Works about GELDANAMYCIN

Results: 83

Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species.

Published in:

Mycopathologia, 2013, v. 175, n. 3/4, p. 273, doi. 10.1007/s11046-012-9612-1

By:

Zhang, Jinqing;
Liu, Wei;
Tan, Jingwen;
Sun, Yi;
Wan, Zhe;
Li, Ruoyu

Publication type:

Article

Modulation of TNFR 1-triggered two opposing signals for inflammation and apoptosis via RIPK 1 disruption by geldanamycin in rheumatoid arthritis.

Published in:

Clinical Rheumatology, 2021, v. 40, n. 6, p. 2395, doi. 10.1007/s10067-021-05579-w

By:

Saeki, Yukihiko;
Okita, Yasutaka;
Igashira-Oguro, Eri;
Udagawa, Chikako;
Murata, Atsuko;
Tanaka, Takashi;
Mukai, Jyunji;
Miyazawa, Keiji;
Hoshida, Yoshihiko;
Ohshima, Shiro

Publication type:

Article

Inhibitors of heat shock protein 90 augment endothelin‑1‑induced heat shock protein 27 through the SAPK/JNK signaling pathway in osteoblasts.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 6, p. 8542, doi. 10.3892/mmr.2018.8878

By:

Fujita, Kazuhiko;
Otsuka, Takanobu;
Kawabata, Tetsu;
Sakai, Go;
Matsushima-Nishiwaki, Rie;
Kozawa, Osamu;
Tokuda, Haruhiko

Publication type:

Article

Effects of salinomycin and 17-AAG on proliferation of human gastric cancer cells in vitro.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 2, p. 1063, doi. 10.3892/mmr.2017.6735

By:

ZUWEN ZHANG;
JUMEI ZHAO;
ZHIKUAN MI;
QIUXIA PANG;
AIHONG WANG;
MEINI CHEN;
XIAOBIN LIU;
XIAOLI WEI;
TAO LIU

Publication type:

Article

Potential inhibition of SARS-CoV-2 infection and its mutation with the novel geldanamycin analogue: Ignaciomycin.

Published in:

Arabian Journal of Chemistry, 2024, v. 17, n. 2, p. N.PAG, doi. 10.1016/j.arabjc.2023.105493

By:

Stalin, Antony;
Saravana Kumar, Pachaiyappan;
Senthamarai Kannan, Balakrishnan;
Saravanan, Rajamanikam;
Ignacimuthu, Savarimuthu;
Zou, Quan

Publication type:

Article

Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.

Published in:

Nature Chemistry, 2013, v. 5, n. 4, p. 307, doi. 10.1038/nchem.1596

By:

Kitson, Russell R. A.;
Chang, Chuan-Hsin;
Xiong, Rui;
Williams, Huw E. L.;
Davis, Adrienne L.;
Lewis, William;
Dehn, Donna L.;
Siegel, David;
Roe, S. Mark;
Prodromou, Chrisostomos;
Ross, David;
Moody, Christopher J.

Publication type:

Article

Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?

Published in:

Molecular & Cellular Biochemistry, 2014, v. 386, n. 1/2, p. 45, doi. 10.1007/s11010-013-1844-y

By:

Paul, Subhankar;
Mahanta, Sailendra

Publication type:

Article

17-allylamino-17-(demethoxy)geldanamycin (17-AAG) is a potent and effective inhibitor of human cytomegalovirus replication in primary fibroblast cells.

Published in:

2012

By:

Evers, David;
Chao, Chih-Fang;
Zhang, Zhigang;
Huang, Eng-Shang

Publication type:

Report

Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells.

Published in:

Experimental & Therapeutic Medicine, 2014, v. 8, n. 5, p. 1559, doi. 10.3892/etm.2014.1930

By:

XUE DU;
YONGMEI LI;
XU JING;
ZHAO, LINA

Publication type:

Article

Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells.

