Works about DRUG repositioning

Results: 1871

Repurposing tafenoquine as a potent antifungal agent against Candida haemulonii sensu stricto.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2025, v. 80, n. 5, p. 1233, doi. 10.1093/jac/dkaf054

By:

Pimentel, Larissa Rodrigues;
Lucini, Fabíola;
Silva, Gabrieli Argueiro da;
Simionatto, Simone;
Rossato, Luana

Publication type:

Article

Computational drug repurposing reveals potential alanine racemase inhibitors for combating drug-resistant tuberculosis.

Published in:

Biologia, 2025, v. 80, n. 6, p. 1513, doi. 10.1007/s11756-025-01916-5

By:

LakshmanaPerumal, Keerthika;
Vetrivel, Umashankar

Publication type:

Article

Repurposing Nitroimidazoles: A New Frontier in Combatting Bacterial Virulence and Quorum Sensing via In Silico, In Vitro, and In Vivo Insights.

Published in:

Drug Development Research, 2025, v. 86, n. 3, p. 1, doi. 10.1002/ddr.70101

By:

Khafagy, El‐Sayed;
Saqr, Ahmed Al;
Almutairy, Bjad K.;
Aldawsari, Mohammed F.;
Lila, Amr Selim Abu;
Ibrahim, Tarek S.;
Hegazy, Wael A. H.;
Salem, Ibrahim M.

Publication type:

Article

Repurposing Alzheimer's disease medications—systemic cholinesterase inhibitors—for the treatment of dry eye syndrome, glaucoma, and age-related macular degeneration.

Published in:

2025

By:

Rajagopal, Shilpa;
Ahuja, Pranati;
Quach, Valerie;
Luong, Cody;
Raji, Mukaila A.

Publication type:

Editorial

H<sup>2</sup>GnnDTI: hierarchical heterogeneous graph neural networks for drug–target interaction prediction Open Access.

Published in:

Bioinformatics, 2025, v. 41, n. 4, p. 1, doi. 10.1093/bioinformatics/btaf117

By:

Jing, Yueying;
Zhang, Dongxue;
Li, Limin

Publication type:

Article

Mechanistic role of pyroptosis in Kawasaki disease: An integrative bioinformatics analysis of immune dysregulation, machine learning-based biomarker discovery, WGCNA, and drug repurposing insights.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0323597

By:

Wang, Chen;
Wu, Qinchao;
Chen, Jie;
Wang, Jun;
Li, Dan

Publication type:

Article

An Open‐Label, Non‐randomized, Drug‐Repurposing Study to Explore the Clinical Effects of Angiotensin II Type 1 (AT1) Receptor Antagonists on Anxiety and Depression in Parkinson's Disease.

Published in:

Movement Disorders Clinical Practice, 2025, v. 12, n. 5, p. 653, doi. 10.1002/mdc3.14326

By:

Bordet, Sofia;
Grasso, Lina;
Udovin, Lucas;
Chevalier, Guenson;
Otero‐Losada, Matilde;
Capani, Francisco;
Perez‐Lloret, Santiago

Publication type:

Article

Propranolol and Capecitabine Synergy on Inducing Ferroptosis in Human Colorectal Cancer Cells: Potential Implications in Cancer Therapy.

Published in:

Cancers, 2025, v. 17, n. 9, p. 1470, doi. 10.3390/cancers17091470

By:

Alzahrani, Shiekhah Mohammad;
Al Doghaither, Huda Abdulaziz;
Alkhatabi, Hind Ali;
Basabrain, Mohammad Abdullah;
Pushparaj, Peter Natesan

Publication type:

Article

Deciphering Nicotine-Driven Oncogenesis in Head and Neck Cancer: Integrative Transcriptomics and Drug Repurposing Insights.

Published in:

Cancers, 2025, v. 17, n. 9, p. 1430, doi. 10.3390/cancers17091430

By:

You, Guo-Rung;
Chang, Daniel Yu;
Huang, Hung-Han;
Chen, Yin-Ju;
Chang, Joseph T.;
Cheng, Ann-Joy

Publication type:

Article

Antimicrobial Proficiency of Amlodipine: Investigating its Impact on Pseudomonas spp. in Urinary Tract Infections.

Published in:

Indian Journal of Microbiology, 2025, v. 65, n. 1, p. 347, doi. 10.1007/s12088-024-01280-z

By:

Sharma, Pooja;
Kalra, Aakanksha;
Tripathi, Abhay Dev;
Chaturvedi, Vivek K.;
Chouhan, Bharti

Publication type:

Article

Pharmacological strategies for targeting biofilms in otorhinolaryngologic infections and overcoming antimicrobial resistance (Review).

