Works about ECULIZUMAB

Results: 828

C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1620996

By:

Guaschino, Valeria;
Santarsiero, Donata;
Gastoldi, Sara;
Thurman, Joshua M.;
Holers, V. Michael;
Violette, Shelia M.;
Liu, Fei;
Fahnoe, Kelly C.;
Guarinoni, Chiara;
Benigni, Ariela;
Remuzzi, Giuseppe;
Noris, Marina;
Aiello, Sistiana

Publication type:

Article

Eculizumab reversed severe distal ischemic syndrome and glomerulonephritis with isolated C3 deposits associated with anti-factor H autoantibodies: a case report.

Published in:

Clinical Rheumatology, 2018, v. 37, n. 4, p. 1119, doi. 10.1007/s10067-018-4058-6

By:

Deshayes, Samuel;
Martin Silva, Nicolas;
Chatelet, Valérie;
Chantepie, Sylvain;
Le Quintrec, Moglie;
Comoz, François;
Bridoux, Frank;
Dragon-Durey, Marie-Agnès;
Aouba, Achille

Publication type:

Article

Use of eculizumab in a systemic lupus erythemathosus patient presenting thrombotic microangiopathy and heterozygous deletion in CFHR1-CFHR3. A case report and systematic review.

Published in:

Clinical Rheumatology, 2017, v. 36, n. 12, p. 2859, doi. 10.1007/s10067-017-3823-2

By:

Holanda, Maria;
Pôrto, Luis;
Wagner, Teresa;
Christiani, Luis;
Palma, Lilian

Publication type:

Article

Eculizumab in the treatment of neuromyelitis optica spectrum disorder.

Published in:

Current Journal of Neurology, 2023, v. 22, n. 2, p. 140, doi. 10.18502/cjn.v22i2.13342

By:

Nabizadeh, Fardin;
Moghadasi, Abdorreza Naser

Publication type:

Article

Acute Myeloid Leukemia as a Trigger for Hemolytic–Uremic Syndrome.

Published in:

2024

By:

El Bachouti, Jonas;
Domínguez-Guasch, Anna;
Arce, Yolanda;
Oñate, Guadalupe;
Marco, Helena;
Diaz, Montserrat;
Guirado, Lluís;
Torra, Roser;
Barros, Xoana

Publication type:

Case Study

Biologics and Non-Biologics Immunosuppressive Treatments for IgA Nephropathy in Both Adults and Children.

Published in:

Journal of Clinical Medicine, 2024, v. 13, n. 9, p. 2465, doi. 10.3390/jcm13092465

By:

Chiarenza, Decimo Silvio;
Verrina, Enrico Eugenio;
La Porta, Edoardo;
Caridi, Gianluca;
Ghiggeri, Gian Marco;
Mortari, Gabriele;
Lugani, Francesca;
Angeletti, Andrea;
Bigatti, Carolina

Publication type:

Article

Recessive SERPING1 Variant Leads to Kinin–Kallikrein System Control Failure in a Consanguineous Brazilian Family with Hereditary Angioedema.

Published in:

Journal of Clinical Medicine, 2023, v. 12, n. 23, p. 7299, doi. 10.3390/jcm12237299

By:

Maia, Luana Sella Motta;
Burger, Bettina;
Ghannam, Arije;
Nunes, Fernanda Leonel;
Ferriani, Mariana Paes Leme;
Dias, Marina Mendonça;
Arruda, Luisa Karla;
Drouet, Christian;
Cichon, Sven

Publication type:

Article

HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus.

Published in:

Journal of Clinical Medicine, 2023, v. 12, n. 16, p. 5405, doi. 10.3390/jcm12165405

By:

García-González, María;
Gómez-Bernal, Fuensanta;
Quevedo-Abeledo, Juan C.;
Fernández-Cladera, Yolanda;
González-Rivero, Agustín F.;
López-Mejías, Raquel;
Díaz-González, Federico;
González-Gay, Miguel Á.;
Ferraz-Amaro, Iván

Publication type:

Article

Complement Inhibitors for Advanced Dry Age-Related Macular Degeneration (Geographic Atrophy): Some Light at the End of the Tunnel?

Published in:

Journal of Clinical Medicine, 2023, v. 12, n. 15, p. 5131, doi. 10.3390/jcm12155131

By:

Cruz-Pimentel, Miguel;
Wu, Lihteh

Publication type:

Article

Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation.

