Works matching DE "DNA topoisomerase inhibitors"

Results: 78

Hypercellular Proinflammatory Microenvironment Inhibits the Etoposide-Induced DNA Damage in Acute Monocytic Leukemia Cells.

Published in:

Biochemistry (00062979), 2025, v. 90, n. 5, p. 553, doi. 10.1134/S000629792560019X

By:

Kobyakova, Margarita I.;
Krasnov, Kirill S.;
Krestinina, Olga V.;
Baburina, Yulia L.;
Senotov, Anatoly S.;
Lomovskaya, Yana V.;
Meshcheriakova, Elena I.;
Lomovsky, Alexey I.;
Zvyagina, Alena I.;
Pyatina, Kira V.;
Fadeeva, Irina S.;
Fadeev, Roman S.

Publication type:

Article

Trex2 responds to damaged replication forks in diverse ways.

Published in:

Molecular & Cellular Oncology, 2021, v. 8, n. 2, p. 1, doi. 10.1080/23723556.2021.1881394

By:

Hasty, Paul

Publication type:

Article

Interference with pathways activated by topoisomerase inhibition alters the surface expression of PD-L1 and MHC I in colon cancer cells.

Published in:

Oncology Letters, 2023, v. 25, n. 1, p. N.PAG

By:

Hassan, Mohamed;
Trung, Vu;
Bedi, Deepa;
Shaddox, Sage;
Gunturu, Dilip;
Yates, Clayton;
Datta, Pran;
Samuel, Temesgen

Publication type:

Article

Resveratrol-3-O-glucuronide and resveratrol-4'-O-glucuronide reduce DNA strand breakage but not apoptosis in Jurkat T cells treated with camptothecin.

Published in:

Oncology Letters, 2017, v. 14, n. 2, p. 2517, doi. 10.3892/ol.2017.6392

By:

ZUNINO, SUSAN J.;
STORMS, DAVID H.

Publication type:

Article

Evaluation by quantitative image analysis of anticancer drug activity on multicellular spheroids grown in 3D matrices.

Published in:

Oncology Letters, 2016, v. 12, n. 6, p. 4371, doi. 10.3892/ol.2016.5221

By:

GOMES, AURÉLIE;
RUSSO, ADRIEN;
VIDAL, GUILLAUME;
DEMANGE, ELISE;
PANNETIER, PAULINE;
SOUGUIR, ZIED;
LAGARDE, JEAN-MICHEL;
DUCOMMUN, BERNARD;
LOBJOIS, VALÉRIE

Publication type:

Article

The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53.

Published in:

Oncogene, 2015, v. 34, n. 25, p. 3336, doi. 10.1038/onc.2014.266

By:

Thomas, A;
Perry, T;
Berhane, S;
Oldreive, C;
Zlatanou, A;
Williams, L R;
Weston, V J;
Stankovic, T;
Kearns, P;
Pors, K;
Grand, R J;
Stewart, G S

Publication type:

Article

Secondary ALL after Successful Treatment of Ewing's Sarcoma: A Case Report.

Published in:

International Journal of Hematology-Oncology & Stem Cell Research, 2016, v. 10, n. 4, p. 236

By:

Pour, Kourosh Goudarzi;
Alavi, Samin;
Shamsian, Shahin;
Aghakhani, Roxana;
Arzanian, Mohammad Taghi;
Tavassol, Hesameddin Hoseini;
Eydian, Zahra;
Kazemi, Reyhaneh

Publication type:

Article

Flexible Approach to (5 Z,9 Z)-Dienoic Fatty Acids Relevant to the Synthesis of Demospongic Acids and Related Natural Products.

Published in:

European Journal of Organic Chemistry, 2016, v. 2016, n. 27, p. 4607, doi. 10.1002/ejoc.201600746

By:

Adrian, Juliane;
Stark, Christian B. W.

Publication type:

Article

Low Doses of Camptothecin Induced Hormetic and Neuroprotective Effects in PC12 Cells.

Published in:

Dose-Response, 2015, v. 13, n. 2, p. 1, doi. 10.1177/1559325815592606

By:

Chao Zhang;
Shenghui Chen;
Jiaolin Bao;
Yulin Zhang;
Borong Huang;
Xuejing Jia;
Meiwan Chen;
Jian-Bo Wan;
Huanxing Su;
Yitao Wang;
Chengwei He

Publication type:

Article

Targeting Metabolic and Epigenetic Vulnerabilities in Glioblastoma with SN-38 and Rabusertib Combination Therapy.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 2, p. 474, doi. 10.3390/ijms26020474

By:

Chiou, Jennifer;
Impedovo, Valeria;
Huynh, Yen Bao;
Gorgoglione, Ruggiero;
Penalva, Luiz O. F.;
Lodi, Alessia;
Brenner, Andrew J.;
Tiziani, Stefano

Publication type:

Article

Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior.

