Works matching DE "FARNESOID X receptor"

Results: 996

Ursodeoxycholic acid alleviates aortic aneurysm and dissection through the intestinal farnesoid X receptor/ceramide synthase 2 axis.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08403-2

By:

Zhang, Zhaofeng;
Xie, Linfeng;
Lin, Xinfan;
He, Jian;
Xie, Yuling;
Li, Jiakang;
Zhuang, Xinghui;
Tang, Lele;
Xie, Rumei;
Wu, Qingsong;
Qiu, Zhihuang;
Chen, Liangwan

Publication type:

Article

Unravelling the Complex Role of Glycine‐Conjugated Bile Acids and Gut‐Liver Axis in Progressive Alcohol‐Related Liver Disease.

Published in:

Liver International, 2025, v. 45, n. 7, p. 1, doi. 10.1111/liv.70176

By:

Yang, Yunyi;
He, Yanming;
Yang, Hongjie

Publication type:

Article

HFD Exacerbates Hepatic Lipid Metabolism Disorders After Cholecystectomy by Regulating the Bile Acid and Neutrophil Recruitment.

Published in:

Liver International, 2025, v. 45, n. 7, p. 1, doi. 10.1111/liv.70130

By:

Xu, Yanting;
Zhang, Feng;
Ke, Ziliang;
Lin, Yiken;
Zhang, Yang;
Liu, Yun;
Zhang, Yifan;
Xu, Jun;
Liu, Yulan

Publication type:

Article

Bile acid receptors regulate the role of intestinal macrophages in inflammatory bowel disease.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1577000

By:

Yang, Hongjie;
Shi, Xianhong;
Wang, Beibei;
Li, Heng;
Li, Bin;
Zhou, Tianqi;
Tian, Lulu;
Wang, Shengjun;
Yin, Kai

Publication type:

Article

Liver Metabolism at the Crossroads: The Reciprocal Control of Nutrient-Sensing Nuclear Receptors and Autophagy.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5825, doi. 10.3390/ijms26125825

By:

Kim, Eun Young;
Lee, Jae Man

Publication type:

Article

Neuroinflammation: Advancements in Pathophysiology and Therapies.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5664, doi. 10.3390/ijms26125664

By:

Martín-Hernández, David

Publication type:

Article

Molecular Diplomacy of Lipids in the War of Immunity: Bridging Rare and Common Disease Mechanisms.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5568, doi. 10.3390/ijms26125568

By:

Pandey, Manoj Kumar

Publication type:

Article

Nuclear Hormone Receptor NHR-49 Controls Fat Consumption and Fatty Acid Composition in C. elegans.

Published in:

PLoS Biology, 2005, v. 3, n. 2, p. 1, doi. 10.1371/journal.pbio.0030053

By:

Gilst, Marc R. Van;
Hadjivassiliou, Haralambos;
Jolly, Amber;
Yamamoto, Keith R

Publication type:

Article

Hepatic farnesoid X receptor protein level and circulating fibroblast growth factor 19 concentration in children with NAFLD.

Published in:

Liver International, 2018, v. 38, n. 2, p. 342, doi. 10.1111/liv.13531

By:

Nobili, Valerio;
Mosca, Antonella;
Della Corte, Claudia;
Veraldi, Silvio;
Alisi, Anna;
De Stefanis, Cristiano;
De Vito, Rita;
D'Oria, Valentina;
Jahnel, Joerg;
Zohrer, Evelyn;
Scorletti, Eleonora;
Byrne, Christopher D.

Publication type:

Article

Bile acids and cardiovascular function in cirrhosis.

Published in:

Liver International, 2017, v. 37, n. 10, p. 1420, doi. 10.1111/liv.13394

By:

Voiosu, Andrei;
Wiese, Signe;
Voiosu, Theodor;
Bendtsen, Flemming;
Møller, Søren

Publication type:

Article

Therapies in non-alcoholic steatohepatitis ( NASH).

Published in:

Liver International, 2017, v. 37, p. 97, doi. 10.1111/liv.13302

By:

Oseini, Abdul M.;
Sanyal, Arun J.

Publication type:

Article

Management of cholestatic disease in 2017.

Published in:

Liver International, 2017, v. 37, p. 123, doi. 10.1111/liv.13306

By:

Vries, Elsemieke;
Beuers, Ulrich

Publication type:

Article

Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal.

Published in:

Liver International, 2015, v. 35, n. 4, p. 1133, doi. 10.1111/liv.12456

By:

Schmitt, Johannes;
Kong, Bo;
Stieger, Bruno;
Tschopp, Oliver;
Schultze, Simon M.;
Rau, Monika;
Weber, Achim;
Müllhaupt, Beat;
Guo, Grace L.;
Geier, Andreas

Publication type:

Article

Transcriptional regulation of microRNA-126a by farnesoid X receptor in vitro and in vivo.

