Works matching DE "GUANINE nucleotide exchange factors"

Results: 715

Ras Guanine Nucleotide-Releasing Protein-4 Inhibits Erythropoietin Production in Diabetic Mice with Kidney Disease by Degrading HIF2A.

Published in:

Diabetes & Metabolism Journal, 2025, v. 49, n. 3, p. 421, doi. 10.4093/dmj.2024.0398

By:

Junmei Wang;
Shuai Huang;
Li Zhang;
Yixian He;
Xian Shao;
A-Shan-Jiang A-Ni-Wan;
Yan Kong;
Xuying Meng;
Pei Yu;
Saijun Zhou

Publication type:

Article

Divergent Functions of Rap1A and Rap1B in Endothelial Biology and Disease.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5372, doi. 10.3390/ijms26115372

By:

Kosuru, Ramoji;
Chrzanowska, Magdalena

Publication type:

Article

Structural and Functional Analysis of the Human IQSEC2 S1474Qfs*133 Mutation.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 635, doi. 10.3390/biom15050635

By:

Israel, Yonat;
Lowenkamp, Aaron;
Shokhen, Michael;
Netser, Shai;
Wagner, Shlomo;
Zarowin, Joseph;
Orth, Shaun;
Borisov, Veronika;
Lache, Orit;
Levy, Nina S.;
Levy, Andrew P.

Publication type:

Article

Development and tissue specific expression of RAPGEF1 (C3G) transcripts having exons encoding disordered segments with predicted regulatory function.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09845-3

By:

Verma, Archana;
Goel, Abhishek;
Koner, Niladri;
Gunasekaran, Gowthaman;
Radha, Vegesna

Publication type:

Article

Development and tissue specific expression of RAPGEF1 (C3G) transcripts having exons encoding disordered segments with predicted regulatory function.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09845-3

By:

Verma, Archana;
Goel, Abhishek;
Koner, Niladri;
Gunasekaran, Gowthaman;
Radha, Vegesna

Publication type:

Article

Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis.

Published in:

Basic Research in Cardiology, 2014, v. 109, n. 2, p. 1, doi. 10.1007/s00395-014-0404-2

By:

Manavski, Yosif;
Carmona, Guillaume;
Bennewitz, Katrin;
Tang, Zhongshu;
Zhang, Fan;
Sakurai, Atsuko;
Zeiher, Andreas;
Gutkind, J.;
Li, Xuri;
Kroll, Jens;
Dimmeler, Stefanie;
Chavakis, Emmanouil

Publication type:

Article

Targeting rho guanine nucleotide exchange factor ARHGEF5/TIM with auto-inhibitory peptides in human breast cancer.

Published in:

Amino Acids, 2015, v. 47, n. 6, p. 1239, doi. 10.1007/s00726-015-1950-0

By:

Huang, Ou;
Wu, Dandan;
Xie, Feiyan;
Lin, Lili;
Wang, Xiaobo;
Jiang, Min;
Li, Yafen;
Chen, Weiguo;
Shen, Kunwei;
Hu, Xiaoqu

Publication type:

Article

Biochemical and NMR characterization of the interactions of Vav2-SH2 domain with lipids and the EphA2 juxtamembrane region on membrane.

Published in:

Biochemical Journal, 2020, v. 477, n. 19, p. 3791, doi. 10.1042/BCJ20200300

By:

Liang Ge;
Bo Wu;
Youjia Zhang;
Jiarong Wang;
Hongxin Zhao;
Junfeng Wang

Publication type:

Article

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.

Published in:

Biochemical Journal, 2020, v. 477, n. 9, p. 1651, doi. 10.1042/BCJ20190664

By:

Vieweg, Sophie;
Mulholland, Katie;
Bräuning, Bastian;
Kachariya, Nitin;
Yu-Chiang Lai;
Toth, Rachel;
Singh, Pawan Kishor;
Volpi, Ilaria;
Sattler, Michael;
Groll, Michael;
Itzen, Aymelt;
Muqit, Miratul M. K.

