Works about ENZYME inhibitors synthesis

Results: 26

Molecular Modeling as a New Approach to the Development of Urokinase Inhibitors.

Published in:

Bulletin of Experimental Biology & Medicine, 2015, v. 158, n. 5, p. 700, doi. 10.1007/s10517-015-2839-3

By:

Beloglazova, I.;
Plekhanova, O.;
Katkova, E.;
Rysenkova, K.;
Stambol'skii, D.;
Sulimov, V.;
Tkachuk, V.

Publication type:

Article

Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses.

Published in:

Molecules, 2019, v. 24, n. 2, p. 312, doi. 10.3390/molecules24020312

By:

Hanif, Muhammad;
Kanwal, Fariha;
Rafiq, Muhammad;
Hassan, Mubashir;
Mustaqeem, Muhammad;
Seo, Sung-Yum;
Zhang, Yunlong;
Lu, Changrui;
Chen, Ting;
Saleem, Muhammad

Publication type:

Article

Exploring N-acyl-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-enes as 11β-HSD1 Inhibitors.

Published in:

Molecules, 2018, v. 23, n. 3, p. 536, doi. 10.3390/molecules23030536

By:

Leiva, Rosana;
McBride, Andrew;
Binnie, Margaret;
Webster, Scott P.;
Vázquez, Santiago

Publication type:

Article

Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a 1H-NMR Method to Assess Deacetylase Activity.

Published in:

Molecules, 2012, v. 17, n. 10, p. 12206, doi. 10.3390/molecules171012206

By:

Pirrie, Lisa;
McCarthy, Anna R.;
Major, Louise L.;
Morkūnaitė, Vaida;
Zubrienė, Asta;
Matulis, Daumantas;
Lain, Sonia;
Lebl, Tomas;
Westwood, Nicholas J.

Publication type:

Article

Ganetespib, an HSP90 inhibitor, kills Epstein–Barr virus (EBV)-infected B and T cells and reduces the percentage of EBV-infected cells in the blood.

Published in:

Leukemia & Lymphoma, 2017, v. 58, n. 4, p. 923, doi. 10.1080/10428194.2016.1213823

By:

Shatzer, Amber;
Ali, Mir A.;
Chavez, Mayra;
Dowdell, Kennichi;
Lee, Min-Jung;
Tomita, Yusuke;
El-Hariry, Iman;
Trepel, Jane B.;
Proia, David A.;
Cohen, Jeffrey I.

Publication type:

Article

Novel biphenyl ester derivatives as tyrosinase inhibitors: Synthesis, crystallographic, spectral analysis and molecular docking studies.

Published in:

PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0170117

By:

Kwong, Huey Chong;
Chidan Kumar, C. S.;
Mah, Siau Hui;
Chia, Tze Shyang;
Quah, Ching Kheng;
Loh, Zi Han;
Chandraju, Siddegowda;
Lim, Gin Keat

Publication type:

Article

Spotlights on our sister journals: Angew. Chem. Int. Ed. 41/2016.

Published in:: Angewandte Chemie International Edition, 2016, v. 55, n. 41, p. 12570, doi. 10.1002/anie.201684113
Publication type:: Article

Total Synthesis of Albicidin: A Lead Structure from Xanthomonas albilineans for Potent Antibacterial Gyrase Inhibitors.

Published in:

Angewandte Chemie International Edition, 2015, v. 54, n. 6, p. 1969, doi. 10.1002/anie.201409584

By:

Kretz, Julian;
Kerwat, Dennis;
Schubert, Vivien;
Grätz, Stefan;
Pesic, Alexander;
Semsary, Siamak;
Süssmuth, Roderich D.;
Cociancich, Stéphane;
Royer, Monique

Publication type:

Article

Crystal structure of 2-(4-chlorophenyl)-5-methyl-1,3-dioxane-5-carboxylic acid, C12H13ClO4.

Published in:

Zeitschrift für Kristallographie / New Crystal Structures, 2013, v. 228, n. 3, p. 393, doi. 10.1524/ncrs.2013.0197

By:

Zhang, Min;
Jia, Guo-Kai;
Yuan, Lin;
Yuan, Xian-You

Publication type:

Article

Sequence analysis of genes mediating extended-spectrum beta-lactamase (ESBL) production in isolates of Enterobacteriaceae in a Lagos Teaching Hospital, Nigeria.

Published in:

BMC Infectious Diseases, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12879-015-1005-x

By:

Raji, Muhabat Adeola;
Jamal, Wafaa;
Ojemeh, Omoh;
Rotimi, Vincent Olubunmi

Publication type:

Article

Synthesis, Antibacterial and Lipoxygenase Inhibition Studies on Some N-(4-{[(Alkyl/aralkyl)(phenethyl)amino]sulfonyl}phenyl) acetamides.

