Works matching DE "GLUTAMINYL-peptide cyclotransferase"
Results: 20
CP-MLR/PLS directed QSAR study on the glutaminyl cyclase inhibitory activity of imidazoles: rationales to advance the understanding of activity profile.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2013, v. 28, n. 3, p. 515, doi. 10.3109/14756366.2011.654111
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- Article
Arabidopsis γ‐glutamylcyclotransferase affects glutathione content and root system architecture during sulfur starvation.
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- New Phytologist, 2019, v. 221, n. 3, p. 1387, doi. 10.1111/nph.15466
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Identifying hQC Inhibitors of Alzheimer's Disease by Effective Customized Pharmacophore-Based Virtual Screening, Molecular Dynamic Simulation, and Binding Free Energy Analysis.
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- Applied Biochemistry & Biotechnology, 2019, v. 187, n. 4, p. 1173, doi. 10.1007/s12010-018-2780-9
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Neurodegenerative disorders: New Huntington disease target identified.
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- Nature Reviews Drug Discovery, 2015, v. 14, n. 6, p. 386, doi. 10.1038/nrd4652
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- Article
Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0431-6
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- Article
Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges.
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- Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0115-2
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IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
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- Biological Chemistry, 2016, v. 397, n. 1, p. 45, doi. 10.1515/hsz-2015-0192
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The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders.
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- Journal of Biological Inorganic Chemistry (JBIC), 2018, v. 23, n. 8, p. 1219, doi. 10.1007/s00775-018-1605-1
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Two insertion/deletion variants in the promoter region of the QPCTL gene are significantly associated with body weight and carcass traits in chickens.
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- Animal Genetics, 2019, v. 50, n. 3, p. 279, doi. 10.1111/age.12741
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Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice.
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- International Journal of Experimental Pathology, 2013, v. 94, n. 3, p. 217, doi. 10.1111/iep.12020
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Probing Secondary Glutaminyl Cyclase (QC) Inhibitor Interactions Applying an in silico-Modeling/Site-Directed Mutagenesis Approach: Implications for Drug Development.
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- Chemical Biology & Drug Design, 2012, v. 80, n. 6, p. 937, doi. 10.1111/cbdd.12046
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Natural Products from Microalgae with Potential against Alzheimer's Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors.
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- Marine Drugs, 2016, v. 14, n. 11, p. 203, doi. 10.3390/md14110203
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Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer's disease patients.
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- Alzheimer's Research & Therapy, 2017, v. 9, p. 1, doi. 10.1186/s13195-017-0266-6
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Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation.
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- Molecules, 2018, v. 23, n. 4, p. 924, doi. 10.3390/molecules23040924
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Engineering ionic liquid-tolerant cellulases for biofuels production.
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- PEDS: Protein Engineering, Design & Selection, 2016, v. 29, n. 4, p. 117, doi. 10.1093/protein/gzv066
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siRNA screen identifies QPCT as a druggable target for Huntington's disease.
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- Nature Chemical Biology, 2015, v. 11, n. 5, p. 347, doi. 10.1038/nchembio.1790
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The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease.
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- Acta Crystallographica: Section F, Structural Biology Communications, 2015, v. 71, n. 8, p. 986, doi. 10.1107/S2053230X15010389
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Linked Production of Pyroglutamate-Modified Proteins via Self-Cleavage of Fusion Tags with TEV Protease and Autonomous N-Terminal Cyclization with Glutaminyl Cyclase <i>In Vivo</i>.
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- PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094812
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Soluble Variants of Human Recombinant Glutaminyl Cyclase.
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- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071657
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Pyroglutamate-Amyloid-β and Glutaminyl Cyclase Are Colocalized with Amyloid-β in Secretory Vesicles and Undergo Activity-Dependent, Regulated Secretion.
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- Neurodegenerative Diseases, 2014, v. 14, n. 2, p. 85, doi. 10.1159/000358430
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- Article