Works matching DE "FURIN protein"

Results: 51

Furin inhibitor D6R suppresses epithelial‑mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo‑YAP signaling pathway.

Published in:

Oncology Letters, 2018, v. 15, n. 3, p. 3192, doi. 10.3892/ol.2017.7672

By:

Zhou, MENg;
Zhang, Youli;
Wei, Hong;
He, Junbo;
Wang, Dawei;
ChEN, Baoding;
ZENg, Jian;
Gong, Aihua;
Xu, Min

Publication type:

Article

A furin inhibitor downregulates osteosarcoma cell migration by downregulating the expression levels of MT1-MMP via the Wnt signaling pathway.

Published in:

Oncology Letters, 2014, v. 7, n. 4, p. 1033, doi. 10.3892/ol.2014.1839

By:

BINGSHAN LIU;
GUOJUN LI;
XIAO WANG;
YANG LIU

Publication type:

Article

Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.

Published in:

PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0212992

By:

Dupays, Laurent;
Towers, Norma;
Wood, Sophie;
David, Anna;
Stuckey, Daniel J.;
Mohun, Timothy

Publication type:

Article

The adjuvant AlhydroGel elicits higher antibody titres than AddaVax when combined with HIV-1 subtype C gp140 from CAP256.

Published in:

PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0208310

By:

van Diepen, Michiel T.;
Chapman, Rosamund;
Moore, Penny L.;
Margolin, Emmanuel;
Hermanus, Tandile;
Morris, Lynn;
Ximba, Phindile;
Rybicki, Edward P.;
Williamson, Anna-Lise

Publication type:

Article

Improved Expression of Recombinant Human Factor IX by Co-expression of GGCX, VKOR and Furin.

Published in:

Protein Journal, 2014, v. 33, n. 2, p. 174, doi. 10.1007/s10930-014-9550-5

By:

Liu, Jianming;
Jonebring, Anna;
Hagström, Jonas;
Nyström, Ann-Christin;
Lövgren, Ann

Publication type:

Article

Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin.

Published in:

PLoS Pathogens, 2015, v. 11, n. 5, p. 1, doi. 10.1371/journal.ppat.1004879

By:

Bergeron, Éric;
Zivcec, Marko;
Chakrabarti, Ayan K.;
Nichol, Stuart T.;
Albariño, César G.;
Spiropoulou, Christina F.

Publication type:

Article

Effects of APRIL ( TNFSF13) polymorphisms and splicing isoforms on the secretion of soluble APRIL.

Published in:

Modern Rheumatology, 2012, v. 22, n. 4, p. 541, doi. 10.3109/s10165-011-0539-z

By:

Furuya, Takumi;
Koga, Minori;
Hikami, Koki;
Kawasaki, Aya;
Tsuchiya, Naoyuki

Publication type:

Article

BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2019, v. 75, n. 4, p. 239, doi. 10.1107/S2053230X19001419

By:

Pearce, Kenneth H.;
Overton, Laurie K.;
Gampe, Robert T.;
Barrett, George B.;
Taylor, J. David;
McKee, David D.;
Campobasso, Nino;
Nolte, Robert T.;
Reid, Robert A.

Publication type:

Article

Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A.

Published in:

Toxins, 2016, v. 8, n. 8, p. 217, doi. 10.3390/toxins8080217

By:

Kaplan, Gilad;
Lee, Fred;
Onda, Masanori;
Kolyvas, Emily;
Bhardwaj, Gaurav;
Baker, David;
Pastan, Ira

Publication type:

Article

Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0130417

By:

Ramos-Molina, Bruno;
Lick, Adam N.;
Nasrolahi Shirazi, Amir;
Oh, Donghoon;
Tiwari, Rakesh;
El-Sayed, Naglaa Salem;
Parang, Keykavous;
Lindberg, Iris

Publication type:

Article

Analysis of Cathepsin and Furin Proteolytic Enzymes Involved in Viral Fusion Protein Activation in Cells of the Bat Reservoir Host.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0115736

By:

El Najjar, Farah;
Lampe, Levi;
Baker, Michelle L.;
Wang, Lin-Fa;
Dutch, Rebecca Ellis

Publication type:

Article

ProSAAS-Derived Peptides Are Differentially Processed and Sorted in Mouse Brain and AtT-20 Cells.