Published in:

Turkish Journal of Pharmaceutical Sciences, 2015, v. 12, n. 3, p. 257

By:

ABBASI, Muhammad A.;
KHIZER, Rabia;
Aziz-ur-REHMAN;
SIDDIQUI, Sabahat Z.;
RUBAB, Kaniz;
MALIK, Rabia;
AHMAD, Irshad;
SHAH, Syed Adnan A.

Publication type:

Article

Synthesis of an impurity in crude roflumilast.

Published in:

Journal of Chemical Research, 2014, v. 38, n. 8, p. 507, doi. 10.3184/174751914X14061300074410

By:

Zhang, Hankang;
Lin, Yan;
Li, Yan;
Dong, Kai;
Chen, Ligong;
Wang, Donghua

Publication type:

Article

Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo.

Published in:

Journal of Neuroinflammation, 2015, v. 12, n. 1, p. 1, doi. 10.1186/s12974-015-0376-7

By:

Haile, Yohannes;
Carmine-Simmen, Katia;
Olechowski, Camille;
Kerr, Bradley;
Bleackley, R. Chris;
Giuliani, Fabrizio

Publication type:

Article

Influence of Polyphenol Extract from Evening Primrose (Oenothera Paradoxa) Seeds on Proliferation of Caco-2 Cells and on Expression, Synthesis and Activity of Matrix Metalloproteinases and Their Inhibitors.

Published in:

Polish Journal of Food & Nutrition Sciences, 2014, v. 64, n. 3, p. 181, doi. 10.2478/pjfns-2013-0003

By:

Szewczyk, Karolina;
Lewandowska, Urszula;
Owczarek, Katarzyna;
Sosnowska, Dorota;
Gorlach, Sylwia;
Koziołkiewicz, Maria;
Hrabec, Zbigniew;
Hrabec, Elżbieta

Publication type:

Article

Fluorinated Adenosine A2A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics.

Published in:

International Journal of Medicinal Chemistry, 2017, p. 1, doi. 10.1155/2017/4852537

By:

Yuan, Gengyang;
Jankins, Tanner C.;
Patrick, Christopher G.;
Philbrook, Phaethon;
Sears, Olivia;
Hatfield, Stephen;
Sitkovsky, Michail;
Vasdev, Neil;
Liang, Steven H.;
Ondrechen, Mary Jo;
Pollastri, Michael P.;
Jones, Graham B.

Publication type:

Article

Multiscale Metabolic Modeling: Dynamic Flux Balance Analysis on a Whole-Plant Scale.

Published in:

Plant Physiology, 2013, v. 163, n. 2, p. 637, doi. 10.1104/pp.113.224006

By:

Grafahrend-Belau, Eva;
Junker, Astrid;
Eschenröder, André;
Müller, Johannes;
Schreiber, Falk;
Junker, Björn H.

Publication type:

Article

Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 28, p. 6788, doi. 10.1002/chem.201700241

By:

Kanfar, Nasreddine;
Tanc, Muhammet;
Dumy, Pascal;
Supuran, Claudiu T.;
Ulrich, Sébastien;
Winum, Jean‐Yves

Publication type:

Article

PURIFICATION AND PHYSICOKINETIC CHARACTERIZATION OF A GLUCONOLACTONE INHIBITION-INSENSITIVE β-GLUCOSIDASE FROM Andrographis paniculata NEES. LEAF.

Published in:

Preparative Biochemistry & Biotechnology, 2013, v. 43, n. 5, p. 481, doi. 10.1080/10826068.2012.759966

By:

Mishra, SiddharthaKumar;
Sangwan, NeelamSingh;
Sangwan, RajenderSingh

Publication type:

Article

SLCO1B1 Variants and Angiotensin Converting Enzyme Inhibitor (Enalapril) -Induced Cough: a Pharmacogenetic Study.

Published in:

Scientific Reports, 2015, p. 17253, doi. 10.1038/srep17253

By:

Luo, Jian-Quan;
He, Fa-Zhong;
Wang, Zhen-Min;
Sun, Ning-Ling;
Wang, Lu-Yan;
Tang, Gen-Fu;
Liu, Mou-Ze;
Li, Qing;
Chen, Xiao-Ping;
Liu, Zhao-Qian;
Zhou, Hong-Hao;
Zhang, Wei

Publication type:

Article

Loss of G2 subunit of vacuolar-type proton transporting ATPase leads to G1 subunit upregulation in the brain.

Published in:

Scientific Reports, 2015, p. 14027, doi. 10.1038/srep14027

By:

Kawamura, Nobuyuki;
Sun-Wada, Ge-Hong;
Wada, Yoh

Publication type:

Article

Are PCSK9 Inhibitors Cost Effective?

Published in:

2018

By:

Korman, Max J.;
Retterstøl, Kjetil;
Kristiansen, Ivar Sønbø;
Wisløff, Torbjørn

Publication type:

journal article

Synthesis of chiral pyrazolo[4,3- e ][1,2,4]triazine sulfonamides with tyrosinase and urease inhibitory activity.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2017, v. 32, n. 1, p. 99, doi. 10.1080/14756366.2016.1238362

By:

Mojzych, Mariusz;
Tarasiuk, Paweł;
Kotwica-Mojzych, Katarzyna;
Rafiq, Muhammad;
Seo, Sung-Yum;
Nicewicz, Michał;
Fornal, Emilia

Publication type:

Article

Synthesis and Characterization of Polysialic Acid-Uricase Conjugates for the Treatment of Hyperuricemia.

