Works matching DE "DRUG lipophilicity"

Results: 689

Fluorine in the Pharmaceutical Industry: FDA‐Approved Fluorine‐Containing Drugs in 2024.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 25, p. 1, doi. 10.1002/chem.202500662

By:

Du, Youlong;
Bian, Yeping;
Baecker, Daniel;
Dhawan, Gagan;
Semghouli, Anas;
Kiss, Loránd;
Zhang, Wei;
Sorochinsky, Alexander E.;
Soloshonok, Vadim A.;
Han, Jianlin

Publication type:

Article

In-vitro red blood cell partitioning of doxycycline.

Published in:

Indian Journal of Pharmacology, 2009, v. 41, n. 4, p. 173, doi. 10.4103/0253-7613.56073

By:

Deshmukh, P. V.;
Badgujar, P. C.;
Gatne, M. M.

Publication type:

Article

Study of the Influence of the Penetration Enhancer Isopropyl Myristate on the Nanostructure of Stratum Corneum Lipid Model Membranes Using Neutron Diffraction and Deuterium Labelling.

Published in:

Skin Pharmacology & Physiology, 2012, v. 25, n. 4, p. 200, doi. 10.1159/000338538

By:

Engelbrecht, T.N.;
Demé, B.;
Dobner, B.;
Neubert, R.H.H.

Publication type:

Article

Interaction of Epicutaneously Applied Lipids with Stratum Corneum Depends on the Presence of either Emulsifiers or Hydrogenated Phosphatidylcholine.

Published in:

Skin Pharmacology & Physiology, 2010, v. 23, n. 6, p. 298

By:

KlapperstÃ¼ck, Wohlrab;
Albrecht, Reinhardt

Publication type:

Article

The PhenionÂ® Full-Thickness Skin Model for Percutaneous Absorption Testing.

Published in:: Skin Pharmacology & Physiology, 2010, v. 23, n. 2, p. 105, doi. 10.1159/000265681
Publication type:: Article

New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum

Published in:

Natural Product Research, 2006, v. 20, n. 11, p. 985, doi. 10.1080/14786410600921466

By:

Li, Canjun;
Li, Yiming;
Sun, Hao H.

Publication type:

Article

Ganoderic acid Sz, a new lanostanoid from the mushroom Ganoderma lucidum.

Published in:

Natural Product Research, 2005, v. 19, n. 5, p. 461, doi. 10.1080/14786410412331272077

By:

Li, Canjun;
Yin, Jianhua;
Guo, Fujiang;
Zhang, Decheng;
Sun, Hao H.

Publication type:

Article

Determination of lipophilic descriptors of antihelmintic 6,7-diaryl-pteridine derivatives useful for bioactivity predictions.

Published in:

Biomedical Chromatography, 2003, v. 17, n. 6, p. 365, doi. 10.1002/bmc.227

By:

Mario Reta;
Liliana Giacomelli;
Marisa Santo;
Rosa Cattana;
Juana J Silber;
Carmen Ochoa;
Mercedes Rodriguez;
Antonia Chana

Publication type:

Article

Estimation of the lipophilicity of antiarrhythmic and antihypertensive active 1-substituted pyrrolidin-2-one and pyrrolidine derivatives.

Published in:

Biomedical Chromatography, 2003, v. 17, n. 5, p. 318, doi. 10.1002/bmc.246

By:

Katarzyna Kulig;
Barbara Malawska

Publication type:

Article

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2003, v. 367, n. 3, p. 318, doi. 10.1007/s00210-002-0669-0

By:

De Luca, Annamaria;
Talon, Sophie;
De Bellis, Michela;
Desaphy, Jean-François;
Franchini, Carlo;
Lentini, Giovanni;
Catalano, Alessia;
Corbo, Filomena;
Tortorella, Vincenzo;
Conte-Camerino, Diana

Publication type:

Article

Liposome formulation of a novel hydrophobic aryl-imidazole compound for anti-cancer therapy.