Published in:

PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0104232

By:

Wardman, Jonathan H.;
Fricker, Lloyd D.

Publication type:

Article

Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0084958

By:

Harihar, Sitaram;
Pounds, Keke M.;
Iwakuma, Tomoo;
Seidah, Nabil G.;
Welch, Danny R.

Publication type:

Article

Small Molecule Proprotein Convertase Inhibitors for Inhibition of Embryo Implantation.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0081380

By:

Ho, Huiting;
Singh, Harmeet;
Heng, Sophea;
Nero, Tracy L.;
Paule, Sarah;
Parker, Michael W.;
Johnson, Alan T.;
Jiao, Guan-Sheng;
Nie, Guiying

Publication type:

Article

Simultaneous Expression of Displayed and Secreted Antibodies for Antibody Screen.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0080005

By:

Zhou, Yuanping;
Wang, Junjie;
Zhou, Ivan;
Lou, Haibo;
Li, Chang-Zheng;
Chen, Zhen-Rui;
Zhang, Zhe-Huan;
Liu, Shuwen;
Wu, Shuguang;
Tan, Wanlong;
Jiang, Shibo;
Zhou, Chen

Publication type:

Article

Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for Monoclonal Antibody Expression Level and Quality in CHO Cells

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0063247

By:

Ho, Steven C. L.;
Bardor, Muriel;
Li, Bin;
Lee, Jia Juan;
Song, Zhiwei;
Tong, Yen Wah;
Goh, Lin-Tang;
Yang, Yuansheng

Publication type:

Article

Proprotein Convertase Furin Regulates Apoptosis and Proliferation of Granulosa Cells in the Rat Ovary.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0050479

By:

Yang, Xiaokui;
Wang, Qingxin;
Gao, Zhiying;
Zhou, Zhi;
Peng, Sha;
Chang, Wen-Lin;
Lin, Hai-Yan;
Zhang, Weiyuan;
Wang, Hongmei

Publication type:

Article

High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054290

By:

Shiryaev, Sergey A.;
Chernov, Andrei V.;
Golubkov, Vladislav S.;
Thomsen, Elliot R.;
Chudin, Eugene;
Chee, Mark S.;
Kozlov, Igor A.;
Strongin, Alex Y.;
Cieplak, Piotr

Publication type:

Article

Furin Overexpression Suppresses Tumor Growth and Predicts a Better Postoperative Disease-Free Survival in Hepatocellular Carcinoma.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0040738

By:

Ya-Hui Huang;
Kwang-Huei Lin;
Chen-Hsin Liao;
Ming-Wei Lai;
Yi-Hsin Tseng;
Chau-Ting Yeh

Publication type:

Article

A Novel Enediynyl Peptide Inhibitor of Furin That Blocks Processing of proPDGF-A, B and proVEGF-C.

Published in:: PLoS ONE, 2009, v. 4, n. 11, p. 1, doi. 10.1371/journal.pone.0007700
Publication type:: Article

The eukaryotic signal sequence, YGRL, targets the chlamydial inclusion.

Published in:

Frontiers in Cellular & Infection Microbiology, 2014, p. 1, doi. 10.3389/fcimb.2014.00129

By:

Kabeiseman, Emily J.;
Cichos, Kyle H.;
Moore, Elizabeth R.

Publication type:

Article

A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells.

