Works about DOUBLE-strand DNA breaks

Results: 2201

Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-01870-x

By:

Semenova, Svetlana A.;
Nammi, Deepthi;
Garrett, Grace B.;
Margolin, Gennady;
Sinclair, Jennifer L.;
Maroofian, Reza;
Caldecott, Keith W.;
Burgess, Harold A.

Publication type:

Article

Spo11: from topoisomerase VI to meiotic recombination initiator.

Published in:

Biochemical Society Transactions, 2025, v. 53, n. 2, p. 383, doi. 10.1042/BST20253019

By:

Harper, Jon A.;
Brown, George G. B.;
Neale, Matthew J.

Publication type:

Article

RNA transcripts serve as a template for double-strand break repair in human cells.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59510-x

By:

Jalan, Manisha;
Brambati, Alessandra;
Shah, Hina;
McDermott, Niamh;
Patel, Juber;
Zhu, Yingjie;
Doymaz, Ahmet;
Wu, Julius;
Anderson, Kyrie S.;
Gazzo, Andrea;
Pareja, Fresia;
Yamaguchi, Takafumi N.;
Vougiouklakis, Theodore;
Ahmed-Seghir, Sana;
Steinberg, Philippa;
Neiman-Golden, Anna;
Azeroglu, Benura;
Gomez-Aguilar, Joan;
da Silva, Edaise M.;
Hussain, Suleman

Publication type:

Article

O <sup>6</sup>-methylguanine DNA methyltransferase (MGMT) expression in U1242 glioblastoma cells enhances in vitro clonogenicity, tumor implantation in vivo , and sensitivity to alisertib-carboplatin combination treatment.

Published in:

Frontiers in Cellular Neuroscience, 2025, p. 1, doi. 10.3389/fncel.2025.1552015

By:

Sak, Müge;
Williams, Brian J.;
Hey, Andrew J.;
Sharma, Mayur;
Schier, Leslie;
Wilson, Megan J.;
Ortega, Mahatma;
Lara, Alyssa I.;
Brentlinger, Mikaela N.;
Lehman, Norman L.

Publication type:

Article

The mechanism accounting for DNA damage strength modulation of p53 dynamical properties.

Published in:

Journal of Bioinformatics & Computational Biology, 2023, v. 21, n. 3, p. 1, doi. 10.1142/S0219720023500117

By:

Ma, Aiqing;
Dai, Xianhua

Publication type:

Article

The Rapid Synthesis of Colibactin Warhead Model Compounds Using New Metal‐Free Photocatalytic Cyclopropanation Reactions Facilitates the Investigation of Biological Mechanisms.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 56, p. 1, doi. 10.1002/chem.202301713

By:

Bosveli, Artemis;
Griboura, Nefeli;
Kampouropoulos, Ioannis;
Kalaitzakis, Dimitris;
Montagnon, Tamsyn;
Vassilikogiannakis, Georgios

Publication type:

Article

Capturing a Pentacyclic Fragment‐Based Library Derived from Perophoramidine: Their Design, Synthesis and Evaluation as Anticancer Compounds by DNA Double‐Strand Breaks (DSB) and PARP‐1 Inhibition.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 63, p. 1, doi. 10.1002/chem.202202405

By:

Guha, Souvik;
Yussif El‐Deeb, Ibrahim;
Yadav, Shalini;
Das, Ranajit;
Dutta Dubey, Kshatresh;
Baruah, Mousumi;
Gremaud, Ludovic;
Sen, Subhabrata

Publication type:

Article

Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells.

Published in:

Biotechnology Letters, 2022, v. 44, n. 1, p. 59, doi. 10.1007/s10529-021-03214-x

By:

Zhu, Xiang-xing;
Pan, Jia-sheng;
Lin, Tao;
Yang, Ye-cheng;
Huang, Qiu-yan;
Yang, Shuai-peng;
Qu, Zi-xiao;
Lin, Zi-sheng;
Wen, Jian-cong;
Yan, Ai-fen;
Feng, Juan;
Liu, Lian;
Zhang, Xiao-li;
Lu, Jia-hong;
Tang, Dong-sheng

Publication type:

Article

Application of the modified cytosine base-editing in the cultured cells of bama minipig.

