Works matching DE "FARNESOID X receptor"

Results: 971

Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction.

Published in:

Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02224-w

By:

Qian, Shuwen;
Su, Zehua;
Lin, Jiaqi;
Hou, Qianhao;
Wang, Xiaomei;
Li, Yuling;
Wang, Jieying;
Huang, Changchun;
Wang, Zetian;
Cubero, Francisco Javier;
Wang, Xiangrui;
Liao, Lijun

Publication type:

Article

Dietary bile acid supplementation improves the intestinal health and growth performance of piglets partially through the FXR/AQPs pathway.

Published in:

Porcine Health Management, 2025, v. 11, n. 1, p. 1, doi. 10.1186/s40813-025-00440-x

By:

Zhang, Beibei;
Tian, Min;
Yang, Yahui;
Qiu, Yueqin;
Wang, Li;
Xiao, Hao;
Zhu, Xiaoping;
Qin, Limei;
Yang, Xuefen;
Jiang, Zongyong

Publication type:

Article

功效性米粉对高脂诱导小鼠血脂的影响.

Published in:

Food Research & Development, 2025, v. 46, n. 9, p. 7, doi. 10.12161/j.issn.1005‐6521.2025.09.002

By:

熊志伟;
张文君;
陶悦;
韩慧缃;
梁伟

Publication type:

Article

Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages.

Published in:

Stem Cell Research & Therapy, 2025, v. 16, n. 1, p. 1, doi. 10.1186/s13287-025-04365-8

By:

Zhou, Mengjiao;
Pei, Bing;
Cai, Peipei;
Yi, Chengxue;
Akanyibah, Francis Atim;
Lyu, Changkun;
Mao, Fei

Publication type:

Article

The role of the farnesoid X receptor in diabetes and its complications.

Published in:

Molecular & Cellular Biochemistry, 2025, v. 480, n. 5, p. 2725, doi. 10.1007/s11010-024-05162-2

By:

Zhang, Shengnan;
Zhang, Dandan;
Xu, Kui;
Huang, Xingqiong;
Chen, Qingjie;
Chen, Mi

Publication type:

Article

Chemoenzymatic Synthesis of Tri‐antennary N‐Glycans Terminating in Sialyl‐Lewisx Reveals the Importance of Glycan Complexity for Influenza A Virus Receptor Binding.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 32, p. 1, doi. 10.1002/chem.202401108

By:

Li, Tiehai;
Spruit, Cindy M.;
Wei, Na;
Liu, Lin;
Wolfert, Margreet A.;
de Vries, Robert P.;
Boons, Geert‐Jan

Publication type:

Article

Transcriptional regulation of microRNA-126a by farnesoid X receptor in vitro and in vivo.

Published in:

Biotechnology Letters, 2020, v. 42, n. 8, p. 1327, doi. 10.1007/s10529-020-02864-7

By:

Yan, Yi;
Wang, Shichao;
Wang, Rui;
Jiang, Puxuan;
Chen, Yaqing;
Zhang, Liang;
Hou, Chenjiao;
Zhang, Lisheng

Publication type:

Article

Farnesoid X receptor (FXR) agonist ameliorates systemic insulin resistance, dysregulation of lipid metabolism, and alterations of various organs in a type 2 diabetic kidney animal model.

Published in:

Acta Diabetologica, 2021, v. 58, n. 4, p. 495, doi. 10.1007/s00592-020-01652-z

By:

Han, Sang Youb;
Song, Hye Kyoung;
Cha, Jin Joo;
Han, Jee Young;
Kang, Young Sun.;
Cha, Dae Ryong

Publication type:

Article

What Comes after Ursodeoxycholic Acid in Primary Biliary Cholangitis?

Published in:

Digestive Diseases, 2017, v. 35, n. 4, p. 359, doi. 10.1159/000467547

By:

Wong, Lin Lee;
Hegade, Vinod S.;
Jones, David E.J.

Publication type:

Article

Protective Effect of Dapagliflozin against Non-alcoholic Fatty Liver in Rats AMPK/SIRT1 Pathway Activation.

Published in:

Zagazig University Medical Journal, 2024, v. 30, n. 9, p. 4391, doi. 10.21608/zumj.2024.306374.3487

By:

Muhammed Abdulaziz Alsafty, Shaimaa Ashraf;
Abd El Motteleb, Dalia M.;
Sekinah, Ameen M.;
EL-sayed, Yassmen Mahmoud

Publication type:

Article

A43 LONG-TERM EFFICACY AND SAFETY OF OBETICHOCLIC ACID IN PRIMARY BILIARY CHOLANGITIS: RESPONDER ANALYSIS OF OVER 5 YEARS OF TREATMENT IN THE POISE TRIAL.