Publication type:

Article

The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs.

Published in:

Bioinformatics, 2013, v. 29, n. 4, p. 499, doi. 10.1093/bioinformatics/bts725

By:

Levine, Timothy P.;
Daniels, Rachel D.;
Gatta, Alberto T.;
Wong, Louise H.;
Hayes, Matthew J.

Publication type:

Article

High expression of ARHGEF5 predicts unfavorable prognosis in acute myeloid leukemia.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01364-8

By:

Xu, Haitao;
Chen, Dangui;
Lu, Jia;
Zhong, Long

Publication type:

Article

Inflammation: The GEF way to MYD88-dependent vascular permeabilization.

Published in:

Nature Reviews Immunology, 2012, v. 12, n. 12, p. 807, doi. 10.1038/nri3354

By:

Papatriantafyllou, Maria

Publication type:

Article

Colocalization of Polycystic Ovary Syndrome Candidate Gene Products in Theca Cells Suggests Novel Signaling Pathways.

Published in:

Journal of the Endocrine Society, 2019, v. 3, n. 12, p. 2204, doi. 10.1210/js.2019-00169

By:

Kulkarni, Rewa;
Teves, Maria E;
Han, Angela X;
McAllister, Jan M;
Strauss, Jerome F

Publication type:

Article

Differential Gene Expression in Circulating CD14+ Monocytes Indicates the Prognosis of Critically Ill Patients with Sepsis.

Published in:

Journal of Clinical Medicine, 2020, v. 9, n. 1, p. 127, doi. 10.3390/jcm9010127

By:

Liepelt, Anke;
Hohlstein, Philipp;
Gussen, Hendrik;
Xue, Jia;
Aschenbrenner, Anna C.;
Ulas, Thomas;
Buendgens, Lukas;
Warzecha, Klaudia T.;
Bartneck, Matthias;
Luedde, Tom;
Trautwein, Christian;
Schultze, Joachim L.;
Koch, Alexander;
Tacke, Frank

Publication type:

Article

Mechanistic insights into the role of truncating PREX2 mutations in melanoma.

Published in:

2016

By:

Lissanu Deribe, Yonathan

Publication type:

Opinion

Mutated RAP1GDS1 causes a new syndrome of dysmorphic feature, intellectual disability & speech delay.

Published in:

Annals of Clinical & Translational Neurology, 2020, v. 7, n. 6, p. 956, doi. 10.1002/acn3.51059

By:

Asiri, Abdulaziz;
Aloyouni, Essra;
Umair, Muhammad;
Alyafee, Yusra;
Al Tuwaijri, Abeer;
Alhamoudi, Kheloud M.;
Almuzzaini, Bader;
Al Baz, Abeer;
Alwadaani, Deemah;
Nashabat, Marwan;
Alfadhel, Majid

Publication type:

Article

Nonselective Chemical Inhibition of Sec7 Domain-Containing ARF GTPase Exchange Factors.

Published in:

Plant Cell, 2018, v. 30, n. 10, p. 2573, doi. 10.1105/tpc.18.00145

By:

Mishev, Kiril;
Lu, Qing;
Denoo, Bram;
Peurois, François;
Dejonghe, Wim;
Hullaert, Jan;
Rycke, Riet De;
Boeren, Sjef;
Bretou, Marine;
Munck, Steven De;
Sharma, Isha;
Goodman, Kaija;
Kalinowska, Kamila;
Storme, Veronique;
Nguyen, Le Son Long;
Drozdzecki, Andrzej;
Martins, Sara;
Nerinckx, Wim;
Audenaert, Dominique;
Vert, Grégory

Publication type:

Article

Inhibitor Endosidin 4 Targets SEC7 Domain-Type ARF GTPase Exchange Factors and Interferes with Subcellular Trafficking in Eukaryotes.

