Works matching DE "DRUG target"

Results: 5000

Platelet indices and biochemical risk factors associated with preeclampsia.

Published in:

Obstetrică şi Ginecologie, 2024, v. 72, n. 4, p. 158, doi. 10.26416/obsgin.72.4.2024.10886

By:

Cionca, Octavia;
Hadnagy, Zoltan;
Gorun, Florin;
Zahner, Mihaela

Publication type:

Article

The role of Artificial Intelligence in drug discovery.

Published in:

Journal of Drug Delivery & Therapeutics, 2025, v. 15, n. 7, p. 102, doi. 10.22270/jddt.v15i7.7251

By:

Rotake, Samiksha B.;
Hatwar, Pooja R.;
Bakal, Ravindra L.;
Meshram, Shruti I.

Publication type:

Article

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Published in:

Mass Spectrometry Reviews, 2025, v. 44, n. 5, p. 715, doi. 10.1002/mas.21880

By:

Walrant, Astrid;
Sachon, Emmanuelle

Publication type:

Article

Glutamate-cysteine ligase as a diagnostic biomarker and therapeutic target in Parkinson's disease: a multi-omics and experimental study.

Published in:

European Journal of Medical Research, 2025, v. 30, n. 1, p. 1, doi. 10.1186/s40001-025-02921-9

By:

Li, Xuzhao;
Wang, Mengfei;
Zhong, Chen;
Xia, Jun;
Tian, Liqiong;
Wang, Jun;
Yang, Dongmei

Publication type:

Article

Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis.

Published in:

Frontiers in Neuroscience, 2025, p. 1, doi. 10.3389/fnins.2025.1558227

By:

Atwal, Manpreet Singh;
Nimac, Jerneja;
Čerček, Urša;
Goesch, Sarah Ricarda;
Goesch, Hannah Rebecca;
Tziortzouda, Paraskevi;
Ercolani, Tiziana;
Zatorska, Anna;
Pasha, Terouz;
Carre, Ivo;
Mitchell, Jacqueline;
Troakes, Claire;
Tummers, Bart;
Župunski, Vera;
Rogelj, Boris;
Hortobágyi, Tibor;
Hirth, Frank

Publication type:

Article

Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinson's Disease.

Published in:

NPJ Parkinson's Disease, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41531-025-01087-9

By:

Ranxhi, Bedri;
Bangash, Zoya R.;
Chbihi, Zachary M.;
Qadri, Zaina;
Islam, Nazin N.;
Todi, Sokol V.;
LeWitt, Peter A.;
Tsou, Wei-Ling

Publication type:

Article

Degradation of IRAK4 for the treatment of lipopolysaccharide-induced acute lung injury in mice.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1609923

By:

Ye, Bijun;
Chen, Shiyan;
Huang, Xiaohao;
Qiu, Yinhong;
Luo, Ruixiang;
Zheng, Lulu

Publication type:

Article

Identification of key molecular targets for stachyose in hepatocellular carcinoma: focus on STAT3 and FN1.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1576449

By:

Chen, Haihua;
Wang, Xianyou;
Ying, Jiongcheng;
Huang, YuQin;
Liu, Yuxi;
Feng, Yifu;
Fang, Binbo

Publication type:

Article

Regulated programmed cell death in acute lung injury: from pathogenesis to therapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1630015

By:

Liu, Shi-wen;
Chen, Yi-jian;
Liu, Yi;
Zhou, Wen;
Liu, Xuan

Publication type:

Article

Immunosuppressive cells in acute myeloid leukemia: mechanisms and therapeutic target.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1627161

By:

Liu, Mengnan;
Yang, Mengting;
Qi, Yue;
Ma, Yuting;
Guo, Qulian;
Guo, Ling;
Liu, Chunyan;
Liu, Wenjun;
Xiao, Lan;
Yang, You

Publication type:

Article

WISP1 drives esophageal squamous cell carcinoma progression via modulation of cancer-associated fibroblasts and immune microenvironment.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1586790

By:

Yi, Zhiqiang;
Zhang, Qiqi;
Tao, Ting;
Liu, Xiaojia;
Li, Hui;
Li, Xiujuan;
Zhang, Zhiqiang

Publication type:

Article

Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson's disease.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1571074

By:

Thome, Aaron D.;
Wang, Jinghong;
Atassi, Farah;
Thonhoff, Jason R.;
Faridar, Alireza;
Zhao, Weihua;
Beers, David R.;
Lai, Eugene C.;
Appel, Stanley H.