Published in:

Journal of Clinical Medicine, 2023, v. 12, n. 6, p. 2335, doi. 10.3390/jcm12062335

By:

Muñoz-Herrera, Claudia M.;
Gutiérrez-Bautista, Juan Francisco;
López-Nevot, Miguel Ángel

Publication type:

Article

Adjuvant Lineage-Negative Cell Therapy as a Potential Silencer of the Complement-Mediated Immune System in ALS Patients.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 22, p. 5251, doi. 10.3390/jcm10225251

By:

Sobuś, Anna;
Baumert, Bartłomiej;
Gołąb-Janowska, Monika;
Kulig, Piotr;
Paczkowska, Edyta;
Łuczkowska, Karolina;
Rogińska, Dorota;
Zawiślak, Alicja;
Milczarek, Sławomir;
Osękowska, Bogumiła;
Pawlukowska, Wioletta;
Meller, Agnieszka;
Machowska-Sempruch, Karolina;
Wełnicka, Agnieszka;
Nowacki, Przemysław;
Machaliński, Bogusław

Publication type:

Article

Complement Factor C5a Inhibits Apoptosis of Neutrophils—A Mechanism in Polytrauma?

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 14, p. 3157, doi. 10.3390/jcm10143157

By:

Ehrnthaller, Christian;
Braumüller, Sonja;
Kellermann, Stephanie;
Gebhard, Florian;
Perl, Mario;
Huber-Lang, Markus

Publication type:

Article

Complement Inhibition for Geographic Atrophy: A Tempting Target with Mixed Results.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 13, p. 2890, doi. 10.3390/jcm10132890

By:

Lin, Jonathan B.;
Halawa, Omar A.;
Miller, Joan W.;
Vavvas, Demetrios G.

Publication type:

Article

A Review of Completed and Ongoing Complement Inhibitor Trials for Geographic Atrophy Secondary to Age-Related Macular Degeneration.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 12, p. 2580, doi. 10.3390/jcm10122580

By:

Halawa, Omar A.;
Lin, Jonathan B.;
Miller, Joan W.;
Vavvas, Demetrios G.

Publication type:

Article

Emerging Therapies in Immune Thrombocytopenia.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 5, p. 1004, doi. 10.3390/jcm10051004

By:

Audia, Sylvain;
Bonnotte, Bernard;
Scully, Marie

Publication type:

Article

Outcomes of Kidney Transplant Patients with Atypical Hemolytic Uremic Syndrome Treated with Eculizumab: A Systematic Review and Meta-Analysis.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 10, p. 919, doi. 10.3390/jcm8070919

By:

Gonzalez Suarez, Maria L.;
Thongprayoon, Charat;
Mao, Michael A.;
Leeaphorn, Napat;
Bathini, Tarun;
Cheungpasitporn, Wisit

Publication type:

Article

Outcomes of Kidney Transplant Patients with Atypical Hemolytic Uremic Syndrome Treated with Eculizumab: A Systematic Review and Meta-Analysis.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 7, p. 919, doi. 10.3390/jcm8070919

By:

Gonzalez Suarez, Maria L.;
Thongprayoon, Charat;
Mao, Michael A.;
Leeaphorn, Napat;
Bathini, Tarun;
Cheungpasitporn, Wisit

Publication type:

Article

The Extended Use of Eculizumab in Pregnancy and Complement Activation–Associated Diseases Affecting Maternal, Fetal and Neonatal Kidneys—The Future Is Now?

Published in:

Journal of Clinical Medicine, 2019, p. 407, doi. 10.3390/jcm8030407

By:

Stefanovic, Vedran

Publication type:

Article

Complement system network in cell physiology and in human diseases.

Published in:

International Reviews of Immunology, 2021, v. 40, n. 3, p. 159, doi. 10.1080/08830185.2020.1833877

By:

Romano, Roberta;
Giardino, Giuliana;
Cirillo, Emilia;
Prencipe, Rosaria;
Pignata, Claudio

Publication type:

Article

Severe Neurological Involvement in an Adult with Shiga Toxin-Producing Escherichia coli-Hemolytic Uremic Syndrome Treated with Eculizumab.