Published in:

Journal of the Canadian Association of Gastroenterology, 2021, v. 4, p. 229, doi. 10.1093/jcag/gwab002.041

By:

Hirschfield, G;
Jones, D;
Carbone, M;
Bowlus, C L;
Nevens, F;
Kremer, A E;
Liberman, A;
MacConell, L;
Hansen, B E

Publication type:

Article

Implications for Farnesoid X Receptor Signaling on Bile Acid Metabolism as a Potential Therapeutic Strategy for Nonalcoholic Fatty Liver Disease.

Published in:

Korean Journal of Obesity (2383-899X), 2016, v. 25, n. 4, p. 167, doi. 10.7570/kjo.2016.25.4.167

By:

Hyekyung Yang;
Cheol-Young Park

Publication type:

Article

糖肾方调控 FXR / vimentin / α-SMA 通路减轻糖尿病肾脏疾病肾脏纤维化的研究.

Published in:

Journal of Beijing University of Traditional Chinese Medicine, 2022, n. 12, p. 1196, doi. 10.3969/j.issn.1006-2157.2022.12.003

By:

刘鹏;
申正日;
王晨;
王昀;
邱新萍;
李平

Publication type:

Article

Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles.

Published in:

Journal of Extracellular Vesicles, 2022, v. 11, n. 4, p. 1, doi. 10.1002/jev2.12211

By:

Record, Michel;
Attia, Mehdi;
Carayon, Kevin;
Pucheu, Laly;
Bunay, Julio;
Soulès, Régis;
Ayadi, Silia;
Payré, Bruno;
Perrin‐Cocon, Laure;
Bourgailh, Florence;
Lamazière, Antonin;
Lotteau, Vincent;
Poirot, Marc;
Silvente‐Poirot, Sandrine;
de Medina, Philippe

Publication type:

Article

FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells.

Published in:

Journal of Diabetes Research, 2019, p. 1, doi. 10.1155/2019/8915818

By:

Kong, Xiangchen;
Li, Bingfeng;
Deng, Yushen;
Ma, Xiaosong

Publication type:

Article

Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91438

By:

Jinjing Chen;
Ruoyu Wang;
Feng Xiong;
Hao Sun;
Kemper, Byron;
Wenbo Li;
Kemper, Jongsook

Publication type:

Article

Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.84782

By:

Thapa, Keshav;
Kadiri, James J.;
Saukkonen, Karla;
Pennanen, Iida;
Ghimire, Bishwa;
Minying Cai;
Savontaus, Eriika;
Rinne, Petteri

Publication type:

Article

Farnesoid X Receptor Regulated Sepsis‐Induced Abnormal Bile Acid Metabolism via the Fibroblast Growth Factor 15/Fibroblast Growth Factor Receptor 4 Pathway.

Published in:

Immunity, Inflammation & Disease, 2025, v. 13, n. 4, p. 1, doi. 10.1002/iid3.70155

By:

Zhou, Ziyang;
Xu, Dan;
Huang, Liou;
Cui, Yuhui;
Chen, Hui;
Tang, Jianguo

Publication type:

Article

Hepatic n-3/n-6 polyunsaturated fatty acid shift improves hepatic steatosis in farnesoid X receptor-null mice.

Published in:

Fisheries Science, 2016, v. 82, n. 3, p. 529, doi. 10.1007/s12562-016-0984-x

By:

Miyata, Masaaki;
Kinoshita, Yuichi;
Shinno, Kouhei;
Sugiura, Yoshimasa;
Harada, Kazuki

Publication type:

Article

The gut-itch connection.

Published in:

Experimental Dermatology, 2016, v. 25, n. 5, p. 344, doi. 10.1111/exd.12994

By:

Sanders, Kristen M.;
Nattkemper, Leigh A.;
Yosipovitch, Gil

Publication type:

Article

Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-53380-x

By:

Tanaka, Chisato;
Harada, Naoki;
Teraoka, Yoshiaki;
Urushizaki, Hiroki;
Shinmori, Yoh;
Onishi, Teruaki;
Yotsumoto, Yusuke;
Ito, Yuta;
Kitakaze, Tomoya;
Inui, Takashi;
Murata, Yuji;
Inui, Hiroshi;
Yamaji, Ryoichi

Publication type:

Article

Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-023-50374-z

By:

de Assis, Leonardo Vinicius Monteiro;
Harder, Lisbeth;
Lacerda, José Thalles;
Parsons, Rex;
Kaehler, Meike;
Cascorbi, Ingolf;
Nagel, Inga;
Rawashdeh, Oliver;
Mittag, Jens;
Oster, Henrik

Publication type:

Article

Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-42358-w

By:

Zhai, Ting;
Wang, Junjun;
Chen, Yong

Publication type:

Article

Construction and validation of a prognostic model for colon adenocarcinoma based on bile acid metabolism-related genes.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-40020-z

By:

Luo, Qinghua;
Zhou, Ping;
Chang, Shuangqing;
Huang, Zhifang;
Zeng, Xuebo

Publication type:

Article

Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-42358-w

By:

Zhai, Ting;
Wang, Junjun;
Chen, Yong

Publication type:

Article

Construction and validation of a prognostic model for colon adenocarcinoma based on bile acid metabolism-related genes.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-40020-z

By:

Luo, Qinghua;
Zhou, Ping;
Chang, Shuangqing;
Huang, Zhifang;
Zeng, Xuebo

Publication type:

Article

Editorial: Cutting edge microscopy and imaging techniques in plant and algal research.

