Works matching DE "DOUBLE-strand DNA breaks"

Results: 2239

Refined DNA repair manipulation enables a universal knock-in strategy in mouse embryos.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61696-z

By:

Chen, Hongyu;
Tan, Qingtong;
Li, Li;
Li, Lanxin;
Fu, Jiqiang;
Zhu, Wencheng;
Li, Jie;
Wang, Yining;
Li, Shiyan;
Li, Huimin;
Sun, Yidi;
Sun, Qiang;
Lu, Zongyang;
Liu, Zhen

Publication type:

Article

Knockdown of USF1 and USF2 drives prolonged changes in the gene expression response of M12-5B3 cells to DNA damage.

Published in:

PLoS ONE, 2025, v. 20, n. 7, p. 1, doi. 10.1371/journal.pone.0328438

By:

Bellingham-Johnstun, Kimberly S.;
Metzger, Lisa A.;
Stone, Jennifer L.;
Gerrish, Kevin;
Bushel, Pierre R.;
Sikes, Michael L.

Publication type:

Article

Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-09937-5

By:

He, Jiang;
Lai, Tangmin;
Zhou, Zhiying;
Yang, Haonan;
Lei, Zheng;
Zhou, Liu;
Li, Nan;
He, Yu;
Zeng, Siwei;
Munai, Erha;
Tan, Yuanyuan;
Wang, Miaomiao;
Zhang, Yang;
Zhou, Wei;
Wu, Yongzhong

Publication type:

Article

Molecular mechanism and biological pathway of high-expressed RAD51 in regulating cell adhesion and potentially affecting oral squamous cell carcinoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03085-y

By:

Tang, Yu-Xing;
Pang, Yu-Yan;
Cui, Yan;
Wu, Guo-Jiao;
Huang, Lin-Qing;
Zhou, Chang-Zhan;
Li, Bin;
Li, Qi;
Chi, Bang-Teng;
He, Rong-Quan;
Qin, Di-Yuan;
Li, Jian-Di;
Chen, Gang;
Li, Dong-Ming;
Dang, Yi-Wu

Publication type:

Article

Correction: SUPPRESOR OF GAMMA RESPONSE 1 promotes early onset of endoreplication upon DNA double-strand breaks by inducing CCS52A1 expression in Arabidopsis roots.

Published in:

2025

By:

Wada, Toshiki;
Sakamoto, Ayako N.;
Umeda, Masaaki;
Takahashi, Naoki

Publication type:

Correction Notice

SUPPRESOR OF GAMMA RESPONSE 1 promotes early onset of endoreplication upon DNA double-strand breaks by inducing CCS52A1 expression in Arabidopsis roots.

Published in:

Journal of Plant Research, 2025, v. 138, n. 4, p. 679, doi. 10.1007/s10265-025-01630-y

By:

Wada, Toshiki;
Sakamoto, Ayako N.;
Umeda, Masaaki;
Takahashi, Naoki

Publication type:

Article

Rapamycin reduces DNA damage of in vitro matured oocytes by promoting Rad51-mediated homologous recombination.

Published in:

Reproductive Biology & Endocrinology, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12958-025-01428-6

By:

Yang, Qiyu;
Chen, Ying;
Huang, Jiayu;
Tang, Junying;
Zhu, Lixia;
Li, Jingyu;
Tong, Chao

Publication type:

Article

Pol θ-mediated end-joining uses microhomologies containing mismatches.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61258-3

By:

Li, Yuzhen;
Dang, Ngoc K.;
He, Wei;
Returan, Mark;
Carvajal-Maldonado, Denisse;
Guerin, Adele T.;
Xu, Han;
Liu, Bin;
Wood, Richard D.