Published in:

2017

By:

Castagnola, Patrizia;
Bellese, Grazia;
Birocchi, Filippo;
Gagliani, Maria Cristina;
Tacchetti, Carlo;
Cortese, Katia

Publication type:

Abstract

Effects of HSP90 inhibitor 17-allylamino-17 -demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.

Published in:

BMC Research Notes, 2012, v. 5, n. 1, p. 250, doi. 10.1186/1756-0500-5-250

By:

Rodrigues, Loretta M;
Chung, Yuen-Li;
Al Saffar, Nada M;
Sharp, Swee Y;
Jackson, Laura E;
Banerji, Udai;
Stubbs, Marion;
Leach, Martin O;
Griffiths, John R;
Workman, Paul

Publication type:

Article

Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells.

Published in:

Journal of Toxicological Sciences, 2012, v. 37, n. 5, p. 1049, doi. 10.2131/jts.37.1049

By:

Kaori Toyomura;
Takeshi Saito;
Syunsuke Emori;
Ikiru Matsumoto;
Erina Kato;
Masayuki Kaneko;
Yasunobu Okuma;
Hiroyuki Nakamura;
Toshihiko Murayama

Publication type:

Article

Synthesis and biological evaluation of geldanamycin analogs against human cancer cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2015, v. 75, n. 4, p. 773, doi. 10.1007/s00280-015-2696-9

By:

Li, Yan-ping;
Chen, Jin-jing;
Shen, Jia-jia;
Cui, Jing;
Wu, Lin-zhuan;
Wang, Zhen;
Li, Zhuo-rong

Publication type:

Article

Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors.

Published in:

2014

By:

Doi, Toshihiko;
Onozawa, Yusuke;
Fuse, Nozomu;
Yoshino, Takayuki;
Yamazaki, Kentaro;
Watanabe, Junichiro;
Akimov, Mikhail;
Robson, Matthew;
Boku, Narikazu;
Ohtsu, Atsushi

Publication type:

Report

Open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of intravenously administered CNF1010 (17-(allylamino)-17-demethoxygeldanamycin [17-AAG]) in patients with solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 5, p. 1345, doi. 10.1007/s00280-013-2134-9

By:

Saif, M.;
Erlichman, C.;
Dragovich, T.;
Mendelson, D.;
Toft, D.;
Burrows, F.;
Storgard, C.;
Hoff, D.

Publication type:

Article

Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 70, n. 1, p. 201, doi. 10.1007/s00280-012-1859-1

By:

Aregbe, Abdulateef;
Sherer, Eric;
Egorin, Merrill;
Scher, Howard;
Solit, David;
Ramanathan, Ramesh;
Ramalingam, Suresh;
Belani, Chandra;
Ivy, Percy;
Bies, Robert

Publication type:

Article

Hsp90 inhibitor reduces porcine circovirus 2 replication in the porcine monocytic line 3D4/31.

Published in:

Virus Genes, 2017, v. 53, n. 1, p. 95, doi. 10.1007/s11262-016-1385-z

By:

Liu, Jie;
Zhang, Xuliang;
Ma, Chang;
Jiang, Ping;
Yun, Shifeng

Publication type:

Article

Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 1898, doi. 10.1080/14756366.2021.1960829

By:

Skrzypczak, Natalia;
Pyta, Krystian;
Ruszkowski, Piotr;
Mikołajczak, Przemysław;
Kucińska, Małgorzata;
Murias, Marek;
Gdaniec, Maria;
Bartl, Franz;
Przybylski, Piotr

Publication type:

Article

Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization.

Published in:

PLoS ONE, 2017, v. 12, n. 3, p. 1, doi. 10.1371/journal.pone.0173640

By:

Kudryavtsev, Vladimir A.;
Khokhlova, Anna V.;
Mosina, Vera A.;
Selivanova, Elena I.;
Kabakov, Alexander E.

Publication type:

Article

P489Geldanamycin-induced IkBa cleavage potentiates autophagy in angiotensin II -mediated hypertrophy.