Publication type:

Article

Identification of key genes associated with infertile endometriosis based on bioinformatic analysis.

Published in:

Frontiers in Genetics, 2025, p. 1, doi. 10.3389/fgene.2025.1615268

By:

Chang, Linlin;
Ye, Hongjuan;
Hou, Min;
Xie, Xin;
Wang, Yang;
Cheng, Jie;
Wang, Rongxiang;
Chen, Xiaocong;
Quan, Xinxin;
Sun, Lihua;
Xue, Songguo;
Shi, Liya

Publication type:

Article

Emotional distress as a therapeutic target against persistent poor glycaemic control in subjects with type 1 diabetes: A systematic review.

Published in:

Diabetes, Obesity & Metabolism, 2025, v. 27, n. 9, p. 4662, doi. 10.1111/dom.16540

By:

Franc, Sylvia;
Charpentier, Guillaume

Publication type:

Article

Exploring the Role and Mechanism of miRNA Dysregulation in Chronic Intermittent Hypoxia-Induced Cognitive Decline in Rats.

Published in:

Molecular Biology, 2025, v. 59, n. 4, p. 522, doi. 10.1134/S0026893325700165

By:

Yue, Y. J.;
Chen, X. D.;
Xue, Z. Y.;
Zhu, X. K.;
Huang, Q.;
Xu, P.

Publication type:

Article

TRIM56 Mediates Autophagy Inhibition in Esophageal Cancer.

Published in:

Molecular Biology, 2025, v. 59, n. 4, p. 598, doi. 10.1134/S0026893325700232

By:

Gao, J.;
Li, R. Z.;
Peng, H.;
Al-Harazi, S. M.;
Luo, S. G.;
Hua, H. M.;
Yang, Y. Y.;
Wang, F. L.;
Wang, J. P.

Publication type:

Article

Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-62528-w

By:

Foerster, Leo Carl;
Kaya, Oguzhan;
Wüst, Valentin;
Danciu, Diana-Patricia;
Akcay, Vuslat;
Bekavac, Milica;
Ziegler, Kevin Chris;
Stinchcombe, Nina;
Tang, Anna;
Kleber, Susanne;
Tang, Joceyln;
Brunken, Jan;
Lois-Bermejo, Irene;
Gesteira-Perez, Noelia;
Ma, Xiujian;
Sadik, Ahmed;
Le, Phuong Uyen;
Petrecca, Kevin;
Opitz, Christiane A.;
Liu, Haikun

Publication type:

Article

CUT&Tag reveals unconventional G-quadruplex landscape in Mycobacterium tuberculosis in response to oxidative stress.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-62485-4

By:

Maurizio, Ilaria;
Ruggiero, Emanuela;
Zanin, Irene;
Conflitti, Marta;
Nicoletto, Giulia;
Provvedi, Roberta;
Richter, Sara N.

Publication type:

Article

Targeting the Werner syndrome protein in microsatellite instability cancers: mechanisms and therapeutic potential.

Published in:

Clinical & Experimental Medicine, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10238-025-01781-1

By:

Chen, Shuling;
Wang, Zhiming;
Cao, Zhifei;
Xu, Mengmeng;
Zhang, Yongsheng

Publication type:

Article

The role and mechanism of ARID1A in immunotherapy of gastric cancer.

Published in:

Clinical & Experimental Medicine, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10238-025-01778-w

By:

He, Wenting;
Chen, Yue;
Yao, Xue;
Wu, Jun;
Zhu, Danxia;
Wang, Jian;
Jiang, Lu;
Shen, Yueping;
Zhang, Dachuan;
Jiang, Jingting

Publication type:

Article

SRPK1 is a significant factor in driving the progression of diabetic kidney fibrosis.