Published in:

NPJ Vaccines, 2021, v. 6, n. 1, p. 1, doi. 10.1038/s41541-021-00346-z

By:

Funnell, Simon G. P.;
Afrough, Babak;
Baczenas, John James;
Berry, Neil;
Bewley, Kevin R.;
Bradford, Rebecca;
Florence, Clint;
Duff, Yann Le;
Lewis, Mark;
Moriarty, Ryan V.;
Connor, Shelby L. O.;
Osman, Karen L.;
Pullan, Steven;
Rashid, Sujatha;
Richards, Kevin S.;
Stemple, Kimberly J.;
Knezevic, Ivana

Publication type:

Article

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2017, v. 32, n. 1, p. 712, doi. 10.1080/14756366.2017.1306521

By:

Kouretova, Jenny;
Hammamy, M. Zouhir;
Epp, Anton;
Hardes, Kornelia;
Kallis, Stephanie;
Zhang, Linlin;
Hilgenfeld, Rolf;
Bartenschlager, Ralf;
Steinmetzer, Torsten

Publication type:

Article

Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk.

Published in:

Scientific Reports, 2015, p. 14176, doi. 10.1038/srep14176

By:

Zhao, Jianguo;
Xu, Weijie;
Ross, Jason W.;
Walters, Eric M.;
Butler, Stephen P.;
Whyte, Jeff J.;
Kelso, Lindsey;
Fatemi, Mostafa;
Vanderslice, Nicholas C.;
Giroux, Keith;
Spate, Lee D.;
Samuel, Melissa S.;
Murphy, Cliff N.;
Wells, Kevin D.;
Masiello, Nick C.;
Prather, Randall S.;
Velander, William H.

Publication type:

Article

O-glycosylated pro-B-type natriuretic peptide is cleaved intracellularly by furin in ventricular and atrial myocytes: importance of the distance between the O-glycosylation and cleavage sites.

Published in:

2013

By:

Toshio Nishikimi;
Yasuaki Nakagawa;
Naoto Minamino;
Masashi Ikeda;
Toshihiko Ishimitsu;
Chinatsu Yamada;
Kazuhiro Nakao;
Takeya Minami;
Yoshihiro Kuwabara;
Hideyuki Kinoshita;
Koichiro Kuwahara;
Kenji Kangawa;
Kazuwa Nakao

Publication type:

Abstract

Evaluating the efficiency of CHEF and CMV promoter with IRES and Furin/2A linker sequences for monoclonal antibody expression in CHO cells.

Published in:

PLoS ONE, 2017, v. 12, n. 10, p. 1, doi. 10.1371/journal.pone.0185967

By:

Ebadat, Saeedeh;
Ahmadi, Samira;
Ahmadi, Maryam;
Nematpour, Fatemeh;
Barkhordari, Farzaneh;
Mahdian, Reza;
Davami, Fatemeh;
Mahboudi, Fereidoun

Publication type:

Article

A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0168122

By:

Toledano, Shira;
Lu, Huayi;
Palacio, Agustina;
Ziv, Keren;
Kessler, Ofra;
Schaal, Shlomit;
Neufeld, Gera;
Barak, Yoreh

Publication type:

Article

Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris.

Published in:

Microbial Cell Factories, 2018, v. 17, n. 1, p. N.PAG, doi. 10.1186/s12934-018-1020-x

By:

Huang, Yide;
Long, Yanyu;
Li, Suhuan;
Lin, Ting;
Wu, Jingwen;
Zhang, Yafei;
Lin, Yao

Publication type:

Article

An arthropod enzyme, Dfurin1, and a vertebrate furin homolog display distinct cleavage site sequence preferences for a shared viral proprotein substrate.

Published in:

Journal of Insect Science, 2010, v. 10, p. 1, doi. 10.1673/031.010.2901

By:

Cano-Monreal, Gina L.;
Williams, Jacqueline C.;
Heidner, Hans W.

Publication type:

Article

Vitamin D, the autonomic nervous system, and cardiovascular risk.

Published in:

2015

By:

Mann, Michelle Catherine;
Hollenberg, Morley D.;
Hanley, David A.;
Ahmed, Sofia B.

Publication type:

Editorial

The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-74101-0

By:

Örd, Mihkel;
Faustova, Ilona;
Loog, Mart

Publication type:

Article

Structural and functional modelling of SARS-CoV-2 entry in animal models.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-72528-z

By:

Brooke, Greg N.;
Prischi, Filippo

Publication type:

Article

Proprotein convertase furin enhances survival and migration of vascular smooth muscle cells via processing of pro-nerve growth factor.