Published in:

Cancer Chemotherapy & Pharmacology, 2006, v. 58, n. 3, p. 306, doi. 10.1007/s00280-005-0161-x

By:

Jubo Liu;
Lee, Helen;
Huesca, Mario;
Young, Aiping;
Allen, Christine

Publication type:

Article

Antimetastatic effect of a lipophilic ascorbic acid derivative with antioxidation through inhibition of tumor invasion.

Published in:

Cancer Chemotherapy & Pharmacology, 2006, v. 57, n. 5, p. 584, doi. 10.1007/s00280-005-0073-9

By:

Jianwen Liu;
Xiaodong Zhang;
Fan Yang;
Ting Li;
Dongzhi Wei;
Yuhong Ren

Publication type:

Article

Toward molecular imaging of the free fatty acid receptor 1.

Published in:

Acta Diabetologica, 2017, v. 54, n. 7, p. 663, doi. 10.1007/s00592-017-0989-7

By:

Hellström-Lindahl, Ewa;
Åberg, Ola;
Ericsson, Cecilia;
O'mahony, Gavin;
Johnström, Peter;
Skrtic, Stanko;
Eriksson, Olof

Publication type:

Article

Efficacy of renin-angiotensin system (RAS) blockers on cardiovascular and renal outcomes in patients with type 2 diabetes.

Published in:

Acta Diabetologica, 2012, v. 49, n. 4, p. 243, doi. 10.1007/s00592-011-0328-3

By:

Cao, Zemin;
Cooper, Mark

Publication type:

Article

Lipophilicity and hydrophobicity considerations in bio‐enabling oral formulations approaches – a PEARRL review.

Published in:

Journal of Pharmacy & Pharmacology, 2019, v. 71, n. 4, p. 464, doi. 10.1111/jphp.12984

By:

Ditzinger, Felix;
Price, Daniel J.;
Ilie, Alexandra‐Roxana;
Köhl, Niklas J.;
Jankovic, Sandra;
Tsakiridou, Georgia;
Aleandri, Simone;
Kalantzi, Lida;
Holm, René;
Nair, Anita;
Saal, Christoph;
Griffin, Brendan;
Kuentz, Martin

Publication type:

Article

Development and characterization of a novel lipohydrogel nanocarrier: repaglinide as a lipophilic model drug.

Published in:

Journal of Pharmacy & Pharmacology, 2016, v. 68, n. 4, p. 450, doi. 10.1111/jphp.12537

By:

Ebrahimi, Hossein Ali;
Javadzadeh, Yousef;
Hamidi, Mehrdad;
Barzegar Jalali, Mohammad

Publication type:

Article

Identification of key factors affecting the oral absorption of salts of lipophilic weak acids: a case example.

Published in:

Journal of Pharmacy & Pharmacology, 2015, v. 67, n. 1, p. 56, doi. 10.1111/jphp.12320

By:

Petrakis, Orestis;
Vertzoni, Maria;
Angelou, Alexandros;
Kesisoglou, Filippos;
Bentz, Kimberly;
Goumas, Konstantinos;
Reppas, Christos

Publication type:

Article

The influence of intestinal lymphatic transport on the systemic exposure and brain deposition of a novel highly lipophilic compound with structural similarity to cholesterol.

Published in:

Journal of Pharmacy & Pharmacology, 2014, v. 66, n. 10, p. 1377, doi. 10.1111/jphp.12268

By:

Caliph, Suzanne M.;
Faassen, Fried W.;
Porter, Christopher J. H.

Publication type:

Article

Relationship between lipophilicity and absorption from the liver surface of paraben derivatives and antipyrine in rats.

Published in:

Journal of Pharmacy & Pharmacology, 2011, v. 63, n. 5, p. 736, doi. 10.1111/j.2042-7158.2011.01276.x

By:

Nishida, Koyo;
Kobayashi, Masanori;
Miyamoto, Hirotaka;
Yoshikawa, Naoki;
Fumoto, Shintaro;
Sasaki, Hitoshi;
Nakamura, Junzo

Publication type:

Article

Enhanced oral bioavailability of etodolac by self-emulsifying systems: in-vitro and in-vivo evaluation.

