Works matching DE "FARNESYLTRANSFERASE"
Results: 45
Altered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment.
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- Histochemistry & Cell Biology, 2012, v. 138, n. 4, p. 643, doi. 10.1007/s00418-012-0977-5
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- Publication type:
- Article
Molecular dynamic simulations and structure-based pharmacophore development for farnesyltransferase inhibitors discovery.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 6, p. 1428, doi. 10.3109/14756366.2016.1144593
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- Article
New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2013, v. 28, n. 1, p. 163, doi. 10.3109/14756366.2011.643302
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- Publication type:
- Article
Loss of protohaem IX farnesyltransferase in mature dentate granule cells impairs short-term facilitation at mossy fibre to CA3 pyramidal cell synapses.
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- Journal of Physiology, 2017, v. 595, n. 6, p. 2147, doi. 10.1113/JP273581
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- Article
Farnesyltransferase inhibitor FTI-277 inhibits PD-L1 expression on septic spleen lymphocytes and promotes spleen lymphocyte activation.
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- Clinical & Experimental Immunology, 2017, v. 190, n. 1, p. 8, doi. 10.1111/cei.12995
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- Article
Farnesyltransferase Inhibitor Manumycin Targets IL1β-Ras-HIF-1α Axis in Tumor Cells of Diverse Origin.
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- Inflammation, 2012, v. 35, n. 2, p. 516, doi. 10.1007/s10753-011-9340-6
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- Article
THE EFFECTS OF FARNESYLTRANSFERASE INHIBITOR L-744,832 AND RADIOTHERAPY ON H-RAS + (SVR A221A) CELL LINE.
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- Nobel Medicus Journal, 2012, v. 8, n. 3, p. 76
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- Article
Farnesyltransferase inhibitors prevent HIV protease inhibitor (lopinavir/ritonavir)-induced lipodystrophy and metabolic syndrome in mice.
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- Experimental & Therapeutic Medicine, 2018, v. 15, n. 2, p. 1314, doi. 10.3892/etm.2017.5526
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- Article
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
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- Nature, 2012, v. 485, n. 7399, p. 517, doi. 10.1038/nature11007
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- Publication type:
- Article
Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.
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- Cell Biology International, 2010, v. 34, n. 8, p. 815, doi. 10.1042/CBI20090288
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- Article
Effect of Farnesyltransferase Inhibitor R115777 on Mitochondria of Plasmodium falciparum.
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- Korean Journal of Parasitology, 2015, v. 53, n. 4, p. 421, doi. 10.3347/kjp.2015.53.4.421
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- Publication type:
- Article
The Aspergillus fumigatus farnesyltransferase Ś-subunit, RamA, mediates growth, virulence, and antifungal susceptibility.
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- Virulence, 2017, v. 8, n. 7, p. 1401, doi. 10.1080/21505594.2017.1328343
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- Publication type:
- Article
Progeria: case report and new drugs perspectives.
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- 2018
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- Publication type:
- Case Study
The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML.
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- British Journal of Haematology, 2012, v. 158, n. 4, p. 519, doi. 10.1111/j.1365-2141.2012.09165.x
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- Publication type:
- Article
IADE: a system for intelligent automatic design of bioisosteric analogs.
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- Journal of Computer-Aided Molecular Design, 2012, v. 26, n. 11, p. 1207, doi. 10.1007/s10822-012-9609-3
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- Publication type:
- Article
Maximization of Extracellular Ftase Production by Aspergillus stallus through Batch Fermentation Using Food Grade Sucrose as Substrate.
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- Journal of Ravishankar University, Part-B Science, 2016, v. 29, p. 122
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- Article
Precision Medicine and Progress in the Treatment of Hutchinson-Gilford Progeria Syndrome.
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- 2018
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- Publication type:
- Editorial
A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.
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- PLoS ONE, 2016, v. 11, n. 6, p. 1, doi. 10.1371/journal.pone.0157537
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- Publication type:
- Article
Molecular dynamics analysis of a series of 22 potential farnesyltransferase substrates containing a CaaX-motif.
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- Journal of Molecular Modeling, 2013, v. 19, n. 2, p. 673, doi. 10.1007/s00894-012-1590-1
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- Publication type:
- Article
Phase 1/1b study of lonafarnib and temozolomide in patients with recurrent or temozolomide refractory glioblastoma.
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- Cancer (0008543X), 2013, v. 119, n. 15, p. 2747, doi. 10.1002/cncr.28031
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- Publication type:
- Article
Evolutionary comparison of prenylation pathway in kinetoplastid Leishmania and its sister Leptomonas.
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- BMC Evolutionary Biology, 2015, v. 15, p. 1, doi. 10.1186/s12862-015-0538-3
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- Publication type:
- Article
Stimulating Effect of Manumycin A on Suicidal Erythrocyte Death.
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- Cellular Physiology & Biochemistry (Karger AG), 2016, v. 38, n. 5, p. 1147, doi. 10.1159/000443065
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- Publication type:
- Article
Farnesyl transferase inhibitor FTI-277 inhibits breast cell invasion and migration by blocking H-Ras activation.
