Works matching DE "DRUG metabolism"

Results: 5000

Polimorfismul genetic și farmacocinetica preparatelor antihipertensive.

Published in:

Farmacist.ro, 2025, v. 221, n. 2, p. 21

By:

Bacinschi, Nicolae;
Petrov, Cristina;
Bacinschi, Georgel;
Catcov, Carolina

Publication type:

Article

Cellular pharmacology of tenofovir alafenamide and emtricitabine in neutrophils and platelets in people with and without HIV.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2025, v. 80, n. 5, p. 1224, doi. 10.1093/jac/dkaf052

By:

Mainella, Vincent A;
Branchford, Brian;
Nemkov, Travis;
Hosford, Seth;
Coyle, Ryan P;
Johnson, Bethany;
Choi, Ye Ji;
Williams, Martin;
Zheng, Jia-Hua;
Bushman, Lane;
Kiser, Jennifer J;
Anderson, Peter L;
Brooks, Kristina M

Publication type:

Article

Opportunities and Challenges of Hepatic Impairment Physiologically Based Pharmacokinetic Modeling in Drug Development—An IQ Perspective.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 6, p. 1682, doi. 10.1002/cpt.3601

By:

Qosa, Hisham;
Younis, Islam R.;
Sahasrabudhe, Vaishali;
Sharma, Ashish;
Yan, Jin;
Galluppi, Gerald;
Posada, Maria M.;
Kanodia, Jitendra Shrawan

Publication type:

Article

Substance P release from rat dura mater is inversely correlated with CGRP release– experiments using glycerol trinitrate and anti-CGRP antibodies.

Published in:

Journal of Headache & Pain, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s10194-025-02050-y

By:

Dux, Mária;
Messlinger, Karl

Publication type:

Article

Progress of arylacetamide deacetylase research in metabolic diseases.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1564419

By:

Yang, Liu;
Liao, Zhe-Zhen;
Ran, Li;
Xiao, Xin-Hua

Publication type:

Article

Development and Characterization of pFluor50, a Fluorogenic-Based Kinetic Assay System for High-Throughput Inhibition Screening and Characterization of Time-Dependent Inhibition and Inhibition Type for Six Human CYPs.

Published in:

Molecules, 2025, v. 30, n. 9, p. 2032, doi. 10.3390/molecules30092032

By:

Shriwas, Pratik;
Revnew, Andre;
Roo, Sarah;
Bender, Alex;
Miller, Kevin;
Hadad, Christopher M.;
Lane, Thomas R.;
Ekins, Sean;
McElroy, Craig A.

Publication type:

Article

INVESTIGATING THE ROLE OF GUT MICROBIOTA IN THE METABOLISM OF ATORVASTATIN FOR HYPERLIPIDEMIA MANAGEMENT.

Published in:

Biochemical & Cellular Archives, 2025, v. 25, n. 1, p. 853, doi. 10.51470/bca.2025.25.1.853

By:

Kriti, Komal;
Bhoi, Mitul;
Muztaba, Mohammad;
Kulkarni, Yogesh P.;
Sebastian, Shyaleen Rose;
Kumar, Nilesh;
Jayasree, N.;
Geetha, V.

Publication type:

Article

Wilhelm Keller MD (1818–1877) and the emergence of xenobiochemistry.

Published in:

Journal of Medical Biography, 2025, v. 33, n. 2, p. 116, doi. 10.1177/09677720241273694

By:

Mitchell, Stephen;
Waring, Rosemary

Publication type:

Article

Unmasking the relationship between CGRP and glutamate: from peripheral excitation to central sensitization in migraine.

Published in:

Journal of Headache & Pain, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s10194-025-02043-x

By:

Martami, Fahimeh;
Holton, Kathleen F.

Publication type:

Article

Genetic determinants of paclitaxel-induced peripheral neuropathy: a review of current literature.