Published in:

2018

By:

Lee, K H;
Cho, H N;
Lee, S R;
Kim, W

Publication type:

Abstract

Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins.

Published in:

Cardiovascular Research, 2013, v. 100, n. 3, p. 520, doi. 10.1093/cvr/cvt200

By:

Iwai, Chisato;
Li, Peili;
Kurata, Yasutaka;
Hoshikawa, Yoshiko;
Morikawa, Kumi;
Maharani, Nani;
Higaki, Katsumi;
Sasano, Tetsuro;
Notsu, Tomomi;
Ishido, Yuko;
Miake, Junichiro;
Yamamoto, Yasutaka;
Shirayoshi, Yasuaki;
Ninomiya, Haruaki;
Nakai, Akira;
Murata, Shigeo;
Yoshida, Akio;
Yamamoto, Kazuhiro;
Hiraoka, Masayasu;
Hisatome, Ichiro

Publication type:

Article

Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy.

Published in:

Cardiovascular Research, 2013, v. 98, n. 2, p. 277, doi. 10.1093/cvr/cvt029

By:

Pedrozo, Zully;
Torrealba, Natalia;
Fernández, Carolina;
Gatica, Damian;
Toro, Barbra;
Quiroga, Clara;
Rodriguez, Andrea E.;
Sanchez, Gina;
Gillette, Thomas G.;
Hill, Joseph A.;
Donoso, Paulina;
Lavandero, Sergio

Publication type:

Article

Hsp90 Inhibitor Can Inhibit UV Carcinogenesis.

Published in:

Journal of Investigative Dermatology, 2015, v. 135, n. 4, p. 945, doi. 10.1038/jid.2014.504

By:

Katiyar, Santosh K

Publication type:

Article

Topically Applied Hsp90 Inhibitor 17AAG Inhibits UVR-Induced Cutaneous Squamous Cell Carcinomas.

Published in:

Journal of Investigative Dermatology, 2015, v. 135, n. 4, p. 1098, doi. 10.1038/jid.2014.460

By:

Singh, Anupama;
Singh, Ashok;
Sand, Jordan M;
Bauer, Samuel J;
Bin Hafeez, Bilal;
Meske, Louise;
Verma, Ajit K

Publication type:

Article

HSP90 INHIBITOR GELDANAMYCIN AS A RADIATION RESPONSE MODIFICATOR IN HUMAN BLOOD CELLS.

Published in:

Dose-Response, 2015, v. 13, n. 1, p. 1, doi. 10.2203/dose-response.14-039.Stankova

By:

Stankova, Katia;
Savova, Gergana;
Nikolov, Vladimir;
Boteva, Rayna

Publication type:

Article

Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 20, p. 11293, doi. 10.3390/ijms252011293

By:

Abdullah, Omeima;
Omran, Ziad

Publication type:

Article

Structural Characterization of Heat Shock Protein 90β and Molecular Interactions with Geldanamycin and Ritonavir: A Computational Study.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 16, p. 8782, doi. 10.3390/ijms25168782

By:

Lima, Carlyle Ribeiro;
Antunes, Deborah;
Caffarena, Ernesto;
Carels, Nicolas

Publication type:

Article

Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1).

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 10, p. 2440, doi. 10.3390/ijms20102440

By:

Gómez-Fernández, Paloma;
Urtasun, Andoni;
Astobiza, Ianire;
Mena, Jorge;
Alloza, Iraide;
Vandenbroeck, Koen

Publication type:

Article

Involvement of Calcium-Mediated Reactive Oxygen Species in Inductive GRP78 Expression by Geldanamycin in 9L Rat Brain Tumor Cells.

Published in:

International Journal of Molecular Sciences, 2013, v. 14, n. 9, p. 19169, doi. 10.3390/ijms140919169

By:

Sun, Fang-Chun;
Shyu, Hsin-Yi;
Lee, Meng-Shiou;
Lee, Meng-Shiunn;
Lai, Yiu-Kay

Publication type:

Article

Improvement of Inhibitor Identification for Heat Shock Protein 90α by Utilizing a Red-Shifted Fluorescence Polarization Probe.