Published in:

Chemistry - A European Journal, 2016, v. 22, n. 48, p. 17269, doi. 10.1002/chem.201603206

By:

Hackl, Carmen M.;
Legina, Maria S.;
Pichler, Verena;
Schmidlehner, Melanie;
Roller, Alexander;
Dömötör, Orsolya;
Enyedy, Eva A.;
Jakupec, Michael A.;
Kandioller, Wolfgang;
Keppler, Bernhard K.

Publication type:

Article

Mechanisms of Secondary Leukemia Development Caused by Treatment with DNA Topoisomerase Inhibitors.

Published in:

Biochemistry (00062979), 2023, v. 88, n. 7, p. 892, doi. 10.1134/S0006297923070040

By:

Lomov, Nikolai A.;
Viushkov, Vladimir S.;
Rubtsov, Mikhail A.

Publication type:

Article

Nostocine A Derivatives as Human DNA Topoisomerase II-alpha Inhibitor.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2020, v. 54, n. 3, p. 698, doi. 10.5530/ijper.54.3.120

By:

Sahoo, Chita Ranjan;
Paidesetty, Sudhir Kumar;
Padhy, Rabindra Nath

Publication type:

Article

DNA binding, photocleavage behavior, and topoisomerase I inhibitory activity of Ru(II) complexes incorporating an asymmetric phenazine-type ligand.

Published in:

Journal of Coordination Chemistry, 2015, v. 68, n. 16, p. 2886, doi. 10.1080/00958972.2015.1057132

By:

Liu, Xue-Wen;
Shu, Jun-Shi;
Xiao, Yang;
Shen, You-Ming;
Zhang, Song-Bai;
Lu, Ji-Lin

Publication type:

Article

Seconeolitsine, the Novel Inhibitor of DNA Topoisomerase I, Protects against Invasive Pneumococcal Disease Caused by Fluoroquinolone-Resistant Strains.

Published in:

Antibiotics (2079-6382), 2021, v. 10, n. 5, p. 573, doi. 10.3390/antibiotics10050573

By:

Tirado-Vélez, Jose Manuel;
Carreño, David;
Sevillano, David;
Alou, Luis;
Yuste, José;
de la Campa, Adela G.;
Simal-Gandara, Jesus

Publication type:

Article

Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan.

Published in:

Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00147

By:

Abu-Sanad, Atlal;
Yunzhe Wang;
Hasheminasab, Fatemeh;
Panasci, Justin;
Noë, Alycia;
Rosca, Lorena;
Davidson, David;
Amrein, Lilian;
Sharif-Askari, Bahram;
Aloyz, Raquel;
Panasci, Lawrence;
Boidot, Romain;
Gazzerro, Patrizia

Publication type:

Article

FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks.

Published in:

Carcinogenesis, 2016, v. 37, n. 1, p. 56, doi. 10.1093/carcin/bgv159

By:

Yukiko Kametani;
Chiaki Takahata;
Takashi Narita;
Kiyoji Tanaka;
Shigenori Iwai;
Isao Kuraoka

Publication type:

Article

Design and in silico Prediction of New Methylenedioxyphenyl Derivatives as DNA Topoisomerase II Inhibitors.

Published in:

International Journal of Pharmaceutical Investigation, 2023, v. 13, n. 3, p. 548, doi. 10.5530/ijpi.13.3.068

By:

Rathore, Swati;
Reddemma, Maadhu;
Rai, Neha;
Tiwari, Richa Tripathy;
Begum, Shaheen;
Patil, Shailendra;
Patil, Asmita Gajbhiye

Publication type:

Article

The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells.

Published in:

PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0132052

By:

Wu, Chun-Chi;
Huang, Keh-Feng;
Yang, Tsung-Ying;
Li, Ya-Ling;
Wen, Chi-Luan;
Hsu, Shih-Lan;
Chen, Tzu-Hsiu

Publication type:

Article

Discovery of 7-Methyl-10-Hydroxyhomocamptothecins with 1,2,3-Triazole Moiety as Potent Topoisomerase I Inhibitors.