Published in:

Plant Cell, 2018, v. 30, n. 10, p. 2553, doi. 10.1105/tpc.18.00127

By:

Kania, Urszula;
Nodzyński, Tomasz;
Lu, Qing;
Hicks, Glenn R.;
Nerinckx, Wim;
Mishev, Kiril;
Peurois, François;
Cherfils, Jacqueline;
Rycke, Riet De;
Grones, Peter;
Robert, Stéphanie;
Russinova, Eugenia;
Friml, Jiří

Publication type:

Article

Basal versus Nonbasal Polarity: Different Endomembrane Trafficking Pathways Establish Different Patterns.

Published in:

Plant Cell, 2017, v. 29, n. 1, p. 1, doi. 10.1105/tpc.17.00065

By:

Hofmann, Nancy R.

Publication type:

Article

HLB1 Is a Tetratricopeptide Repeat Domain-Containing Protein That Operates at the Intersection of the Exocytic and Endocytic Pathways at the TGN/EE in Arabidopsis.

Published in:

Plant Cell, 2016, v. 28, n. 3, p. 746, doi. 10.1105/tpc.15.00794

By:

Sparks, J. Alan;
Kwon, Taegun;
Renna, Luciana;
Liao, Fuqi;
Brandizzi, Federica;
Blancaflor, Elison B.

Publication type:

Article

Salt-Induced Remodeling of Spatially Restricted Clathrin-Independent Endocytic Pathways in Arabidopsis Root.

Published in:

Plant Cell, 2015, v. 27, n. 4, p. 1297, doi. 10.1105/tpc.15.00154

By:

Baral, Anirban;
Irani, Niloufer G.;
Fujimoto, Masaru;
Nakano, Akihiko;
Mayor, Satyajit;
Mathew, M.K.

Publication type:

Article

Overexpression of the Tomato Pollen Receptor Kinase LePRK1 Rewires Pollen Tube Growth to a Blebbing Mode.

Published in:

Plant Cell, 2014, v. 26, n. 9, p. 3538, doi. 10.1105/tpc.114.127381

By:

Gui, Cai-Ping;
Dong, Xin;
Liu, Hai-Kuan;
Huang, Wei-Jie;
Zhang, Dong;
Wang, Shu-Jie;
Barberini, María Laura;
Gao, Xiao-Yan;
Muschietti, Jorge;
McCormick, Sheila;
Tang, Wei-Hua

Publication type:

Article

Activation of the Rab7 GTPase by the MON1-CCZ1 Complex Is Essential for PVC-to-Vacuole Trafficking and Plant Growth in Arabidopsis.

Published in:

Plant Cell, 2014, v. 26, n. 5, p. 2080, doi. 10.1105/tpc.114.123141

By:

Cui, Yong;
Zhao, Qiong;
Gao, Caiji;
Ding, Yu;
Zeng, Yonglun;
Ueda, Takashi;
Nakano, Akihiko;
Jiang, Liwen

Publication type:

Article

Mediation of Clathrin-Dependent Trafficking during Cytokinesis and Cell Expansion by Arabidopsis STOMATAL CYTOKINESIS DEFECTIVE Proteins.

Published in:

Plant Cell, 2013, v. 25, n. 10, p. 3910, doi. 10.1105/tpc.113.115162

By:

McMichael, Colleen M.;
Reynolds, Gregory D.;
Koch, Lisa M.;
Wang, Chao;
Jiang, Nan;
Nadeau, Jeanette;
Sack, Fred D.;
Gelderman, Max B.;
Pan, Jianwei;
Bednarek, Sebastian Y.

Publication type:

Article

ARF1 Localizes to the Golgi and the Trans-Golgi Network.

