Works matching DE "GENE clusters"
Results: 3001
New solutions for antibiotic discovery: Prioritizing microbial biosynthetic space using ecology and machine learning.
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- PLoS Biology, 2025, v. 23, n. 2, p. 1, doi. 10.1371/journal.pbio.3003058
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Genome mining and metabolite profiling illuminate the taxonomy status and the cytotoxic activity of a mangrove-derived Microbacterium alkaliflavum sp. nov.
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- BMC Microbiology, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12866-025-03801-2
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Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching.
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- Cells (2073-4409), 2025, v. 14, n. 4, p. 312, doi. 10.3390/cells14040312
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Product Speculation from Carotenogenic Gene Cluster of Nonlabens spongiae Genome, and Identification of Myxol and Functional Analysis of Each Gene.
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- Genes, 2025, v. 16, n. 2, p. 202, doi. 10.3390/genes16020202
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Identification, Genome Characterization, and Growth Optimization of Paenibacillus peoriae MHJL1 for Biocontrol and Growth Promotion of Cotton Seedlings.
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- Microorganisms, 2025, v. 13, n. 2, p. 261, doi. 10.3390/microorganisms13020261
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γBMGC: A Comprehensive and Accurate Database for Screening TMAO-Associated Cardiovascular Diseases.
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- Microorganisms, 2025, v. 13, n. 2, p. 225, doi. 10.3390/microorganisms13020225
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Direct Cloning and Heterologous Expression of the Dmxorosin Biosynthetic Gene Cluster from Streptomyces thermolilacinus SPC6, a Halotolerant Actinomycete Isolated from the Desert in China.
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- International Journal of Molecular Sciences, 2025, v. 26, n. 4, p. 1492, doi. 10.3390/ijms26041492
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Genomics-Driven Discovery of Plantariitin A, a New Lipopeptide in Burkholderia plantarii DSM9509.
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- Molecules, 2025, v. 30, n. 4, p. 868, doi. 10.3390/molecules30040868
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Metabolomic and genomic insights into Micromonospora carbonacea subsp. caeruleus for anti-colorectal compound.
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- Applied Microbiology & Biotechnology, 2025, v. 109, n. 1, p. 1, doi. 10.1007/s00253-025-13427-z
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Exploration of the metabolic potential of the Corallococcus genus: a rich source of secondary metabolites and CAZymes.
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- Biologia, 2025, v. 80, n. 3, p. 685, doi. 10.1007/s11756-025-01866-y
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Comprehensive blueprint of Salmonella genomic plasticity identifies hotspots for pathogenicity genes.
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- PLoS Biology, 2024, v. 22, n. 8, p. 1, doi. 10.1371/journal.pbio.3002746
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Reassignment of the Structure of a Tryptophan‐Containing Cyclic Tripeptide Produced by the Biarylitide Crosslinking Cytochrome P450<sub>blt</sub>.
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- Chemistry - A European Journal, 2024, v. 30, n. 38, p. 1, doi. 10.1002/chem.202400988
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Identification of the Cirratiomycin Biosynthesis Gene Cluster in Streptomyces Cirratus: Elucidation of the Biosynthetic Pathways for 2,3‐Diaminobutyric Acid and Hydroxymethylserine.
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- Chemistry - A European Journal, 2024, v. 30, n. 28, p. 1, doi. 10.1002/chem.202400271
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GNPS‐Guided Discovery of Madurastatin Siderophores from the Termite‐Associated Actinomadura sp. RB99.
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- Chemistry - A European Journal, 2022, v. 28, n. 36, p. 1, doi. 10.1002/chem.202200612
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Investigation of the Odilorhabdin Biosynthetic Gene Cluster Using NRPS Engineering.
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- Angewandte Chemie, 2024, v. 136, n. 33, p. 1, doi. 10.1002/ange.202406389
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Detection of Sulfoquinovosidase Activity in Cell Lysates Using Activity‐Based Probes.
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- Angewandte Chemie, 2024, v. 136, n. 26, p. 1, doi. 10.1002/ange.202401358
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A Semisynthesis Platform for the Efficient Production and Exploration of Didemnin‐Based Drugs.