Published in:

Biotechnology Letters, 2021, v. 43, n. 9, p. 1699, doi. 10.1007/s10529-021-03159-1

By:

Pan, Jia-sheng;
Lin, Zi-sheng;
Wen, Jian-cong;
Guo, Jian-feng;
Wu, Xia-hui;
Liu, Ying-ying;
Lai, Wen-jun;
Liang, Qi-ying;
Xie, Yong-shi;
Chen, Yi-rou;
Chen, Yi-hong;
Yan, Ai-fen;
Feng, Juan;
Liu, Lian;
Gong, Dao-yuan;
Zhu, Xiang-xing;
Lu, Jia-hong;
Tang, Dong-sheng

Publication type:

Article

Sequence modification on demand: search and replace tools for precise gene editing in plants.

Published in:

Transgenic Research, 2021, v. 30, n. 4, p. 353, doi. 10.1007/s11248-021-00253-y

By:

Čermák, Tomáš

Publication type:

Article

Clarifying the regulation of genome editing in Australia: situation for food.

Published in:

Transgenic Research, 2019, v. 28, p. 161, doi. 10.1007/s11248-019-00159-w

By:

Kelly, Lisa

Publication type:

Article

Precision plant breeding using genome editing technologies.

Published in:

Transgenic Research, 2019, v. 28, p. 53, doi. 10.1007/s11248-019-00132-7

By:

Gao, Caixia

Publication type:

Article

Co-Cultivation with Mesenchymal Stem Cells Does Not Affect the Efficiency of DNA Double-Strand Break Repair in Irradiated Human Non-Small Cell Lung Cancer Cells.

Published in:

Bulletin of Experimental Biology & Medicine, 2025, v. 178, n. 4, p. 473, doi. 10.1007/s10517-025-06358-2

By:

Molodtsova, D. V.;
Osipov, A. N.

Publication type:

Article

The Effect of Inactivating Heterozygous Mutation in NBS1 Gene on DNA Damage and Repair Markers and Apoptosis Markers in Mice.

Published in:

Bulletin of Experimental Biology & Medicine, 2023, v. 175, n. 2, p. 234, doi. 10.1007/s10517-023-05841-y

By:

Yurova, M. N.;
Golubev, A. G.;
Aleksakhina, S. N.;
Fedoros, E. I.;
Tumanyan, I. A.;
Otradnova, E. A.;
Soloviev, I. V.;
Sergiev, P. V.;
Imyanitov, E. N.

Publication type:

Article

Increased Yield of Residual γH2AX Foci in p53-Deficient Human Lung Carcinoma Cells Exposed to Subpicosecond Beams of Accelerated Electrons.

Published in:

Bulletin of Experimental Biology & Medicine, 2022, v. 172, n. 6, p. 756, doi. 10.1007/s10517-022-05472-9

By:

Vorobyeva, N. Yu.;
Babayan, N. S.;
Grigoryan, B. A.;
Sargsyan, A. A.;
Khondkaryan, L. G.;
Apresyan, L. S.;
Chigasova, A. K.;
Yashkina, E. I.;
Guryev, D. V.;
Rodneva, S. M.;
Tsishnatti, A. A.;
Fedotov, Yu. A.;
Arutyunyan, R. M.;
Osipov, A. N.

Publication type:

Article

Tightly Focused Femtosecond Laser Radiation Induces DNA Double-Strand Breaks in Human Tumor Cells.

Published in:

Bulletin of Experimental Biology & Medicine, 2022, v. 172, n. 6, p. 743, doi. 10.1007/s10517-022-05469-4

By:

Fedotov, Yu. A.;
Zalessky, A. D.;
Yashkina, E. I.;
Zrilova, Yu. A.;
Osipov, A. N.

Publication type:

Article

Comparative Study of the γH2AX Foci Forming in Human Lung Fibroblasts Incubated in Media Containing Tritium-Labeled Thymidine or Amino Acids.

Published in:

Bulletin of Experimental Biology & Medicine, 2021, v. 172, n. 2, p. 245, doi. 10.1007/s10517-021-05370-6

By:

Rodneva, S. M.;
Osipov, A. A.;
Guryev, D. V.;
Tsishnatti, A. A.;
Fedotov, Y. А.;
Yashkina, E. I.;
Vorobyova, N. Y.;
Maksimov, A. A.;
Kochetkov, O. A.;
Samoylov, A. S.;
Osipov, A. N.

Publication type:

Article

Long-Term Persistence of Increased Number of γH2AX<sup>+</sup> Peripheral Blood Lymphocytes in Monkeys Exposed to Negative Factors of Space Flights: Ionizing Radiation and Simulated Hypogravity.