Published in:

Diabetology & Metabolic Syndrome, 2025, v. 17, p. 1, doi. 10.1186/s13098-025-01889-0

By:

Han, Shichao;
Ma, Shuaijun;
Liu, Kepu;
Qi, Ruochen;
Wang, Guohui;
Qin, Weijun;
Zhang, Xutao

Publication type:

Article

Associations of Leukocyte-Derived Chemotaxin-2 (LECT2) with Insulin Resistance and Metabolic Syndrome in Type 2 Diabetes: A Cross-Sectional Study.

Published in:

Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2025, v. 18, p. 2131, doi. 10.2147/DMSO.S527941

By:

Sha, Yujing;
Lu, Jiaping;
Jin, Rui;
Li, Lian;
Zhang, Min

Publication type:

Article

Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic Mechanisms.

Published in:

Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2025, v. 18, p. 2399, doi. 10.2147/DMSO.S528669

By:

Lu, Xinyue;
Ji, Lianhong;
Chen, Dong;
Lian, Xiaoyang;
Yuan, Mengqian

Publication type:

Article

Exploring the Potential of 5-HT1 Receptor Subtypes as Therapeutic Targets for Obesity Treatment in Animal Models.

Published in:

Journal of Young Pharmacists, 2025, v. 17, n. 2, p. 353, doi. 10.5530/jyp.20251548

By:

Kaur, Navpreet;
Gulati, Puja

Publication type:

Article

Unlocking the secret of glioblastoma multiforme: the role of lactylation in tumor progression, drug resistance and immune microenvironment.

Published in:

Cancer Cell International, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12935-025-03933-5

By:

Xiao, Yifei;
Zheng, Ruipeng;
Lv, Fengjun;
Yang, Guang;
Ge, Haitao;
Yang, Mingchun;
Wang, Kan;
Cheng, Yu

Publication type:

Article

Multi-context modeling of driver pathways reveals common and specific mechanisms across 23 cancer types.

Published in:

PLoS Computational Biology, 2025, v. 21, n. 8, p. 1, doi. 10.1371/journal.pcbi.1013349

By:

Zhou, Wenjia;
Zhang, Junhua

Publication type:

Article

Electrophotochemical Radical Relay for Remote Alkenylation of Unactivated C(sp3)–H Sites in Alcohols.

Published in:

China Oncology, 2025, v. 35, n. 6, p. 570, doi. 10.19401/j.cnki.1007-3639.2025.06.006

By:

范素梅;
信聪伶;
朱来芳;
刘畅;
徐蕊;
周正荣;
程玺

Publication type:

Article

PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.

Published in:

Connective Tissue Research, 2025, v. 66, n. 4, p. 298, doi. 10.1080/03008207.2025.2508841

By:

Wei, Xiaodong;
Yu, Chao;
Wang, Jingjie

Publication type:

Article

Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis.

Published in:

Military Medical Research, 2025, v. 12, n. 1, p. 1, doi. 10.1186/s40779-025-00631-1

By:

Jia, Ze-Xi;
Guo, Meng-Tian;
Li, Mei-Mei;
Liao, Pan;
Yan, Bo;
Zhang, Wei;
Cheng, Fang-Yuan;
Liu, Ya-Ru;
Zhang, Zi-Han;
Wei, Cheng;
Zhou, Jie;
Chen, Fang-Lian;
Lei, Ping;
Ge, Xin-Tong

Publication type:

Article

miR-144-3p Regulates the Radiation Sensitivity of Nasopharyngeal Carcinoma Through Targeting the NFE2L2 Pathway.

Published in:

Radiation Research, 2025, v. 204, n. 2, p. 143, doi. 10.1667/RADE-24-00130.1

By:

Chen, Jingjing;
Wang, Yilong;
Zhao, Na;
Song, Jie;
Feng, Yongjun

Publication type:

Article

Evaluation of HOTAIRM1, miR-196b, and HOXA9 as Oncogenic Markers in Patients with Acute Myeloblastic Leukemia.