Published in:

Frontiers in Plant Science, 2024, p. 1, doi. 10.3389/fpls.2024.1496941

By:

van de Meene, Allison M. L.;
Arcalis, Elsa

Publication type:

Article

Inhibition of ACOX1 enhances the therapeutic efficacy of obeticholic acid in treating non-alcoholic fatty liver disease and mitigates its lipotoxicity.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1366479

By:

Yuping Yang;
Weinan Yuan;
Kun He;
Chuangzhen Lin;
Shenshen Du;
Yanqi Kou;
Biao Nie

Publication type:

Article

Understanding the role of ursodeoxycholic acid and gut microbiome in non-alcoholic fatty liver disease: current evidence and perspectives.

Published in:

Frontiers in Pharmacology, 2024, p. 01, doi. 10.3389/fphar.2024.1371574

By:

Qingyi Mao;
Beibei Lin;
Wenluo Zhang;
Yu Zhang;
Qian Cao;
Mengque Xu

Publication type:

Article

Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1308655

By:

Shu-Yan Gao;
Jing-Cheng Zhao;
Qing Xia;
Chen Sun;
Aili, Maimaiti;
Talifu, Ainiwaer;
Shi-Xia Huo;
Yun Zhang;
Zhi-Jian Li

Publication type:

Article

Chaihu Shugan prevents cholesterol gallstone formation by ameliorating the microbiota dysbiosis and metabolic disturbance in mice.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2023.1291236

By:

Wei Wang;
Kun Zhang;
Bin Liu;
Tong Zhou;
Yu Tang;
Yuliang Li

Publication type:

Article

The application of mirabilite in traditional Chinese medicine and its chemical constituents, processing methods, pharmacology, toxicology and clinical research.

Published in:

Frontiers in Pharmacology, 2024, p. 01, doi. 10.3389/fphar.2023.1293097

By:

Lianbo Tao;
Jiaqing Fu;
Fangjie Wang;
Yinglian Song;
Yi Li;
Jingwen Zhang;
Zhang Wang

Publication type:

Article

The regulatory role of bile acid microbiota in the progression of liver cirrhosis.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1214685

By:

Feng Zhu;
Shudan Zheng;
Mei Zhao;
Fan Shi;
Lihong Zheng;
Haiqiang Wang

Publication type:

Article

Licraside as novel potent FXR agonist for relieving cholestasis: structure-based drug discovery and biological evaluation studies.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1197856

By:

Lili Xi;
Axi Shi;
Tiantian Shen;
Guoxu Wang;
Yuhui Wei;
Jingjing Guo

Publication type:

Article

Genetic alterations and molecular mechanisms underlying hereditary intrahepatic cholestasis.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1173542

By:

Shuying Xie;
Shizhang Wei;
Xiao Ma;
Ruilin Wang;
Tingting He;
Zhao Zhang;
Ju Yang;
Jiawei Wang;
Lei Chang;
Manyi Jing;
Haotian Li;
Xuelin Zhou;
Yanling Zhao

Publication type:

Article

Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1205323

By:

Xiaowei Sun;
Zhenhui Chen;
Lu Yu;
Weisen Zeng;
Boyuan Sun;
Hongying Fan;
Yang Bai

Publication type:

Article

Alterations in the gut microbiota and serum metabolomics of spontaneous cholestasis caused by loss of FXR signal in mice.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1197847

By:

Shizhang Wei;
Tingting He;
Xu Zhao;
Manyi Jing;
Haotian Li;
Lisheng Chen;
Ruimao Zheng;
Yanling Zhao

Publication type:

Article

Ameliorative effect of Aconite aqueous extract on diarrhea is associated with modulation of the gut microbiota and bile acid metabolism.