Published in:

Journal of Biochemistry, 2013, v. 153, n. 2, p. 197, doi. 10.1093/jb/mvs137

By:

Urban, Daniel;
Lorenz, Janina;
Meyborg, Heike;
Ghosh, Sanchita;
Kintscher, Ulrich;
Kaufmann, Jan;
Fleck, Eckart;
Kappert, Kai;
Stawowy, Philipp

Publication type:

Article

Targeted Coating With Antigenic Peptide Renders Tumor Cells Susceptible to CD8<sup>+</sup> T Cell-mediated Killing.

Published in:

Molecular Therapy, 2013, v. 21, n. 3, p. 542, doi. 10.1038/mt.2012.233

By:

Kang, Tae Heung;
Ma, Barbara;
Wang, Connie;
Wu, T.-C.;
Hung, Chien-Fu

Publication type:

Article

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.

Published in:

Journal of Cell Biology, 2015, v. 210, n. 7, p. 1185, doi. 10.1083/jcb.201503042

By:

Bessonnard, Sylvain;
Mesnard, Daniel;
Constam, Daniel B.

Publication type:

Article

Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following Na<sup>+</sup> restriction.

Published in:

Journal of Physiology, 2024, v. 602, n. 17, p. 4309, doi. 10.1113/JP286559

By:

Nickerson, Andrew J.;
Sheng, Shaohu;
Cox, Natalie A.;
Szekely, Kennedy G.;
Marciszyn, Allison L.;
Lam, Tracey;
Chen, Jingxin;
Gingras, Sebastien;
Kashlan, Ossama B.;
Kirabo, Annet;
Hughey, Rebecca P.;
Ray, Evan C.;
Kleyman, Thomas R.

Publication type:

Article

PACE4 regulates apoptosis in human pancreatic cancer Panc-1 cells via the mitochondrial signaling pathway.

Published in:

Molecular Medicine Reports, 2016, v. 14, n. 6, p. 5205, doi. 10.3892/mmr.2016.5885

By:

XIAO-FENG TIAN;
GUO-MIN HUANG;
HONG-LIANG ZANG;
HONG CAO

Publication type:

Article

Sialylation of extracellular superoxide dismutase (EC-SOD) enhances furin-mediated cleavage and secretion.

Published in:

Glycobiology, 2017, v. 27, n. 12, p. 1081, doi. 10.1093/glycob/cwx087

By:

Fumi Ota;
Yasuhiko Kizuka;
Miyako Nakano;
Yoshiki Yamaguchi;
Shinobu Kitazume;
Tomomi Ookawara;
Naoyuki Taniguchi

Publication type:

Article

Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection.

Published in:

Viruses (1999-4915), 2015, v. 7, n. 11, p. 5813, doi. 10.3390/v7112910

By:

Cruz, Linda;
Biryukov, Jennifer;
Conway, Michael J.;
Meyers, Craig

Publication type:

Article

A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity.

Published in:

PLoS ONE, 2016, v. 11, n. 7, p. 1, doi. 10.1371/journal.pone.0159868

By:

Ferguson, Timothy E. G.;
Reihill, James A.;
Walker, Brian;
Hamilton, Robert A.;
Martin, S. Lorraine

Publication type:

Article

Proconvertase Furin Is Downregulated in Postural Orthostatic Tachycardia Syndrome.

Published in:

Frontiers in Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnins.2019.00301

By:

Spahic, Jasmina Medic;
Ricci, Fabrizio;
Aung, Nay;
Axelsson, Jonas;
Melander, Olle;
Sutton, Richard;
Hamrefors, Viktor;
Fedorowski, Artur

Publication type:

Article

Engineering of α1-antitrypsin variants with improved specificity for the proprotein convertase furin using site-directed random mutagenesis.

