Works matching DE "GLUCURONIDATION"

Results: 312

An LC-MS Method to Quantify Rhein and Its Metabolites in Plasma: Application to a Pharmacokinetic Study in Rats.

Published in:

Metabolites (2218-1989), 2025, v. 15, n. 6, p. 407, doi. 10.3390/metabo15060407

By:

Siddiqui, Nyma;
Chen, Yuan;
Du, Ting;
Wang, Yang;
Buck, Charmeyce;
Gao, Song

Publication type:

Article

UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population.

Published in:

Liver International, 2017, v. 37, n. 9, p. 1345, doi. 10.1111/liv.13411

By:

De Mattia, Elena;
Cecchin, Erika;
Polesel, Jerry;
Lupo, Francesco;
Tiribelli, Claudio;
Crovatto, Marina;
Buonadonna, Angela;
Toffoli, Giuseppe

Publication type:

Article

UGT1As and predisposition to liver cancer: Still important, more elusive.

Published in:

2017

By:

Pineau, Pascal

Publication type:

Editorial

Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.

Published in:

Liver International, 2014, v. 34, n. 7, p. e171, doi. 10.1111/liv.12514

By:

Michaut, Anaïs;
Moreau, Caroline;
Robin, Marie-Anne;
Fromenty, Bernard

Publication type:

Article

Pharmacokinetic and metabolic studies of Vortioxetine in rats using ultra high performance liquid chromatography with tandem mass spectrometry.

Published in:

Journal of Separation Science, 2018, v. 41, n. 24, p. 4469, doi. 10.1002/jssc.201800607

By:

Guan, Su;
Zou, Yake;
Jia, Bingjie;
Wu, Lvying;
Yang, Zhicheng;
Yuan, Fang;
Zhang, Lei

Publication type:

Article

Cannabinoid spoilage, metabolism and cannabidiol(CBD) conversion to Tetrahydrocannabinol(THC) mechanisms with energetic parameters.

Published in:

Journal of Cannabis Research, 2025, v. 7, n. 1, p. 1, doi. 10.1186/s42238-024-00239-7

By:

Henriques, Alwyn

Publication type:

Article

Assessing and Optimising Several Enzymes Used for Drug Analysis in Urine.

Published in:

Multi-Knowledge Electronic Comprehensive Journal For Education & Science Publications (MECSJ), 2022, n. 56, p. 1

By:

Algethami, Fatimah Abdullah

Publication type:

Article

Anastrozole as aromatase inhibitor - new approaches to breast cancer treatment in postmenopausal women.

Published in:

Nowotwory, 2019, v. 69, n. 1, p. 26, doi. 10.5603/NJO.2019.0005

By:

Piotrowska, Izabela;
Piotrowska, Magdalena

Publication type:

Article

First‐in‐Human Single‐Ascending‐Dose, Multiple‐Dose, and Food Interaction Studies of NRD.E1, an Innovative Nonopioid Therapy for Painful Diabetic Peripheral Neuropathy.

Published in:

Clinical Pharmacology in Drug Development, 2022, v. 11, n. 9, p. 1012, doi. 10.1002/cpdd.1103

By:

Tiecke, Eva;
Rainisio, Maurizio;
Guentert, Theodor;
Müller, Stephan;
Hochman, Liat;
Kaplan, Eli;
Mangialaio, Sara

Publication type:

Article

Pharmacokinetics, Safety, and Tolerability of Fevipiprant (QAW039), a Novel CRTh2 Receptor Antagonist: Results From 2 Randomized, Phase 1, Placebo-Controlled Studies in Healthy Volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2016, v. 5, n. 4, p. 306, doi. 10.1002/cpdd.244

By:

Erpenbeck, Veit J.;
Vets, Eva;
Gheyle, Lien;
Osuntokun, Wande;
Larbig, Michael;
Neelakantham, Srikanth;
Sandham, David;
Dubois, Gerald;
Elbast, Walid;
Goldsmith, Paul;
Weiss, Markus

Publication type:

Article

Age-related change of hepatic uridine diphosphate glucuronosyltransferase and sulfotransferase activities in male chickens and pigs.

Published in:

Journal of Veterinary Pharmacology & Therapeutics, 2017, v. 40, n. 3, p. 270, doi. 10.1111/jvp.12355

By:

Hu, S. X.

Publication type:

Article

Rapid separation and characterization of comprehensive ingredients in Yangxinshi tablet and rat plasma by ultrahigh-performance liquid chromatography–quadrupole time-of-flight mass spectrometry.

