Works matching DE "GENE knockout"

Results: 1298

ACOT11 基因敲除后促进 UUO 模型小鼠肾脏组织纤维化.

Published in:

Progress in Modern Biomedicine, 2025, v. 25, n. 9, p. 1441, doi. 10.13241/j.cnki.pmb.2025.09.001

By:

柯波亮;
何雏江;
唐麒麟;
牟伟明;
庄严;
邵怡

Publication type:

Article

大肠杆菌lysR 基因敲除和表达对氨基糖苷类抗生素耐受性分析.

Published in:

Fujian Agricultural Science & Technology, 2025, v. 56, n. 3, p. 45, doi. 10.13651/j.cnki.fjnykj.2025.03.007

By:

陆诗妍;
严沛文;
王悦;
蔡雅雯;
王妍

Publication type:

Article

CRISPR/Cas12a-based genome editing for cyanophage of Anabeana sp.

Published in:

Synthetic & Systems Biotechnology, 2025, v. 10, n. 1, p. 140, doi. 10.1016/j.synbio.2024.09.011

By:

Shengjian Yuan;
Yanchen Li;
Chunhua Kou;
YiChen Sun;
Yingfei Ma

Publication type:

Article

Hydrogen Sulfide (H 2 S) Mitigates Sepsis-Induced Adrenal Dysfunction via Inhibition of TNFα-Mediated Necroptosis.

Published in:

Pathogens, 2025, v. 14, n. 5, p. 439, doi. 10.3390/pathogens14050439

By:

Ma, Kai;
Huang, Jingwen;
Zhang, Jin;
Tian, Yuan;
Hu, Jing;
Ma, Linhao;
Wang, Changnan

Publication type:

Article

Isolation and Characterization of β-Phenylethylamine-Producing Lactic Acid Bacteria from Dairy Products.

Published in:

Microorganisms, 2025, v. 13, n. 5, p. 966, doi. 10.3390/microorganisms13050966

By:

Casado, Angel;
Fernández, Eva;
González, Héctor;
Fernández, María;
Alvarez, Miguel A.;
Ladero, Victor

Publication type:

Article

Plasma Metabolic Outliers Identified in Estonian Human Knockouts.

Published in:

Metabolites (2218-1989), 2025, v. 15, n. 5, p. 323, doi. 10.3390/metabo15050323

By:

Yu, Ketian;
Estrada, Karol;
Esko, Tõnu;
Kals, Mart;
Nikopensius, Tiit;
Kronberg, Jaanika;
Võsa, Urmo;
Wuster, Arthur;
Bomba, Lorenzo

Publication type:

Article

Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I Open Access.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2025, v. 110, n. 5, p. e1303, doi. 10.1210/clinem/dgaf010

By:

Punt, Lauren D;
Kooijman, Sander;
Mutsters, Noa J M;
Yue, Kaiming;
Kaay, Daniëlle C M van der;
Tellingen, Vera van;
Waarde, Willie M Bakker-van;
Boot, Annemiek M;
Akker, Erica L T van den;
Boekholt, Anneke A van;
Groote, Kirsten de;
Kruijsen, Anne R;
Maren, Nancy H G van Nieuwaal-van;
Woltering, M Claire;
Heijligers, Malou;
Heyden, Josine C van der;
Bannink, Ellen M N;
Rinne, Tuula;
Hannema, Sabine E;
Waal, Wouter J de

Publication type:

Article

The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70075

By:

Juhász, László;
Spisák, Krisztina;
Szolnoki, Boglárka Zsuzsa;
Nászai, Anna;
Szabó, Ágnes;
Rutai, Attila;
Tallósy, Szabolcs Péter;
Szabó, Andrea;
Toldi, József;
Tanaka, Masaru;
Takeda, Keiko;
Ozaki, Kinuyo;
Inoue, Hiromi;
Yamamoto, Sayo;
Ono, Etsuro;
Boros, Mihály;
Kaszaki, József;
Vécsei, László

Publication type:

Article

A Comprehensive Review of Hypotheses About the Biological Function of Zearalenone, and a New Hypothesis for the Function of Resorcylic and Dihydroxyphenylacetic Macrolactones in Fungi.

Published in:

Toxins, 2025, v. 17, n. 5, p. 226, doi. 10.3390/toxins17050226

By:

Viñas, María;
Karlovsky, Petr

Publication type:

Article

Myeloid PGGT1B Deficiency Promotes Psoriasiform Dermatitis by Promoting the Secretion of Inflammatory Factors.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4901, doi. 10.3390/ijms26104901

By:

Yu, Shanshan;
Long, Fangyuan;
Wei, Xuecui;
Gu, Heng;
Hao, Zhimin

Publication type:

Article

The regulatory variant rs1950834 confers the risk of depressive disorder by reducing LRFN5 expression.

