Works matching DE "GLUTAMINYL-peptide cyclotransferase"

Results: 20

Engineering ionic liquid-tolerant cellulases for biofuels production.

Published in:

PEDS: Protein Engineering, Design & Selection, 2016, v. 29, n. 4, p. 117, doi. 10.1093/protein/gzv066

By:

Wolski, Paul W.;
Dana, Craig M.;
Clark, Douglas S.;
Blanch, Harvey W.

Publication type:

Article

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.

Published in:

Biological Chemistry, 2016, v. 397, n. 1, p. 45, doi. 10.1515/hsz-2015-0192

By:

Becker, Andreas;
Eichentopf, Rico;
Sedlmeier, Reinhard;
Waniek, Alexander;
Cynis, Holger;
Koch, Birgit;
Stephan, Anett;
Bäuscher, Christoph;
Kohlmann, Stephanie;
Hoffmann, Torsten;
Kehlen, Astrid;
Berg, Sabine;
Freyse, Ernst-Joachim;
Osmand, Alexander;
Plank, Anne-Christine;
Roßner, Steffen;
von Hörsten, Stephan;
Graubner, Sigrid;
Demuth, Hans-Ulrich;
Schilling, Stephan

Publication type:

Article

Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation.

Published in:

Molecules, 2018, v. 23, n. 4, p. 924, doi. 10.3390/molecules23040924

By:

Hartlage-Rübsamen, Maike;
Bluhm, Alexandra;
Piechotta, Anke;
Linnert, Miriam;
Rahfeld, Jens-Ulrich;
Demuth, Hans-Ulrich;
Lues, Inge;
Kuhn, Peer-Hendrik;
Lichtenthaler, Stefan F.;
Roßner, Steffen;
Höfling, Corinna;
Schilling, Stephan

Publication type:

Article

Probing Secondary Glutaminyl Cyclase (QC) Inhibitor Interactions Applying an in silico-Modeling/Site-Directed Mutagenesis Approach: Implications for Drug Development.

Published in:

Chemical Biology & Drug Design, 2012, v. 80, n. 6, p. 937, doi. 10.1111/cbdd.12046

By:

Koch, Birgit;
Buchholz, Mirko;
Wermann, Michael;
Heiser, Ulrich;
Schilling, Stephan;
Demuth, Hans-Ulrich

Publication type:

Article

The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders.

Published in:

Journal of Biological Inorganic Chemistry (JBIC), 2018, v. 23, n. 8, p. 1219, doi. 10.1007/s00775-018-1605-1

By:

Pozzi, Cecilia;
Di Pisa, Flavio;
Benvenuti, Manuela;
Mangani, Stefano

Publication type:

Article

Two insertion/deletion variants in the promoter region of the QPCTL gene are significantly associated with body weight and carcass traits in chickens.

Published in:

Animal Genetics, 2019, v. 50, n. 3, p. 279, doi. 10.1111/age.12741

By:

Ren, T.;
Li, W.;
Liu, D.;
Liang, K.;
Wang, X.;
Li, H.;
Jiang, R.;
Tian, Y.;
Kang, X.;
Li, Z.

Publication type:

Article

Neurodegenerative disorders: New Huntington disease target identified.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 6, p. 386, doi. 10.1038/nrd4652

By:

Crunkhorn, Sarah

Publication type:

Article

Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice.

Published in:

International Journal of Experimental Pathology, 2013, v. 94, n. 3, p. 217, doi. 10.1111/iep.12020

By:

Cynis, Holger;
Kehlen, Astrid;
Haegele, Monique;
Hoffmann, Torsten;
Heiser, Ulrich;
Fujii, Masato;
Shibazaki, Yuichiro;
Yoneyama, Hiroyuki;
Schilling, Stephan;
Demuth, Hans‐Ulrich

Publication type:

Article

Pyroglutamate-Amyloid-β and Glutaminyl Cyclase Are Colocalized with Amyloid-β in Secretory Vesicles and Undergo Activity-Dependent, Regulated Secretion.

Published in:

Neurodegenerative Diseases, 2014, v. 14, n. 2, p. 85, doi. 10.1159/000358430

By:

Cynis, Holger;
Funkelstein, Lydiane;
Toneff, Thomas;
Mosier, Charles;
Ziegler, Michael;
Koch, Birgit;
Demuth, Hans-Ulrich;
Hook, Vivian

Publication type:

Article

Natural Products from Microalgae with Potential against Alzheimer's Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors.