Published in:

Journal of Liquid Chromatography & Related Technologies, 2017, v. 40, n. 12, p. 616, doi. 10.1080/10826076.2017.1335213

By:

Li, Yang;
Li, Chengjian;
Yu, Jing;
Gao, Yue;
Zhao, Yahong;
Xue, Dan;
Zhang, Guoqing;
Chai, Yifeng;
Ke, Ying;
Zhang, Hai

Publication type:

Article

IDENTIFICATION OF MAJOR CHEMICAL CONSTITUENTS AND THEIR METABOLITES IN RAT PLASMA AND VARIOUS ORGANS AFTER ORAL ADMINISTRATION OF EFFECTIVE XIANG-FU-SI-WU DECOCTION FRACTION BY UPLC-Q-TOF-MS AND METABOLYNX.

Published in:

Journal of Liquid Chromatography & Related Technologies, 2013, v. 36, n. 12, p. 1736, doi. 10.1080/10826076.2012.698676

By:

Liu, Pei;
Duan, Jin-Ao;
Guo, Jian-Ming;
Shang, Er-Xin;
Qian, Da-Wei;
Su, Shu-Lan;
Tang, Yu-Ping

Publication type:

Article

Enhancing structural characterisation of glucuronidated O-linked glycans using negative mode ion trap higher energy collision-induced dissociation mass spectrometry.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2017, v. 31, n. 10, p. 851, doi. 10.1002/rcm.7851

By:

Ashwood, Christopher;
Abrahams, Jodie L.;
Nevalainen, Helena;
Packer, Nicolle H.

Publication type:

Article

Identification of metabolites of palmatine in rats after oral administration using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2017, v. 31, n. 6, p. 523, doi. 10.1002/rcm.7819

By:

Wang, Kun;
Chai, Liwei;
Ding, Liqin;
Qiu, Feng

Publication type:

Article

Stereoselective Steady‐State Disposition and Bioequivalence of Brand and Generic Bupropion in Adults.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 5, p. 1036, doi. 10.1002/cpt.1888

By:

Kharasch, Evan D.;
Neiner, Alicia;
Kraus, Kristin;
Blood, Jane;
Stevens, Angela;
Miller, J. Philip;
Lenze, Eric J.

Publication type:

Article

Antiepileptic drug treatment in pregnancy: Changes in drug disposition and their clinical implications.

Published in:

Epilepsia (Series 4), 2013, v. 54, n. 3, p. 405, doi. 10.1111/epi.12109

By:

Tomson, Torbjörn;
Landmark, Cecilie Johannessen;
Battino, Dina

Publication type:

Article

Common variants in glucuronidation enzymes and membrane transporters as potential risk factors for colorectal cancer: a case control study.

Published in:

2017

By:

Falkowski, Sabrina;
Woillard, Jean-Baptiste;
Postil, Deborah;
Tubiana-Mathieu, Nicole;
Terrebonne, Eric;
Pariente, Antoine;
Smith, Denis;
Guimbaud, Rosine;
Thalamas, Claire;
Rouguieg-Malki, Koukeb;
Marquet, Pierre;
Picard, Nicolas

Publication type:

journal article

The effect of liver dysfunction on the pharmacokinetic disposition of belinostat and its five metabolites in patients with advanced cancers.

Published in:

Cancer Chemotherapy & Pharmacology, 2024, v. 94, n. 2, p. 157, doi. 10.1007/s00280-024-04651-x

By:

Dunn, Allison;
Takebe, Naoko;
Chen, Alice;
Kummar, Shivaani;
Piekarz, Richard;
Kiesel, Brian;
Moore, Nancy;
Doroshow, James;
Beumer, Jan H.;
Gobburu, Jogarao V. S.

Publication type:

Article

Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro.

Published in:

Archives of Toxicology, 2024, v. 98, n. 9, p. 2879, doi. 10.1007/s00204-024-03790-7

By:

Gao, Yujie;
Shi, Kaiting;
Wang, Peipei;
Liu, Xinyu;
Liu, Chenxi;
Luo, Liya;
Lin, Yanchen;
Yang, Lin;
Yang, Rongji;
Liao, Linchuan

Publication type:

Article

Hepatic glucuronidation of tetrabromobisphenol A and tetrachlorobisphenol A: interspecies differences in humans and laboratory animals and responsible UDP-glucuronosyltransferase isoforms in humans.