Published in:

BMC Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12916-025-04141-8

By:

Luan, Di;
Li, Yifan;
Zhang, Aini;
Bai, Qingqing;
Zhao, Te;
Chen, Xi;
Dang, Xinglun;
Wang, Junyang;
Jiang, Shaolei;
Sun, Yun;
Zhu, Yingjie;
Kong, Yan;
Luo, Xiong-Jian;
Zhang, Zhijun

Publication type:

Article

Development and Characterization of an Inducible Bacterial Artificial Chromosome System for Studying Lytic Replication and Pathogenesis of Kaposi's Sarcoma‐Associated Herpesvirus.

Published in:

Journal of Medical Virology, 2025, v. 97, n. 5, p. 1, doi. 10.1002/jmv.70392

By:

Xu, Xue;
Dong, Peixian;
Li, Wenwei;
Wang, Xiaoqian;
Ming, Zizhen;
Liu, Zhenshan;
Zhu, Fanxiu;
Liang, Qiming

Publication type:

Article

Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 9, p. 3106, doi. 10.1002/chem.202004444

By:

Zhang, Haili;
Hantke, Verena;
Bruhnke, Pia;
Skellam, Elizabeth J.;
Cox, Russell J.

Publication type:

Article

PREditOR: a synthetic biology approach to removing heterochromatin from cells.

Published in:

Chromosome Research, 2016, v. 24, n. 4, p. 495, doi. 10.1007/s10577-016-9539-3

By:

Molina, Oscar;
Carmena, Mar;
Maudlin, Isabella;
Earnshaw, William

Publication type:

Article

Genome engineering in cattle: recent technological advancements.

Published in:

Chromosome Research, 2015, v. 23, n. 1, p. 17, doi. 10.1007/s10577-014-9452-6

By:

Wang, Zhongde

Publication type:

Article

Pyramidal cell-selective GluN1 knockout causes impairments in salience attribution and related EEG activity.

Published in:

Experimental Brain Research, 2018, v. 236, n. 3, p. 837, doi. 10.1007/s00221-017-5152-8

By:

Forrest, Alexandra D.;
Bang, Jakyung;
Featherstone, Robert E.;
Bloom, Jonathan H.;
Luminais, Matthew S.;
Zhang, Rebecca V.;
Gajewski, Christopher R.;
McMullen, Mary F.;
Liang, Yuling;
Siegel, Steven J.

Publication type:

Article

Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation.

Published in:

Basic Research in Cardiology, 2023, v. 118, n. 1, p. 1, doi. 10.1007/s00395-023-01010-4

By:

Zhong, Lingfeng;
Han, Jibo;
Fan, Xiaoxi;
Huang, Zhouqing;
Su, Lan;
Cai, Xueli;
Lin, Shuang;
Chen, Xudong;
Huang, Weijian;
Dai, Shanshan;
Ye, Bozhi

Publication type:

Article

Increasing l-lysine production in Corynebacterium glutamicum by engineering amino acid transporters.

Published in:

Amino Acids, 2020, v. 52, n. 10, p. 1363, doi. 10.1007/s00726-020-02893-6

By:

Xiao, Jing;
Wang, Datao;
Wang, Lei;
Jiang, Yanjun;
Xue, Le;
Sui, Songsen;
Wang, Jianbin;
Guo, Chuanzhuang;
Wang, Ruiming;
Wang, Junqing;
Li, Nan;
Fan, Han;
Lv, Maocui

Publication type:

Article

Green listed--a CRISPR screen tool.

Published in:

Bioinformatics, 2017, v. 33, n. 7, p. 1099, doi. 10.1093/bioinformatics/btw739

By:

Panda, Sudeepta Kumar;
Boddul, Sanjay V.;
Jiménez-Andrade, Guillermina Yanek;
Jiang, Long;
Kasza, Zsolt;
Fernandez-Ricaud, Luciano;
Wermeling, Fredrik

Publication type:

Article

CRISPR-DO for genome-wide CRISPR design and optimization.

Published in:

Bioinformatics, 2016, v. 32, n. 21, p. 3336, doi. 10.1093/bioinformatics/btw476

By:

Jian Ma;
Köster, Johannes;
Qian Qin;
Shengen Hu;
Wei Li;
Chenhao Chen;
Qingyi Cao;
Jinzeng Wang;
Shenglin Mei;
Qi Liu;
Han Xu;
Xiaole Shirley Liu

Publication type:

Article

MIRA: mutual information-based reporter algorithm for metabolic networks.