Published in:

Chemical Biology & Drug Design, 2016, v. 88, n. 3, p. 398, doi. 10.1111/cbdd.12767

By:

Xu, Xiguo;
Wu, Yuelin;
Liu, Wenfeng;
Sheng, Chuanquan;
Yao, Jianzhong;
Dong, Guoqiang;
Fang, Kun;
Li, Jin;
Yu, Zhiliang;
Min, Xiao;
Zhang, Huojun;
Miao, Zhenyuan;
Zhang, Wannian

Publication type:

Article

Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors.

Published in:

BMC Cancer, 2016, v. 16, p. 1, doi. 10.1186/s12885-016-2925-6

By:

Pawlak, Alicja;
Ziolo, Ewa;
Fiedorowicz, Anna;
Fidyt, Klaudyna;
Strzadala, Leon;
Kalas, Wojciech

Publication type:

Article

Effect of cell treatment procedures on in vitro genotoxicity assessment.

Published in:

Archives of Toxicology, 2024, v. 98, n. 4, p. 1225, doi. 10.1007/s00204-024-03690-w

By:

Recoules, Cynthia;
Mirey, Gladys;
Audebert, Marc

Publication type:

Article

MOLECULAR DOCKING STUDIES ON SOME BENZAMIDE DERIVATIVES AS TOPOISOMERASE INHIBITORS.

Published in:

Journal of Faculty of Pharmacy of Ankara University / Ankara Üniversitesi Eczacilik Fakültesi Dergisi, 2020, v. 44, n. 3, p. 470, doi. 10.33483/jfpau.789537

By:

YILMAZ, Serap;
ATAEI, Sanaz;
YILDIZ, İlkay

Publication type:

Article

DB-1310, a HER3-targeting antibody-drug conjugate, has synergistic anti-tumor activity with trastuzumab in HER2- and HER3-expressing breast cancer.

Published in:

Cancer Biology & Medicine, 2025, v. 22, n. 3, p. 231, doi. 10.20892/j.issn.2095-3941.2024.0586

By:

Xi Li;
Liwen Liang;
Zhongyuan Zhu;
Haiqing Hua;
Yang Qiu

Publication type:

Article

Synergistic anticancer effect of panobinostat and topoisomerase inhibitors through ROS generation and intrinsic apoptotic pathway induction in cervical cancer cells.

Published in:

Cellular Oncology (2211-3428), 2018, v. 41, n. 2, p. 201, doi. 10.1007/s13402-017-0366-0

By:

Wasim, Lubna;
Chopra, Madhu

Publication type:

Article

Suppressive effect of topoisomerase inhibitors on JC polyomavirus propagation in human neuroblastoma cells.

Published in:

Microbiology & Immunology, 2016, v. 60, n. 4, p. 253, doi. 10.1111/1348-0421.12372

By:

Nukuzuma, Souichi;
Nakamichi, Kazuo;
Kameoka, Masanori;
Sugiura, Shigeki;
Nukuzuma, Chiyoko;
Tasaki, Takafumi;
Takegami, Tsutomu

Publication type:

Article

Overexpression of TIMP-1 and Sensitivity to Topoisomerase Inhibitors in Glioblastoma Cell Lines.

Published in:

Pathology & Oncology Research, 2019, v. 25, n. 1, p. 59, doi. 10.1007/s12253-017-0312-5

By:

Aaberg-Jessen, Charlotte;
Fogh, Louise;
Sørensen, Mia Dahl;
Halle, Bo;
Brünner, Nils;
Kristensen, Bjarne Winther

Publication type:

Article

Phase Ib study of irinotecan and ramucirumab for advanced gastric cancer previously treated with fluoropyrimidine with/without platinum and taxane.

Published in:

2018

By:

Satake, Hironaga;
Sagawa, Tamotsu;
Fujikawa, Koshi;
Hatachi, Yukimasa;
Yasui, Hisateru;
Kotaka, Masahito;
Kato, Takeshi;
Tsuji, Akihito

Publication type:

journal article

Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors.

Published in:

2018

By:

Sy, Sherwin K. B.;
Chia, Yen Lin;
Gordi, Toufigh;
Hoch, Ute;
Eldon, Michael A.

Publication type:

journal article

Randomized study of etirinotecan pegol versus irinotecan as second-line treatment for metastatic colorectal cancer.

Published in:

2017

By:

Lenz, Heinz-Josef;
Philip, Philip;
Saunders, Mark;
Kolevska, Tatjana;
Mukherjee, Kalyan;
Samuel, Leslie;
Bondarde, Shailesh;
Dobbs, Tracy;
Tagliaferri, Mary;
Hoch, Ute;
Hannah, Alison;
Berkowitz, Maurice;
Hannah, Alison L

Publication type:

journal article

Plasma pharmacokinetics of the indenoisoquinoline topoisomerase I inhibitor, NSC 743400, in rats and dogs.