Published in:

Assay & Drug Development Technologies, 2012, v. 10, n. 4, p. 375, doi. 10.1089/adt.2011.429

By:

Qian, Jie;
Holskin, Beverly P.;
Theroff, Jay;
Underiner, Ted;
Meyer, Sheryl L.;
Angeles, Thelma S.

Publication type:

Article

Correction to geldanamycin ameliorates multiple organ dysfunction and microthrombosis in septic mice by inhibiting the formation of the neutrophil extracellular network by activating heat shock factor 1 HSF1.

Published in:: 2023
Publication type:: Correction Notice

Geldanamycin ameliorates multiple organ dysfunction and microthrombosis in septic mice by inhibiting the formation of the neutrophil extracellular network by activating heat shock factor 1 HSF1.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2023, v. 50, n. 8, p. 698, doi. 10.1111/1440-1681.13798

By:

Li, Jing;
Xuan, Ruijing;
Wu, Weidong;
Zhang, Hailong;
Zhao, Jie;
Zhang, Shan

Publication type:

Article

17-(allylamino)-17-demethoxygeldanamycin drives Hsp70 expression but fails to improve morphological or functional recovery in injured skeletal muscle.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2015, v. 42, n. 12, p. 1308, doi. 10.1111/1440-1681.12477

By:

Baumann, Cory W;
Otis, Jeffrey S

Publication type:

Article

17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model.

Published in:

PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0191264

By:

Joshi, Sandeep S.;
Jiang, Shunlin;
Unni, Emmanual;
Goding, Stephen R.;
Fan, Tao;
Antony, Paul A.;
Hornyak, Thomas J.

Publication type:

Article

HSP90C interacts with PsbO1 and facilitates its thylakoid distribution from chloroplast stroma in Arabidopsis.

Published in:

PLoS ONE, 2017, v. 12, n. 12, p. 1, doi. 10.1371/journal.pone.0190168

By:

Jiang, Tim;
Oh, Edward Saehong;
Bonea, Diana;
Zhao, Rongmin

Publication type:

Article

Addition of 17-(allylamino)-17-demethoxygeldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy.

Published in:

PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0180961

By:

Refos, Jeannine M.;
Vonk, Alieke G.;
ten Kate, Marian T.;
Eadie, Kimberly;
Verbrugh, Henri A.;
Bakker-Woudenberg, Irma A. J. M.;
van de Sande, Wendy W. J.

Publication type:

Article

Delivery of HSP90 Inhibitor Using Water Soluble Polymeric Conjugates with High Drug Payload.

Published in:

Pharmaceutical Research, 2017, v. 34, n. 12, p. 2735, doi. 10.1007/s11095-017-2249-5

By:

Suárez del Pino, Jose;
Kolhatkar, Rohit

Publication type:

Article

Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia.

Published in:

Molecular Cancer, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1476-4598-13-116

By:

Haaland, Ingvild;
Opsahl, Jill A.;
Berven, Frode S.;
Reikvam, Håkon;
Fredly, Hanne K.;
Haugse, Ragnhild;
Thiede, Bernd;
McCormack, Emmet;
Lain, Sonia;
Bruserud, Øystein;
Tore Gjertsen, Bjørn

Publication type:

Article

A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-51239-0

By:

Palma, Luana Carneiro;
Ferreira, Luiz Felipe Gomes Rebello;
Petersen, Antonio Luis de Oliveira Almeida;
Dias, Beatriz Rocha Simões;
Menezes, Juliana Perrone Bezerra de;
Moreira, Diogo Rodrigo de Magalhães;
Hernandes, Marcelo Zaldini;
Veras, Patricia Sampaio Tavares

Publication type:

Article

Brassinosteroid nuclear signaling recruits HSP90 activity.