Published in:

Biomedical Reports, 2025, v. 22, n. 6, p. N.PAG, doi. 10.3892/br.2025.1973

By:

Empitu, Maulana A.;
Kadariswantiningsih, Ika N.;
Shakri, Nadhirah Mohd

Publication type:

Article

Rare Disease Drug Repurposing.

Published in:

JAMA Network Open, 2025, v. 8, n. 5, p. e258330, doi. 10.1001/jamanetworkopen.2025.8330

By:

Nijim, Sally;
Korsunska, Ania;
Zinski, Joseph;
Bolden, Sarah E.;
Zuccato, Mary;
Repasky, Mileva;
Fajgenbaum, David C.

Publication type:

Article

Strategies to Advance Drug Repurposing for Rare Diseases.

Published in:

2025

By:

Hong, Dongzhe;
Kesselheim, Aaron S.

Publication type:

Opinion

Identifying suppressive factors of Alzheimer's disease through comprehensive analysis of real-world data: a single-center retrospective study.

Published in:

BMC Geriatrics, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12877-025-05982-x

By:

Shiotani, Mana;
Hyohdoh, Yuki;
Hatakeyama, Yutaka;
Kazui, Hiroaki;
Okuhara, Yoshiyasu

Publication type:

Article

In silico approach for uncovering inhibitors of SARS-CoV-2 by targeting TMPRSS2 via molecular networking-based strategies.

Published in:

Indian Journal of Biochemistry & Biophysics, 2025, v. 62, n. 5, p. 544, doi. 10.56042/ijbb.v62i5.4034

By:

Parameswaran, Dakshinesh;
Thangavelu, Saravanan;
Jubie, Selvaraj;
Swaroop, Akey Krishna;
Chellappa, Selvinthanuja;
Vivekanandan, Lalitha;
Thangavel, Sivakumar;
Thangavelu, Prabha

Publication type:

Article

Inhibitory effect of emododstat on respiratory syncytial virus.

Published in:

Tropical Journal of Pharmaceutical Research, 2025, v. 24, n. 4, p. 493, doi. 10.4314/tjpr.v24i4.6

By:

San Li;
Hui-Ming Dang;
Shan Xu;
Lei Liu;
Yi-gang Tong

Publication type:

Article

Reproducibility of genetic risk factors identified for long COVID using combinatorial analysis across US and UK patient cohorts with diverse ancestries.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06535-x

By:

Sardell, J.;
Pearson, M.;
Chocian, K.;
Das, S.;
Taylor, K.;
Strivens, M.;
Gupta, R.;
Rochlin, A.;
Gardner, S.

Publication type:

Article

INSILICO PREDICTION OF ANTI-INFLAMMATORY POTENTIAL OF BENZIMIDAZOLE BASED ANALOGUES AGAINST FATTY ACID AMIDE HYDROLASE.

Published in:

Biochemical & Cellular Archives, 2025, v. 25, n. 1, p. 587, doi. 10.51470/bca.2025.25.1.587

By:

Surana, Khemchand R.;
Sonawane, Vijayraj N.;
Fakir, Jubershaha S.;
Patil, Vinod R.;
Sharma, Yogesh P.;
Ahamad, Ayaz A.

Publication type:

Article

Finding patterns in lung cancer protein sequences for drug repurposing.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0322546

By:

Otero-Carrasco, Belén;
Nevado, Paloma Tejera;
Muñoz, Rafael Artiñano;
Ferreiro, Gema Díaz;
Pérez, Aurora Pérez;
Caraça-Valente Hernández, Juan Pedro;
Rodríguez-González, Alejandro

Publication type:

Article

Structural Insights and Drug Repurposing of FDA-Approved Molecules against Human Agmatinase in Cancer Therapy.

Published in:

Journal of Computational Biophysics & Chemistry, 2025, v. 24, n. 6, p. 767, doi. 10.1142/S2737416524500820

By:

Khan, Zeeshan;
Ikram, Saima;
Ahmad, Jamshaid;
Ur Rehman, Irshad;
Ahsan, Hina;
Ullah, Amin;
Alshaya, Dalal Sulaiman;
Fayad, Eman;
Hassan, Hesham M.;
Eldeen, Muhammad Alaa

Publication type:

Article

Novel target identification towards drug repurposing based on biological activity profiles.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0319865

By:

Xue, Binghan;
Xu, Yanji;
Huang, Ruili;
Zhu, Qian

Publication type:

Article

Relational similarity-based graph contrastive learning for DTI prediction.