Published in:

Frontiers in Pharmacology, 2023, p. 01, doi. 10.3389/fphar.2023.1189971

By:

Dandan Zhang;
Hao Cheng;
Yuxi Zhang;
Yaochuan Zhou;
Jing Wu;
Juan Liu;
Wuwen Feng;
Cheng Peng

Publication type:

Article

Vitamin C and vitamin D3 alleviate metabolic-associated fatty liver disease by regulating the gut microbiota and bile acid metabolism via the gut-liver axis.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2023.1163694

By:

Qingling Chen;
Lili Zhao;
Ling Mei;
Xiaotong Zhao;
Ping Han;
Jie Liu;
Chao Meng;
Ruifang Li;
Rui Zhong;
Kai Wang;
Jia Li

Publication type:

Article

Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2023.1148737

By:

Hongshan Li;
Yingfei Xi;
Xin Xin;
Qin Feng;
Yiyang Hu

Publication type:

Article

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00468

By:

Ladurner, Angela;
Zehl, Martin;
Grienke, Ulrike;
Hofstadler, Christoph;
Faur, Nadina;
Pereira, Fátima C.;
Berry, David;
Dirsch, Verena M.;
Rollinger, Judith M.

Publication type:

Article

Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases.

Published in:

Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00162

By:

Festa, Carmen;
De Marino, Simona;
Carino, Adriana;
Sepe, Valentina;
Marchianò, Silvia;
Cipriani, Sabrina;
Di Leva, Francesco S.;
Limongelli, Vittorio;
Monti, Maria C.;
Capolupo, Angela;
Distrutti, Eleonora;
Fiorucci, Stefano;
Zampella, Angela

Publication type:

Article

The renal apical sodium‐dependent bile acid transporter expression rescue attenuates renal damage in diabetic nephropathy via farnesoid X receptor activation.

Published in:

Nephrology, 2024, v. 29, n. 10, p. 627, doi. 10.1111/nep.14338

By:

Li, Youmei;
Pang, Shuguang;
Guo, Honggang;
Yang, Shuo

Publication type:

Article

Dr. Xiaoru Huang and Dr. Xuening Liu reviewed the role and mechanism of bile acids and their receptors in Coronavirus disease 2019.

Published in:: Journal of Chinese Pharmaceutical Sciences, 2024, v. 33, n. 2, p. 184
Publication type:: Article

The Novel Monolithic Pr1-xCexCo0.5Mn0.5O3 Oxides Catalysts for the Selective Catalytic Reduction of NOx by NH3.

Published in:

Catalysis Letters, 2022, v. 152, n. 12, p. 3642, doi. 10.1007/s10562-022-03922-7

By:

Nie, Wen;
Zhou, Weiwei;
Li, Na;
Yuan, Mingyue;
Yan, Jiayi;
Hua, Yun;
Bao, Qiu;
Yu, Fengning;
Niu, Wenjin

Publication type:

Article

Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41061-8

By:

Zhong, Jing;
He, Xiaofang;
Gao, Xinxin;
Liu, Qiaohong;
Zhao, Yu;
Hong, Ying;
Zhu, Weize;
Yan, Juan;
Li, Yifan;
Li, Yan;
Zheng, Ningning;
Bao, Yiyang;
Wang, Hao;
Ma, Junli;
Huang, Wenjin;
Liu, Zekun;
Lyu, Yuanzhi;
Ke, Xisong;
Jia, Wei;
Xie, Cen

Publication type:

Article

Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40565-7

By:

Wang, Yue;
Yu, Yanbo;
Li, Lixiang;
Zheng, Mengqi;
Zhou, Jiawei;
Gong, Haifan;
Feng, Bingcheng;
Wang, Xiao;
Meng, Xuanlin;
Cui, Yanyan;
Xia, Yanan;
Chu, Shuzheng;
Lin, Lin;
Chang, Huijun;
Zhou, Ruchen;
Ma, Mingjun;
Li, Zhen;
Ji, Rui;
Lu, Ming;
Yang, Xiaoyun

Publication type:

Article

A gut feeling for drugs that have metabolic benefits.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40167-3

By:

Zhang, Eryun;
Agua, Alon;
Huang, Wendong

Publication type:

Article

Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets.

Published in:

Journal of Animal Science & Biotechnology, 2024, v. 15, n. 1, p. 1, doi. 10.1186/s40104-024-01037-0

By:

Xue, Chenyu;
Jia, Hongpeng;
Cao, Rujing;
Cai, Wenjie;
Hong, Weichen;
Tu, Jianing;
Wang, Songtao;
Jiang, Qianzhi;
Bi, Chongpeng;
Shan, Anshan;
Dong, Na

Publication type:

Article

Supplemental Clostridium butyricum modulates lipid metabolism by reshaping the gut microbiota composition and bile acid profile in IUGR suckling piglets.

Published in:

Journal of Animal Science & Biotechnology, 2023, v. 14, n. 1, p. 1, doi. 10.1186/s40104-023-00828-1

By:

Zhang, Xin;
Yun, Yang;
Lai, Zheng;
Ji, Shuli;
Yu, Ge;
Xie, Zechen;
Zhang, Hao;
Zhong, Xiang;
Wang, Tian;
Zhang, Lili

Publication type:

Article