Published in:

Journal of Pharmacy & Pharmacology, 2010, v. 62, n. 2, p. 173, doi. 10.1211/jpp.62.02.0004

By:

Barakat, Nahla S.

Publication type:

Article

A bioassay for mosquito repellency against Aedes aegypti: method validation and bioactivities of DEET analogues.

Published in:

Journal of Pharmacy & Pharmacology, 2010, v. 62, n. 1, p. 91, doi. 10.1211/jpp.62.01.0010

By:

Jahn, Alexander;
Kim, Seok Yong;
Choi, Joon-Ho;
Kim, Dae-Duk;
Ahn, Young-Joon;
Yong, Chul Soon;
Kim, Jung Sun

Publication type:

Article

The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons.

Published in:

Journal of Pharmacy & Pharmacology, 2009, v. 61, n. 1, p. 31, doi. 10.1211/jpp.61.01.0005

By:

Pavel Gershkovich;
Joseph Fanous;
Bashir Qadri;
Avihai Yacovan;
Shimon Amselem;
Amnon Hoffman

Publication type:

Article

An evaluation of the relative roles of the unstirred water layer and receptor sink in limiting the in-vitro intestinal permeability of drug compounds of varying lipophilicity.

Published in:

Journal of Pharmacy & Pharmacology, 2008, v. 60, n. 10, p. 1311, doi. 10.1211/jpp.60.10.0007

By:

Kasiram Katneni;
Susan A. Charman;
Christopher J. H. Porter

Publication type:

Article

Synthesis and binding profile of constrained analogues of N-[4-(4-arylpiperazin-1-yl)butyl]-3-methoxybenzamides, a class of potent dopamine D3 receptor ligands.

Published in:

Journal of Pharmacy & Pharmacology, 2006, v. 58, n. 2, p. 209

By:

Marcello Leopoldo;
Enza Lacivita;
Nicola A. Colabufo;
Francesco Berardi;
Roberto Perrone

Publication type:

Article

The Activity of the Lipophilic Nucleoside Derivatives Elacytarabine and CP-4126 in a Panel of Tumor Cell Lines Resistant to Nucleoside Analogues.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2010, v. 29, n. 4-6, p. 386, doi. 10.1080/15257771003729625

By:

Sandvold, MaritLiland;
Galmarini, Carlos;
Myhren, Finn;
Peters, Godefridus

Publication type:

Article

Induction of Resistance to the Lipophilic Cytarabine Prodrug Elacytarabine (CP-4055) in CEM Leukemic Cells.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2010, v. 29, n. 4-6, p. 394, doi. 10.1080/15257771003741166

By:

Adema, A.D.;
Losekoot, N.;
Smid, K.;
Kathmann, I.;
Myhren, F.;
Sandvold, M.L.;
Peters, G.J.

Publication type:

Article

New Developments of the "Lock-in" Modified cycloSal-d4TMPs.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2007, v. 26, n. 10-12, p. 1325, doi. 10.1080/15257770701530707

By:

Vukadinović-Tenter, Dalibor;
Balzarini, Jan;
Meier, Chris

Publication type:

Article

Influence of Drug Lipophilicity on Terpenes as Transdermal Penetration Enhancers.

Published in:

Drug Development & Industrial Pharmacy, 1999, v. 25, n. 8, p. 905, doi. 10.1081/DDC-100102251

By:

Godwin, D. A.;
Michniak, B. B.

Publication type:

Article

Leadlikeness and structural diversity of synthetic screening libraries.

Published in:

Plant Foods for Human Nutrition, 2006, v. 61, n. 3, p. 377, doi. 10.1007/s11030-006-9040-6

By:

Verheij, Herman J.

Publication type:

Article

SVM approach for predicting LogP.

Published in:

Plant Foods for Human Nutrition, 2006, v. 61, n. 3, p. 301, doi. 10.1007/s11030-006-9036-2

By:

Quan Liao;
Jianhua Yao;
Shengang Yuan

Publication type:

Article

Artemether and Lumefantrine Loaded Self-nanoemulsifying drug Delivery System for Enhancement of Bioavailability.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2022, v. 56, p. S171, doi. 10.5530/ijper.56.2s.88

By:

Raghavendra Prasad, Rao Monica;
Pardeshi Amol A.