Publication type:

Article

A large C-terminal Rad52 segment acts as a chaperone to Form and Stabilize Rad51 Filaments.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60664-x

By:

Ma, Emilie;
Lakhal, Fadma;
Litsardaki, Eleni;
Ruault, Myriam;
Audin, Maxime;
Levrier, Natacha;
Navarro, Emilie;
Garnier, Mickaël;
Maloisel, Laurent;
Depagne, Jordane;
Brocas, Clémentine;
Thureau, Aurelien;
Busso, Didier;
Veaute, Xavier;
Guerois, Raphaël;
Taddei, Angela;
Ochsenbein, Françoise;
Coïc, Eric

Publication type:

Article

A mathematical model for the investigation of combined treatment of radiopharmaceutical therapy and PARP inhibitors.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2025, v. 52, n. 9, p. 3252, doi. 10.1007/s00259-025-07144-y

By:

Ryhiner, Marc;
Song, Yangmeihui;
Hong, Jimin;
Ferreira, Carlos Vinícius Gomes;
Rominger, Axel;
Kossatz, Susanne;
Glatting, Gerhard;
Weber, Wolfgang;
Shi, Kuangyu

Publication type:

Article

Ozone Aggravated the Toxicity of Fine Particulate Matter by Impairing Membrane Stability and Facilitating Particle Internalization.

Published in:

Toxics, 2025, v. 13, n. 6, p. 446, doi. 10.3390/toxics13060446

By:

He, Jing;
Wang, Tong;
Li, Han;
Zhou, Yemian;
Liu, Yun;
Xu, An

Publication type:

Article

Development of an Experimental Platform for Gamma Knife Radiosurgery in Mouse Brains.

Published in:

Radiation Research, 2025, v. 204, n. 1, p. 46, doi. 10.1667/RADE-24-00198.1

By:

Feng, Yueshan;
Yu, Jiaxing;
Xu, Lixin;
Lu, Haohan;
Zhang, Hongyun;
Li, Zhengsong;
Kungulli, Roberta;
Hong, Tao;
Zhang, Mo;
Lu, Jie;
Zhang, Hongqi;
Xiang, Sishi

Publication type:

Article

Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes.

Published in:

PLoS Biology, 2004, v. 2, n. 5, p. 1, doi. 10.1371/journal.pbio.0020110

By:

Costanzo, Vincenzo;
Paull, Tanya;
Gottesman, Max;
Gautier, Jean

Publication type:

Article

Role of Saccharomyces Single-Stranded DNA-Binding Protein RPA in the Strand Invasion Step of Double-Strand Break Repair.

Published in:

PLoS Biology, 2004, v. 2, n. 1, p. 1, doi. 10.1371/journal.pbio.0020021

By:

Wang, Xuan;
Haber, James E

Publication type:

Article

Efficient RNA interference method by feeding in Brachionus plicatilis (Rotifera).

Published in:

Biotechnology Letters, 2024, v. 46, n. 6, p. 961, doi. 10.1007/s10529-024-03524-w

By:

Zhang, Yu;
Kan, Dongqi;
Zhou, Yang;
Lian, Hairong;
Ge, Lingling;
Shen, Jing;
Dai, Zhongqi;
Shi, Yan;
Han, Cui;
Liu, Xiaojie;
Yang, Jiaxin

Publication type:

Article

Novel CRISPR/Cas9-mediated knockout of LIG4 increases efficiency of site-specific integration in Chinese hamster ovary cell line.

Published in:

Biotechnology Letters, 2022, v. 44, n. 9, p. 1063, doi. 10.1007/s10529-022-03282-7

By:

Wang, Chuanjie;
Sun, Zhaolin;
Wang, Ming;
Jiang, Zhiyang;
Zhang, Mengmeng;
Cao, Hongxu;
Luo, Longlong;
Qiao, Chunxia;
Xiao, He;
Chen, Guojiang;
Li, Xinying;
Liu, Jinqing;
Wei, Zeliang;
Shen, Beifen;
Wang, Jing;
Feng, Jiannan

Publication type:

Article

Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells.

Published in:

Biotechnology Letters, 2022, v. 44, n. 1, p. 59, doi. 10.1007/s10529-021-03214-x

By:

Zhu, Xiang-xing;
Pan, Jia-sheng;
Lin, Tao;
Yang, Ye-cheng;
Huang, Qiu-yan;
Yang, Shuai-peng;
Qu, Zi-xiao;
Lin, Zi-sheng;
Wen, Jian-cong;
Yan, Ai-fen;
Feng, Juan;
Liu, Lian;
Zhang, Xiao-li;
Lu, Jia-hong;
Tang, Dong-sheng

Publication type:

Article

Application of the modified cytosine base-editing in the cultured cells of bama minipig.