Published in:

Plant Cell, 2011, v. 23, n. 3, p. 846, doi. 10.1105/tpc.110.082099

By:

Robinson, David G.;
Scheuring, David;
Naramoto, Satoshi;
Friml, Jirí

Publication type:

Article

Transgenerational Obesity and Alteration of ARHGEF11 in the Rat Liver Induced by Intrauterine Hyperglycemia.

Published in:

Journal of Diabetes Research, 2019, p. 1, doi. 10.1155/2019/6320839

By:

Zhang, Wanyi;
Su, Rina;
Feng, Hui;
Lin, Li;
Wang, Chen;
Yang, Huixia

Publication type:

Article

Integrated analysis and validation reveal CYTH4 as a potential prognostic biomarker in acute myeloid leukemia.

Published in:

Oncology Letters, 2024, v. 27, n. 3, p. N.PAG, doi. 10.3892/ol.2024.14236

By:

Wang, Hong;
Xiao, Yishu;
Zhou, Wei;
Li, Yonghui

Publication type:

Article

GEFT protein expression in digestive tract malignant tumors and its clinical significance.

Published in:

Oncology Letters, 2019, v. 18, n. 5, p. 5577, doi. 10.3892/ol.2019.10915

By:

Wang, Yuanyuan;
Zhang, Bing;
Gao, Ge;
Zhang, Yinping;
Xia, Qingxin

Publication type:

Article

Epithelial cell transforming sequence 2 expression is associated with the progression of laryngeal squamous cell carcinoma.

Published in:

Oncology Letters, 2019, v. 17, n. 6, p. 5699

By:

Zhu, Lin;
Qin, Gang;
Ye, Lin;
Jiang, Li-Zhu;
Zhou, Tie-Jun;
Luo, Bo;
Wen, Tao-Yu;
Liu, Ya-Lan;
Chen, Hong-Yan

Publication type:

Article

Total alkaloids of Corydalis saxicola bunting inhibits migration of A549 cells by suppressing Cdc42 or Vav1.

Published in:

Oncology Letters, 2018, v. 15, n. 1, p. 475, doi. 10.3892/ol.2017.7273

By:

Li, Mimi;
Wang, Jiying;
Mo, Biwen;
Zeng, Jinrong;
Yao, Dong;
Chen, Feng;
Jiang, Ming;
Rao, Lizong;
Du, Yinjun

Publication type:

Article

Overexpression of ECT2 is a strong poor prognostic factor in ER(+) breast cancer.

Published in:

Molecular & Clinical Oncology, 2019, v. 10, n. 5, p. 497

By:

Xiu, Yingying;
Liu, Wei;
Wang, Tianyi;
Liu, Yi;
Ha, Minwen

Publication type:

Article

A novel mutation in the ALS2 gene in an iranian kurdish family with juvenile amyotrophic lateral sclerosis.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2023, v. 24, n. 1/2, p. 148, doi. 10.1080/21678421.2022.2100263

By:

Daneshmandpour, Yousef;
Bahmanpour, Zahra;
Kazeminasab, Somayeh;
Aghaei Moghadam, Ehsan;
Alehabib, Elham;
Chapi, Marjan;
Tafakhori, Abbas;
Aghaei, Negar;
Darvish, Hossein;
Emamalizadeh, Babak

Publication type:

Article

Detection of a novel frameshift mutation and regions with homozygosis within ARHGEF28 gene in familial amyotrophic lateral sclerosis.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2013, v. 14, n. 5/6, p. 444, doi. 10.3109/21678421.2012.758288

By:

Droppelmann, Cristian A.;
Wang, Jian;
Campos-Melo, Danae;
Keller, Brian;
Volkening, Kathryn;
Hegele, Robert A.;
Strong, Michael J.

Publication type:

Article

endosome as an effector target to mediate plant immunity?

Published in:

Journal of Experimental Botany, 2023, v. 74, n. 1, p. 12, doi. 10.1093/jxb/erac460

By:

Reilly, Aisling;
Feechan, Angela

Publication type:

Article

The small GTPase Rab5a and its guanine nucleotide exchange factors are involved in post-Golgi trafficking of storage proteins in developing soybean cotyledon.