Published in:

2023

By:

Vanesse, Pauline;
Georgery, Hélène;
Duprez, Thierry;
Gerard, Ludovic;
Collienne, Christine;
Verroken, Alexia;
Crombé, Florence;
Morelle, Johann;
Hantson, Philippe

Publication type:

Case Study

Complement-Mediated Thrombotic Microangiopathy Associated with Lupus Nephritis Treated with Eculizumab: A Case Report.

Published in:

Case Reports in Nephrology & Dialysis, 2021, v. 11, n. 1, p. 95, doi. 10.1159/000512227

By:

Torres, Everardo Arias;
Chang, Yongen;
Desai, Sheetal;
Chang, Ian;
Zuckerman, Jonathan E.;
Burwick, Richard;
Kalantar-Zadeh, Kamyar;
Hanna, Ramy M.

Publication type:

Article

C3 Glomerulopathy and Atypical Hemolytic Uremic Syndrome: Two Important Manifestations of Complement System Dysfunction.

Published in:

2018

By:

Bajwa, Ravneet;
De Palma, John A.;
Khan, Taimoor;
Cheema, Anmol;
Kalathil, Sheila A.;
Hossain, Mohammad A.;
Haroon, Attiya;
Madhurima, Anne;
Zheng, Min;
Nayer, Ali;
Asif, Arif

Publication type:

Case Study

Discontinuation of Peritoneal Dialysis after Late Initiation of Eculizumab in a Case of Familial Atypical Hemolytic-Uremic Syndrome: A Case Report.

Published in:

2017

By:

Alonso Valente, Rafael;
García Rodríguez, Giannina Elena;
García Marcote, Yanina;
Fidalgo Díaz, Manuel;
Becerra Mosquera, Vanesa;
Novoa García, Daniel;
Cordal Martínez, Teresa;
Díaz Rodríguez, Cándido

Publication type:

Case Study

Hypertensive Emergency and Atypical Hemolytic Uremic Syndrome Associated with Cocaine Use: A Diagnostic and Therapeutic Challenge.

Published in:

2025

By:

Jiménez Mayor, Elena;
De La Flor, José C.;
Rocha Rodrigues, André;
Rodríguez Tudero, Celia;
Zamora González-Mariño, Rocío;
Apaza, Jacqueline;
Moral Berrio, Esperanza;
Deira Lorenzo, Javier

Publication type:

Case Study

Eculizumab treatment in pregnant women with paroxysmal nocturnal hemoglobinuria: A Polish experience.

Published in:

2022

By:

Czyż, Jarosław;
Szukalski, Łukasz;
Szukalska, Adriana;
Budziszewska, Bożena Katarzyna;
Lech-Marańda, Ewa;
Zdziarska, Joanna;
Sacha, Tomasz

Publication type:

Case Study

Diagnosis of Atypical Hemolytic Uremic Syndrome and Response to Eculizumab Therapy.

Published in:

2014

By:

Nguyen, May H.;
Mathew, Jacob J.;
Denunzio, Troy M.;
Carmichael, Mark G.

Publication type:

Case Study

Protective role of complement factor H against the development of preeclampsia.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1351898

By:

Yasmin, Hadida;
Agostinis, Chiara;
Toffoli, Miriam;
Roy, Tamali;
Pegoraro, Silvia;
Balduit, Andrea;
Zito, Gabriella;
Di Simone, Nicoletta;
Ricci, Giuseppe;
Madan, Taruna;
Kishore, Uday;
Bulla, Roberta

Publication type:

Article

The human factor H protein family -- an update.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1135490

By:

Sándor, Noémi;
Schneider, Andrea E.;
Matola, Alexandra T.;
Barbai, Veronika H.;
Bencze, Dániel;
Hammad, Hani Hashim;
Papp, Alexandra;
Kövesdi, Dorottya;
Uzonyi, Barbara;
Józsi, Mihály

Publication type:

Article

Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1152000

By:

Menon, Smrithi S.;
Ramirez-Toloza, Galia;
Wycoff, Keith L.;
Ehinger, Sean;
Shaughnessy, Jutamas;
Ram, Sanjay;
Ferreira, Viviana P.