Published in:

Bioinformatics, 2014, v. 30, n. 12, p. i175, doi. 10.1093/bioinformatics/btu290

By:

Cicek, A. Ercument;
Roeder, Kathryn;
Ozsoyoglu, Gultekin

Publication type:

Article

Development and Applications of a Kinetic Model for Resveratrol Production in Escherichia coli Cell Factories.

Published in:

Trends in Sciences, 2025, v. 22, n. 5, p. 1, doi. 10.48048/tis.2025.9529

By:

Sirinapa Kumsuwan;
Chonnikan Tothong;
Apinun Limmongkon;
Pakpoom Subsoontorn

Publication type:

Article

A streamlined strain engineering workflow with genome-wide screening detects enhanced protein secretion in Komagataella phaffii.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03475-w

By:

Ito, Yoichiro;
Ishigami, Misa;
Terai, Goro;
Nakamura, Yasuyuki;
Hashiba, Noriko;
Nishi, Teruyuki;
Nakazawa, Hikaru;
Hasunuma, Tomohisa;
Asai, Kiyoshi;
Umetsu, Mitsuo;
Ishii, Jun;
Kondo, Akihiko

Publication type:

Article

CHEMICALLY MODIFIED FILTROPORATION DEVICES ENABLE CRISPR/CAS9-MEDIATED GENE KNOCKOUT IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS.

Published in:

Genetics & Applications, 2023, p. 8

By:

Isaura, Frost M.;
Alexandra, Mendoza M.;
Chiou Tzu-Ting;
Philseok, Kim;
Joanna, Aizenberg;
Donald, Kohn B.;
Satiro, De Oliveira N.;
Paul, Weiss S.;
Steven, Jonas J.

Publication type:

Article

Effects of Tcte1 knockout on energy chain transportation and spermatogenesis: implications for male infertility.

Published in:

Human Reproduction Open, 2024, v. 2024, n. 2, p. 1, doi. 10.1093/hropen/hoae020

By:

Olszewska, Marta;
Malcher, Agnieszka;
Stokowy, Tomasz;
Pollock, Nijole;
Berman, Andrea J;
Budkiewicz, Sylwia;
Kamieniczna, Marzena;
Jackowiak, Hanna;
Suszynska-Zajczyk, Joanna;
Jedrzejczak, Piotr;
Yatsenko, Alexander N;
Kurpisz, Maciej

Publication type:

Article

TPK3基因敲除对酿酒酵母耐受性的影响.

Published in:

Food Research & Development, 2021, v. 42, n. 18, p. 153, doi. 10.12161/j.issn.1005-6521.2021.18.023

By:

刘凯毅;
任剑星;
张晓晓;
董胜胜;
董健

Publication type:

Article

Combinatorial Metabolic Engineering in Saccharomyces cerevisiae for the Enhanced Production of the FPP-Derived Sesquiterpene Germacrene.

Published in:

Bioengineering (Basel), 2020, v. 7, n. 4, p. 1, doi. 10.3390/bioengineering7040135

By:

Bröker, Jan Niklas;
Müller, Boje;
Prüfer, Dirk;
Gronover, Christian Schulze

Publication type:

Article

Investigating the effects of global gene knockout of MrgF on motor performance and pain sensitivity in mice.

Published in:

Hereditas, 2025, v. 162, n. 1, p. 1, doi. 10.1186/s41065-025-00377-9

By:

Chen, Xuejiao;
Chen, Yan;
Shu, Runzhe;
Lu, Shunyuan;
Gu, Ming-Min;
Shen, Chunling;
Wang, Zhugang;
Cui, Xiaofang

Publication type:

Article

The Use of Genetically Engineered Mouse Models for Studying the Function of Mutated Driver Genes in Pancreatic Cancer.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 9, p. 1369, doi. 10.3390/jcm8091369

By:

Weng, Ching-Chieh;
Lin, Yu-Chun;
Cheng, Kuang-Hung

Publication type:

Article

ABA Inhibits Rice Seed Aging by Reducing H 2 O 2 Accumulation in the Radicle of Seeds.

Published in:

Plants (2223-7747), 2024, v. 13, n. 6, p. 809, doi. 10.3390/plants13060809

By:

Zheng, Qin;
Teng, Zhenning;
Zhang, Jianhua;
Ye, Nenghui

Publication type:

Article

CRISPR/Cas9 Based Cell-Type Specific Gene Knock-Out in Arabidopsis Roots.