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- Angewandte Chemie, 2024, v. 136, n. 12, p. 1, doi. 10.1002/ange.202318784
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Structure of Staphylococcus aureus ClpP Bound to the Covalent Active‐Site Inhibitor Cystargolide A.
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- Angewandte Chemie, 2024, v. 136, n. 3, p. 1, doi. 10.1002/ange.202314028
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- Article
Innenrücktitelbild: Membrane‐Vesicle‐Mediated Interbacterial Communication Activates Silent Secondary Metabolite Production (Angew. Chem. 42/2023).
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- Angewandte Chemie, 2023, v. 135, n. 42, p. 1, doi. 10.1002/ange.202312432
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Analysis of Rhizonin Biosynthesis Reveals Origin of Pharmacophoric Furylalanine Moieties in Diverse Cyclopeptides.
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- Angewandte Chemie, 2023, v. 135, n. 42, p. 1, doi. 10.1002/ange.202308540
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- Article
Membrane‐Vesicle‐Mediated Interbacterial Communication Activates Silent Secondary Metabolite Production.
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- Angewandte Chemie, 2023, v. 135, n. 42, p. 1, doi. 10.1002/ange.202307304
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Polyketide Synthase‐Mediated O‐Methyloxime Formation in the Biosynthesis of the Oximidine Anticancer Agents.
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- Angewandte Chemie, 2023, v. 135, n. 34, p. 1, doi. 10.1002/ange.202304476
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Discovery of the Azaserine Biosynthetic Pathway Uncovers a Biological Route for α‐Diazoester Production.
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- Angewandte Chemie, 2023, v. 135, n. 28, p. 1, doi. 10.1002/ange.202304646
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Discovery and Biosynthesis of Cihunamides, Macrocyclic Antibacterial RiPPs with a Unique C−N Linkage Formed by CYP450 Catalysis.
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- Angewandte Chemie, 2023, v. 135, n. 26, p. 1, doi. 10.1002/ange.202300998
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Somalactams A–D: Anti‐inflammatory Macrolide Lactams with Unique Ring Systems from an Arctic Actinomycete Strain.
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- Angewandte Chemie, 2023, v. 135, n. 18, p. 1, doi. 10.1002/ange.202218085
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The Biosynthetic Gene Cluster of Mushroom‐Derived Antrocin Encodes Two Dual‐Functional Haloacid Dehalogenase‐like Terpene Cyclases.
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- Angewandte Chemie, 2023, v. 135, n. 9, p. 1, doi. 10.1002/ange.202215566
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Coordination of Polyketide Release and Multiple Detoxification Pathways for Tolerable Production of Fungal Mycotoxins.
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- Angewandte Chemie, 2023, v. 135, n. 5, p. 1, doi. 10.1002/ange.202214814
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Cytochrome P450 Catalyzes Benzene Ring Formation in the Biosynthesis of Trialkyl‐Substituted Aromatic Polyketides.
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- Angewandte Chemie, 2023, v. 135, n. 5, p. 1, doi. 10.1002/ange.202214026
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The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis.
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- Angewandte Chemie, 2023, v. 135, n. 3, p. 1, doi. 10.1002/ange.202213053
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Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate‐Containing Natural Products in Diverse Bacteria.
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- Angewandte Chemie, 2022, v. 134, n. 51, p. 1, doi. 10.1002/ange.202206106
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Biosynthesis of Nodulisporic Acids: A Multifunctional Monooxygenase Delivers a Complex and Highly Branched Array.
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- Angewandte Chemie, 2022, v. 134, n. 49, p. 1, doi. 10.1002/ange.202213364
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Expanded Sequence Space of Radical S‐Adenosylmethionine‐Dependent Enzymes Involved in Post‐translational Macrocyclization**.
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- Angewandte Chemie, 2022, v. 134, n. 48, p. 1, doi. 10.1002/ange.202212447
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Biosynthetic Elucidation and Structural Revision of Brevione E: Characterization of the Key Dioxygenase for Pathway Branching from Setosusin Biosynthesis.