Publication type:

Article

Rational use of eculizumab in secondary atypical hemolytic uremic syndrome.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2023.1310469

By:

Cordero, Lucía;
Cavero, Teresa;
Gutiérrez, Eduardo;
Trujillo, Hernando;
Sandino, Justo;
Auñón, Pilar;
Rivero, Marta;
Morales, Enrique

Publication type:

Article

Modeling complement activation on human glomerular microvascular endothelial cells.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1206409

By:

Stevens, Kes H.;
Baas, Laura M.;
van der Velden, Thea J. A. M.;
Bouwmeester, Romy N.;
van Dillen, Niels;
Dorresteijn, Eiske M.;
van Zuilen, Arjan D.;
Wetzels, Jack F. M.;
Michels, Marloes A. H. M.;
van de Kar, Nicole C. A. J.;
van den Heuvel, Lambertus P.

Publication type:

Article

Evaluating distinct KRAS subtypes as potential biomarkers for immune checkpoint inhibitor efficacy in lung adenocarcinoma.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1297588

By:

Qi Wang;
Zhuoran Tang;
Chunyu Li;
Xuefei Li;
Chunxia Su

Publication type:

Article

Evaluating distinct KRAS subtypes as potential biomarkers for immune checkpoint inhibitor efficacy in lung adenocarcinoma.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1297588

By:

Qi Wang;
Zhuoran Tang;
Chunyu Li;
Xuefei Li;
Chunxia Su

Publication type:

Article

Heterogenous lung inflammation CT patterns distinguish pneumonia and immune checkpoint inhibitor pneumonitis and complement blood biomarkers in acute myeloid leukemia: proof of concept.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1249511

By:

Aminu, Muhammad;
Daver, Naval;
Godoy, Myrna C. B.;
Shroff, Girish;
Wu, Carol;
Torre-Sada, Luis F.;
Goizueta, Alberto;
Shannon, Vickie R.;
Faiz, Saadia A.;
Altan, Mehmet;
Garcia-Manero, Guillermo;
Kantarjian, Hagop;
Ravandi-Kashani, Farhad;
Kadia, Tapan;
Konopleva, Marina;
DiNardo, Courtney;
Pierce, Sherry;
Aung Naing;
Kim, Sang T.;
Kontoyiannis, Dimitrios P.

Publication type:

Article

Corrigendum: Zilucoplan, a macrocyclic peptide inhibitor of human complement component 5, uses a dual mode of action to prevent terminal complement pathway activation.

Published in:: Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1282155
Publication type:: Article

Zilucoplan, a macrocyclic peptide inhibitor of human complement component 5, uses a dual mode of action to prevent terminal complement pathway activation.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1213920

By:

Guo-Qing Tang;
Yalan Tang;
Dhamnaskar, Ketki;
Hoarty, Michelle D.;
Vyasamneni, Rohit;
Vadysirisack, Douangsone D.;
Zhong Ma;
Nanqun Zhu;
Jian-Guo Wang;
Bu, Charlie;
Cong, Bestine;
Palmer, Elizabeth;
Duda, Petra W.;
Sayegh, Camil;
Ricardo, Alonso

Publication type:

Article

Properdin inhibition ameliorates hepatic ischemia/reperfusion injury without interfering with liver regeneration in mice.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1174243

By:

Jiro Kusakabe;
Koichiro Hata;
Tetsuya Tajima;
Hidetaka Miyauchi;
Xiangdong Zhao;
Shoichi Kageyama;
Tatsuaki Tsuruyama;
Etsuro Hatano

Publication type:

Article

Brensocatib (an oral, reversible inhibitor of dipeptidyl peptidase-1) attenuates disease progression in two animal models of rheumatoid arthritis.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1231047

By:

McDonald, Patrick P.;
Leifer, Franziska Graf;
Basso, Jessica;
Lasala, Dan;
Dedong Li;
Kuan-Ju Chen;
Jimin Zhang;
Perkins, Walter R.;
Cipolla, David C.