Published in:

Drug Metabolism Reviews, 2025, v. 57, n. 2, p. 190, doi. 10.1080/03602532.2025.2485055

By:

Sivadas, Swathi Krishna;
Das, Aiswarya;
Vijayakumar, Nandana;
Shaji, Nandana;
Mangalath, Sabitha;
Pavithran, Keechilat;
Biswas, Lalitha

Publication type:

Article

Scaling factors to inform in vitro-in vivo extrapolation from preclinical and livestock animals: state of the field and recommendations for development of missing data.

Published in:

Drug Metabolism Reviews, 2025, v. 57, n. 2, p. 91, doi. 10.1080/03602532.2025.2462527

By:

Zimmer, Austin A.;
Collier, Abby C.

Publication type:

Article

Artificial intelligence to predict inhibitors of drug-metabolizing enzymes and transporters for safer drug design.

Published in:

Expert Opinion on Drug Discovery, 2025, v. 20, n. 5, p. 621, doi. 10.1080/17460441.2025.2491669

By:

Bhattacharjee, Arnab;
Kumar, Ankur;
Ojha, Probir Kumar;
Kar, Supratik

Publication type:

Article

Food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinoma.

Published in:

Contemporary Oncology / Współczesna Onkologia, 2025, v. 29, n. 1, p. 1, doi. 10.5114/wo.2025.148229

By:

Sałek-Zań, Agata;
Püsküllüoğlu, Mirosława;
Syrek-Kaplita, Karolina;
Banaś, Tomasz

Publication type:

Article

Investigation of in vitro absorption, distribution, metabolism, and excretion and in vivo pharmacokinetics of paromomycin: Influence on oral bioavailability.

Published in:

Indian Journal of Pharmacology, 2017, v. 49, n. 4, p. 297, doi. 10.4103/ijp.IJP_651_16

By:

M. Jakir S. K. Pinjari;
Somani, Rahul;
Gilhotra, Ritu M.

Publication type:

Article

Comparative bioavailability of three oral formulations of sustained release theophylline in healthy human subjects.

Published in:

Indian Journal of Pharmacology, 2004, v. 36, n. 1, p. 29

By:

Parvez, N.;
Ahmed, T.;
Monif, T.;
Saha, N.;
Sharma, P.L.

Publication type:

Article

Turning Theory into Practice: The Development of Modern Transdermal Drug Delivery Systems and Future Trends.

Published in:

Skin Pharmacology & Physiology, 2013, v. 26, n. 4-6, p. 331, doi. 10.1159/000351815

By:

Perumal, O.;
Murthy, S.N.;
Kalia, Y.N.

Publication type:

Article

Cutaneous in vivo Metabolism of Topical Lidocaine Formulation in Human Skin.

Published in:

Skin Pharmacology & Physiology, 2009, v. 22, n. 3, p. 124, doi. 10.1159/000189800

By:

K. Rolsted;
E. Benfeldt;
A.-M. Kissmeyer;
G.M. Rist;
S.H. Hansen

Publication type:

Article

Estimated impact of tafenoquine for Plasmodium vivax control and elimination in Brazil: A modelling study.

Published in:

2021

By:

Nekkab, Narimane;
Lana, Raquel;
Lacerda, Marcus;
Obadia, Thomas;
Siqueira, André;
Monteiro, Wuelton;
Villela, Daniel;
Mueller, Ivo;
White, Michael

Publication type:

journal article

Knowledge-driven approaches for the guidance of first-in-children dosing.

Published in:

Pediatric Anesthesia, 2011, v. 21, n. 3, p. 206, doi. 10.1111/j.1460-9592.2010.03473.x

By:

Edginton, Andrea N.

Publication type:

Article

Diclofenac pharmacokinetic meta-analysis and dose recommendations for surgical pain in children aged 1-12 years.

Published in:

Pediatric Anesthesia, 2011, v. 21, n. 3, p. 316, doi. 10.1111/j.1460-9592.2010.03509.x

By:

Standing, Joseph F.;
Tibboel, Dick;
Korpela, Reijo;
Olkkola, Klaus T.