Published in:

Plants (2223-7747), 2023, v. 12, n. 12, p. 2365, doi. 10.3390/plants12122365

By:

Li, Meng;
Niu, Xufang;
Li, Shuang;
Fu, Shasha;
Li, Qianfang;
Xu, Meizhi;
Wang, Chunhua;
Wu, Shuang

Publication type:

Article

Transcriptional Profile of Soybean Seeds with Contrasting Seed Coat Color.

Published in:

Plants (2223-7747), 2023, v. 12, n. 7, p. 1555, doi. 10.3390/plants12071555

By:

Kafer, João M.;
Molinari, Mayla D. C.;
Henning, Fernando A.;
Koltun, Alessandra;
Marques, Viviani V.;
Marin, Silvana R. R.;
Nepomuceno, Alexandre L.;
Mertz-Henning, Liliane M.

Publication type:

Article

The Role of Carbonic Anhydrase αCA4 in Photosynthetic Reactions in Arabidopsis thaliana Studied, Using the Cas9 and T-DNA Induced Mutations in Its Gene.

Published in:

Plants (2223-7747), 2022, v. 11, n. 23, p. 3303, doi. 10.3390/plants11233303

By:

Rudenko, Natalia N.;
Permyakova, Natalya V.;
Ignatova, Lyudmila K.;
Nadeeva, Elena M.;
Zagorskaya, Alla A.;
Deineko, Elena V.;
Ivanov, Boris N.

Publication type:

Article

Knockout of SlMS10 Gene (Solyc02g079810) Encoding bHLH Transcription Factor Using CRISPR/Cas9 System Confers Male Sterility Phenotype in Tomato.

Published in:

Plants (2223-7747), 2020, v. 9, n. 9, p. 1189, doi. 10.3390/plants9091189

By:

Jung, Yu Jin;
Kim, Dong Hyun;
Lee, Hyo Ju;
Nam, Ki Hong;
Bae, Sangsu;
Nou, Ill Sup;
Cho, Yong-Gu;
Kim, Myong Kwon;
Kang, Kwon Kyoo

Publication type:

Article

Cas9 和 PE 介导湖羊骨骼肌卫星细胞 MSTN 基因敲除的研究.

Published in:

Journal of Nanjing Agricultural University / Nanjuing Nongye Daxue Xuebao, 2025, v. 48, n. 2, p. 419, doi. 10.7685/jnau.202311027

By:

周磊;
李东旭;
冒魏佳;
刘孜斐;
高雪;
万永杰

Publication type:

Article

禾谷镰刀菌异质核糖核蛋白 FGSG_07478 功能研究.

Published in:

Journal of Nanjing Agricultural University / Nanjuing Nongye Daxue Xuebao, 2024, v. 47, n. 6, p. 1178, doi. 10.7685/jnau.202312036

By:

于伊楠;
范楷;
胡政;
郑思民;
孟佳佳;
张志岐;
黄晴雯;
聂冬霞;
韩铮

Publication type:

Article

解淀粉芽胞杆菌 SQR9亲缘识别与辨别相关基因的筛选.

Published in:

Journal of Nanjing Agricultural University / Nanjuing Nongye Daxue Xuebao, 2021, v. 44, n. 1, p. 119, doi. 10.7685/jnau.202003038

By:

严无瑕;
仇美华;
刘妍;
薛妍生;
陶丽丽;
徐志辉;
沈标;
张瑞福;
沈其荣

Publication type:

Article

荧光素酶报告系统检测大肠杆菌代谢产物调控STC-1细胞表达胆囊收缩素研究.

Published in:

Journal of Nanjing Agricultural University / Nanjuing Nongye Daxue Xuebao, 2019, v. 42, n. 6, p. 1133, doi. 10.7685/jnau.201810007

By:

余倩;
张玉宇;
张曾娣;
朱伟云;
黄赞

Publication type:

Article

BREEDIT: a multiplex genome editing strategy to improve complex quantitative traits in maize.

Published in:

Plant Cell, 2023, v. 35, n. 1, p. 218, doi. 10.1093/plcell/koac243

By:

Lorenzo, Christian Damian;
Debray, Kevin;
Herwegh, Denia;
Develtere, Ward;
Impens, Lennert;
Schaumont, Dries;
Vandeputte, Wout;
Aesaert, Stijn;
Coussens, Griet;
De Boe, Yara;
Demuynck, Kirin;
Van Hautegem, Tom;
Pauwels, Laurens;
Jacobs, Thomas B;
Ruttink, Tom;
Nelissen, Hilde;
Inzé, Dirk

Publication type:

Article

Multipurpose Toolkit to Enable Advanced Genome Engineering in Plants.