Publication type:

Article

Zilucoplan, a macrocyclic peptide inhibitor of human complement component 5, uses a dual mode of action to prevent terminal complement pathway activation.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1213920

By:

Guo-Qing Tang;
Yalan Tang;
Dhamnaskar, Ketki;
Hoarty, Michelle D.;
Vyasamneni, Rohit;
Vadysirisack, Douangsone D.;
Zhong Ma;
Nanqun Zhu;
Jian-Guo Wang;
Bu, Charlie;
Cong, Bestine;
Palmer, Elizabeth;
Duda, Petra W.;
Sayegh, Camil;
Ricardo, Alonso

Publication type:

Article

Dupilumab effectively and rapidly treats bullous pemphigoid by inhibiting the activities of multiple cell types.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1194088

By:

Tianmeng Yan;
Yinghan Xie;
Yuhua Liu;
Ying Shan;
Xiaoyan Wu;
Jing Wang;
Ya-Gang Zuo;
Zhenying Zhang

Publication type:

Article

In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1180833

By:

Ispasanie, Emma;
Muri, Lukas;
Schmid, Marc;
Schubart, Anna;
Thorburn, Christine;
Zamurovic, Natasa;
Holbro, Thomas;
Kammüller, Michael;
Pluschke, Gerd

Publication type:

Article

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1203506

By:

Martin, Myriam;
Nilsson, Sara C.;
Eikrem, David;
Fromell, Karin;
Scavenius, Carsten;
Vogt, Leonie M.;
Bielecka, Ewa;
Potempa, Jan;
Enghild, Jan J.;
Nilsson, Bo;
Ekdahl, Kristina N.;
Kapetanovic, Meliha C.;
Blom, Anna M.

Publication type:

Article

Increased plasma level of terminal complement complex in AMD patients: potential functional consequences for RPE cells.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1200725

By:

Busch, Catharina;
Rau, Saskia;
Sekulic, Andjela;
Perie, Luce;
Huber, Christian;
Gehrke, Miranda;
Joussen, Antonia M.;
Zipfel, Peter F.;
Wildner, Gerhild;
Skerka, Christine;
Strauß, Olaf

Publication type:

Article

Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1192767

By:

Ali, Youssif M.;
Lynch, Nicholas J.;
Shaaban, Ahmed A.;
Rizk, Dina E.;
Abdel-Rahman, Shaymaa H.;
Khatri, Priyanka;
Yabuki, Munehisa;
Yaseen, Sadam;
Dudler, Thomas;
Demopulos, Gregory;
Schwaeble, Wilhelm J.

Publication type:

Article

Quantification of the zymogenicity and the substrate-induced activity enhancement of complement factor D.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1197023

By:

Dani, Ráhel;
Oroszlán, Gábor;
Martinusz, Róbert;
Farkas, Bence;
Dobos, Bernadett;
Vadas, Evelin;
Závodszky, Péter;
Gál, Péter;
Dobó, József

Publication type:

Article

An update on the biologics for the treatment of antiphospholipid syndrome.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1145145

By:

Zelin Yun;
Lizhi Duan;
Xiangjun Liu;
Qingmeng Cai;
Chun Li

Publication type:

Article

Evaluating the comorbidities of age and cigarette smoking on stroke outcomes in the context of anti-complement mitigation strategies.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1161051

By:

Couch, Christine;
Alawieh, Ali M.;
Toutonji, Amer;
Atkinson, Carl;
Tomlinson, Stephen

Publication type:

Article

In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model.

Published in:

Frontiers in Immunology, 2023, v. 14, p. 01, doi. 10.3389/fimmu.2023.1101387

By:

Gerogianni, Alexandra;
Bal, Melissa;
Mohlin, Camilla;
Woodruff, Trent M.;
Lambris, John D.;
Mollnes, Tom E.;
Sjöström, Dick J.;
Nilsson, Per H.

Publication type:

Article

Eculizumab Treatment of Massive Hemolysis Occurring in a Rare Co-Existence of Paroxysmal Nocturnal Hemoglobinuria and Myasthenia Gravis.

Published in:

2024

By:

Bicskó, Ráhel Réka;
Illés, Árpád;
Hevessy, Zsuzsanna;
Ivády, Gergely;
Kerekes, György;
Méhes, Gábor;
Csépány, Tünde;
Gergely, Lajos

Publication type:

Case Study

Analysis of Costs per Responder in US Adults with Paroxysmal Nocturnal Hemoglobinuria with a Suboptimal Response to Prior Eculizumab Treatment.

Published in:

Hematology Reports, 2023, v. 15, n. 4, p. 578, doi. 10.3390/hematolrep15040060

By:

Fishman, Jesse;
Anderson, Seri;
Talbird, Sandra E.;
Dingli, David

Publication type:

Article