Publication type:

Article

Age and size are the major covariates for prediction of levobupivacaine clearance in children.

Published in:

Pediatric Anesthesia, 2006, v. 16, n. 3, p. 275, doi. 10.1111/j.1460-9592.2005.01778.x

By:

Chalkiadis, George A.;
Anderson, Brian J.

Publication type:

Article

Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysis.

Published in:

Pediatric Anesthesia, 2005, v. 15, n. 4, p. 282, doi. 10.1111/j.1460-9592.2005.01455.x

By:

Anderson, Brian J.;
Pons, Gerard;
Autret-Leca, Elisabeth;
Allegaert, Karel;
Boccard, Eric

Publication type:

Article

Clinical guideline: antiepileptic drugs of choice for epileptic syndromes and epilepsies in pediatric patients.

Published in:

Revista Mexicana de Neurociencia, 2019, v. 20, n. 2, p. 89, doi. 10.24875/RMN.M19000028

By:

Reséndiz-Aparicio, Juan C.;
Padilla-Huicab, Jesús M.;
Martínez-Juárez, Iris E.;
Hernández-Martínez, Gustavo;
López-Correa, Eunice;
Vázquez-Juárez, Benjamín;
Huerta-Albarrán, Rosana;
Rivera-Acuña, Claudia

Publication type:

Article

Pharmacokinetics of drospirenone and ethinylestradiol in Caucasian and Japanese women.

Published in:

European Journal of Contraception & Reproductive Health Care, 2012, v. 17, n. 4, p. 284, doi. 10.3109/13625187.2012.677076

By:

Blode, Hartmut;
Kowal, Kristin;
Roth, Katrin;
Reif, Stefanie

Publication type:

Article

TRANSFER LEARNING FOR CYTOCHROME P450 ISOZYME SELECTIVITY PREDICTION.

Published in:

Journal of Bioinformatics & Computational Biology, 2011, v. 9, n. 4, p. 521, doi. 10.1142/S0219720011005434

By:

TERAMOTO, REIJI;
KATO, TSUYOSHI

Publication type:

Article

Evaluation of hepatic drug-metabolism for glioblastoma using liver-brain chip.

Published in:

Biotechnology Letters, 2021, v. 43, n. 2, p. 383, doi. 10.1007/s10529-020-03043-4

By:

Li, Zhongyu;
Li, Dong;
Guo, Yaqiong;
Wang, Yaqing;
Su, Wentao

Publication type:

Article

Drug metabolism in microorganisms.

Published in:

Biotechnology Letters, 2015, v. 37, n. 1, p. 19, doi. 10.1007/s10529-014-1653-8

By:

Murphy, Cormac

Publication type:

Article

Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species.

Published in:

Biotechnology Letters, 2011, v. 33, n. 2, p. 321, doi. 10.1007/s10529-010-0425-3

By:

Amadio, Jessica;
Murphy, Cormac D.

Publication type:

Article

Modulating the pharmacokinetics of therapeutic antibodies.

Published in:

Biotechnology Letters, 2010, v. 32, n. 5, p. 609, doi. 10.1007/s10529-010-0214-z

By:

Constantinou, A.;
Chen, C.;
Deonarain, M.

Publication type:

Article

Effect of polymorphisms on the pharmacokinetics, pharmacodynamics, and safety of risperidone in healthy volunteers.

Published in:

Human Psychopharmacology: Clinical & Experimental, 2014, v. 29, n. 5, p. 459, doi. 10.1002/hup.2420

By:

Cabaleiro, Teresa;
Ochoa, Dolores;
López‐Rodríguez, Rosario;
Román, Manuel;
Novalbos, Jesús;
Ayuso, Carmen;
Abad‐Santos, Francisco

Publication type:

Article

Plasma fluvoxamine levels and OCD symptoms/response in adult patients.

