Works matching DE "GELDANAMYCIN"

Results: 83

Effect of geldanamycin on the expression of the matrix molecules and angiogenetic factors in a gastric cancer cell line.

Published in:

Biotechnic & Histochemistry, 2021, v. 96, n. 2, p. 111, doi. 10.1080/10520295.2020.1772507

By:

Gürpınar, T.;
Kosova, F.;
Kurt, F. O.;
Cambaz, S. U.;
Yücel, A. T.;
Umur, N.;
Tuğlu, M. I.

Publication type:

Article

Combined Effect of Hsp90 Inhibitor Geldanamycin and Parthenolide via Reactive Oxygen Species-Mediated Apoptotic Process on Epithelial Ovarian Cancer Cells.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2012, v. 111, n. 3, p. 173, doi. 10.1111/j.1742-7843.2012.00883.x

By:

Lee, Chung S.;
Kim, Yun J.;
Lee, Seon A.;
Myung, Soon C.;
Kim, Wonyong

Publication type:

Article

Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells.

Published in:

Oncology Letters, 2017, v. 14, n. 2, p. 2177, doi. 10.3892/ol.2017.6442

By:

XUERONG ZHAO;
JIANPING WANG;
LIJUN XIAO;
QIAN XU;
ENHONG ZHAO;
XIN ZHENG;
HUACHUAN ZHENG;
SHUANG ZHAO;
SHI DING

Publication type:

Article

17AAG-induced internalisation of HER2-specific Affibody molecules.

Published in:

Oncology Letters, 2016, v. 12, n. 4, p. 2574, doi. 10.3892/ol.2016.4990

By:

GÖSTRING, LOVISA;
LINDEGREN, STURE;
GEDDA, LARS

Publication type:

Article

Geldanamycin induces apoptosis in human gastric carcinomas by affecting multiple oncogenic kinases that have synergic effects with TNF-related apoptosis-inducing ligand.

Published in:

Oncology Letters, 2015, v. 10, n. 6, p. 3732, doi. 10.3892/ol.2015.3807

By:

HUI CHEN;
LIANG-QING LI;
DUN PAN

Publication type:

Article

Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.

Published in:

PLoS ONE, 2018, v. 13, n. 11, p. 1, doi. 10.1371/journal.pone.0203978

By:

Kanamoto, Mayu;
Tsuchiya, Yoshihiro;
Nakao, Yuki;
Suzuki, Takafumi;
Motohashi, Hozumi;
Yamamoto, Masayuki;
Kamata, Hideaki

Publication type:

Article

17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model.

Published in:

PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0191264

By:

Joshi, Sandeep S.;
Jiang, Shunlin;
Unni, Emmanual;
Goding, Stephen R.;
Fan, Tao;
Antony, Paul A.;
Hornyak, Thomas J.

Publication type:

Article

17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.

Published in:

Journal of Bioenergetics & Biomembranes, 2015, v. 47, n. 5, p. 373, doi. 10.1007/s10863-015-9620-1

By:

Zhao, Surong;
Li, Hongmei;
Jiang, Chenchen;
Ma, Tao;
Wu, Chengzhu;
Huo, Qiang;
Liu, Hao

Publication type:

Article

HSP90 INHIBITOR GELDANAMYCIN AS A RADIATION RESPONSE MODIFICATOR IN HUMAN BLOOD CELLS.

Published in:

Dose-Response, 2015, v. 13, n. 1, p. 1, doi. 10.2203/dose-response.14-039.Stankova

By:

Stankova, Katia;
Savova, Gergana;
Nikolov, Vladimir;
Boteva, Rayna

Publication type:

Article

Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells.

Published in:

Journal of Toxicological Sciences, 2012, v. 37, n. 5, p. 1049, doi. 10.2131/jts.37.1049

By:

Kaori Toyomura;
Takeshi Saito;
Syunsuke Emori;
Ikiru Matsumoto;
Erina Kato;
Masayuki Kaneko;
Yasunobu Okuma;
Hiroyuki Nakamura;
Toshihiko Murayama

Publication type:

Article

Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines.

