Works about GELDANAMYCIN
Results: 82
Modulation of TNFR 1-triggered two opposing signals for inflammation and apoptosis via RIPK 1 disruption by geldanamycin in rheumatoid arthritis.
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- Clinical Rheumatology, 2021, v. 40, n. 6, p. 2395, doi. 10.1007/s10067-021-05579-w
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- Article
Hsp90 inhibitor reduces porcine circovirus 2 replication in the porcine monocytic line 3D4/31.
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- Virus Genes, 2017, v. 53, n. 1, p. 95, doi. 10.1007/s11262-016-1385-z
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- Article
Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 1898, doi. 10.1080/14756366.2021.1960829
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- Article
Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells.
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- 2017
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- Abstract
A secreted Heat shock protein 90 of Trichomonas vaginalis.
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- PLoS Neglected Tropical Diseases, 2018, v. 12, n. 5, p. 1, doi. 10.1371/journal.pntd.0006493
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- Article
Effects of HSP90 inhibitor 17-allylamino-17 -demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.
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- BMC Research Notes, 2012, v. 5, n. 1, p. 250, doi. 10.1186/1756-0500-5-250
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- Article
Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro.
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- Virology Journal, 2014, v. 11, n. 1, p. 1, doi. 10.1186/1743-422X-11-17
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- Article
Geldanamycin Enhances the Radioprotective Effect of Peroxyredoxin 6 in Irradiated 3T3 Fibroblasts.
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- Doklady Biochemistry & Biophysics, 2022, v. 506, n. 1, p. 202, doi. 10.1134/S160767292205012X
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- Article
Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells.
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- Experimental & Therapeutic Medicine, 2014, v. 8, n. 5, p. 1559, doi. 10.3892/etm.2014.1930
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- Article
A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-51239-0
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- Article
Brassinosteroid nuclear signaling recruits HSP90 activity.
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- New Phytologist, 2014, v. 203, n. 3, p. 743, doi. 10.1111/nph.12843
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- Article
The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes
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- FEBS Open Bio, 2012, v. 2, p. 47, doi. 10.1016/j.fob.2012.03.002
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- Article
P489Geldanamycin-induced IkBa cleavage potentiates autophagy in angiotensin II -mediated hypertrophy.
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- 2018
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- Abstract
Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins.
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- Cardiovascular Research, 2013, v. 100, n. 3, p. 520, doi. 10.1093/cvr/cvt200
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- Article
Improvement of Inhibitor Identification for Heat Shock Protein 90α by Utilizing a Red-Shifted Fluorescence Polarization Probe.
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- Assay & Drug Development Technologies, 2012, v. 10, n. 4, p. 375, doi. 10.1089/adt.2011.429
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- Article
Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?
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- Molecular & Cellular Biochemistry, 2014, v. 386, n. 1/2, p. 45, doi. 10.1007/s11010-013-1844-y
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- Article
Human epidermal growth factor receptor 2-positive breast cancer: which cytotoxic agent best complements trastuzumab's efficacy in vitro?
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- OncoTargets & Therapy, 2013, v. 6, p. 693, doi. 10.2147/OTT.S46883
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- Article
Potent Antitrypanosomal Activities of Heat Shock Protein 90 Inhibitors In Vitro and In Vivo.
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- Journal of Infectious Diseases, 2013, v. 208, n. 3, p. 489, doi. 10.1093/infdis/jit179
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- Article
Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus.
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- Critical Reviews in Microbiology, 2016, v. 42, n. 2, p. 310, doi. 10.3109/1040841X.2014.947239
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- Article
17-allylamino-17-(demethoxy)geldanamycin (17-AAG) is a potent and effective inhibitor of human cytomegalovirus replication in primary fibroblast cells.
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- 2012
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- Publication type:
- Report
Improving Geldanamycin Production in Streptomyces geldanamycininus Through UV Mutagenesis of Protoplast.
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- Microorganisms, 2025, v. 13, n. 1, p. 186, doi. 10.3390/microorganisms13010186
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- Article
Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells.
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- PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0129214
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- Article
Hsp90 Inhibitor Can Inhibit UV Carcinogenesis.
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- Journal of Investigative Dermatology, 2015, v. 135, n. 4, p. 945, doi. 10.1038/jid.2014.504
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- Article
Topically Applied Hsp90 Inhibitor 17AAG Inhibits UVR-Induced Cutaneous Squamous Cell Carcinomas.
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- Journal of Investigative Dermatology, 2015, v. 135, n. 4, p. 1098, doi. 10.1038/jid.2014.460
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- Article
Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells in vitro.
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- Journal of Veterinary Science, 2017, v. 18, n. 2, p. 129, doi. 10.4142/jvs.2017.18.2.129
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- Article
Geldanamycin-Induced Phosphatidylserine Translocation in the Erythrocyte Membrane.
