieri, Gianluca;
Di Marcotullio, Lucia;
Ferretti, Elisabetta;
Moretti, Marta;
De Smaele, Enrico

Publication type:

Article

Immunotherapy in Basal Cell Carcinoma.

Published in:

Journal of Clinical Medicine, 2024, v. 13, n. 19, p. 5730, doi. 10.3390/jcm13195730

By:

Ungureanu, Loredana;
Vasilovici, Alina Florentina;
Halmágyi, Salomea-Ruth;
Trufin, Ioana Irina;
Apostu, Adina Patricia;
Prisecaru, Manuela;
Șenilă, Simona Corina

Publication type:

Article

Metabolic Imaging of Advanced Basal Cell Carcinoma Treated with Sonidegib: A Retrospective Case Series Study.

Published in:

Journal of Clinical Medicine, 2024, v. 13, n. 17, p. 5087, doi. 10.3390/jcm13175087

By:

Proietti, Ilaria;
Filippi, Luca;
Bagni, Oreste;
Potenza, Concetta

Publication type:

Article

Epidermal-Derived Hedgehog Signaling Drives Mesenchymal Proliferation during Digit Tip Regeneration.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 18, p. 4261, doi. 10.3390/jcm10184261

By:

Maan, Zeshaan N.;
Rinkevich, Yuval;
Barrera, Janos;
Chen, Kellen;
Henn, Dominic;
Foster, Deshka;
Bonham, Clark Andrew;
Padmanabhan, Jagannath;
Sivaraj, Dharshan;
Duscher, Dominik;
Hu, Michael;
Yan, Kelley;
Januszyk, Michael;
Longaker, Michael T.;
Weissman, Irving L.;
Gurtner, Geoffrey C.

Publication type:

Article

毛兰素通过Hedgehog信号通路调控结直肠癌HT29细胞的上皮间质转化和血管生成.

Published in:

Chinese Journal of Cancer Biotherapy, 2023, v. 30, n. 8, p. 689, doi. 10.3872/j.issn.1007-385x.2023.08.006

By:

张国;
张波;
马刚;
胡安祥

Publication type:

Article

Awardee Talk: Pursuit of Novel Factors that Regulate Ovarian Follicular Function.

Published in:

2021

By:

Spicer, Leon J.

Publication type:

Abstract

Dicer1 Ablation Impairs Responsiveness of Cerebellar Granule Neuron Precursors to Sonic Hedgehog and Disrupts Expression of Distinct Cell Cycle Regulator Genes.

Published in:

Cerebellum, 2017, v. 16, n. 2, p. 450, doi. 10.1007/s12311-016-0821-x

By:

Liu, Qian;
Jiang, Mei;
Kuang, Yi;
Shu, Xiaoqiong;
Li, Jun;
Li, Matthew;
Li, Hedong

Publication type:

Article

Treatment of Acute Myeloid Leukemia in the Community Setting.

Published in:

Oncologist, 2024, v. 29, n. 9, p. 801, doi. 10.1093/oncolo/oyae051

By:

Al-Juhaishi, Taha;
Cruz, Servillano Dela;
Gupta, Rohan;
Keiffer, Gina;
Morrison, Vicki A;
Shapira, Iuliana;
Woods, Ashley;
Norsworthy, Kelly;
Claro, Romeo Angelo de;
Theoret, Marc R;
Garg, Ravin;
Pulte, Elizabeth Dianne

Publication type:

Article

Hedgehog Inhibitors Beyond Clinical Complete Response in Basal Cell Carcinoma: Should I Stop or Should I Go?

Published in:

Oncologist, 2024, v. 29, n. 5, p. e699, doi. 10.1093/oncolo/oyad319

By:

Alfieri, Salvatore;
Romanò, Rebecca;
Marceglia, Sara;
Giorgi, Vincenzo De;
Peris, Ketty;
Sollena, Pietro;
Piccerillo, Alfredo;
Moro, Ruggero;
Gualdi, Giulio;
Ascierto, Paolo Antonio;
Palla, Marco;
Paone, Miriam;
Eibenschutz, Laura;
Spagnolo, Francesco;
Queirolo, Paola;
Filippini, Daria Maria;
Cavalieri, Stefano;
Resteghini, Carlo;
Bergamini, Cristiana;
Manocchio, Antonello

Publication type:

Article

Sonidegib with and Without Adjunctive Treatment for Locally Advanced Basal Cell Carcinomas.

Published in:

Oncologist, 2022, v. 27, n. 6, p. e533, doi. 10.1093/oncolo/oyac063

By:

Villani, Alessia;
Fabbrocini, Gabriella;
Costa, Claudia;
Potestio, Luca;
Scalvenzi, Massimiliano

Publication type:

Article