Published in:

International Journal of Peptide Research & Therapeutics, 2014, v. 20, n. 4, p. 465, doi. 10.1007/s10989-014-9411-2

By:

Punnappuzha, Ardra;
PonnanEttiyappan, JagadeeshBabu;
Nishith, Reval;
Hadigal, Sanjay;
Pai, Preethi

Publication type:

Article

Synthesis and biological applications of selenoureas.

Published in:

Applied Organometallic Chemistry, 2014, v. 28, n. 2, p. 61, doi. 10.1002/aoc.3093

By:

Hussain, Raja Azadar;
Badshah, Amin;
Shah, Afzal

Publication type:

Article

Structural and biochemical analysis of a thermostable membrane-bound stomatin-specific protease.

Published in:

Journal of Synchrotron Radiation, 2013, v. 20, n. 6, p. 933, doi. 10.1107/S0909049513021328

By:

Yokoyama, Hideshi;
Kobayashi, Daisuke;
Takizawa, Naoto;
Fujii, Satoshi;
Matsui, Ikuo

Publication type:

Article

The mononuclear metal center of type-I dihydroorotase from aquifex aeolicus.

Published in:

BMC Biochemistry, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2091-14-36

By:

Edwards, Brian F. P.;
Fernando, Roshini;
Martin, Philip D.;
Grimley, Edward;
Cordes, Melissa;
Vaishnav, Asmita;
Brunzelle, Joseph S.;
Evans, Hedeel Guy;
Evans, David R.

Publication type:

Article

Works about ENZYME inhibitors synthesis

Molecular Modeling as a New Approach to the Development of Urokinase Inhibitors.

Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses.

Exploring N-acyl-4-azatetracyclo[5.3.2.0<sup>2,6</sup>.0<sup>8,10</sup>]dodec-11-enes as 11β-HSD1 Inhibitors.

Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a <sup>1</sup>H-NMR Method to Assess Deacetylase Activity.

Ganetespib, an HSP90 inhibitor, kills Epstein–Barr virus (EBV)-infected B and T cells and reduces the percentage of EBV-infected cells in the blood.

Novel biphenyl ester derivatives as tyrosinase inhibitors: Synthesis, crystallographic, spectral analysis and molecular docking studies.

Spotlights on our sister journals: Angew. Chem. Int. Ed. 41/2016.

Total Synthesis of Albicidin: A Lead Structure from Xanthomonas albilineans for Potent Antibacterial Gyrase Inhibitors.

Crystal structure of 2-(4-chlorophenyl)-5-methyl-1,3-dioxane-5-carboxylic acid, C<sub>12</sub>H<sub>13</sub>ClO<sub>4</sub>.

Sequence analysis of genes mediating extended-spectrum beta-lactamase (ESBL) production in isolates of Enterobacteriaceae in a Lagos Teaching Hospital, Nigeria.

Synthesis, Antibacterial and Lipoxygenase Inhibition Studies on Some N-(4-{[(Alkyl/aralkyl)(phenethyl)amino]sulfonyl}phenyl) acetamides.

Synthesis of an impurity in crude roflumilast.

Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo.

Influence of Polyphenol Extract from Evening Primrose (Oenothera Paradoxa) Seeds on Proliferation of Caco-2 Cells and on Expression, Synthesis and Activity of Matrix Metalloproteinases and Their Inhibitors.

Fluorinated Adenosine A<sub>2A</sub> Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics.

Multiscale Metabolic Modeling: Dynamic Flux Balance Analysis on a Whole-Plant Scale.

Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation.

PURIFICATION AND PHYSICOKINETIC CHARACTERIZATION OF A GLUCONOLACTONE INHIBITION-INSENSITIVE β-GLUCOSIDASE FROM Andrographis paniculata NEES. LEAF.

SLCO1B1 Variants and Angiotensin Converting Enzyme Inhibitor (Enalapril) -Induced Cough: a Pharmacogenetic Study.

Loss of G2 subunit of vacuolar-type proton transporting ATPase leads to G1 subunit upregulation in the brain.

Are PCSK9 Inhibitors Cost Effective?

Synthesis of chiral pyrazolo[4,3- e ][1,2,4]triazine sulfonamides with tyrosinase and urease inhibitory activity.

Synthesis and Characterization of Polysialic Acid-Uricase Conjugates for the Treatment of Hyperuricemia.

Synthesis and biological applications of selenoureas.

Structural and biochemical analysis of a thermostable membrane-bound stomatin-specific protease.

The mononuclear metal center of type-I dihydroorotase from aquifex aeolicus.