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- Cellular Physiology & Biochemistry (Karger AG), 2013, v. 32, n. 6, p. 1600, doi. 10.1159/000356596
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- Article
Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells.
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- Oncology Letters, 2017, v. 14, n. 2, p. 2177, doi. 10.3892/ol.2017.6442
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- Article
17AAG-induced internalisation of HER2-specific Affibody molecules.
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- Oncology Letters, 2016, v. 12, n. 4, p. 2574, doi. 10.3892/ol.2016.4990
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- Article
Geldanamycin induces apoptosis in human gastric carcinomas by affecting multiple oncogenic kinases that have synergic effects with TNF-related apoptosis-inducing ligand.
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- Oncology Letters, 2015, v. 10, n. 6, p. 3732, doi. 10.3892/ol.2015.3807
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- Article
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
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- Journal of Experimental & Clinical Cancer Research (17569966), 2016, v. 35, p. 1, doi. 10.1186/s13046-016-0428-6
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- Article
Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB.
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- Journal of Experimental & Clinical Cancer Research (17569966), 2014, v. 33, n. 1, p. 1, doi. 10.1186/1756-9966-33-16
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- Article
17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.
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- Journal of Bioenergetics & Biomembranes, 2015, v. 47, n. 5, p. 373, doi. 10.1007/s10863-015-9620-1
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- Article
Geldanamycin Analog 17-DMAG Limits Apoptosis in Human Peripheral Blood Cells by Inhibition of p53 Activation and its Interaction with Heat-Shock Protein 90 kDa after Exposure to Ionizing Radiation.
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- Radiation Research, 2011, v. 176, n. 3, p. 333, doi. 10.1667/RR2534.1
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- Article
Discovery of Novel 17-Phenylethylaminegeldanamycin Derivatives as Potent Hsp90 Inhibitors.
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- Chemical Biology & Drug Design, 2015, v. 85, n. 2, p. 181, doi. 10.1111/cbdd.12371
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- Article
Biological and Chemical Diversity of Bacteria Associated with a Marine Flatworm.
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- Marine Drugs, 2017, v. 15, n. 9, p. 281, doi. 10.3390/md15090281
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- Article
Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines.
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- Cancer Cell International, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1475-2867-13-11
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- Article
First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90.
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- Scientific Reports, 2015, p. 17015, doi. 10.1038/srep17015
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- Article
Addition of 17-(allylamino)-17-demethoxygeldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy.
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- PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0180961
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- Article
Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization.
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- PLoS ONE, 2017, v. 12, n. 3, p. 1, doi. 10.1371/journal.pone.0173640
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- Article
Structural Characterization of Heat Shock Protein 90β and Molecular Interactions with Geldanamycin and Ritonavir: A Computational Study.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 16, p. 8782, doi. 10.3390/ijms25168782
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- Article
Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1).
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- International Journal of Molecular Sciences, 2019, v. 20, n. 10, p. 2440, doi. 10.3390/ijms20102440
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- Article
Involvement of Calcium-Mediated Reactive Oxygen Species in Inductive GRP78 Expression by Geldanamycin in 9L Rat Brain Tumor Cells.
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- International Journal of Molecular Sciences, 2013, v. 14, n. 9, p. 19169, doi. 10.3390/ijms140919169
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- Article
Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.
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- Archives of Toxicology, 2017, v. 91, n. 1, p. 365, doi. 10.1007/s00204-016-1690-2
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- Article
Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma.
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- PLoS ONE, 2023, v. 18, n. 5, p. 1, doi. 10.1371/journal.pone.0274364
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- Article
Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species.
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- Mycopathologia, 2013, v. 175, n. 3/4, p. 273, doi. 10.1007/s11046-012-9612-1
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- Article
Molecular evidence of the involvement of heat shock protein 90 in brassinosteroid signaling in Arabidopsis T87 cultured cells.
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- Plant Cell Reports, 2014, v. 33, n. 3, p. 499, doi. 10.1007/s00299-013-1550-y
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- Article
Synthesis and biological evaluation of geldanamycin analogs against human cancer cells.
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- Cancer Chemotherapy & Pharmacology, 2015, v. 75, n. 4, p. 773, doi. 10.1007/s00280-015-2696-9
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- Article
Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors.
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- 2014
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- Publication type:
- Report
Open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of intravenously administered CNF1010 (17-(allylamino)-17-demethoxygeldanamycin [17-AAG]) in patients with solid tumors.
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- Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 5, p. 1345, doi. 10.1007/s00280-013-2134-9
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- Article
Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors.
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- Cancer Chemotherapy & Pharmacology, 2012, v. 70, n. 1, p. 201, doi. 10.1007/s00280-012-1859-1
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- Article