Published in:

Cancer Cell International, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1475-2867-13-11

By:

Karkoulis, Panagiotis K.;
Stravopodis, Dimitrios J.;
Konstantakou, Eumorphia G.;
Voutsinas, Gerassimos E.

Publication type:

Article

Evaluation of the Synthetic Potential of an AHBA Knockout Mutant of the Rifamycin Producer Amycolatopsis mediterranei.

Published in:

Chemistry - A European Journal, 2015, v. 21, n. 52, p. 19231, doi. 10.1002/chem.201503548

By:

Bułyszko, Ilona;
Dräger, Gerald;
Klenge, Anja;
Kirschning, Andreas

Publication type:

Article

Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?

Published in:

Molecular & Cellular Biochemistry, 2014, v. 386, n. 1/2, p. 45, doi. 10.1007/s11010-013-1844-y

By:

Paul, Subhankar;
Mahanta, Sailendra

Publication type:

Article

Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0129214

By:

Lingelem, Anne Berit Dyve;
Hjelseth, Ieva Ailte;
Simm, Roger;
Torgersen, Maria Lyngaas;
Sandvig, Kirsten

Publication type:

Article

Heat Shock Protein 90 Positively Regulates Chikungunya Virus Replication by Stabilizing Viral Non-Structural Protein nsP2 during Infection.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100531

By:

Das, Indrani;
Basantray, Itishree;
Mamidi, Prabhudutta;
Nayak, Tapas K.;
B. M., Pratheek;
Chattopadhyay, Subhasis;
Chattopadhyay, Soma

Publication type:

Article

Hsp90 Blockers Inhibit Adipocyte Differentiation and Fat Mass Accumulation.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094127

By:

Desarzens, Sébastien;
Liao, Wan-Hui;
Mammi, Caterina;
Caprio, Massimiliano;
Faresse, Nourdine

Publication type:

Article

Chronic Treatment with Novel Small Molecule Hsp90 Inhibitors Rescues Striatal Dopamine Levels but Not α-Synuclein-Induced Neuronal Cell Loss.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0086048

By:

McFarland, Nikolaus R.;
Dimant, Hemi;
Kibuuka, Laura;
Ebrahimi-Fakhari, Darius;
Desjardins, Cody A.;
Danzer, Karin M.;
Danzer, Michael;
Fan, Zhanyun;
Schwarzschild, Michael A.;
Hirst, Warren;
McLean, Pamela J.

Publication type:

Article

Heat Shock protein 90: Role in Enterovirus 71 Entry and Assembly and Potential Target for Therapy.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0077133

By:

Tsou, Yueh-Liang;
Lin, Yi-Wen;
Chang, Hsuen-Wen;
Lin, Hsiang-Yin;
Shao, Hsiao-Yun;
Yu, Shu-Ling;
Liu, Chia-Chyi;
Chitra, Ebenezer;
Sia, Charles;
Chow, Yen-Hung

Publication type:

Article

Geldanamycin-Induced <i>Osteosarcoma</i> Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60).

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071135

By:

Gorska, Magdalena;
Marino Gammazza, Antonella;
Zmijewski, Michal Aleksander;
Campanella, Claudia;
Cappello, Francesco;
Wasiewicz, Tomasz;
Kuban-Jankowska, Alicja;
Daca, Agnieszka;
Sielicka, Alicja;
Popowska, Urszula;
Knap, Narcyz;
Antoniewicz, Jakub;
Wakabayashi, Takashi;
Wozniak, Michal

Publication type:

Article

Targeting Heat Shock Protein 90 for the Treatment of Malignant Pheochromocytoma.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0056083

By:

Giubellino, Alessio;
Sourbier, Carole;
Lee, Min-Jung;
Scroggins, Brad;
Bullova, Petra;
Landau, Michael;
Ying, Weiwen;
Neckers, Len;
Trepel, Jane B.;
Pacak, Karel

Publication type:

Article

Geldanamycin Derivative Ameliorates High Fat Diet- Induced Renal Failure in Diabetes.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0032746

By:

Hong-Mei Zhang;
Howard Dang;
Kamat, Amrita;
Chih-Ko Yeh;
Bin-Xian Zhang

Publication type:

Article

Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins.