Published in:

Biotechnology Letters, 2021, v. 43, n. 9, p. 1699, doi. 10.1007/s10529-021-03159-1

By:

Pan, Jia-sheng;
Lin, Zi-sheng;
Wen, Jian-cong;
Guo, Jian-feng;
Wu, Xia-hui;
Liu, Ying-ying;
Lai, Wen-jun;
Liang, Qi-ying;
Xie, Yong-shi;
Chen, Yi-rou;
Chen, Yi-hong;
Yan, Ai-fen;
Feng, Juan;
Liu, Lian;
Gong, Dao-yuan;
Zhu, Xiang-xing;
Lu, Jia-hong;
Tang, Dong-sheng

Publication type:

Article

Rad1 attenuates DNA double-strand breaks and cell cycle arrest in type II alveolar epithelial cells of rats with bronchopulmonary dysplasia.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00660-3

By:

Tong, Xin;
Li, Danni;
Liu, Na;
Huang, Wanjie;
Zhao, Xinyi;
Zhang, Dan;
Xue, Xindong;
Fu, Jianhua

Publication type:

Article

Image Analysis Using Imaris 10.1 Machine Learning to Quantitate γH2AX Foci in U87 Cells.

Published in:

Microscopy & Microanalysis, 2024, v. 30, p. 1, doi. 10.1093/mam/ozae044.201

By:

Planck, Emma;
Teoli, Dominic;
Yasui, Linda

Publication type:

Article

Off-target effects of base editors: what we know and how we can reduce it.

Published in:

Current Genetics, 2022, v. 68, n. 1, p. 39, doi. 10.1007/s00294-021-01211-1

By:

Slesarenko, Yana S.;
Lavrov, Alexander V.;
Smirnikhina, Svetlana A.

Publication type:

Article

Homology length dictates the requirement for Rad51 and Rad52 in gene targeting in the Basidiomycota yeast Naganishia liquefaciens.

Published in:

Current Genetics, 2021, v. 67, n. 6, p. 919, doi. 10.1007/s00294-021-01201-3

By:

Palihati, Maierdan;
Tsubouchi, Hideo;
Argunhan, Bilge;
Kajitani, Rei;
Bakenova, Omirgul;
Han, Yong-Woon;
Murayama, Yasuto;
Itoh, Takehiko;
Iwasaki, Hiroshi

Publication type:

Article

Mutagenicity in haploid yeast meiosis resulting from repair of DSBs by the sister chromatid.

Published in:

Current Genetics, 2021, v. 67, n. 5, p. 799, doi. 10.1007/s00294-021-01189-w

By:

Simchen, Giora;
Mansour, Osama;
Morciano, Liat;
Zenvirth, Drora;
Arbel-Eden, Ayelet

Publication type:

Article

Single-strand template repair: key insights to increase the efficiency of gene editing.

Published in:

Current Genetics, 2021, v. 67, n. 5, p. 747, doi. 10.1007/s00294-021-01186-z

By:

Gallagher, Danielle N.;
Haber, James E.

Publication type:

Article

How do small chromosomes know they are small? Maximizing meiotic break formation on the shortest yeast chromosomes.

Published in:

Current Genetics, 2021, v. 67, n. 3, p. 431, doi. 10.1007/s00294-021-01160-9

By:

Murakami, Hajime;
Mu, Xiaojing;
Keeney, Scott

Publication type:

Article

Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis.

Published in:

Current Genetics, 2021, v. 67, n. 3, p. 389, doi. 10.1007/s00294-020-01151-2

By:

Woo, Tai-Ting;
Chuang, Chi-Ning;
Wang, Ting-Fang

Publication type:

Article

Single-molecule fluorescence microscopy reveals modulation of DNA polymerase IV-binding lifetimes by UmuD (K97A) and UmuD′.