Publication type:

Article

CREATION OF PREDICTIVE MODELS OF AQUATIC TOXICITY OF ENVIRONMENTAL POLLUTANTS WITH DIFFERENT MECHANISMS OF ACTION ON THE BASIS OF MOLECULAR SIMILARITY AND HYBOT DESCRIPTORS.

Published in:

SAR & QSAR in Environmental Research, 2004, v. 15, n. 5/6, p. 433, doi. 10.1080/10629360412331297498

By:

Raevsky, O. A.;
Dearden, J. C.

Publication type:

Article

Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.

Published in:

Free Radical Research, 2009, v. 43, n. 4, p. 329, doi. 10.1080/10715760902736283

By:

Wise-Faberowski, Lisa;
Warner, David S.;
Spasojevic, Ivan;
Batinic-Haberle, Ines

Publication type:

Article

氮酮对不同亲脂性中药有效成分的经皮促透作用研究.

Published in:

Journal of Beijing University of Traditional Chinese Medicine, 2016, v. 39, n. 2, p. 155, doi. 10.3969/j.issn.1006-2157.2016.02.014

By:

王景雁;
兰颐;
茹庆国;
王逸飞;
刘艳;
于竞新;
吴清

Publication type:

Article

Novel Cyclopropyl Appended 1,3‐Thiazole‐2‐Imines as Multi‐Target Agents: Design, Synthesis, Biological Evaluation and Computational Studies.

Published in:

Asian Journal of Organic Chemistry, 2025, v. 14, n. 2, p. 1, doi. 10.1002/ajoc.202400598

By:

Zaman, Hina;
Saeed, Aamer;
ul Muntaha, Tamknat;
Ismail, Hammad;
Rashid, Muhammad

Publication type:

Article

Influence of the application area on finite dose permeation in relation to drug type applied.

Published in:

Experimental Dermatology, 2012, v. 21, n. 3, p. 233, doi. 10.1111/j.1600-0625.2011.01424.x

By:

Hahn, Tsambika;
Selzer, Dominik;
Neumann, Dirk;
Kostka, Karl-Heinz;
Lehr, Claus-Michael;
Schaefer, Ulrich F.

Publication type:

Article

Lipophilization of β-lactoglobulin: Effect on Hydrophobicity, Conformation and Surface Functional Properties.

Published in:

Journal of Food Science (Wiley-Blackwell), 1990, v. 55, n. 3, p. 711, doi. 10.1111/j.1365-2621.1990.tb05213.x

By:

AKITA, E. M.;
NAKAI, S.

Publication type:

Article

Lipophilization of β-lactoglobulin: Effect on allergenicity and digestibility.

Published in:

Journal of Food Science (Wiley-Blackwell), 1990, v. 55, n. 3, p. 718, doi. 10.1111/j.1365-2621.1990.tb05214.x

By:

AKITA, E. M.;
NAKAI, S.

Publication type:

Article

In Vitro Dissolution Enhancement of Felodipine.

Published in:

Indo Global Journal of Pharmaceutical Sciences, 2011, v. 1, n. 2, p. 194, doi. 10.35652/igjps.2011.19

By:

Patel, V. P.;
Gohel, M. C.;
Parikh, R. K.

Publication type:

Article

Reversed-phase thin-layer chromatography behavior of aldopentose derivatives.

Published in:

Chemical Industry / Hemijska Industrija, 2012, v. 66, n. 3, p. 365, doi. 10.2298/HEMIND111012099L

By:

Livaja-Popović, Dragana J.;
Lončar, Eva S.;
Jevrić, Lidija R.;
MalbaŠa, Radomir V.

Publication type:

Article

Augmented reduction of islet β-cell mass in Goto-Kakizaki rats fed high-fat diet and its suppression by pitavastatin treatment.