Published in:

Cardiovascular Research, 2013, v. 100, n. 3, p. 520, doi. 10.1093/cvr/cvt200

By:

Iwai, Chisato;
Li, Peili;
Kurata, Yasutaka;
Hoshikawa, Yoshiko;
Morikawa, Kumi;
Maharani, Nani;
Higaki, Katsumi;
Sasano, Tetsuro;
Notsu, Tomomi;
Ishido, Yuko;
Miake, Junichiro;
Yamamoto, Yasutaka;
Shirayoshi, Yasuaki;
Ninomiya, Haruaki;
Nakai, Akira;
Murata, Shigeo;
Yoshida, Akio;
Yamamoto, Kazuhiro;
Hiraoka, Masayasu;
Hisatome, Ichiro

Publication type:

Article

Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy.

Published in:

Cardiovascular Research, 2013, v. 98, n. 2, p. 277, doi. 10.1093/cvr/cvt029

By:

Pedrozo, Zully;
Torrealba, Natalia;
Fernández, Carolina;
Gatica, Damian;
Toro, Barbra;
Quiroga, Clara;
Rodriguez, Andrea E.;
Sanchez, Gina;
Gillette, Thomas G.;
Hill, Joseph A.;
Donoso, Paulina;
Lavandero, Sergio

Publication type:

Article

Geldanamycin Analog 17-DMAG Limits Apoptosis in Human Peripheral Blood Cells by Inhibition of p53 Activation and its Interaction with Heat-Shock Protein 90 kDa after Exposure to Ionizing Radiation.

Published in:

Radiation Research, 2011, v. 176, n. 3, p. 333, doi. 10.1667/RR2534.1

By:

Fukumoto, Risaku;
Kiang, Juliann G.

Publication type:

Article

Discovery of Novel 17-Phenylethylaminegeldanamycin Derivatives as Potent Hsp90 Inhibitors.

Published in:

Chemical Biology & Drug Design, 2015, v. 85, n. 2, p. 181, doi. 10.1111/cbdd.12371

By:

Li, Zhenyu;
Jia, Lejiao;
Wang, Jifeng;
Wu, Xingkang;
Shi, Guowei;
Lu, Chunhua;
Shen, Yuemao

Publication type:

Article

Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii.

Published in:: Malaria Journal, 2012, v. 11, n. 1, p. 54, doi. 10.1186/1475-2875-11-54
Publication type:: Article

Improvement of Inhibitor Identification for Heat Shock Protein 90α by Utilizing a Red-Shifted Fluorescence Polarization Probe.

Published in:

Assay & Drug Development Technologies, 2012, v. 10, n. 4, p. 375, doi. 10.1089/adt.2011.429

By:

Qian, Jie;
Holskin, Beverly P.;
Theroff, Jay;
Underiner, Ted;
Meyer, Sheryl L.;
Angeles, Thelma S.

Publication type:

Article

Geldanamycin Enhances the Radioprotective Effect of Peroxyredoxin 6 in Irradiated 3T3 Fibroblasts.

Published in:

Doklady Biochemistry & Biophysics, 2022, v. 506, n. 1, p. 202, doi. 10.1134/S160767292205012X

By:

Novoselova, E. G.;
Glushkova, O. V.;
Sharapov, M. G.;
Khrenov, M. O.;
Parfenyuk, S. B.;
Lunin, S. M.;
Novoselova, T. V.;
Mubarakshina, A. K.;
Goncharov, R. G.;
Fesenko, E. E.

Publication type:

Article

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.

Published in:

Archives of Toxicology, 2017, v. 91, n. 1, p. 365, doi. 10.1007/s00204-016-1690-2

By:

Colaianna, Marilena;
Ilmjärv, Sten;
Peterson, Hedi;
Kern, Ilse;
Julien, Stephanie;
Baquié, Mathurin;
Pallocca, Giorgia;
Bosgra, Sieto;
Sachinidis, Agapios;
Hengstler, Jan;
Leist, Marcel;
Krause, Karl-Heinz

Publication type:

Article

Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells.