Published in:

Briefings in Bioinformatics, 2025, v. 26, n. 2, p. 1, doi. 10.1093/bib/bbaf122

By:

Bian, Jilong;
Lu, Hao;
Wei, Limin;
Li, Yang;
Wang, Guohua

Publication type:

Article

GiGs: graph-based integrated Gaussian kernel similarity for virus–drug association prediction.

Published in:

Briefings in Bioinformatics, 2025, v. 26, n. 2, p. 1, doi. 10.1093/bib/bbaf117

By:

Jin, Yixuan;
Huang, Juanjuan;
Sun, Xu;
Fang, Yabo;
Wu, Jiageng;
Du, Jianshi;
Jia, Jiwei;
Wang, Guoqing

Publication type:

Article

Drug repurposing a compelling cancer strategy with bottomless opportunities: Recent advancements in computational methods and molecular mechanisms.

Published in:

Indian Journal of Pharmacology, 2023, v. 55, n. 5, p. 322, doi. 10.4103/ijp.ijp_626_22

By:

Dash, Rasmita;
Yadav, Madhulika;
Biswal, Jyotirmaya;
Samanta, Shrabani;
Sharma, Tripti;
Mohapatra, Sujata

Publication type:

Article

SS-DTI: A deep learning method integrating semantic and structural information for drug-target interaction prediction.

Published in:

Journal of Bioinformatics & Computational Biology, 2025, v. 23, n. 1, p. 1, doi. 10.1142/S0219720025500027

By:

Chun, Yujie;
Li, Huaihu;
Wang, Shunfang

Publication type:

Article

Drug repurposing for non-small cell lung cancer by predicting drug response using pathway-level graph convolutional network.

Published in:

Journal of Bioinformatics & Computational Biology, 2025, v. 23, n. 1, p. 1, doi. 10.1142/S0219720025500015

By:

Anjusha, I. T.;
Abdul Nazeer, K. A.;
Saleena, N.

Publication type:

Article

ASAP-DTA: Predicting drug-target binding affinity with adaptive structure aware networks.

Published in:

Journal of Bioinformatics & Computational Biology, 2024, v. 22, n. 6, p. 1, doi. 10.1142/S0219720024500288

By:

Ding, Weibin;
Jiang, Shaohua;
Xu, Ting;
Lyu, Zhijian

Publication type:

Article

Facilitating the drug repurposing with iC/E strategy: A practice on novel nNOS inhibitor discovery.

Published in:

Journal of Bioinformatics & Computational Biology, 2023, v. 21, n. 4, p. 1, doi. 10.1142/S021972002350018X

By:

Hu, Zhaoyang;
Liu, Qingsen;
Ni, Zhong

Publication type:

Article

Differential DNA Recognitions of Benzimidazole Based Astemizole, Omeprazole, Lansoprazole, and Thiabendazole.

Published in:

Macromolecular Symposia, 2024, v. 413, n. 1, p. 1, doi. 10.1002/masy.202300137

By:

Sur, Souvik

Publication type:

Article

Non‐Medical Applications of Inorganic Medicines. A Switch Based on Mechanistic Knowledge.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 60, p. 1, doi. 10.1002/chem.202402647

By:

Cirri, Damiano;
Di Leo, Riccardo;
Chiaverini, Lorenzo;
Tolbatov, Iogann;
Marrone, Alessandro;
Messori, Luigi;
Pratesi, Alessandro;
La Mendola, Diego;
Marzo, Tiziano

Publication type:

Article

Emerging therapeutic strategies in glioblastsoma: drug repurposing, mechanisms of resistance, precision medicine, and technological innovations.

Published in:

Clinical & Experimental Medicine, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10238-025-01631-0

By:

Anwer, Mohamed S.;
Abdel-Rasol, Mohammed A.;
El-Sayed, Wael M.

Publication type:

Article

Drug repositioning: a brief overview.

Published in:

Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 11, p. 1145, doi. 10.1111/jphp.13273

By:

Jourdan, Jean-Pierre;
Bureau, Ronan;
Rochais, Christophe;
Dallemagne, Patrick

Publication type:

Article

REPURPOSING EMPAGLIFLOZIN TO TREAT NEUTROPENIA IN A TURKISH GIRL WITH GLYCOGEN STORAGE DISEASE TYPE 1B.