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- Angewandte Chemie, 2022, v. 134, n. 48, p. 1, doi. 10.1002/ange.202210938
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Two Radical SAM Enzymes Are Necessary and Sufficient for the In Vitro Production of the Oxetane Nucleoside Antiviral Agent Albucidin.
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- Angewandte Chemie, 2022, v. 134, n. 42, p. 1, doi. 10.1002/ange.202210362
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- Article
Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus.
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- Angewandte Chemie, 2022, v. 134, n. 39, p. 1, doi. 10.1002/ange.202208573
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- Article
Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold.
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- Angewandte Chemie, 2022, v. 134, n. 32, p. 1, doi. 10.1002/ange.202205409
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- Article
Biosynthesis of Chuangxinmycin Featuring a Deubiquitinase‐like Sulfurtransferase.
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- Angewandte Chemie, 2021, v. 133, n. 46, p. 24623, doi. 10.1002/ange.202107745
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- Article
Metagenome‐Guided Analogue Synthesis Yields Improved Gram‐Negative‐Active Albicidin‐ and Cystobactamid‐Type Antibiotics.
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- Angewandte Chemie, 2021, v. 133, n. 41, p. 22346, doi. 10.1002/ange.202104874
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- Article
Nocathioamides, Uncovered by a Tunable Metabologenomic Approach, Define a Novel Class of Chimeric Lanthipeptides.
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- Angewandte Chemie, 2021, v. 133, n. 30, p. 16608, doi. 10.1002/ange.202102571
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Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin.
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- Angewandte Chemie, 2021, v. 133, n. 24, p. 13691, doi. 10.1002/ange.202102224
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Genetic Engineering in Combination with Semi‐Synthesis Leads to a New Route for Gram‐Scale Production of the Immunosuppressive Natural Product Brasilicardin A.
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- Angewandte Chemie, 2021, v. 133, n. 24, p. 13648, doi. 10.1002/ange.202015852
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- Article
Discovery of Cyanobacterial Natural Products Containing Fatty Acid Residues.
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- Angewandte Chemie, 2021, v. 133, n. 18, p. 10152, doi. 10.1002/ange.202015105
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- Article
One Polyketide Synthase, Two Distinct Products: Trans‐Acting Enzyme‐Controlled Product Divergence in Calbistrin Biosynthesis.
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- Angewandte Chemie, 2021, v. 133, n. 16, p. 8933, doi. 10.1002/ange.202016525
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Structural Revision of Natural Cyclic Depsipeptide MA026 Established by Total Synthesis and Biosynthetic Gene Cluster Analysis.
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- Angewandte Chemie, 2021, v. 133, n. 16, p. 8874, doi. 10.1002/ange.202015193
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- Article
Cryptic Sulfur Incorporation in Thioangucycline Biosynthesis.
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- Angewandte Chemie, 2021, v. 133, n. 13, p. 7216, doi. 10.1002/ange.202015570
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- Article
The Utilization of Lanthipeptide Synthetases Is a General Strategy for the Biosynthesis of 2‐Aminovinyl‐Cysteine Motifs in Thioamitides**.
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- Angewandte Chemie, 2021, v. 133, n. 4, p. 1979, doi. 10.1002/ange.202012871
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- Article
Berichtigung: Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI‐MS‐Guided High‐Throughput Elicitor Screening.
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- Angewandte Chemie, 2020, v. 132, n. 51, p. 23017, doi. 10.1002/ange.202014201
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- Article
Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI‐MS‐Guided High‐Throughput Elicitor Screening.
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- Angewandte Chemie, 2020, v. 132, n. 51, p. 23205, doi. 10.1002/ange.202009611
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- Article
Discovery and Biosynthesis of Bolagladins: Unusual Lipodepsipeptides from Burkholderia gladioli Clinical Isolates.
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- Angewandte Chemie, 2020, v. 132, n. 48, p. 21737, doi. 10.1002/ange.202009110
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- Article
Quinolactacin Biosynthesis Involves Non‐Ribosomal‐Peptide‐Synthetase‐Catalyzed Dieckmann Condensation to Form the Quinolone‐γ‐lactam Hybrid.
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- Angewandte Chemie, 2020, v. 132, n. 43, p. 19270, doi. 10.1002/ange.202005770
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- Article