Published in:

Plant Cell, 2017, v. 29, n. 6, p. 1196, doi. 10.1105/tpc.16.00922

By:

Čermák, Tomáš;
Curtin, Shaun J.;
Gil-Humanes, Javier;
Čegan, Radim;
Kono, Thomas J.Y.;
Konečná, Eva;
Belanto, Joseph J.;
Starker, Colby G.;
Mathre, Jade W.;
Greenstein, Rebecca L.;
Voytas, Daniel F.

Publication type:

Article

Molecular Profiles of Contrasting Shade Response Strategies in Wild Plants: Differential Control of Immunity and Shoot Elongation.

Published in:

Plant Cell, 2017, v. 29, n. 2, p. 331, doi. 10.1105/tpc.16.00790

By:

Gommers, Charlotte M.M.;
Keuskamp, Diederik H.;
Buti, Sara;
Veen, Hans van;
Koevoets, Iko T.;
Reinen, Emilie;
Voesenek, Laurentius A.C.J.;
Pierik, Ronald

Publication type:

Article

Correction.

Published in:: Plant Cell, 2016, v. 28, n. 1, p. 266, doi. 10.1105/tpc.15.01061
Publication type:: Article

Identification of Myosin XI Receptors in Arabidopsis Defines a Distinct Class of Transport Vesicles.

Published in:

Plant Cell, 2013, v. 25, n. 8, p. 3022, doi. 10.1105/tpc.113.113704

By:

Peremyslov, Valera V.;
Morgun, Eva A.;
Kurth, Elizabeth G.;
Makarova, Kira S.;
Koonin, Eugene V.;
Dolja, Valerian V.

Publication type:

Article

YSL16 Is a Phloem-Localized Transporter of the Copper-Nicotianamine Complex That Is Responsible for Copper Distribution in Rice.

Published in:

Plant Cell, 2012, v. 24, n. 9, p. 3767, doi. 10.1105/tpc.112.103820

By:

Zheng, Luqing;
Yamaji, Naoki;
Yokosho, Kengo;
Ma, Jian Feng

Publication type:

Article

Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer's, and liver cancer.

Published in:

European Journal of Medical Research, 2024, v. 29, n. 1, p. 1, doi. 10.1186/s40001-024-02225-4

By:

Yan, Lu;
Song, Yin-Sen;
Zhou, Jian;
Zhu, Lin;
Shi, Tian-Wei;
Yu, Hui-Qian;
Dong, Zi-Qing;
Wang, Wei;
Long, Ting;
Liu, Hao-Ying;
Shi, Zhe-Ye;
Li, Jian-Guo

Publication type:

Article

ATG5 knockout promotes paclitaxel sensitivity in drug-resistant cells via induction of necrotic cell death.

Published in:

Korean Journal of Physiology & Pharmacology, 2020, v. 24, n. 3, p. 233, doi. 10.4196/kjpp.2020.24.3.233

By:

Sung-Hee Hwang;
Hojin Yeom;
Lee, Michael

Publication type:

Article

Effect of lncRNA XLOC_005950 knockout by CRISPR/Cas9 gene editing on energy metabolism and proliferation in osteosarcoma MG63 cells mediated by hsa-miR-542-3p.

Published in:

Oncology Letters, 2021, v. 22, n. 3, p. N.PAG, doi. 10.3892/ol.2021.12930

By:

Jia, Zhen;
Wang, Yadong;
Sun, Xiaoya;
Zhao, Xuefeng;
Zhang, Yan;
Xu, Shuangyan;
Wang, Yisheng;
Li, Yuebai

Publication type:

Article

Establishment of an miR‑137‑knockout cell model using CRISPR/Cas9 genome editing.

Published in:

Oncology Letters, 2018, v. 16, n. 3, p. 4027, doi. 10.3892/ol.2018.9096

By:

ChEN, Wei;
Li, Qi;
Du, Jingjie;
Li, Xiaodi;
Jiang, Songshan;
He, Yuanli

Publication type:

Article

Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.

Published in:

Oncology Letters, 2018, v. 15, n. 4, p. 4541, doi. 10.3892/ol.2018.7832

By:

Chen, Cheng;
Zhang, Bojia;
Wu, Shanshan;
Song, Yongxiang;
Li, Jian

Publication type:

Article

Aspirin inhibits growth of ovarian cancer by upregulating caspase-3 and downregulating bcl-2.

Published in:

Oncology Letters, 2016, v. 12, n. 1, p. 93, doi. 10.3892/ol.2016.4607

By:

LIN LI;
XIAOGANG MAO;
XIAOMIN QIN;
MIN ZHOU;
HUI XING;
FAN DONG;
XIAOYUAN JIANG;
WENHUI ZHUANG

Publication type:

Article