Published in:

Biotechnology Letters, 2020, v. 42, n. 8, p. 1327, doi. 10.1007/s10529-020-02864-7

By:

Yan, Yi;
Wang, Shichao;
Wang, Rui;
Jiang, Puxuan;
Chen, Yaqing;
Zhang, Liang;
Hou, Chenjiao;
Zhang, Lisheng

Publication type:

Article

Nuclear receptors: a bridge linking the gut microbiome and the host.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00407-y

By:

Wang, Zixuan;
Chen, Wei-Dong;
Wang, Yan-Dong

Publication type:

Article

β‐lapachone protects against doxorubicin‐induced hepatotoxicity through modulation of NAD<sup>+</sup>/SIRT‐1/FXR/p‐AMPK/NF‐kB and Nrf2 signaling axis.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 1, p. 1, doi. 10.1002/jbt.23564

By:

Kalantary‐Charvadeh, Ashkan;
Nazari Soltan Ahmad, Saeed;
Aslani, Somayeh;
Beyrami, Mehdi;
Mesgari‐Abbasi, Mehran

Publication type:

Article

Lactobacillus rhamnosus GG maintains gut microbiota stability and promotes intestinal adaptation via activated intestinal farnesoid X receptor signaling in short bowel syndrome.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08254-x

By:

Gui, Linling;
Duan, Xufei;
Wang, Hanfei;
Xie, Hua;
Zhang, Ruyi;
Jiang, Weiwei;
Tang, Weibing

Publication type:

Article

Effects of dietary cypermethrin exposure on swimming performance and expression of lipid homeostatic genes in livers of juvenile Chinook salmon, Oncorhynchus tshawytscha.

Published in:

Ecotoxicology, 2021, v. 30, n. 2, p. 257, doi. 10.1007/s10646-021-02352-2

By:

Fuller, Neil;
Magnuson, Jason T.;
Huff Hartz, Kara E.;
Fulton, Corie A.;
Whitledge, Gregory W.;
Acuña, Shawn;
Schlenk, Daniel;
Lydy, Michael J.

Publication type:

Article

Microbiota: Not Just a Gut Feeling.

Published in:

2022

By:

Candelli, Marcello

Publication type:

Editorial

Modulation of Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 1, p. 4, doi. 10.3390/jcm11010004

By:

Zhang, Boyan;
Kuipers, Folkert;
de Boer, Jan Freark;
Kuivenhoven, Jan Albert

Publication type:

Article

The Management of Cholestatic Liver Diseases: Current Therapies and Emerging New Possibilities.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 8, p. 1763, doi. 10.3390/jcm10081763

By:

Mazzetti, Marta;
Marconi, Giulia;
Mancinelli, Martina;
Benedetti, Antonio;
Marzioni, Marco;
Maroni, Luca

Publication type:

Article

The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 12, p. 2227, doi. 10.3390/jcm8122227

By:

Yu, Yijing;
Raka, Fitore;
Adeli, Khosrow

Publication type:

Article

The Effect of Natural Products on the Metabolism of Boar Taint Compounds in Porcine Hepatocytes.

Published in:

Journal of Animal Science, 2023, v. 101, p. 314, doi. 10.1093/jas/skad281.374

By:

Bone, Christine;
Squires, E. James

Publication type:

Article

Characterization of the Cerebrospinal Fluid Proteome in Patients with Fragile X-Associated Tremor/Ataxia Syndrome.

Published in:

Cerebellum, 2022, v. 21, n. 1, p. 86, doi. 10.1007/s12311-021-01262-7

By:

Abbasi, Diana A.;
Nguyen, Thu T. A.;
Hall, Deborah A.;
Robertson-Dick, Erin;
Berry-Kravis, Elizabeth;
Cologna, Stephanie M.

Publication type:

Article

Primary Biliary Cholangitis and Bile Acid Farnesoid X Receptor Agonists.

Published in:

Diseases, 2020, v. 8, n. 2, p. 20, doi. 10.3390/diseases8020020

By:

Abenavoli, Ludovico;
Procopio, Anna Caterina;
Fagoonee, Sharmila;
Pellicano, Rinaldo;
Carbone, Marco;
Luzza, Francesco;
Invernizzi, Pietro

Publication type:

Article

Emerging Therapeutic Targets and Experimental Drugs for the Treatment of NAFLD.

Published in:

Diseases, 2018, v. 6, n. 3, p. 83, doi. 10.3390/diseases6030083

By:

Dibba, Pratima;
Li, Andrew A.;
Perumpail, Brandon J.;
John, Nimy;
Sallam, Sandy;
Shah, Neha D.;
Kwong, Waiyee;
Cholankeril, George;
Kim, Donghee;
Ahmed, Aijaz

Publication type:

Article

Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD.