Published in:

PEDS: Protein Engineering, Design & Selection, 2013, v. 26, n. 2, p. 123, doi. 10.1093/protein/gzs091

By:

Hada, Koichiro;
Isshiki, Kinuka;
Matsuda, Shinya;
Yuasa, Keizo;
Tsuji, Akihiko

Publication type:

Article

Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies.

Published in:

Retrovirology, 2014, v. 11, n. 1, p. 1, doi. 10.1186/1742-4690-11-33

By:

Chung, Nancy P. Y.;
Matthews, Katie;
Kim, Helen J.;
Ketas, Thomas J.;
Golabek, Michael;
de los Reyes, Kevin;
Korzun, Jacob;
Yasmeen, Anila;
Sanders, Rogier W.;
Klasse, Per Johan;
Wilson, Ian A.;
Ward, Andrew B.;
Marozsan, Andre J.;
Moore, John P.;
Cupo, Albert

Publication type:

Article

Generation and characterization of non-competitive furin-inhibiting nanobodies.

Published in:

Biochemical Journal, 2012, v. 448, n. 1, p. 73, doi. 10.1042/BJ20120537

By:

Jingjing ZHU;
DECLERCQ, Jeroen;
ROUCOURT, Bart;
GHASSABEH, Gholamreza H.;
MEULEMANS, Sandra;
KINNE, Jórg;
DAVID, Guido;
VERMORKEN, Alphons J. M.;
VAN DE VEN, Wim J. M.;
LINDBERG, Iris;
MUYLDERMANS, Serge;
CREEMERS, John W. M.

Publication type:

Article

Constitutive Stimulation of Vascular Smooth Muscle Cells by Angiotensin II Derived From an Adenovirus Encoding a Furin-Cleavable Fusion Protein.

Published in:

American Journal of Hypertension, 2012, v. 25, n. 3, p. 280, doi. 10.1038/ajh.2011.221

By:

Takayanagi, Takehiko;
Bourne, Allison M.;
Kimura, Keita;
Takaguri, Akira;
Elliott, Katherine J.;
Eguchi, Kunie;
Eguchi, Satoru

Publication type:

Article

Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement.

Published in:

Biochemistry Research International, 2011, p. 1, doi. 10.1155/2011/630319

By:

Pavlaki, Maria;
Zucker, Stanley;
Dufour, Antoine;
Calabrese, Nikki;
Bahou, Wadie;
Jian Cao

Publication type:

Article

Emergence of the Spike Furin Cleavage Site in SARS-CoV-2.

Published in:

Molecular Biology & Evolution, 2022, v. 39, n. 1, p. 1, doi. 10.1093/molbev/msab327

By:

Chan, Yujia Alina;
Zhan, Shing Hei

Publication type:

Article

A Small-Molecule FRET Reporter for the Real-Time Visualization of Cell-Surface Proteolytic Enzyme Functions.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 52, p. 14357, doi. 10.1002/anie.201407182

By:

Mu, Jing;
Liu, Fang;
Rajab, Muhammad Shafiq;
Shi, Meng;
Li, Shuang;
Goh, Chiching;
Lu, Lei;
Xu, Qing‐Hua;
Liu, Bin;
Ng, Lai Guan;
Xing, Bengang

Publication type:

Article

Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.

Published in:

Cellular & Molecular Life Sciences, 2018, v. 75, n. 13, p. 2473, doi. 10.1007/s00018-017-2742-3

By:

Zhu, Binglin;
Zhao, Lige;
Luo, Dong;
Xu, Demei;
Tan, Tao;
Dong, Zhifang;
Tang, Ying;
Min, Zhuo;
Deng, Xiaojuan;
Sun, Fei;
Yan, Zhen;
Chen, Guojun

Publication type:

Article

A third HSAN5 mutation disrupts the nerve growth factor furin cleavage site.

Published in:

Molecular Pain, 2018, v. 14, p. 1, doi. 10.1177/1744806918809223

By:

Shaikh, Samiha S.;
Nahorski, Michael S.;
Woods, C. Geoffrey

Publication type:

Article