Published in:

Experimental & Therapeutic Medicine, 2014, v. 8, n. 5, p. 1559, doi. 10.3892/etm.2014.1930

By:

XUE DU;
YONGMEI LI;
XU JING;
ZHAO, LINA

Publication type:

Article

Potential inhibition of SARS-CoV-2 infection and its mutation with the novel geldanamycin analogue: Ignaciomycin.

Published in:

Arabian Journal of Chemistry, 2024, v. 17, n. 2, p. N.PAG, doi. 10.1016/j.arabjc.2023.105493

By:

Stalin, Antony;
Saravana Kumar, Pachaiyappan;
Senthamarai Kannan, Balakrishnan;
Saravanan, Rajamanikam;
Ignacimuthu, Savarimuthu;
Zou, Quan

Publication type:

Article

Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro.

Published in:

Virology Journal, 2014, v. 11, n. 1, p. 1, doi. 10.1186/1743-422X-11-17

By:

Jintao Gao;
Shuqi Xiao;
Xiaohong Liu;
Liangliang Wang;
Xiaoyu Zhang;
Qianqian Ji;
Yue Wang;
Delin Mo;
Yaosheng Chen

Publication type:

Article

Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species.

Published in:

Mycopathologia, 2013, v. 175, n. 3/4, p. 273, doi. 10.1007/s11046-012-9612-1

By:

Zhang, Jinqing;
Liu, Wei;
Tan, Jingwen;
Sun, Yi;
Wan, Zhe;
Li, Ruoyu

Publication type:

Article

Molecular evidence of the involvement of heat shock protein 90 in brassinosteroid signaling in Arabidopsis T87 cultured cells.

Published in:

Plant Cell Reports, 2014, v. 33, n. 3, p. 499, doi. 10.1007/s00299-013-1550-y

By:

Shigeta, Tomoaki;
Zaizen, Yuichi;
Asami, Tadao;
Yoshida, Shigeo;
Nakamura, Yasushi;
Okamoto, Shigehisa;
Matsuo, Tomoaki;
Sugimoto, Yasushi

Publication type:

Article

Synthesis and biological evaluation of geldanamycin analogs against human cancer cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2015, v. 75, n. 4, p. 773, doi. 10.1007/s00280-015-2696-9

By:

Li, Yan-ping;
Chen, Jin-jing;
Shen, Jia-jia;
Cui, Jing;
Wu, Lin-zhuan;
Wang, Zhen;
Li, Zhuo-rong

Publication type:

Article

Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors.

Published in:

2014

By:

Doi, Toshihiko;
Onozawa, Yusuke;
Fuse, Nozomu;
Yoshino, Takayuki;
Yamazaki, Kentaro;
Watanabe, Junichiro;
Akimov, Mikhail;
Robson, Matthew;
Boku, Narikazu;
Ohtsu, Atsushi

Publication type:

Report

Open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of intravenously administered CNF1010 (17-(allylamino)-17-demethoxygeldanamycin [17-AAG]) in patients with solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 5, p. 1345, doi. 10.1007/s00280-013-2134-9

By:

Saif, M.;
Erlichman, C.;
Dragovich, T.;
Mendelson, D.;
Toft, D.;
Burrows, F.;
Storgard, C.;
Hoff, D.