Published in:

Human Psychopharmacology: Clinical & Experimental, 2012, v. 27, n. 4, p. 397, doi. 10.1002/hup.2240

By:

Marazziti, Donatella;
Baroni, Stefano;
Giannaccini, Gino;
Piccinni, Armando;
Picchetti, Michela;
Massimetti, Gabriele;
Schiavi, Elisa;
Palego, Lionella;
Catena-Dell'Osso, Mario

Publication type:

Article

Human Gut Microbiota and Drug Metabolism.

Published in:

Microbial Ecology, 2023, v. 86, n. 1, p. 97, doi. 10.1007/s00248-022-02081-x

By:

Pant, Archana;
Maiti, Tushar K.;
Mahajan, Dinesh;
Das, Bhabatosh

Publication type:

Article

Critical role of natural killer cells in the rejection of human hepatocytes after xenotransplantation into immunodeficient mice.

Published in:

Transplant International, 2010, v. 23, n. 9, p. 934, doi. 10.1111/j.1432-2277.2010.01063.x

By:

Kawahara, Toshiyasu;
Douglas, Donna N.;
Lewis, Jamie;
Lund, Garry;
Addison, William;
Tyrrell, David Lorne;
Churchill, Thomas A.;
Kneteman, Norman M.

Publication type:

Article

Drug transporters in pharmacokinetics.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2006, v. 372, n. 6, p. 465, doi. 10.1007/s00210-006-0042-9

By:

Petzinger, Ernst;
Geyer, Joachim

Publication type:

Article

A phase I trial and PK study of cediranib (AZD2171), an orally bioavailable pan-VEGFR inhibitor, in children with recurrent or refractory primary CNS tumors.

Published in:

Child's Nervous System, 2015, v. 31, n. 9, p. 1433, doi. 10.1007/s00381-015-2812-5

By:

Kieran, Mark;
Chi, Susan;
Goldman, Stewart;
Onar-Thomas, Arzu;
Poussaint, Tina;
Vajapeyam, Sridhar;
Fahey, Frederic;
Wu, Shengjie;
Turner, David;
Stewart, Clinton;
Moses, Marsha;
Packer, Roger;
Jakacki, Regina;
Banerjee, Anu;
Boyett, James;
Fouladi, Maryam;
Kun, Larry

Publication type:

Article

Pharmacokinetics, metabolism and excretion of [C]-lenalidomide following oral administration in healthy male subjects.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 3, p. 789, doi. 10.1007/s00280-011-1760-3

By:

Chen, Nianhang;
Wen, Lian;
Lau, Henry;
Surapaneni, Sekhar;
Kumar, Gondi

Publication type:

Article

Physiologically based pharmacokinetic modelling of high- and low-dose etoposide: from adults to children.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 2, p. 397, doi. 10.1007/s00280-011-1706-9

By:

Kersting, Gisela;
Willmann, Stefan;
Würthwein, Gudrun;
Lippert, Jörg;
Boos, Joachim;
Hempel, Georg

Publication type:

Article

Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 4, p. 1093, doi. 10.1007/s00280-011-1715-8

By:

Weiss, Johanna;
Haefeli, Walter

Publication type:

Article

Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 2, p. 513, doi. 10.1007/s00280-010-1518-3

By:

Jia, Lee;
Gorman, Gregory;
Coward, Lori;
Noker, Patricia;
McCormick, David;
Horn, Thomas;
Harder, J.;
Muzzio, Miguel;
Prabhakar, Bellur;
Ganesh, Balaji;
Das Gupta, Tapas;
Beattie, Craig

Publication type:

Article

A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 67, n. 3, p. 503, doi. 10.1007/s00280-010-1343-8

By:

Ramanathan, Ramesh;
Abbruzzese, James;
Dragovich, Tomislav;
Kirkpatrick, Lynn;
Guillen, Jose;
Baker, Amanda;
Pestano, Linda;
Green, Sylvan;
Hoff, Daniel

Publication type:

Article

Pretreatment with anti-oxidants sensitizes oxidatively stressed human cancer cells to growth inhibitory effect of suberoylanilide hydroxamic acid (SAHA).