Published in:

Journal of Experimental Botany, 2020, v. 71, n. 3, p. 808, doi. 10.1093/jxb/erz454

By:

Wei, Zhongyan;
Pan, Tian;
Zhao, Yuyang;
Su, Bohong;
Ren, Yulong;
Qiu, Lijuan

Publication type:

Article

Selective sets of mRNAs localize to extracellular paramural bodies in a rice glup6 mutant.

Published in:

Journal of Experimental Botany, 2018, v. 69, n. 21, p. 5045, doi. 10.1093/jxb/ery297

By:

Yang, Yongil;
Chou, Hong-Li;
Crofts, Andrew J;
Zhang, Laining;
Tian, Li;
Washida, Haruhiko;
Fukuda, Masako;
Kumamaru, Toshihiro;
Oviedo, Oliver J;
Starkenburg, Shawn R

Publication type:

Article

α2-COP is involved in early secretory traffic in Arabidopsis and is required for plant growth.

Published in:

Journal of Experimental Botany, 2017, v. 68, n. 3, p. 391, doi. 10.1093/jxb/erw446

By:

Gimeno-Ferrer, Fátima;
Pastor-Cantizano, Noelia;
Bernat-Silvestre, César;
Selvi-Martínez, Pilar;
Vera-Sirera, Francisco;
Caiji Gao;
Perez-Amador, Miguel Angel;
Liwen Jiang;
Aniento, Fernando;
Marcote, María Jesús

Publication type:

Article

Guanine nucleotide exchange factor 2 for Rab5 proteins coordinated with GLUP6/GEF regulates the intracellular transport of the proglutelin from the Golgi apparatus to the protein storage vacuole in rice endosperm.

Published in:

Journal of Experimental Botany, 2015, v. 66, n. 20, p. 6137, doi. 10.1093/jxb/erv325

By:

Liuying Wen;
Masako Fukuda;
Mariko Sunada;
Sonoko Ishino;
Yoshizumi Ishino;
Okita, Thomas W.;
Masahiro Ogawa;
Takashi Ueda;
Toshihiro Kumamaru

Publication type:

Article

Designer GPCRs as Novel Tools to Identify Metabolically Important Signaling Pathways.

Published in:

Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.706957

By:

Wess, Jürgen

Publication type:

Article

The Vps21 signalling pathway regulates white-opaque switching and mating in Candida albicans.

Published in:

Mycology: An International Journal on Fungal Biology, 2025, v. 16, n. 1, p. 357, doi. 10.1080/21501203.2024.2376533

By:

Zhao, Fei;
Du, Han;
Zheng, Qiushi;
Bing, Jian;
Tao, Li;
Nobile, Clarissa J.;
Huang, Guanghua

Publication type:

Article

A Novel GBF1 Variant in a Charcot-Marie-Tooth Type 2: Insights from Familial Analysis.

Published in:

Genes, 2024, v. 15, n. 12, p. 1556, doi. 10.3390/genes15121556

By:

Ciampana, Valentina;
Corrado, Lucia;
Magistrelli, Luca;
Contaldi, Elena;
Comi, Cristoforo;
D'Alfonso, Sandra;
Vecchio, Domizia

Publication type:

Article

PLEKHG1 : New Potential Candidate Gene for Periventricular White Matter Abnormalities.

Published in:

Genes, 2024, v. 15, n. 8, p. 1096, doi. 10.3390/genes15081096

By:

Calì, Francesco;
Vinci, Mirella;
Treccarichi, Simone;
Papa, Carla;
Gloria, Angelo;
Musumeci, Antonino;
Federico, Concetta;
Vitello, Girolamo Aurelio;
Nicotera, Antonio Gennaro;
Di Rosa, Gabriella;
Vetri, Luigi;
Saccone, Salvatore;
Elia, Maurizio

Publication type:

Article

Optical Genome Mapping Reveals Disruption of the RASGRF2 Gene in a Patient with Developmental Delay Carrying a De Novo Balanced Reciprocal Translocation.