Publication type:

Article

Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 70, n. 1, p. 201, doi. 10.1007/s00280-012-1859-1

By:

Aregbe, Abdulateef;
Sherer, Eric;
Egorin, Merrill;
Scher, Howard;
Solit, David;
Ramanathan, Ramesh;
Ramalingam, Suresh;
Belani, Chandra;
Ivy, Percy;
Bies, Robert

Publication type:

Article

Geldanamycin-Induced Phosphatidylserine Translocation in the Erythrocyte Membrane.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2013, v. 32, n. 6, p. 1600, doi. 10.1159/000356596

By:

Jilani, Kashif;
Qadri, Syed M.;
Lang, Florian

Publication type:

Article

Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 1898, doi. 10.1080/14756366.2021.1960829

By:

Skrzypczak, Natalia;
Pyta, Krystian;
Ruszkowski, Piotr;
Mikołajczak, Przemysław;
Kucińska, Małgorzata;
Murias, Marek;
Gdaniec, Maria;
Bartl, Franz;
Przybylski, Piotr

Publication type:

Article

First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90.

Published in:

Scientific Reports, 2015, p. 17015, doi. 10.1038/srep17015

By:

Raman, Swetha;
Singh, Meetali;
Tatu, Utpal;
Suguna, Kaza

Publication type:

Article

HSP90C interacts with PsbO1 and facilitates its thylakoid distribution from chloroplast stroma in Arabidopsis.

Published in:

PLoS ONE, 2017, v. 12, n. 12, p. 1, doi. 10.1371/journal.pone.0190168

By:

Jiang, Tim;
Oh, Edward Saehong;
Bonea, Diana;
Zhao, Rongmin

Publication type:

Article

Addition of 17-(allylamino)-17-demethoxygeldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy.

Published in:

PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0180961

By:

Refos, Jeannine M.;
Vonk, Alieke G.;
ten Kate, Marian T.;
Eadie, Kimberly;
Verbrugh, Henri A.;
Bakker-Woudenberg, Irma A. J. M.;
van de Sande, Wendy W. J.

Publication type:

Article

Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization.

Published in:

PLoS ONE, 2017, v. 12, n. 3, p. 1, doi. 10.1371/journal.pone.0173640

By:

Kudryavtsev, Vladimir A.;
Khokhlova, Anna V.;
Mosina, Vera A.;
Selivanova, Elena I.;
Kabakov, Alexander E.

Publication type:

Article

Hsp-90 Inhibitor Geldanamycin Attenuates Liver Oxidative Stress and Toxicity in Thiram-Induced Tibial Dyschondroplasia.

Published in:

Pakistan Veterinary Journal, 2014, v. 34, n. 4, p. 545

By:

Shahzad, Muhammad;
Jingying Liu;
Jianfeng Gao;
Zhi Wang;
Ding Zhang;
Fazul Nabi;
Jiakui Li

Publication type:

Article

Brassinosteroid nuclear signaling recruits HSP90 activity.

Published in:

New Phytologist, 2014, v. 203, n. 3, p. 743, doi. 10.1111/nph.12843

By:

Samakovli, Despina;
Margaritopoulou, Theoni;
Prassinos, Constantinos;
Milioni, Dimitra;
Hatzopoulos, Polydefkis

Publication type:

Article

The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes

Published in:

FEBS Open Bio, 2012, v. 2, p. 47, doi. 10.1016/j.fob.2012.03.002

By:

Miyoshi, Sadanori;
Yamazaki, Shota;
Uchiumi, Asato;
Katagata, Yohtaro

Publication type:

Article

Deleterious effect of geldanamaycin on human sperm motility attenuated by trolox.

Published in:

Iranian Journal of Reproductive Medicine, 2013, p. 71

By:

Forootan Jahromi, F.;
Keshtgar, S.;
Ghani, E.

Publication type:

Article

Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus.

Published in:

Critical Reviews in Microbiology, 2016, v. 42, n. 2, p. 310, doi. 10.3109/1040841X.2014.947239

By:

Lamoth, Frédéric;
Juvvadi, Praveen R.;
Steinbach, William J.

Publication type:

Article

Improving Geldanamycin Production in Streptomyces geldanamycininus Through UV Mutagenesis of Protoplast.

Published in:

Microorganisms, 2025, v. 13, n. 1, p. 186, doi. 10.3390/microorganisms13010186

By:

Yuan, Yuan;
Yang, Lu;
Fang, Zhikai;
Chen, Haimin;
Sun, Fei;
Jiang, Hong;
Zhou, Jian

Publication type:

Article