Published in:

Archives of Toxicology, 2024, v. 98, n. 3, p. 837, doi. 10.1007/s00204-023-03659-1

By:

Hanioka, Nobumitsu;
Isobe, Takashi;
Saito, Keita;
Nagaoka, Kenjiro;
Mori, Yoko;
Jinno, Hideto;
Ohkawara, Susumu;
Tanaka-Kagawa, Toshiko

Publication type:

Article

Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo.

Published in:

Archives of Toxicology, 2020, v. 94, n. 11, p. 3737, doi. 10.1007/s00204-020-02867-3

By:

Rong, Yi;
Tu, Yifan;
Yin, Taijun;
Meng, Zhiyun;
Dou, Guifang;
Hu, Ming

Publication type:

Article

The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol.

Published in:

Archives of Toxicology, 2019, v. 93, n. 6, p. 1729, doi. 10.1007/s00204-019-02459-w

By:

Woelflingseder, Lydia;
Warth, Benedikt;
Vierheilig, Immina;
Schwartz-Zimmermann, Heidi;
Hametner, Christian;
Nagl, Veronika;
Novak, Barbara;
Šarkanj, Bojan;
Berthiller, Franz;
Adam, Gerhard;
Marko, Doris

Publication type:

Article

Correlations between metabolism and structural elements of the alicyclic fentanyl analogs cyclopropyl fentanyl, cyclobutyl fentanyl, cyclopentyl fentanyl, cyclohexyl fentanyl and 2,2,3,3-tetramethylcyclopropyl fentanyl studied by human hepatocytes and LC-QTOF-MS

Published in:

Archives of Toxicology, 2019, v. 93, n. 1, p. 95, doi. 10.1007/s00204-018-2330-9

By:

Åstrand, Anna;
Töreskog, Amanda;
Watanabe, Shimpei;
Kronstrand, Robert;
Gréen, Henrik;
Vikingsson, Svante

Publication type:

Article

Correction to: Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows.

Published in:

2018

By:

Schwartz-Zimmermann, Heidi E.;
Hametner, Christian;
Nagl, Veronika;
Fiby, Iris;
Macheiner, Lukas;
Winkler, Janine;
Dänicke, Sven;
Clark, Erica;
Pestka, James J.;
Berthiller, Franz

Publication type:

Correction Notice

Deglucosylation of zearalenone-14-glucoside in animals and human liver leads to underestimation of exposure to zearalenone in humans.

Published in:

Archives of Toxicology, 2018, v. 92, n. 9, p. 2779, doi. 10.1007/s00204-018-2267-z

By:

Yang, Shupeng;
Zhang, Huiyan;
Zhang, Jinzhen;
Li, Yanshen;
Jin, Yue;
Zhang, Suxia;
De Saeger, Sarah;
Li, Yi;
Zhou, Jinhui;
Sun, Feifei;
De Boevre, Marthe

Publication type:

Article

Regioselective glucuronidation of daidzein in liver and intestinal microsomes of humans, monkeys, rats, and mice.

Published in:

Archives of Toxicology, 2018, v. 92, n. 9, p. 2809, doi. 10.1007/s00204-018-2265-1

By:

Hanioka, Nobumitsu;
Ohkawara, Susumu;
Isobe, Takashi;
Ochi, Sadayuki;
Tanaka-Kagawa, Toshiko;
Jinno, Hideto

Publication type:

Article

Determination of Enzymatic Hydrolysis Efficiency in Detection of Cannabis Use by UPLC–MS-MS.

Published in:

Journal of Analytical Toxicology, 2022, v. 46, n. 3, p. 257, doi. 10.1093/jat/bkab017

By:

Kul, Aykut;
Sagirli, Olcay

Publication type:

Article

Simultaneous Determination of Sulfation and Glucuronidation of Flavones in FVB Mouse Intestine in Vitro and in Vivo.

Published in:

Journal of Applied Toxicology, 2013, v. 33, n. 4, p. 273, doi. 10.1002/jat.1737

By:

Fan, Yanfang;
Tang, Lan;
Zhou, Juan;
Feng, Qian;
Xia, Bijun;
Liu, Zhongqiu

Publication type:

Article

Synthesis and antitubercular activity of first glucuronosyl phosphates and amidophosphates containing polymethylene chains.