Published in:

Iranian Journal of Pathology, 2025, v. 20, n. 3, p. 307, doi. 10.30699/ijp.2025.2030358.3309

By:

Norozi, Fahime;
Allahbakhshian, Mehdi;
Vazifeshiran, Nader;
Hasanpour, Zahra;
Hamidpour, Mohsen

Publication type:

Article

Cannabidiol and microRNAs: shared cellular targets and new insights for developing anti-seizure modalities.

Published in:

Journal of Pharmacy & Pharmacology, 2025, v. 77, n. 8, p. 1011, doi. 10.1093/jpp/rgaf039

By:

Afrooghe, Arya;
Ahmadi, Elham;
Shayan, Maryam;
Ohadi, Mohammad Amin Dabbagh;
Behnoush, Amir Hossein;
Dehpour, Ahmad Reza

Publication type:

Article

Correction to: Upcoming drug targets for kidney protective effects in chronic kidney disease Open Access.

Published in:: Nephrology Dialysis Transplantation, 2025, v. 40, n. 8, p. 1636, doi. 10.1093/ndt/gfaf099
Publication type:: Article

N6-methyladenosine methylation: a novel key to unlocking mental disorders Open Access.

Published in:

International Journal of Neuropsychopharmacology, 2025, v. 28, n. 7, p. 1, doi. 10.1093/ijnp/pyaf044

By:

Wang, Yinuo;
Li, Xiaobing;
Liu, Min;
Xu, Xiaoxu;
Ma, Yue;
Luo, Yang;
Wang, Yue

Publication type:

Article

Integrin β5 interacts with G3BP1 through activating FAK/Src signaling pathway to promote gastric carcinogenesis.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-14067-z

By:

Liu, Dongliang;
Cao, Jianjian;
Hu, Kongwang;
Peng, Zhiwei

Publication type:

Article

Vibrational spectroscopy unveils distinct cell cycle features of cancer stem cells in melanoma.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-14018-8

By:

Uslu, Bensu Rüya;
Ozdil, Berrin;
Tarhan, Enver;
Özçelik, Serdar;
Aktuğ, Hüseyin;
Güler, Günnur

Publication type:

Article

Activated eosinophil plays a role in promoting fibrosis in endometriotic lesion.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-13855-x

By:

Ono, Yosuke;
Tanaka, Kota;
Sato, Erina;
Ito, Masami;
Zhang, Di;
Honda, Masako;
Ogawa, Tatsuyuki;
Tagaya, Hikaru;
Fukuda, Tomohiko;
Shinozaki, Youichi;
Kato, Kazuyoshi;
Koizumi, Schuichi;
Yoshino, Osamu

Publication type:

Article

Integrated single-cell and transcriptomic analysis of bone marrow-derived metastatic neuroblastoma reveals molecular mechanisms of metabolic reprogramming.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-13626-8

By:

Chu, Jing;
Qin, Rong;
Wang, Shu-Jing;
Wang, Qiang;
Wu, Qiang

Publication type:

Article

Deciphering anti-colorectal cancer potential of Avicennia alba bioactives via network pharmacology and in vitro validation.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-12500-x

By:

Irham, Lalu Muhammad;
Adikusuma, Wirawan;
Illian, Didi Nurhadi;
Mazaya, Maulida;
Mubaraq, Alfian;
Ma'ruf, Muhammad;
Rizki, Novi Kurnia;
Mutia, Maya Sari;
Ali, Hayssam M.;
Basyuni, Mohammad

Publication type:

Article

Exploring the interplay between LDHA and ABCC1 in breast cancer using computational approach.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03354-w

By:

Alshehri, Bader

Publication type:

Article

Integrative analysis of efferocytosis- and invasion-related genes as potential biomarkers and therapeutic targets in breast cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03346-w

By:

Yang, Jing;
Zhang, Rong;
Sun, Lamei;
Wang, Cong;
Feng, Ming;
Su, Bin;
Jiang, Lixin