Published in:

Bulletin of Experimental Biology & Medicine, 2021, v. 172, n. 1, p. 81, doi. 10.1007/s10517-021-05336-8

By:

Blokhinа, T. M.;
Yashkina, E. I.;
Belyaeva, A. G.;
Perevezentsev, A. A.;
Shtemberg, A. S.;
Osipov, A. N.

Publication type:

Article

Behavioral Responses and Immune and Cytogenetic Parameters of Food-Restricted Mice.

Published in:

Bulletin of Experimental Biology & Medicine, 2020, v. 169, n. 2, p. 258, doi. 10.1007/s10517-020-04863-0

By:

Ivanov, A. A.;
Andrianova, I. E.;
Blokhina, T. M.;
Bychkova, T. M.;
Vorob'eva, N. Yu.;
Karaulova, T. A.;
Nikitenko, O. V.;
Parfenova, I. M.;
Sycheva, L. P.;
Yaschkina, E. I.;
Osipov, A. N.

Publication type:

Article

A three-gene cluster in Trichoderma reesei reveals a potential role of dmm2 in DNA repair and cellulase production.

Published in:

Biotechnology for Biofuels & Bioproducts, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13068-022-02132-y

By:

Cai, Wanchuan;
Chen, Yumeng;
Zhang, Lei;
Fang, Xu;
Wang, Wei

Publication type:

Article

Helicases at Work: The Importance of Nucleic Acids Unwinding Under Cold Stress.

Published in:

DNA (2673-8856), 2024, v. 4, n. 4, p. 455, doi. 10.3390/dna4040031

By:

Pavankumar, Theetha L.;
Rai, Navneet;
Pandey, Pramod K.;
Vincent, Nishanth

Publication type:

Article

Exploring the Roles of Different DNA Repair Proteins in Short Inverted Repeat Mediated Genomic Instability: A Pilot Study.

Published in:

DNA (2673-8856), 2024, v. 4, n. 2, p. 141, doi. 10.3390/dna4020008

By:

Mandke, Pooja;
Vasquez, Karen M.

Publication type:

Article

Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers.

Published in:

NPJ Precision Oncology, 2022, v. 6, n. 1, p. 1, doi. 10.1038/s41698-022-00298-0

By:

Alblihy, Adel;
Ali, Reem;
Algethami, Mashael;
Shoqafi, Ahmed;
Toss, Michael S.;
Brownlie, Juliette;
Tatum, Natalie J.;
Hickson, Ian;
Moran, Paloma Ordonez;
Grabowska, Anna;
Jeyapalan, Jennie N.;
Mongan, Nigel P.;
Rakha, Emad A.;
Madhusudan, Srinivasan

Publication type:

Article

The Cohesin Complex and Its Interplay with Non-Coding RNAs.

Published in:

Non-Coding RNA, 2021, v. 7, n. 4, p. 67, doi. 10.3390/ncrna7040067

By:

Kuru-Schors, Merve;
Haemmerle, Monika;
Gutschner, Tony

Publication type:

Article

Bleomycin-treated myoblasts undergo p21-associated cellular senescence and have severely impaired differentiation.

Published in:

GeroScience, 2024, v. 46, n. 2, p. 1843, doi. 10.1007/s11357-023-00929-9

By:

Kamal, Michael;
Joanisse, Sophie;
Parise, Gianni

Publication type:

Article

The anti-tumor effect of trifluridine via induction of aberrant mitosis is unaffected by mutations modulating p53 activity.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02083-3

By:

Wakasa, Takeshi;
Nonaka, Kentaro;
Harada, Akihito;
Ohkawa, Yasuyuki;
Kikutake, Chie;
Suyama, Mikita;
Kobunai, Takashi;
Tsunekuni, Kenta;
Matsuoka, Kazuaki;
Kataoka, Yuki;
Ochiiwa, Hiroaki;
Miyadera, Kazutaka;
Sagara, Takeshi;
Oki, Eiji;
Ohdo, Shigehiro;
Maehara, Yoshihiko;
Iimori, Makoto;
Kitao, Hiroyuki

Publication type:

Article

Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02059-3

By:

Fabbrizi, Maria Rita;
Doggett, Thomas J.;
Hughes, Jonathan R.;
Melia, Emma;
Dufficy, Elizabeth R.;
Hill, Rhianna M.;
Goula, Amalia;
Phoenix, Ben;
Parsons, Jason L.