Published in:

Antioxidants, 2025, v. 14, n. 1, p. 56, doi. 10.3390/antiox14010056

By:

Termite, Fabrizio;
Archilei, Sebastiano;
D'Ambrosio, Francesca;
Petrucci, Lucrezia;
Viceconti, Nicholas;
Iaccarino, Roberta;
Liguori, Antonio;
Gasbarrini, Antonio;
Miele, Luca

Publication type:

Article

Elevated Bile Acid 3β,5α,6β-Trihydroxycholanoyl Glycine in a Subset of Adult Ataxias Including Niemann–Pick Type C.

Published in:

Antioxidants, 2024, v. 13, n. 5, p. 561, doi. 10.3390/antiox13050561

By:

Motamed-Gorji, Nazgol;
Khalil, Youssef;
Gonzalez-Robles, Cristina;
Khan, Shamsher;
Mills, Philippa;
Garcia-Moreno, Hector;
Ging, Heather;
Tariq, Ambreen;
Clayton, Peter T.;
Giunti, Paola

Publication type:

Article

Microbiota-Liver-Bile Salts Axis, a Novel Mechanism Involved in the Contrasting Effects of Sodium Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Development in Adolescent Rats.

Published in:

Antioxidants, 2023, v. 12, n. 5, p. 1123, doi. 10.3390/antiox12051123

By:

Ojeda, María Luisa;
Nogales, Fátima;
Carrasco López, José A.;
Gallego-López, María del Carmen;
Carreras, Olimpia;
Alcudia, Ana;
Pajuelo, Eloísa

Publication type:

Article

Total Flavonoids of Rhizoma Drynariae Mitigates Aflatoxin B1-Induced Liver Toxicity in Chickens via Microbiota-Gut-Liver Axis Interaction Mechanisms.

Published in:

Antioxidants, 2023, v. 12, n. 4, p. 819, doi. 10.3390/antiox12040819

By:

Huang, Shucheng;
Lin, Luxi;
Wang, Shiqiong;
Ding, Wenli;
Zhang, Chaodong;
Shaukat, Aftab;
Xu, Bowen;
Yue, Ke;
Zhang, Cai;
Liu, Fang

Publication type:

Article

Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91438

By:

Jinjing Chen;
Ruoyu Wang;
Feng Xiong;
Hao Sun;
Kemper, Byron;
Wenbo Li;
Kemper, Jongsook

Publication type:

Article

Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.84782

By:

Thapa, Keshav;
Kadiri, James J.;
Saukkonen, Karla;
Pennanen, Iida;
Ghimire, Bishwa;
Minying Cai;
Savontaus, Eriika;
Rinne, Petteri

Publication type:

Article

Front Cover: Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning (ChemistryOpen 1/2019).

Published in:

ChemistryOpen, 2019, v. 8, n. 1, p. 1, doi. 10.1002/open.201800271

By:

Merk, Daniel;
Grisoni, Francesca;
Schaller, Kay;
Friedrich, Lukas;
Schneider, Gisbert

Publication type:

Article

Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning.

Published in:

ChemistryOpen, 2019, v. 8, n. 1, p. 3, doi. 10.1002/open.201800270

By:

Merk, Daniel;
Grisoni, Francesca;
Schaller, Kay;
Friedrich, Lukas;
Schneider, Gisbert

Publication type:

Article

The role of gut microbiota on skeletal muscle strength in LDLR knockdown aging mice.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-00059-6

By:

Li, Ying;
Fang, Ziyang;
Luo, Yinjun;
Liu, Huiling;
Zhao, Dianchen;
Feng, Tao;
Zhang, Xin;
Mo, Songyi;
Fang, Xiaoyan;
Huang, Lingling;
Wang, Jinhua

Publication type:

Article

Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep06437

By:

Chia-Wen Hsu;
Jinghua Zhao;
Ruili Huang;
Jui-Hua Hsieh;
Hamm, Jon;
Xiaoqing Chang;
Houck, Keith;
Menghang Xia

Publication type:

Article

Evaluation of the Effects of Meal Type and Acid‐Reducing Agents on the Pharmacokinetics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist.

Published in:

Clinical Pharmacology in Drug Development, 2024, v. 13, n. 6, p. 677, doi. 10.1002/cpdd.1384

By:

Weber, Elijah J.;
Younis, Islam R.;
Wang, Lulu;
Xiao, Deqing;
Barchuk, William T.;
Othman, Ahmed A.

Publication type:

Article

A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants.