Published in:

Russian Journal of Organic Chemistry, 2017, v. 53, n. 1, p. 51, doi. 10.1134/S1070428017010092

By:

Izmest'ev, E.;
Andreeva, O.;
Sharipova, R.;
Kravchenko, M.;
Garifullin, B.;
Strobykina, I.;
Kataev, V.;
Mironov, V.

Publication type:

Article

PPAR-Mediated Bile Acid Glucuronidation: Therapeutic Targets for the Treatment of Cholestatic Liver Diseases.

Published in:

Cells (2073-4409), 2024, v. 13, n. 15, p. 1296, doi. 10.3390/cells13151296

By:

Gallucci, Gina M.;
Hayes, Colleen M.;
Boyer, James L.;
Barbier, Olivier;
Assis, David N.;
Ghonem, Nisanne S.

Publication type:

Article

Obstetric Obesity is Associated with Neonatal Hyperbilirubinemia with High Prevalence in Native Hawaiians and Pacific Island Women.

Published in:

Hawaii Journal of Medicine & Public Health, 2016, v. 75, n. 12, p. 373

By:

Rougée, Luc R. A.;
Miyagi, Shogo J.;
Collie, Abby C.

Publication type:

Article

Metabolite Profiling, Pharmacokinetics, and In Vitro Glucuronidation of Icaritin in Rats by Ultra-Performance Liquid Chromatography Coupled with Mass Spectrometry.

Published in:

Journal of Analytical Methods in Chemistry, 2017, p. 1, doi. 10.1155/2017/1073607

By:

Zhang, Beibei;
Chen, Xiaoli;
Zhang, Rui;
Zheng, Fangfang;
Du, Shuzhang;
Zhang, Xiaojian

Publication type:

Article

Cannabinoid-Induced Inhibition of Morphine Glucuronidation and the Potential for In Vivo Drug–Drug Interactions.

Published in:

Pharmaceutics, 2024, v. 16, n. 3, p. 418, doi. 10.3390/pharmaceutics16030418

By:

Coates, Shelby;
Bardhi, Keti;
Lazarus, Philip

Publication type:

Article

Cannabinoid-Induced Stereoselective Inhibition of R-S-Oxazepam Glucuronidation: Cannabinoid–Oxazepam Drug Interactions.

Published in:

Pharmaceutics, 2024, v. 16, n. 2, p. 243, doi. 10.3390/pharmaceutics16020243

By:

Bardhi, Keti;
Coates, Shelby;
Chen, Gang;
Lazarus, Philip

Publication type:

Article

Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats.

Published in:

Pharmaceutics, 2020, v. 12, n. 2, p. 134, doi. 10.3390/pharmaceutics12020134

By:

López-Yerena, Anallely;
Vallverdú-Queralt, Anna;
Mols, Raf;
Augustijns, Patrick;
Lamuela-Raventós, Rosa M.;
Escribano-Ferrer, Elvira

Publication type:

Article

Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)--How Does the Endoplasmic Reticulum Membrane Influence Their Function?

Published in:

Pharmaceutics, 2017, v. 9, n. 3, p. 32, doi. 10.3390/pharmaceutics9030032

By:

Yuejian Liu;
Coughtrie, Michael W. H.

Publication type:

Article

Simultaneous Quantification of Propylthiouracil and Its N -β-d Glucuronide by HPLC-MS/MS: Application to a Metabolic Study.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 11, p. 1194, doi. 10.3390/ph14111194

By:

Li, Min;
He, Qingfeng;
Yao, Li;
Wang, Xiaofeng;
Tang, Zhijia;
Zhu, Xiao;
Lin, Hai-Shu;
Xiang, Xiaoqiang

Publication type:

Article

Real life dabigatran and metabolite concentrations, focused on inter-patient variability and assay differences in patients with atrial fibrillation.

Published in:

Clinical Chemistry & Laboratory Medicine, 2017, v. 55, n. 12, p. 2002, doi. 10.1515/cclm-2016-0681

By:

Boonen, Kristel;
Schmitz, Ellen;
Rozestraten, Fleur;
van den Heuvel, Dennis;
Brunsveld, Luc;
van der Voort, Pepijn;
van de Kerkhof, Daan

Publication type:

Article

Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1.

Published in:

PLoS ONE, 2019, v. 14, n. 11, p. 1, doi. 10.1371/journal.pone.0225244

By:

Takaoka, Yutaka;
Takeuchi, Atsuko;
Sugano, Aki;
Miura, Kenji;
Ohta, Mika;
Suzuki, Takashi;
Kobayashi, Daisuke;
Kimura, Takuji;
Sato, Juichi;
Ban, Nobutaro;
Nishio, Hisahide;
Sakaeda, Toshiyuki

Publication type:

Article

Comparison of Relative Activity versus Relative Expression Factors (RAF versus REF) in Predicting Glucuronidation Mediated Drug Clearance Using Recombinant UGTs.