Published in:

Cancer Chemotherapy & Pharmacology, 2015, v. 75, n. 5, p. 1015, doi. 10.1007/s00280-015-2722-y

By:

Muzzio, Miguel;
Hu, Shu-Chieh;
Holleran, Julianne;
Parise, Robert;
Eiseman, Julie;
Yellow-Duke, Archibong;
Covey, Joseph;
Glaze, Elizabeth;
Engelke, Kory;
Egorin, Merrill;
McCormick, David;
Beumer, Jan

Publication type:

Article

Triggering of Suicidal Erythrocyte Death by Topotecan.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2015, v. 37, n. 4, p. 1607, doi. 10.1159/000438527

By:

Bissinger, Rosi;
Bouguerra, Ghada;
Stockinger, Katja;
abbès, Salem;
Lang, Florian

Publication type:

Article

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2171029

By:

Farouk, Faten;
Elmaaty, Ayman Abo;
Elkamhawy, Ahmed;
Tawfik, Haytham O.;
Alnajjar, Radwan;
Abourehab, Mohammed A. S.;
Saleh, Mohamed A.;
Eldehna, Wagdy M.;
Al‐Karmalawy, Ahmed A.

Publication type:

Article

Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2022.2157825

By:

El-Behairy, Mohammed Farrag;
Abd-Allah, Walaa Hamada;
Khalifa, Mohamed M.;
Nafie, Mohamed S.;
Saleh, Mohamed A.;
Abdel-Maksoud, Mohammed S.;
Al-Warhi, Tarfah;
Eldehna, Wagdy M.;
Al‐Karmalawy, Ahmed A.

Publication type:

Article

Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 192, doi. 10.1080/14756366.2022.2140420

By:

Kaproń, Barbara;
Płazińska, Anita;
Płaziński, Wojciech;
Plech, Tomasz

Publication type:

Article

From Antarctica to cancer research: a novel human DNA topoisomerase IB inhibitor from Antarctic sponge Dendrilla antarctica.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1404, doi. 10.1080/14756366.2022.2078320

By:

Ottaviani, Alessio;
Welsch, Joshua;
Agama, Keli;
Pommier, Yves;
Desideri, Alessandro;
Baker, Bill J.;
Fiorani, Paola

Publication type:

Article

Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo.

Published in:

Scientific Reports, 2015, p. 12082, doi. 10.1038/srep12082

By:

Jain, Chetan Kumar;
Pradhan, Bhola Shankar;
Majumder, Subeer S.;
Banerjee, Sukdeb;
Mondal, Nirup Bikash;
Bhattacharyya, Madhumita;
Chakrabarti, Saikat;
Roychoudhury, Susanta;
Majumder, Hemanta Kumar

Publication type:

Article

L-4. Cell model of inducible AML1-ETO translocation.

Published in:

Biopolymers & Cell, 2019, v. 35, n. 3, p. 223, doi. 10.7124/bc.0009ED

By:

Lomov, Nikolai A.;
Viushkov, Vladimir S.;
Rubtsov, Mikhail A.

Publication type:

Article

Phase II pilot study of single-agent etirinotecan pegol (NKTR-102) in bevacizumab-resistant high grade glioma.

Published in:

Journal of Neuro-Oncology, 2015, v. 123, n. 2, p. 277, doi. 10.1007/s11060-015-1795-0

By:

Nagpal, Seema;
Recht, Cathy;
Bertrand, Sophie;
Thomas, Reena;
Ajlan, Abdulrazag;
Pena, Justine;
Gershon, Megan;
Coffey, Gwen;
Kunz, Pamela;
Li, Gordon;
Recht, Lawrence

Publication type:

Article

Sacituzumab govitecan -- a new therapy for patients with triple-negative breast cancer.

Published in:

Oncology in Clinical Practice (2450-1654), 2023, v. 19, n. 1, p. 43, doi. 10.5603/OCP.2022.0003

By:

Pogoda, Katarzyna;
Jagiełło-Gruszfeld, Agnieszka;
Niwińska, Anna;
Nowecki, Zbigniew

Publication type:

Article

Modern Trends in Bio-Organometallic Ferrocene Chemistry.

Published in:

Inorganics, 2022, v. 10, n. 12, p. 226, doi. 10.3390/inorganics10120226

By:

Snegur, Lubov V.