Published in:

Marine Drugs, 2016, v. 14, n. 11, p. 203, doi. 10.3390/md14110203

By:

Hielscher-Michael, Stephanie;
Griehl, Carola;
Buchholz, Mirko;
Demuth, Hans-Ulrich;
Arnold, Norbert;
Wessjohann, Ludger A.

Publication type:

Article

Linked Production of Pyroglutamate-Modified Proteins via Self-Cleavage of Fusion Tags with TEV Protease and Autonomous N-Terminal Cyclization with Glutaminyl Cyclase <i>In Vivo</i>.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094812

By:

Shih, Yan-Ping;
Chou, Chi-Chi;
Chen, Yi-Ling;
Huang, Kai-Fa;
Wang, Andrew H.- J.

Publication type:

Article

Soluble Variants of Human Recombinant Glutaminyl Cyclase.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071657

By:

Castaldo, Cristiana;
Ciambellotti, Silvia;
de Pablo-Latorre, Raquel;
Lalli, Daniela;
Porcari, Valentina;
Turano, Paola

Publication type:

Article

Identifying hQC Inhibitors of Alzheimer's Disease by Effective Customized Pharmacophore-Based Virtual Screening, Molecular Dynamic Simulation, and Binding Free Energy Analysis.

Published in:

Applied Biochemistry & Biotechnology, 2019, v. 187, n. 4, p. 1173, doi. 10.1007/s12010-018-2780-9

By:

Lin, Weicong;
Zheng, Xiaojie;
Fang, Danqing;
Zhou, Shengfu;
Wu, Wenjuan;
Zheng, Kangcheng

Publication type:

Article

CP-MLR/PLS directed QSAR study on the glutaminyl cyclase inhibitory activity of imidazoles: rationales to advance the understanding of activity profile.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2013, v. 28, n. 3, p. 515, doi. 10.3109/14756366.2011.654111

By:

Kumar, Viney;
Gupta, Manish K.;
Singh, Gagandip;
Prabhakar, Yenamandra S.

Publication type:

Article

The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2015, v. 71, n. 8, p. 986, doi. 10.1107/S2053230X15010389

By:

DiPisa, Flavio;
Pozzi, Cecilia;
Benvenuti, Manuela;
Andreini, Matteo;
Marconi, Guido;
Mangani, Stefano

Publication type:

Article

Arabidopsis γ‐glutamylcyclotransferase affects glutathione content and root system architecture during sulfur starvation.

Published in:

New Phytologist, 2019, v. 221, n. 3, p. 1387, doi. 10.1111/nph.15466

By:

Joshi, Naveen C.;
Meyer, Andreas J.;
Bangash, Sajid A. K.;
Zheng, Zhi‐Liang;
Leustek, Thomas

Publication type:

Article

Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges.

Published in:

Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0115-2

By:

Cynis, Holger;
Frost, Jeffrey L.;
Crehan, Helen;
Lemere, Cynthia A.

Publication type:

Article

siRNA screen identifies QPCT as a druggable target for Huntington's disease.

Published in:

Nature Chemical Biology, 2015, v. 11, n. 5, p. 347, doi. 10.1038/nchembio.1790

By:

Jimenez-Sanchez, Maria;
Lam, Wun;
Hannus, Michael;
Sönnichsen, Birte;
Imarisio, Sara;
Fleming, Angeleen;
Tarditi, Alessia;
Menzies, Fiona;
Ed Dami, Teresa;
Xu, Catherine;
Gonzalez-Couto, Eduardo;
Lazzeroni, Giulia;
Heitz, Freddy;
Diamanti, Daniela;
Massai, Luisa;
Satagopam, Venkata P;
Marconi, Guido;
Caramelli, Chiara;
Nencini, Arianna;
Andreini, Matteo

Publication type:

Article

Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study.

Published in:

Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0431-6

By:

Scheltens, Philip;
Hallikainen, Merja;
Grimmer, Timo;
Duning, Thomas;
Gouw, Alida A;
Teunissen, Charlotte E;
Wink, Alle Meije;
Maruff, Paul;
Harrison, John;
van Baal, Caroline M;
Bruins, Suzanne;
Lues, Inge;
Prins, Niels D

Publication type:

Article

Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer's disease patients.

Published in:

Alzheimer's Research & Therapy, 2017, v. 9, p. 1, doi. 10.1186/s13195-017-0266-6

By:

Bridel, Claire;
Hoffmann, Torsten;
Meyer, Antje;
Durieux, Sisi;
Koel-Simmelink, Marleen A.;
Orth, Matthias;
Scheltens, Philip;
Lues, Inge;
Teunissen, Charlotte E.

Publication type:

Article