Published in:

New Phytologist, 2014, v. 203, n. 3, p. 743, doi. 10.1111/nph.12843

By:

Samakovli, Despina;
Margaritopoulou, Theoni;
Prassinos, Constantinos;
Milioni, Dimitra;
Hatzopoulos, Polydefkis

Publication type:

Article

Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii.

Published in:: Malaria Journal, 2012, v. 11, n. 1, p. 54, doi. 10.1186/1475-2875-11-54
Publication type:: Article

Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus.

Published in:

Critical Reviews in Microbiology, 2016, v. 42, n. 2, p. 310, doi. 10.3109/1040841X.2014.947239

By:

Lamoth, Frédéric;
Juvvadi, Praveen R.;
Steinbach, William J.

Publication type:

Article

Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells in vitro.

Published in:

Journal of Veterinary Science, 2017, v. 18, n. 2, p. 129, doi. 10.4142/jvs.2017.18.2.129

By:

Xiao-Hui Zhang;
Hong Wu;
Shu Tang;
Qiao-Ning Li;
Jiao Xu;
Miao Zhang;
Ya-Nan Su;
Bin Yin;
Qi-Ling Zhao;
Nicole Kemper;
Joerg Hartung;
En-Dong Bao

Publication type:

Article

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.

Published in:

Archives of Toxicology, 2017, v. 91, n. 1, p. 365, doi. 10.1007/s00204-016-1690-2

By:

Colaianna, Marilena;
Ilmjärv, Sten;
Peterson, Hedi;
Kern, Ilse;
Julien, Stephanie;
Baquié, Mathurin;
Pallocca, Giorgia;
Bosgra, Sieto;
Sachinidis, Agapios;
Hengstler, Jan;
Leist, Marcel;
Krause, Karl-Heinz

Publication type:

Article

Human epidermal growth factor receptor 2-positive breast cancer: which cytotoxic agent best complements trastuzumab's efficacy in vitro?

Published in:

OncoTargets & Therapy, 2013, v. 6, p. 693, doi. 10.2147/OTT.S46883

By:

Hurrell, Tracey;
Outhoff, Kim

Publication type:

Article

Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.

Published in:

PLoS ONE, 2018, v. 13, n. 11, p. 1, doi. 10.1371/journal.pone.0203978

By:

Kanamoto, Mayu;
Tsuchiya, Yoshihiro;
Nakao, Yuki;
Suzuki, Takafumi;
Motohashi, Hozumi;
Yamamoto, Masayuki;
Kamata, Hideaki

Publication type:

Article

Hsp-90 Inhibitor Geldanamycin Attenuates Liver Oxidative Stress and Toxicity in Thiram-Induced Tibial Dyschondroplasia.

Published in:

Pakistan Veterinary Journal, 2014, v. 34, n. 4, p. 545

By:

Shahzad, Muhammad;
Jingying Liu;
Jianfeng Gao;
Zhi Wang;
Ding Zhang;
Fazul Nabi;
Jiakui Li

Publication type:

Article

17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.

Published in:

Journal of Bioenergetics & Biomembranes, 2015, v. 47, n. 5, p. 373, doi. 10.1007/s10863-015-9620-1

By:

Zhao, Surong;
Li, Hongmei;
Jiang, Chenchen;
Ma, Tao;
Wu, Chengzhu;
Huo, Qiang;
Liu, Hao

Publication type:

Article

Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines.

Published in:

Cancer Cell International, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1475-2867-13-11

By:

Karkoulis, Panagiotis K.;
Stravopodis, Dimitrios J.;
Konstantakou, Eumorphia G.;
Voutsinas, Gerassimos E.

Publication type:

Article

Evaluation of the Synthetic Potential of an AHBA Knockout Mutant of the Rifamycin Producer Amycolatopsis mediterranei.

Published in:

Chemistry - A European Journal, 2015, v. 21, n. 52, p. 19231, doi. 10.1002/chem.201503548

By:

Bułyszko, Ilona;
Dräger, Gerald;
Klenge, Anja;
Kirschning, Andreas

Publication type:

Article