Publication type:

Article

Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01878-8

By:

Bidany-Mizrahi, Tirza;
Shweiki, Aya;
Maroun, Kian;
Abu-Tair, Lina;
Mali, Bella;
Aqeilan, Rami I.

Publication type:

Article

RMI1 facilitates repair of ionizing radiation–induced DNA damage and maintenance of genomic stability.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01726-1

By:

Fang, Lianying;
Sun, Yuxiao;
Dong, Mingxin;
Yang, Mengmeng;
Hao, Jianxiu;
Li, Jiale;
Zhang, Huanteng;
He, Ningning;
Du, Liqing;
Xu, Chang

Publication type:

Article

Establishing safe high hydrostatic pressure devitalization thresholds for autologous head and neck cancer vaccination and reconstruction.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01671-z

By:

Maletzki, Claudia;
Freiin Grote, Vivica;
Kalle, Friederike;
Kleitke, Thoralf;
Zimpfer, Annette;
Becker, Anne-Sophie;
Bergmann-Ewert, Wendy;
Jonitz-Heincke, Anika;
Bader, Rainer;
Vollmar, Brigitte;
Hackenberg, Stephan;
Scherzad, Agmal;
Mlynski, Robert;
Strüder, Daniel

Publication type:

Article

SOSSB1 and SOSSB2 mutually regulate protein stability through competitive binding of SOSSA.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01619-3

By:

Zhang, Qi;
Hao, Rongjiao;
Chen, Hongxia;
Zhou, Gangqiao

Publication type:

Article

Association between papillary thyroid cancer and XRCC6 gene polymorphisms in the Turkish population.

Published in:

Turkish Journal of Medical Sciences, 2024, v. 54, n. 6, p. 1215, doi. 10.55730/1300-0144.5902

By:

AKGÜN, Egemen;
İÇDUYGU, Fadime MUTLU;
ŞENGÜL, Demet;
ALP, Ebru;
ALKANAT, Mehmet;
ÇEBİ, Ayşegül;
ÖZTÜRK, Tuncer

Publication type:

Article

Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters.

Published in:

Journal of Cosmetic Dermatology, 2024, v. 23, n. 1, p. 308, doi. 10.1111/jocd.15893

By:

Fontbonne, Arnaud;
Teme, Baba;
Abric, Elise;
Lecerf, Guillaume;
Callejon, Sylvie;
Moga, Alain;
Cadars, Benoît;
Giraud, Félix;
Chavagnac‐Bonneville, Marlène;
Ardiet, Nathalie;
Guyoux, Aurélie;
Trompezinski, Sandra

Publication type:

Article

The Activation оf DNА Repair Pathways after Ultra-Short Pulsed Electron Beam Irradiation in Human Cells.

Published in:

National Academy of Sciences of Armenia Reports / Doklady Nacionalnaâ Akademiâ Nauk Armenii, 2022, v. 122, n. 2, p. 161, doi. 10.54503/0321-1339-2022.122.2-161

By:

Manukyan, A. T.

Publication type:

Article

A Transcriptomic Analysis of Tobacco Leaf with the Functional Loss of the Plastid rpoB Operon Caused by TALEN-Mediated Double-Strand Breakage.

Published in:

Plants (2223-7747), 2022, v. 11, n. 21, p. 2860, doi. 10.3390/plants11212860

By:

Liu, Yu-Chang;
Huang, Chih-Hao;
Chang, Ching-Chun

Publication type:

Article

Chemical Composition of Various Nepeta cataria Plant Organs' Methanol Extracts Associated with In Vivo Hepatoprotective and Antigenotoxic Features as well as Molecular Modeling Investigations.

Published in:

Plants (2223-7747), 2022, v. 11, n. 16, p. 2114, doi. 10.3390/plants11162114

By:

Vukić, Milena D.;
Vuković, Nenad L.;
Mladenović, Milan;
Tomašević, Nevena;
Matić, Sanja;
Stanić, Snežana;
Sapienza, Filippo;
Ragno, Rino;
Božović, Mijat;
Kačániová, Miroslava

Publication type:

Article

Transcriptome Profiling Identifies Candidate Genes Contributing to Male and Female Gamete Development in Synthetic Brassica Allohexaploids.