Publication type:

Article

Absolute configuration by vibrational circular dichroism of anti-inflammatory macrolide briarane diterpenoids from the Gorgonian Briareum asbestinum.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-020-79774-1

By:

Pech-Puch, Dawrin;
Joseph-Nathan, Pedro;
Burgueño-Tapia, Eleuterio;
González-Salas, Carlos;
Martínez-Matamoros, Diana;
Pereira, David M.;
Pereira, Renato B.;
Jiménez, Carlos;
Rodríguez, Jaime

Publication type:

Article

Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors.

Published in:

Journal of Hematology & Oncology, 2016, v. 9, p. 1, doi. 10.1186/s13045-016-0304-z

By:

Turner, Joel G.;
Dawson, Jana L.;
Grant, Steven;
Shain, Kenneth H.;
Dalton, William S.;
Yun Dai;
Meads, Mark;
Baz, Rachid;
Kauffman, Michael;
Shacham, Sharon;
Sullivan, Daniel M.

Publication type:

Article

cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.

Published in:

2019

By:

Zining Wang;
Jiemin Chen;
Jie Hu;
Hongxia Zhang;
Feifei Xu;
Wenzhuo He;
Xiaojuan Wang;
Mengyun Li;
Wenhua Lu;
Gucheng Zeng;
Penghui Zhou;
Peng Huang;
Siyu Chen;
Wende Li;
Liang-ping Xia;
Xiaojun Xia;
Wang, Zining;
Chen, Jiemin;
Hu, Jie;
Zhang, Hongxia

Publication type:

journal article

MSN8C: A Promising Candidate for Antitumor Applications as a Novel Catalytic Inhibitor of Topoisomerase II.

Published in:

Molecules, 2023, v. 28, n. 14, p. 5598, doi. 10.3390/molecules28145598

By:

Ou, Jie-Bin;
Huang, Wei-Hao;
Liu, Xing-Zi;
Dai, Guo-Yao;
Wang, Lu;
Huang, Zhi-Shu;
Huang, Shi-Liang

Publication type:

Article

New Potential Pharmacological Targets of Plant-Derived Hydroxyanthraquinones from Rubia spp.

Published in:

Molecules, 2022, v. 27, n. 10, p. 3274, doi. 10.3390/molecules27103274

By:

Alov, Petko;
Al Sharif, Merilin;
Najdenski, Hristo;
Pencheva, Tania;
Tsakovska, Ivanka;
Zaharieva, Maya Margaritova;
Pajeva, Ilza

Publication type:

Article

Design, Synthesis and Cytotoxicity of Thiazole-Based Stilbene Analogs as Novel DNA Topoisomerase IB Inhibitors.

Published in:

Molecules, 2022, v. 27, n. 3, p. 1009, doi. 10.3390/molecules27031009

By:

Liu, Jin-Chuan;
Chen, Bo;
Yang, Jia-Lin;
Weng, Jian-Quan;
Yu, Qian;
Hu, De-Xuan

Publication type:

Article

MHY440, a Novel Topoisomerase Ι Inhibitor, Induces Cell Cycle Arrest and Apoptosis via a ROS-Dependent DNA Damage Signaling Pathway in AGS Human Gastric Cancer Cells.

Published in:

Molecules, 2019, v. 24, n. 1, p. 96, doi. 10.3390/molecules24010096

By:

Jang, Jung Yoon;
Kang, Yong Jung;
Sung, Bokyung;
Kim, Min Jeong;
Park, Chaeun;
Kang, Dongwan;
Moon, Hyung Ryong;
Chung, Hae Young;
Kim, Nam Deuk;
Tuccinardi, Tiziano

Publication type:

Article

Molecular Docking studies and in-silico ADMET Screening of Some novel Oxazine substituted 9-Anilinoacridines as Topoisomerase II Inhibitors.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2017, v. 51, n. 1, p. 110, doi. 10.5530/ijper.51.1.15

By:

Kalirajan, Rajagopal;
Sankar, Sundaram;
Jubie, Selvaraj;
Gowramma, Byran

Publication type:

Article

Developing a Phosphospecific IHC Assay as a Predictive Biomarker for Topoisomerase I Inhibitors.

Published in:

Journal of Histochemistry & Cytochemistry, 2018, v. 66, n. 8, p. 549, doi. 10.1369/0022155418766503

By:

Ando, Koji;
Tohme, Yara Hamade;
Srinivasiah, Adithi;
Taylor-Parker, Julian;
Harrington, Yevgeniya;
Shah, Ankur K.;
Oki, Eiji;
Brahmandam, Mohan;
Bharti, Ajit K.

Publication type:

Article