Published in:

Current Genetics, 2021, v. 67, n. 2, p. 295, doi. 10.1007/s00294-020-01134-3

By:

Henrikus, Sarah S.;
van Oijen, Antoine M.;
Robinson, Andrew

Publication type:

Article

Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescue.

Published in:

Current Genetics, 2020, v. 66, n. 6, p. 1085, doi. 10.1007/s00294-020-01106-7

By:

Appanah, Rowin;
Jones, David;
Falquet, Benoît;
Rass, Ulrich

Publication type:

Article

Emerging non-canonical roles for the Rad51–Rad52 interaction in response to double-strand breaks in yeast.

Published in:

Current Genetics, 2020, v. 66, n. 5, p. 917, doi. 10.1007/s00294-020-01081-z

By:

Ngo, Katrina;
Epum, Esther A.;
Friedman, Katherine L.

Publication type:

Article

Activation of ATR-related protein kinase upon DNA damage recognition.

Published in:

Current Genetics, 2020, v. 66, n. 2, p. 327, doi. 10.1007/s00294-019-01039-w

By:

Ma, Minh;
Rodriguez, Anibian;
Sugimoto, Katsunori

Publication type:

Article

Rejuvenation of ribosomal RNA gene repeats at the nuclear pore.

Published in:

Current Genetics, 2020, v. 66, n. 1, p. 7, doi. 10.1007/s00294-019-01024-3

By:

Horigome, Chihiro;
Kobayashi, Takehiko

Publication type:

Article

Double-strand breaks in motion: implications for chromosomal rearrangement.

Published in:

Current Genetics, 2020, v. 66, n. 1, p. 1, doi. 10.1007/s00294-019-01015-4

By:

Wilson, Thomas E.;
Sunder, Sham

Publication type:

Article

The functional complexity of the RNA-binding protein Yra1: mRNA biogenesis, genome stability and DSB repair.

Published in:

Current Genetics, 2020, v. 66, n. 1, p. 63, doi. 10.1007/s00294-019-01011-8

By:

Infantino, Valentina;
Stutz, Françoise

Publication type:

Article

Moving forward one step back at a time: reversibility during homologous recombination.

Published in:

Current Genetics, 2019, v. 65, n. 6, p. 1333, doi. 10.1007/s00294-019-00995-7

By:

Piazza, Aurèle;
Heyer, Wolf-Dietrich

Publication type:

Article

DksA and DNA double-strand break repair.

Published in:

Current Genetics, 2019, v. 65, n. 6, p. 1297, doi. 10.1007/s00294-019-00983-x

By:

Myka, Kamila K.;
Gottesman, Max E.

Publication type:

Article

Keep moving and stay in a good shape to find your homologous recombination partner.

Published in:

Current Genetics, 2019, v. 65, n. 1, p. 29, doi. 10.1007/s00294-018-0873-1

By:

Bordelet, Hélène;
Dubrana, Karine

Publication type:

Article

Trinucleotide repeat instability during double-strand break repair: from mechanisms to gene therapy.

Published in:

Current Genetics, 2019, v. 65, n. 1, p. 17, doi. 10.1007/s00294-018-0865-1

By:

Mosbach, Valentine;
Poggi, Lucie;
Richard, Guy-Franck

Publication type:

Article

Structure-function relationships of the Mre11 protein in the control of DNA end bridging and processing.

Published in:

Current Genetics, 2019, v. 65, n. 1, p. 11, doi. 10.1007/s00294-018-0861-5

By:

Marsella, Antonio;
Cassani, Corinne;
Casari, Erika;
Tisi, Renata;
Longhese, Maria Pia

Publication type:

Article

Chromatin mobility upon DNA damage: state of the art and remaining questions.

Published in:

Current Genetics, 2019, v. 65, n. 1, p. 1, doi. 10.1007/s00294-018-0852-6

By:

Zimmer, Christophe;
Fabre, Emmanuelle

Publication type:

Article

The conserved histone variant H2A.Z illuminates meiotic recombination initiation.