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 67, n. 3, p. 705, doi. 10.1007/s00280-010-1364-3

By:

Basu, Hirak;
Mahlum, Amy;
Mehraein-Ghomi, Farideh;
Kegel, Stacy;
Guo, Song;
Peters, Noel;
Wilding, George

Publication type:

Article

Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3′,4′,5′,5,7-pentamethoxyflavone and tricin (4′,5,7-trihydroxy-3′,5′-dimethoxyflavone).

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 67, n. 2, p. 255, doi. 10.1007/s00280-010-1313-1

By:

Cai, Hong;
Sale, Stewart;
Britton, Robert;
Brown, Karen;
Steward, William;
Gescher, Andreas

Publication type:

Article

Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 67, n. 2, p. 421, doi. 10.1007/s00280-010-1337-6

By:

Beumer, Jan;
Eiseman, Julie;
Gilbert, Judith;
Holleran, Julianne;
Yellow-Duke, Archibong;
Clausen, Dana;
D'Argenio, David;
Ames, Matthew;
Hershberger, Pamela;
Parise, Robert;
Bai, Lihua;
Covey, Joseph;
Egorin, Merrill

Publication type:

Article

The maximum tolerated dose and biologic effects of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) in combination with irinotecan for patients with refractory solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 5, p. 973, doi. 10.1007/s00280-010-1250-z

By:

Choi, Brian S.;
Alberti, Dona B.;
Schelman, William R.;
Kolesar, Jill M.;
Thomas, James P.;
Marnocha, Rebecca;
Eickhoff, Jens C.;
Ivy, S. Percy;
Wilding, George;
Holen, Kyle D.

Publication type:

Article

Pharmacokinetics of sunitinib malate in subjects with hepatic impairment.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 4, p. 699, doi. 10.1007/s00280-009-1213-4

By:

Bello, Carlo L.;
Garrett, May;
Sherman, Laurie;
Smeraglia, John;
Ryan, Bob;
Toh, Melvin

Publication type:

Article

The effects of drug transporter inhibitors on the pharmacokinetics and tissue distribution of methotrexate in normal and tumor-bearing mice: a microdialysis study.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 1, p. 159, doi. 10.1007/s00280-009-1146-y

By:

Sani, Shabnam N.;
Henry, Katherine;
Böhlke, Mark;
Kim, Jonghan;
Stricker-Krongrad, Alain;
Maher, Timothy J.

Publication type:

Article

A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer.

Published in:

2010

By:

Rathkopf, Dana;
Wong, Bryan Y.;
Ross, Robert W.;
Anand, Aseem;
Tanaka, Erika;
Woo, Margaret M.;
Hu, Jing;
Dzik-Jurasz, Andy;
Yang, Wei;
Howard I. Scher

Publication type:

Report

Population pharmacokinetic study of a test dose oral busulfan in Japanese adult patients undergoing hematopoietic stem cell transplantation.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 65, n. 6, p. 1203, doi. 10.1007/s00280-010-1263-7

By:

Takamatsu, Yasushi;
Sasaki, Noriaki;
Ogata, Kentaro;
Yukawa, Eiji;
Jimi, Shiro;
Hara, Shuuji;
Tamura, Kazuo

Publication type:

Article

The effect of transcatheter arterial chemoembolization on phase II drug metabolism enzymes in patients with hepatocellular carcinoma.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 65, n. 2, p. 347, doi. 10.1007/s00280-009-1040-7

By:

Yan Zhang;
Yanyan Jia;
Xinyou Liu;
Linna Liu;
Qingwei Wang;
Aidong Wen

Publication type:

Article

Pharmacokinetics of temozolomide administered in combination with O<sup>6</sup>-benzylguanine in children and adolescents with refractory solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2009, v. 65, n. 1, p. 137, doi. 10.1007/s00280-009-1015-8

By:

Meany, Holly J.;
Warren, Katherine E.;
Fox, Elizabeth;
Cole, Diane E.;
Aikin, Alberta A.;
Balis, Frank M.

Publication type:

Article