Published in:

Turkish Medical Student Journal, 2024, v. 11, n. 2, p. 50, doi. 10.4274/tmsj.galenos.2024.2024-2-1

By:

Özkan, Hasan Selçuk;
Aydın, Ece Derin;
Mammadova, Sakina;
Çoker, Mahmut

Publication type:

Article

The intersection of artificial intelligence and big data in drug discovery: A review of current trends and future implications.

Published in:

Matrix Science Pharma, 2023, v. 7, n. 2, p. 36, doi. 10.4103/mtsp.mtsp_14_23

By:

Ashiwaju, Bankole;
Orikpete, Ochuko;
Uzougbo, Chinedum

Publication type:

Article

C9orf72 dipeptides activate the NLRP3 inflammasome.

Published in:

Brain Communications, 2024, v. 6, n. 5, p. 1, doi. 10.1093/braincomms/fcae282

By:

Rivers-Auty, Jack;
Hoyle, Christopher;
Pointer, Ayesha;
Lawrence, Catherine;
Pickering-Brown, Stuart;
Brough, David;
Ryan, Sarah

Publication type:

Article

Repurposing the mucolytic agent ambroxol for treatment of sub-acute and chronic ischaemic stroke.

Published in:

Brain Communications, 2023, v. 5, n. 2, p. 1, doi. 10.1093/braincomms/fcad099

By:

Patzwaldt, Kristin;
Berezhnoy, Georgy;
Ionescu, Tudor;
Schramm, Linda;
Yi Wang;
Owczorz, Miriam;
Calderón, Eduardo;
Poli, Sven;
Higuita, Lina M. Serna;
Gonzalez-Menendez, Irene;
Quintanilla-Martinez, Leticia;
Herfert, Kristina;
Pichler, Bernd;
Trautwein, Christoph;
Castaneda-Vega, Salvador

Publication type:

Article

No association between initiation of phosphodiesterase-5 inhibitors and risk of incident Alzheimer's disease and related dementia: results from the Drug Repurposing for Effective Alzheimer's Medicines study.

Published in:

Brain Communications, 2022, v. 4, n. 5, p. 1, doi. 10.1093/braincomms/fcac247

By:

Desai, Rishi J.;
Mahesri, Mufaddal;
Su Been Lee;
Varma, Vijay R.;
Loeffler, Tina;
Schilcher, Irene;
Gerhard, Tobias;
Segal, Jodi B.;
Ritchey, Mary E.;
Horton, Daniel B.;
Kim, Seoyoung C.;
Schneeweiss, Sebastian;
Thambisetty, Madhav

Publication type:

Article

Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency.

Published in:

NPJ Precision Oncology, 2022, v. 6, n. 1, p. 1, doi. 10.1038/s41698-022-00326-z

By:

Chabot, Thomas;
Nemati, Fariba;
Herbette, Aurélie;
Demeyer, Alexandre;
Dayot, Stéphane;
Ganier, Olivier;
Alsafadi, Samar;
Gardrat, Sophie;
Mariani, Pascale;
Luporsi, Marie;
Corbé, Maxime;
Servois, Vincent;
Cassoux, Nathalie;
Decaudin, Didier;
Roman, Sergio Roman;
Del Nery, Elaine;
Piperno-Neumann, Sophie;
Stern, Marc-Henri;
Rodrigues, Manuel

Publication type:

Article

Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus.

Published in:

Therapeutic Advances in Vaccines & Immunotherapy, 2022, v. 10, p. 1, doi. 10.1177/25151355221144845

By:

Oliver, Josidel Conceição;
Silva, Evandro Neves;
Soares, Letícia Martins;
Scodeler, Gislaine Cristina;
Santos, Ana de Souza;
Corsetti, Patrícia Paiva;
Prudêncio, Carlos Roberto;
de Almeida, Leonardo Augusto

Publication type:

Article

Desloratadine via its anti-inflammatory and antioxidative properties ameliorates TNBS-induced experimental colitis in rats.

Published in:

Immunopharmacology & Immunotoxicology, 2024, v. 46, n. 4, p. 436, doi. 10.1080/08923973.2024.2360043

By:

Bhat, Mohammad Aadil;
Roy, Supriya;
Dhaneshwar, Suneela;
Kumar, Swatantra;
Saxena, Shailendra K.