Published in:

Current Genetics, 2018, v. 64, n. 5, p. 1015, doi. 10.1007/s00294-018-0825-9

By:

Yamada, Shintaro;
Kugou, Kazuto;
Ding, Da-Qiao;
Fujita, Yurika;
Hiraoka, Yasushi;
Murakami, Hiroshi;
Ohta, Kunihiro;
Yamada, Takatomi

Publication type:

Article

Chromosome ends as adaptive beginnings: the potential role of dysfunctional telomeres in subtelomeric evolvability.

Published in:

Current Genetics, 2018, v. 64, n. 5, p. 997, doi. 10.1007/s00294-018-0822-z

By:

Mason, Jennifer M. O.;
McEachern, Michael J.

Publication type:

Article

Oxygen and RNA in stress-induced mutation.

Published in:

Current Genetics, 2018, v. 64, n. 4, p. 769, doi. 10.1007/s00294-017-0801-9

By:

Correa, Raul;
Thornton, Philip C.;
Hastings, P. J.;
Rosenberg, Susan M.

Publication type:

Article

Fumarase is involved in DNA double-strand break resection through a functional interaction with Sae2.

Published in:

Current Genetics, 2018, v. 64, n. 3, p. 697, doi. 10.1007/s00294-017-0786-4

By:

Leshets, Michael;
Ramamurthy, Dharanidharan;
Lisby, Michael;
Lehming, Norbert;
Pines, Ophry

Publication type:

Article

Interaction of the <italic>Saccharomyces cerevisiae</italic> RING-domain protein Nse1 with Nse3 and the Smc5/6 complex is required for chromosome replication and stability.

Published in:

Current Genetics, 2018, v. 64, n. 3, p. 599, doi. 10.1007/s00294-017-0776-6

By:

Wani, Saima;
Maharshi, Neelam;
Kothiwal, Deepash;
Mahendrawada, Lakshmi;
Kalaivani, Raju;
Laloraya, Shikha

Publication type:

Article

Modelling Potential Candidates for Targeted Auger Therapy.

Published in:

Biophysica, 2024, v. 4, n. 4, p. 711, doi. 10.3390/biophysica4040046

By:

Buchanan, Conor M. J.;
Aboagye, Eric O.;
Evitts, Lee J.;
Rushton, Michael J. D.;
Smith, Tim A. D.

Publication type:

Article

Dual Nucleosomal Double-Strand Breaks Are the Key Effectors of Curative Radiation Therapy.

Published in:

Biophysica, 2023, v. 3, n. 4, p. 668, doi. 10.3390/biophysica3040045

By:

Brahme, Anders;
Lorat, Yvonne

Publication type:

Article

Understanding oocyte ageing.

Published in:

Minerva Obstetrics & Gynecology, 2024, v. 76, n. 3, p. 284, doi. 10.23736/S2724-606X.24.05343-0

By:

HOMER, Hayden A.

Publication type:

Article

PLECTRANTHUS: FROM TRADITIONAL MEDICINE TO BRAIN TUMOR THERAPY WITH DITERPENES.

Published in:

Journal of Research in Pharmacy, 2023, v. 27, p. 9, doi. 10.29228/jrp.381

By:

María DOMÍNGUEZ-MARTÍN, Eva;
MAGALHÃES, Mariana;
SITAREK, Przemysław;
María DÍAZ-LANZA, Ana;
GÓMEZ, Ana M.;
EFFERTH, Thomas;
CABRAL, Célia;
RIJO, Patricia

Publication type:

Article

PLECTRANTHUS: FROM TRADITIONAL MEDICINE TO BRAIN TUMOR THERAPY WITH DITERPENES.

Published in:

Journal of Research in Pharmacy, 2023, v. 27, p. 9, doi. 10.29228/jrp.381

By:

DOMÍNGUEZ-MARTÍN, Eva María;
MAGALHÃES, Mariana;
SITAREK, Przemysław;
DÍAZ-LANZA, Ana María;
GÓMEZ, Ana M.;
EFFERTH, Thomas;
CABRAL, Célia;
RIJO, Patricia

Publication type:

Article

Condensin II interacts with BLM helicase in S phase to maintain genome stability.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07916-0

By:

Rodemoyer, Brian;
Kariyawasam, Ganesha;
Subramanian, Veena;
Schmidt, Kristina

Publication type:

Article