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- Oncology Letters, 2016, v. 12, n. 3, p. 2222, doi. 10.3892/ol.2016.4837
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- Publication type:
- Article
Absence of Protoheme IX Farnesyltransferase CtaB Causes Virulence Attenuation but Enhances Pigment Production and Persister Survival in MRSA.
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- Frontiers in Microbiology, 2016, v. 7, p. 1, doi. 10.3389/fmicb.2016.01625
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- Publication type:
- Article
Transformation by Hras<sup>G12V</sup> is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition.
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- Oncogene, 2014, v. 33, n. 47, p. 5442, doi. 10.1038/onc.2013.489
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- Publication type:
- Article
Dysregulation of astrocyte extracellular signaling in Costello syndrome.
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- Science Translational Medicine, 2015, v. 7, n. 286, p. 1, doi. 10.1126/scitranslmed.aaa5645
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- Publication type:
- Article
Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin
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- FEBS Letters, 2012, v. 586, n. 20, p. 3665, doi. 10.1016/j.febslet.2012.08.024
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- Publication type:
- Article
Site-Specific Labeling of Proteins and Peptides with Trans-cyclooctene Containing Handles Capable of Tetrazine Ligation.
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- Chemical Biology & Drug Design, 2014, v. 84, n. 2, p. 140, doi. 10.1111/cbdd.12303
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- Publication type:
- Article
Toxic effects of phytol and retinol on human glioblastoma cells are associated with modulation of cholesterol and fatty acid biosynthetic pathways.
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- Journal of Neuro-Oncology, 2018, v. 136, n. 3, p. 435, doi. 10.1007/s11060-017-2672-9
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- Publication type:
- Article
Tipifarnib and tanespimycin show synergic proapoptotic activity in U937 cells.
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- Journal of Cancer Research & Clinical Oncology, 2012, v. 138, n. 3, p. 537, doi. 10.1007/s00432-011-1131-9
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- Publication type:
- Article
Mutagenesis and biochemical studies on AuaA confirmed the importance of the two conserved aspartate-rich motifs and suggested difference in the amino acids for substrate binding in membrane-bound prenyltransferases.
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- Archives of Microbiology, 2012, v. 194, n. 7, p. 589, doi. 10.1007/s00203-012-0795-0
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- Publication type:
- Article
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.
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- Science Translational Medicine, 2019, v. 11, n. 485, p. N.PAG, doi. 10.1126/scitranslmed.aat3005
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- Article
Progeria: A rare genetic premature ageing disorder.
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- Indian Journal of Medical Research, 2014, v. 139, n. 5, p. 667
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- Publication type:
- Article
Increased susceptibility to oxidative stress- and ultraviolet A-induced apoptosis in fibroblasts in atypical progeroid syndrome/atypical Werner syndrome with LMNA mutation.
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- Experimental Dermatology, 2016, v. 25, p. 20, doi. 10.1111/exd.13086
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- Publication type:
- Article
Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).
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- Journal of Translational Medicine, 2012, v. 10, n. 1, p. 246, doi. 10.1186/1479-5876-10-246
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- Publication type:
- Article
In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida.
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- Annals of Clinical Microbiology & Antimicrobials, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1476-0711-12-37
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- Publication type:
- Article
Probing the function of protein farnesyltransferase in Tripterygium wilfordii.
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- Plant Cell Reports, 2019, v. 38, n. 2, p. 211, doi. 10.1007/s00299-018-2363-9
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- Publication type:
- Article
The FNTB promoter polymorphism rs11623866 as a potential predictive biomarker for lonafarnib treatment of ovarian cancer patients.
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- British Journal of Clinical Pharmacology, 2015, v. 80, n. 5, p. 1139, doi. 10.1111/bcp.12688
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- Publication type:
- Article
Progeria drug trial promising.
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- Australian Journal of Pharmacy, 2012, v. 93, n. 1110, p. 50
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- Article
Sensing Enzymatic Activity by Exposure and Selection of DNA-Encoded Probes.
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- Angewandte Chemie, 2016, v. 128, n. 33, p. 9714, doi. 10.1002/ange.201603387
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- Publication type:
- Article
Identification of tipifarnib sensitivity biomarkers in T-cell acute lymphoblastic leukemia and T-cell lymphoma.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-63434-5
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- Publication type:
- Article
Synthesis and biological evaluation of a new class of triazin-triazoles as potential inhibitors of human farnesyltransferase.
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- Research on Chemical Intermediates, 2016, v. 42, n. 3, p. 1999, doi. 10.1007/s11164-015-2131-1
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- Publication type:
- Article
Tipifarnib-mediated suppression of T-bet-dependent signaling pathways.
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- Cancer Immunology, Immunotherapy, 2012, v. 61, n. 4, p. 523, doi. 10.1007/s00262-011-1109-0
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- Publication type:
- Article
Effect of farnesyltransferase inhibitor on the function of mitochondria of Plasmodium falciparum.
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- 2012
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- Publication type:
- Abstract
Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines.
- Published in:
- Molecular Cancer, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1476-4598-12-88
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- Publication type:
- Article