Published in:

Journal of Diabetes Investigation, 2012, v. 3, n. 3, p. 235, doi. 10.1111/j.2040-1124.2011.00173.x

By:

Mizukami, Hiroki;
Inaba, Wataru;
Takahashi, Kazunori;
Inoue, Keisuke;
Sawanobori, Kimio;
Yagihashi, Soroku

Publication type:

Article

A New Multi-Phase Feature Selection Framework for The Prediction of Breast Cancer Drug Using Machine Learning Techniques.

Published in:

Journal of Algebraic Statistics, 2022, v. 13, n. 2, p. 300

By:

Shobana, G.;
Priya, N.

Publication type:

Article

Iodinated curcumin bearing dermal cream augmented drug delivery, antimicrobial and antioxidant activities.

Published in:

Journal of Microencapsulation, 2018, v. 35, n. 1, p. 49, doi. 10.1080/02652048.2018.1425749

By:

Manchanda, Gagandeep;
Sodhi, Rupinder Kaur;
Jain, Upendra Kumar;
Chandra, Ramesh;
Madan, Jitender

Publication type:

Article

Encapsulation of low lipophilic and slightly water-soluble dihydroartemisinin in PLGA nanoparticles with phospholipid to enhance encapsulation efficiency and in vitro bioactivity.

Published in:

Journal of Microencapsulation, 2016, v. 33, n. 1, p. 43, doi. 10.3109/02652048.2015.1114042

By:

Wang, Lu;
Wang, Yafang;
Wang, Xueqing;
Sun, Lin;
Zhou, Zhengzheng;
Lu, Jinjian;
Zheng, Ying

Publication type:

Article

The transport effect of submicron emulsions on 5-flurouracil topical application.

Published in:

Journal of Microencapsulation, 2013, v. 30, n. 5, p. 425, doi. 10.3109/02652048.2012.746748

By:

Huang, Yaw-Bin;
Huang, Chi-Te;
Tsou, Hsin-Yeh;
Fu, Li-Tse;
Fu, Yaw-Sya;
Tsai, Yi-Hung;
Wu, Pao-Chu

Publication type:

Article

Effect of vesicle's membrane packing behaviour on skin penetration of model lipophilic drug.

Published in:

Journal of Microencapsulation, 2013, v. 30, n. 3, p. 265, doi. 10.3109/02652048.2012.720723

By:

Aripin, Nurul Fadhilah Kamalul;
Hashim, Rauzah;
Heidelberg, Thorsten;
Kweon, Dong-Keon;
Park, Hyun Jin

Publication type:

Article

A ''drug cocktail'' delivered by microspheres for the local treatment of rat glioblastoma.

Published in:

Journal of Microencapsulation, 2013, v. 30, n. 2, p. 1, doi. 10.3109/02652048.2013.774446

By:

Allhenn, Daniela;
Neumann, Dirk;
Béduneau, Arnaud;
Pellequer, Yann;
Lamprecht, Alf

Publication type:

Article

Microencapsulation of lipid nanoparticles containing lipophilic drug.

Published in:

Journal of Microencapsulation, 2003, v. 20, n. 4, p. 489, doi. 10.1080/0265204031000093032

By:

Lee, K. E.;
Cho, S. H.;
Lee, H. B.;
Jeong, S. Y.;
Yuk, S. H.

Publication type:

Article

A double‑blind randomized control trial to compare the effect of varying doses of intrathecal fentanyl on clinical efficacy and side effects in parturients undergoing cesarean section.

Published in:

Journal of Anaesthesiology Clinical Pharmacology, 2018, v. 34, n. 2, p. 221, doi. 10.4103/joacp.JOACP_271_16

By:

Ali, Muhammad Asghar;
Ismail, Samina;
Sohaib, Muhammad;
Aman, Asiyah

Publication type:

Article

Serum levetiracetam concentrations after transdermal levetiracetam administration, 3 times daily, to healthy cats.

Published in:

Journal of Veterinary Internal Medicine, 2019, v. 33, n. 2, p. 827, doi. 10.1111/jvim.15412

By:

Smith, Casey;
Barnes Heller, Heidi L.;
Reif, Nicole;
Van Hesteren, Matthew;
Reinhart, Jennifer M.

Publication type:

Article