Published in:

Clinical Pharmacology in Drug Development, 2023, v. 12, n. 2, p. 122, doi. 10.1002/cpdd.1208

By:

Stringer, Rowan;
Chen, Jin;
Shah, Bharti;
Gu, Jessie;
Zhang, Yiming;
Prince, William;
Klickstein, Lloyd B.;
Woessner, Ralph

Publication type:

Article

Drug‐Drug Interaction Studies to Evaluate the Effect of Inhibition of UGT1A1 and CYP3A4 and Induction of CYP3A4 on the Pharmacokinetics of Tropifexor in Healthy Subjects.

Published in:

Clinical Pharmacology in Drug Development, 2022, v. 11, n. 11, p. 1253, doi. 10.1002/cpdd.1140

By:

Chen, Jin;
Stringer, Rowan;
Shah, Bharti;
Gu, Jessie;
Zhang, Yiming;
Hackling, Melissa;
Prince, William;
Woessner, Ralph

Publication type:

Article

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2020, v. 9, n. 3, p. 395, doi. 10.1002/cpdd.762

By:

Badman, Michael K.;
Chen, Jin;
Desai, Sachin;
Vaidya, Soniya;
Neelakantham, Srikanth;
Zhang, Jie;
Gan, Lu;
Danis, Kate;
Laffitte, Bryan;
Klickstein, Lloyd B.

Publication type:

Article

Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1586141

By:

Hu, Manhang;
Hua, Xiaolu;
Xiong, Wei;
Zheng, Enhui;
Yang, Xingyue;
Lu, Yu;
He, Bing;
Zhong, Xiaolin;
Jiang, Zongzhe;
Zhang, Qingbi;
Liu, Yan

Publication type:

Article

Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1569856

By:

Sun, Yewen;
Qu, Yuchen;
Yang, Zhuan;
Lv, Bo;
Wang, Guanjun;
Fan, Kai;
Wang, Yuyuan;
Pan, Jie;
Du, Ziyan;
Yu, Yunli

Publication type:

Article

Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1569856

By:

Sun, Yewen;
Qu, Yuchen;
Yang, Zhuan;
Lv, Bo;
Wang, Guanjun;
Fan, Kai;
Wang, Yuyuan;
Pan, Jie;
Du, Ziyan;
Yu, Yunli

Publication type:

Article

Editorial: Mendelian randomization and cardiovascular remodeling.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1593325

By:

Qiang, Jianxin;
Yang, Jia;
Liu, Yanwu;
Zhang, Ji;
Sun, Hao;
Li, Lijuan;
Wang, Duo;
Liu, Yanping;
Hao, Panpan

Publication type:

Article

Takeda G protein–coupled receptor 5 (TGR5): an attractive therapeutic target for aging-related cardiovascular diseases.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1493662

By:

He, Yufeng;
Liu, Siqi;
Zhang, Yali;
Zuo, Yumei;
Huang, Keming;
Deng, Li;
Liao, Bin;
Zhong, Yi;
Feng, Jian

Publication type:

Article

The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2024.1510080

By:

Du, Jiangxia;
Shen, Minhui;
Chen, Jiajia;
Yan, Hao;
Xu, Zhifei;
Yang, Xiaochun;
Yang, Bo;
Luo, Peihua;
Ding, Kefeng;
Hu, Yuhuai;
He, Qiaojun

Publication type:

Article

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00468

By:

Ladurner, Angela;
Zehl, Martin;
Grienke, Ulrike;
Hofstadler, Christoph;
Faur, Nadina;
Pereira, Fátima C.;
Berry, David;
Dirsch, Verena M.;
Rollinger, Judith M.

Publication type:

Article

Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases.

Published in:

Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00162

By:

Festa, Carmen;
De Marino, Simona;
Carino, Adriana;
Sepe, Valentina;
Marchianò, Silvia;
Cipriani, Sabrina;
Di Leva, Francesco S.;
Limongelli, Vittorio;
Monti, Maria C.;
Capolupo, Angela;
Distrutti, Eleonora;
Fiorucci, Stefano;
Zampella, Angela

Publication type:

Article

Dual soluble epoxide hydrolase inhibitor – farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2023.1269261

By:

Abdul Hye Khan, Md.;
Nolan, Benjamin;
Stavniichuk, Anna;
Merk, Daniel;
Imig, John D.

Publication type:

Article

Elucidating the glucose‐lowering effect of the bile acid sequestrant sevelamer.

Published in:

Diabetes, Obesity & Metabolism, 2024, v. 26, n. 4, p. 1252, doi. 10.1111/dom.15421

By:

Nerild, Henriette H.;
Brønden, Andreas;
Haddouchi, Abdullah E.;
Ellegaard, Anne‐Marie;
Hartmann, Bolette;
Rehfeld, Jens F.;
Holst, Jens J.;
Sonne, David P.;
Vilsbøll, Tina;
Knop, Filip K.

Publication type:

Article