Published in:

2024

By:

Lederbogen, Rosa Catalina;
Hoffjan, Sabine;
Thiels, Charlotte;
Mau-Holzmann, Ulrike Angelika;
Singer, Sylke;
Yusenko, Maria Viktorovna;
Nguyen, Hoa Huu Phuc;
Gerding, Wanda Maria

Publication type:

Case Study

Novel Polymorphisms in RAPGEF6 Gene Associated with Egg-Laying Rate in Chinese Jing Hong Chicken using Genome-Wide SNP Scan.

Published in:

Genes, 2019, v. 10, n. 5, p. 384, doi. 10.3390/genes10050384

By:

Azmal, Syed Ali;
Bhuiyan, Ali Akbar;
Omar, Abdullah Ibne;
Ma, Shuai;
Sun, Chenghao;
Han, Zhongdong;
Zhang, Meikuen;
Zhao, Shuhong;
Li, Shijun

Publication type:

Article

Small Papillae Regulated by SPD25 are Critical for Balancing Photosynthetic CO<sub>2</sub> Assimilation and Water Loss in Rice.

Published in:

Rice (19398425), 2023, v. 16, n. 1, p. 1, doi. 10.1186/s12284-023-00676-7

By:

Zhu, Lin;
Zeng, Faliang;
Liang, Yinpei;
Wang, Qi;
Chen, Hongwei;
Feng, Pulin;
Fan, Mingqian;
Cheng, Yanshuang;
Wang, Jiayu

Publication type:

Article

Rice Carbohydrate-Binding Malectin-Like Protein, OsCBM1, Contributes to Drought-Stress Tolerance by Participating in NADPH Oxidase-Mediated ROS Production.

Published in:

Rice (19398425), 2021, v. 14, n. 1, p. 1, doi. 10.1186/s12284-021-00541-5

By:

Jing, Xiu-Qing;
Li, Wen-Qiang;
Zhou, Meng-Ru;
Shi, Peng-Tao;
Zhang, Ran;
Shalmani, Abdullah;
Muhammad, Izhar;
Wang, Gang-Feng;
Liu, Wen-Ting;
Chen, Kun-Ming

Publication type:

Article

Dynamic Coupling of MAPK Signaling to the Guanine Nucleotide Exchange Factor GEF-H1.

Published in:

OncoTargets & Therapy, 2025, v. 18, p. 147, doi. 10.2147/OTT.S496228

By:

Leguay, Kévin;
Kent, Oliver A

Publication type:

Article

Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 9481, doi. 10.2147/OTT.S265592

By:

Qiu, Wancheng;
Chang, Yanhua;
Liu, Jing;
Yang, Xu;
Yu, Yan;
Li, Jiajia;
Liang, Qing;
Sun, Guangchun

Publication type:

Article

KNDC1 Is a Predictive Marker of Malignant Transformation in Borderline Ovarian Tumors.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 709, doi. 10.2147/OTT.S223304

By:

Yu, Shuqian;
Shen, Jiayu;
Fei, Jing;
Zhu, Xiaoqing;
Yin, Meichen;
Zhou, Jianwei

Publication type:

Article

Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.

Published in:

Molecular Brain, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13041-015-0130-1

By:

Kyungmin Lee;
Yuki Kobayashi;
Hyunhyo Seo;
Ji-Hye Kwak;
Akira Masuda;
Chae-Seok Lim;
Hye-Ryeon Lee;
SukJae Joshua Kang;
Pojeong Park;
Su-Eon Sim;
Naomi Kogo;
Hiroaki Kawasaki;
Bong-Kiun Kaang;
Shigeyoshi Itohara

Publication type:

Article