Published in:

Plants (2223-7747), 2022, v. 11, n. 12, p. 1556, doi. 10.3390/plants11121556

By:

Ji, Chengyan;
Tian, Zhaoran;
Liu, Yue;
Shi, Gongyao;
Tian, Baoming;
Chen, Weiwei;
Xie, Zhengqing;
Han, Xingzhou;
Liang, Niannian;
Wei, Fang;
Wei, Xiaochun

Publication type:

Article

A direct role of RNA polymerase III and RNA in DNA homologous recombination.

Published in:

Molecular & Cellular Oncology, 2021, v. 8, n. 4, p. 1, doi. 10.1080/23723556.2021.1935173

By:

Liu, Sijie;
Kong, Daochun

Publication type:

Article

It takes three to the DNA damage response tango.

Published in:

Molecular & Cellular Oncology, 2021, v. 8, n. 2, p. 1, doi. 10.1080/23723556.2021.1881395

By:

Schlam-Babayov, Sapir;
Ziv, Yael;
Shiloh, Yosef

Publication type:

Article

Mapping the breakome reveals tight regulation on oncogenic super-enhancers.

Published in:

Molecular & Cellular Oncology, 2020, v. 7, n. 3, p. 1, doi. 10.1080/23723556.2019.1698933

By:

Oster, Sara;
Aqeilan, Rami I.

Publication type:

Article

Transcription-dependent DNA double-strand breaks and human disease.

Published in:

2020

By:

Cristini, Agnese;
Gromak, Natalia;
Sordet, Olivier

Publication type:

Opinion

Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane.

Published in:

2019

By:

Fontana, Gabriele A.;
Rass, Ulrich

Publication type:

Opinion

Genome instability triggered by the V(D)J recombination by-product.

Published in:

Molecular & Cellular Oncology, 2019, v. 6, n. 4, p. N.PAG, doi. 10.1080/23723556.2019.1610323

By:

Kirkham, Christopher M.;
Boyes, Joan

Publication type:

Article

A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks.

Published in:

Molecular & Cellular Oncology, 2019, v. 6, n. 4, p. N.PAG, doi. 10.1080/23723556.2019.1605820

By:

Bartke, Till;
Groth, Anja

Publication type:

Article

UBQLN4 promotes non-homologous end joining by repressing DNA end-resection.

Published in:

Molecular & Cellular Oncology, 2019, v. 6, n. 2, p. 1, doi. 10.1080/23723556.2019.1575692

By:

Jachimowicz, Ron D.;
Reinhardt, H. Christian

Publication type:

Article

The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase.

Published in:

Molecular & Cellular Oncology, 2018, v. 5, n. 3, p. 1, doi. 10.1080/23723556.2016.1154123

By:

Gelot, Camille;
Guirouilh-Barbat, Josée;
Lopez, Bernard S.

Publication type:

Article

A TAD closer to ATM.

Published in:

2016

By:

Aymard, Francois;
Legube, Gaëlle

Publication type:

Opinion

Ginger modulates Gene Expression of Oxidative stress, Single and Double DNA strand breaks, and Micronucleus induced by variant durations and doses of Monosodium Glutamate in Mice.

Published in:

Alexandria Journal of Veterinary Sciences, 2022, v. 75, n. 2, p. 78, doi. 10.5455/ajvs.17182

By:

Bakier, Marwa;
Hemeda, Shaban A.;
El-Nahas, Abeer F.;
Abd El Naby, Walaa S. H.

Publication type:

Article

Hypoxia‐stimulated ATM activation regulates autophagy‐associated exosome release from cancer‐associated fibroblasts to promote cancer cell invasion.

Published in:

Journal of Extracellular Vesicles, 2021, v. 10, n. 11, p. 1, doi. 10.1002/jev2.12146

By:

Xi, Lei;
Peng, Meixi;
Liu, Shuiqing;
Liu, Yongcan;
Wan, Xueying;
Hou, Yixuan;
Qin, Yilu;
Yang, Liping;
Chen, Shanchun;
Zeng, Huan;
Teng, Yong;
Cui, Xiaojiang;
Liu, Manran

Publication type:

Article

Cyclic di-GMP as an antitoxin regulates bacterial genome stability and antibiotic persistence in biofilms.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.99194

By:

Hebin Liao;
Xiaodan Yan;
Chenyi Wang;
Chun Huang;
Wei Zhang;
Leyi Xiao;
Jun Jiang;
Yongjia Bao;
Tao Huang;
Hanbo Zhang;
Chunming Guo;
Yufeng Zhang;
Yingying Pu

Publication type:

Article