Publication type:

Article

Targeting PDCD4 in cancer and atrial fibrillation: mechanistic insights from integrated multi-omics and single-cell analysis.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1593815

By:

Hailati, Juledezi;
Liu, Zhiqiang;
Zhang, Lei;
Wulasihan, Muhuyati

Publication type:

Article

Identification of novel molecular subtypes and construction of a prognostic signature via multi-omics analysis and machine learning in lung adenocarcinoma.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1590216

By:

Ma, Ke;
Xu, Jie;
Wang, Congyue;
Cao, Xu;
Yu, Wenjie;
Xi, Jingjing;
Zhang, Xuan;
Zhan, Jiamin;
Liu, Yang;
Yu, Aoyang;
Liu, Shuhan;
Liu, Yanhua;
Chen, Chong;
Mai, Xiaoli

Publication type:

Article

Ferroptosis: a key driver and therapeutic target in the pathogenesis of acute respiratory distress syndrome.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1567980

By:

Yao, Mingjun;
Liao, Jinfeng;
Liu, Zheng;
Zhao, Wei;
Song, Siyuan;
Huang, Xiaobo;
Wang, Yi

Publication type:

Article

Development and validation of a machine-learning-based model for identification of genes associated with sepsis-associated acute kidney injury.

Published in:

Frontiers in Genetics, 2025, p. 1, doi. 10.3389/fgene.2025.1561331

By:

Lin, Chen;
Zheng, Meng;
Wu, Wensi;
Wang, Zhishan;
Lu, Guofeng;
Feng, Shaodan;
Zhang, Xinlan

Publication type:

Article

MicroRNA-27b alleviates septic cardiomyopathy by targeting the Mff/MAVS axis.

Published in:

Frontiers in Cellular & Infection Microbiology, 2025, p. 1, doi. 10.3389/fcimb.2025.1588461

By:

Wang, Xincai;
Huang, Long;
Xu, Jingqing;
Li, Min;
Zhang, Hongxuan;
Yao, Yuqing;
Liu, Yaqing;
Lin, Xingsheng;
Shang, Xiuling

Publication type:

Article

SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-62565-5

By:

Huang, Yue;
Ma, Gan;
Xie, Shan;
Wei, Runa;
Liu, Ya;
Zeng, Ying;
Zhao, Yaxuan;
Wang, Qihui;
Yang, Li;
Huang, Huiying;
Hao, Lingyun;
Zhao, Xiaotian;
Wang, Hongjun;
Shen, Wen;
Wong, Stanley Sau Ching;
Cao, Jun-Li;
Tao, Yuan-Xiang;
Pan, Zhi-Qiang

Publication type:

Article

MMP14 as a central mediator of TGF-β1−induced extracellular matrix remodeling in graves' orbitopathy.

Published in:

Frontiers in Endocrinology, 2025, p. 1, doi. 10.3389/fendo.2025.1623842

By:

Wang, Xing;
Lu, Jing;
He, Yuxia;
Shu, Qinxin;
Lin, Yuxin;
Su, Wenqi;
Wang, Peng

Publication type:

Article

Inhibition of ferroptosis in inflammatory macrophages alleviates intestinal injury in neonatal necrotizing enterocolitis.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02665-9

By:

Shen, Leiting;
Chen, Jiayu;
Tou, Jinfa

Publication type:

Article

Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-62252-5

By:

Włodarczyk, Tomasz;
Lun, Aaron;
Wu, Diana;
Shi, Minyi;
Ye, Xiaofen;
Menon, Shreya;
Toneyan, Shushan;
Seidel, Kerstin;
Wang, Liang;
Tan, Jenille;
Chen, Shang-Yang;
Keyes, Timothy;
Chlebowski, Aleksander;
Waddell, Adrian;
Zhou, Wei;
Wang, Yangmeng;
Yuan, Qiuyue;
Guo, Yu;
Chen, Liang-Fu;
Daniel, Bence

Publication type:

Article