Published in:

Pharmaceutical Research, 2024, v. 41, n. 8, p. 1621, doi. 10.1007/s11095-024-03750-x

By:

Subash, Sandhya;
Ahire, Deepak;
Patel, Mitesh;
Shaikh, Sahil;
Singh, Dilip Kumar;
Deshmukh, Sujal;
Prasad, Bhagwat

Publication type:

Article

Age-and Region-Dependent Disposition of Raloxifene in Rats.

Published in:

Pharmaceutical Research, 2021, v. 38, n. 8, p. 1357, doi. 10.1007/s11095-021-03084-y

By:

Du, Ting;
Sun, Rongjin;
Etim, Imoh;
Zheng, Zicong;
Liang, Dong;
Hu, Ming;
Gao, Song

Publication type:

Article

Genetic polymorphism of UDP-glucuronosyltransferase (UGT2B15) and glucuronidation of paracetamol in healthy population.

Published in:

Pakistan Journal of Pharmaceutical Sciences, 2016, v. 29, p. 1037

By:

Mehboob, Huma;
Iqbal, Tahira;
Jamil, Amer;
Khaliq, Tanweer

Publication type:

Article

Acylglucuronide in alkaline conditions: migration vs. hydrolysis.

Published in:

Journal of Molecular Modeling, 2013, v. 19, n. 6, p. 2423, doi. 10.1007/s00894-013-1790-3

By:

Di Meo, Florent;
Steel, Michele;
Nicolas, Picard;
Marquet, Pierre;
Duroux, Jean-Luc;
Trouillas, Patrick

Publication type:

Article

Dolutegravir metabolism: impact of genetic variations on uridine diphosphate glucuronosyltransferase subfamilies.

Published in:

Xenobiotica, 2025, v. 55, n. 2, p. 43, doi. 10.1080/00498254.2025.2453983

By:

Tagawa, Kouji;
Maruo, Yoshihiro

Publication type:

Article

In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1.

Published in:

Xenobiotica, 2024, v. 54, n. 6, p. 304, doi. 10.1080/00498254.2024.2357765

By:

Kerins, Anna;
Butler, Phil;
Riley, Rob;
Koszyczarek, Marta;
Smith, Caroline;
Cruickshank, Faye;
Madgula, Vamsi;
Naik, Nilkanth;
Redinbo, Matthew R.;
Wilson, Ian D.

Publication type:

Article

The metabolite profiling of YR-1702 injection in human plasma, urine and feces by HPLC-Q-TOF-MS/MS.

Published in:

Xenobiotica, 2023, v. 53, n. 8/9, p. 536, doi. 10.1080/00498254.2023.2272193

By:

Yuxuan Fan;
Yufeng Ni;
Minlu Cheng;
Wenjing Guo;
Huaye Gao;
WenHui Hu;
Chang Shu;
Li Ding

Publication type:

Article

Mass balance study of [<sup>14</sup>C]SHR0302, a selective and potent JAK1 inhibitor in humans.

Published in:

Xenobiotica, 2023, v. 53, n. 2, p. 69, doi. 10.1080/00498254.2023.2176267

By:

Ge, Xinyu;
Ma, Sheng;
Yan, Shu;
Wu, Yali;
Chen, Chong;
Tang, Chongzhuang;
Zhan, Yan;
Bian, Yi-cong;
Shen, Kai;
Feng, Sheng;
Gao, Xuehu;
Zhong, Dafang;
Zhang, Hua;
Miao, Li-yan;
Diao, Xing-xing

Publication type:

Article

In vitro hepatic metabolism of the natural product quebecol.

Published in:

Xenobiotica, 2023, v. 53, n. 1, p. 1, doi. 10.1080/00498254.2023.2180691

By:

Bernardes, Gabriel;
Krol, Ed S.

Publication type:

Article

Species and tissue differences in regorafenib glucuronidation.

Published in:

Xenobiotica, 2022, v. 52, n. 2, p. 129, doi. 10.1080/00498254.2022.2055507

By:

Kojima, Ayaka;
Nadai, Masayuki;
Katoh, Miki

Publication type:

Article