Publication type:

Article

"Drug Repurposing" Policies and Statutes: Lessons from the COVID-19 Pandemic: A Review.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2023, v. 57, n. 1, p. 301, doi. 10.5530/001954641939

By:

Ravi, Srividya;
Jadhav, Sammita;
Ghooi, Ravindra

Publication type:

Article

Validation of Rapid and Simple HPLC-UV Method for Diflunisal Determination in Bulk Drug and Human Plasma.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2023, v. 57, n. 1, p. 278, doi. 10.5530/001954641926

By:

Smerikarova, Miglena;
Bozhanov, Stanislav;
Maslarska, Vania

Publication type:

Article

Drug Repurposing: A Potentially Emerging Discipline.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2022, v. 56, p. S121, doi. 10.5530/ijper.56.2s.83

By:

Kumar, Praveen;
Mammen, Mariam;
Madhusoodhanan, Aswathy;
Mohanan, Archana Geetha;
Ravindrannair, Pradeep Kumar;
Kuttan, Anilkumar Appu;
Sathi, Sheeba Madhavan;
Steephan, Mathew

Publication type:

Article

Identification of Some DPP-4 Inhibitors Using QSAR Modeling Based Drug Repurposing Approach.

Published in:

Journal of Drug Delivery & Therapeutics, 2025, v. 15, n. 3, p. 53, doi. 10.22270/jddt.v15i3.7030

By:

Sonu;
Bhattacharya, Arijit;
Lal Kori, Mohan

Publication type:

Article

Consultant (Siddha), Siddha Clinical Research Unit, Ribandar, Goa.

Published in:

Journal of Drug Delivery & Therapeutics, 2025, v. 15, n. 3, p. 36, doi. 10.22270/jddt.v15i3.7029

By:

Sonu;
Lal Kori, Mohan

Publication type:

Article

Enhanced in vivo antimalarial activity of artemether by clotrimazole against drug-sensitive and resistant Plasmodium berghei.

Published in:

Journal of Drug Delivery & Therapeutics, 2025, v. 15, n. 3, p. 1, doi. 10.22270/jddt.v15i3.7007

By:

Kenechukwu, Franklin C.;
Okachi, Joshua C.;
Anikwe, Celestine C.;
Nwagwu, Chinekwu S.;
Odo, Bonaventure A.;
Odoh, Tochukwu;
Obila, Mary U.;
Nweke, Linda C.;
Nzekwe, Ezichim F.;
Ogbonna, Jude E.;
Nwobodo, Joy I.;
Nnamani, Daniel O.;
Ugwuoke, Wilfred I.;
Momoh, Mumuni A.;
Attama, Anthony A.

Publication type:

Article

In vitro investigation of antifungal efficacy of diclofenac sodium salt against Aspergillus spp. strains causing food spoilage: a drug repurposing approach.

Published in:

Journal of Drug Delivery & Therapeutics, 2025, v. 15, n. 2, p. 49, doi. 10.22270/jddt.v15i2.6994

By:

Kulkarni, Ruturaj;
Sawant, Anurag R.;
Jadhav, Atharva B.;
Chavan, Nikhil;
Jadhav, Mahadev A.;
Halbandge, Shivkrupa Devrao

Publication type:

Article

Repurposing drugs for solid tumor treatment: focus on immune checkpoint inhibitors.

Published in:

Cancer Biology & Medicine, 2023, v. 20, n. 11, p. 856, doi. 10.20892/j.issn.2095-3941.2023.0281

By:

Qingxu Liu;
Long Li;
Wan Qin;
Tengfei Chao

Publication type:

Article

Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network.

Published in:

Cancer Biology & Medicine, 2022, v. 19, n. 1, p. 74, doi. 10.20892/j.issn.2095-3941.2020.0218

By:

Xi Cheng;
Wensi Zhao;
Mengdi Zhu;
Bo Wang;
Xuege Wang;
Xiaoyun Yang;
Yuqi Huang;
Minjia Tan;
Jing Li

Publication type:

Article

Transcriptomic profiling of recessive dystrophic epidermolysis bullosa wounded skin highlights drug repurposing opportunities to improve wound healing.

Published in:

Experimental Dermatology, 2022, v. 31, n. 3, p. 420, doi. 10.1111/exd.14481

By:

Onoufriadis, Alexandros;
Proudfoot, Laura E.;
Ainali, Chrysanthi;
Torre, Denis;
Papanikolaou, Maria;
Rayinda, Tuntas;
Rashidghamat, Ellie;
Danarti, Retno;
Mellerio, Jemima E.;
Ma'ayan, Avi;
McGrath, John A.

Publication type:

Article